OpenPV Signal Explorer
FAERS disproportionality dashboard
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Drug

Phentermine And Topiramate

133 flagged reaction(s) · 6,467 total co-reports · max PRR 18.1
Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.
Reaction Co-reports (a) PRR ROR Signal
1 Hunger 67 18.1 18.3 signal
2 Pregnancy 81 14.6 14.8 signal
3 Dry Mouth 273 12.2 12.8 signal
4 Feeling Jittery 63 12.0 12.1 signal
5 Brain Fog 44 11.0 11.0 signal
6 Thyroid Disorder 45 10.6 10.7 signal
7 Taste Disorder 55 10.0 10.1 signal
8 Incorrect Product Administration Duration 46 8.2 8.3 signal
9 Increased Appetite 39 7.5 7.6 signal
10 Paraesthesia 323 7.4 7.8 signal
11 Thirst 36 7.3 7.4 signal
12 Dysgeusia 125 6.1 6.2 signal
13 Ocular Discomfort 17 5.7 5.7 signal
14 Intraocular Pressure Increased 20 5.6 5.7 signal
15 Hypothyroidism 49 5.6 5.6 signal
16 Mood Altered 41 5.5 5.5 signal
17 Irritability 79 4.8 4.8 signal
18 Palpitations 151 4.7 4.8 signal
19 Disturbance In Attention 69 4.6 4.7 signal
20 Glaucoma 23 4.3 4.3 signal
21 Weight Increased 262 4.3 4.4 signal
22 Adverse Drug Reaction 102 4.1 4.2 signal
23 Seasonal Allergy 16 4.1 4.1 signal
24 Vision Blurred 153 4.1 4.1 signal
25 Inappropriate Schedule Of Product Administration 195 4.0 4.1 signal
26 Nephrolithiasis 49 3.9 3.9 signal
27 Mental Impairment 26 3.9 3.9 signal
28 Hypoaesthesia Oral 16 3.9 3.9 signal
29 Insomnia 277 3.8 3.9 signal
30 Mood Swings 30 3.4 3.4 signal
31 Hypoaesthesia 140 3.4 3.4 signal
32 Constipation 201 3.4 3.5 signal
33 Heart Rate Increased 91 3.3 3.4 signal
34 Feeling Abnormal 218 3.3 3.4 signal
35 Aphasia 27 3.2 3.2 signal
36 Alopecia 174 3.2 3.3 signal
37 Nervousness 46 3.2 3.2 signal
38 Abortion Induced 8 3.1 3.1 signal
39 Vitreous Floaters 8 3.0 3.0 signal
40 Ligament Sprain 8 2.9 2.9 signal
41 Intentional Dose Omission 22 2.9 2.9 signal
42 Thinking Abnormal 15 2.9 2.9 signal
43 Adverse Event 72 2.8 2.9 signal
44 Eye Pain 43 2.8 2.8 signal
45 Euphoric Mood 8 2.8 2.8 signal
46 Weight Fluctuation 8 2.8 2.8 signal
47 Paraesthesia Oral 11 2.8 2.8 signal
48 Adverse Reaction 10 2.7 2.7 signal
49 Laryngitis 8 2.7 2.7 signal
50 Product Dispensing Error 16 2.7 2.7 signal
51 Aphonia 10 2.6 2.6 signal
52 Impaired Driving Ability 8 2.5 2.5 signal
53 Eating Disorder 15 2.5 2.5 signal
54 Memory Impairment 95 2.5 2.5 signal
55 Product Prescribing Error 16 2.4 2.5 signal
56 Depression 153 2.4 2.5 signal
57 Migraine 62 2.4 2.4 signal
58 Anxiety 186 2.4 2.4 signal
59 Illness 65 2.3 2.4 signal
60 Personality Change 6 2.3 2.3 no signal
61 Depressed Mood 33 2.3 2.3 signal
62 Dysmenorrhoea 8 2.2 2.2 signal
63 Poor Quality Sleep 13 2.2 2.2 signal
64 Crying 22 2.2 2.2 signal
65 Drug Intolerance 58 2.2 2.2 signal
66 Sluggishness 6 2.1 2.1 no signal
67 Initial Insomnia 6 2.1 2.1 no signal
68 Eye Discharge 6 2.1 2.1 no signal
69 Hypoacusis 25 2.1 2.1 signal
70 Drug Dispensing Error 9 2.1 2.1 signal
71 Peripheral Coldness 8 2.1 2.1 no signal
72 Headache 362 2.1 2.2 signal
73 Dry Eye 28 2.1 2.1 signal
74 Anger 19 2.0 2.0 signal
75 Blood Cholesterol Increased 26 2.0 2.0 signal
76 Dizziness 262 1.9 1.9 no signal
77 Tinnitus 24 1.9 1.9 no signal
78 Visual Impairment 63 1.9 1.9 no signal
79 Coeliac Disease 5 1.8 1.8 no signal
80 Product Dose Omission Issue 145 1.8 1.9 no signal
81 Oral Discomfort 7 1.8 1.8 no signal
82 Lacrimation Increased 15 1.8 1.8 no signal
83 Diplopia 13 1.8 1.8 no signal
84 Ovarian Cyst 5 1.8 1.8 no signal
85 Gastroenteritis Viral 9 1.8 1.8 no signal
86 Sinusitis 51 1.8 1.8 no signal
87 Blindness 20 1.8 1.8 no signal
88 Covid-19 86 1.8 1.8 no signal
89 Inappropriate Schedule Of Drug Administration 35 1.8 1.8 no signal
90 Psychomotor Hyperactivity 8 1.7 1.7 no signal
91 Aggression 24 1.7 1.7 no signal
92 Mydriasis 6 1.7 1.7 no signal
93 Panic Attack 17 1.7 1.7 no signal
94 Metrorrhagia 8 1.7 1.7 no signal
95 Suicidal Ideation 42 1.7 1.7 no signal
96 Ankle Fracture 7 1.6 1.6 no signal
97 Sinus Congestion 6 1.6 1.6 no signal
98 Psychotic Disorder 13 1.6 1.6 no signal
99 Cholecystectomy 5 1.6 1.6 no signal
100 Ageusia 11 1.6 1.6 no signal
101 Sensory Disturbance 7 1.6 1.6 no signal
102 Accident 5 1.5 1.5 no signal
103 Affect Lability 4 1.5 1.5 no signal
104 Thyroid Cancer 5 1.5 1.5 no signal
105 Nasopharyngitis 75 1.5 1.5 no signal
106 Paranoia 7 1.5 1.5 no signal
107 Libido Decreased 5 1.5 1.5 no signal
108 Ocular Hyperaemia 18 1.4 1.4 no signal
109 Withdrawal Syndrome 16 1.4 1.4 no signal
110 Blood Glucose Abnormal 7 1.4 1.4 no signal
111 Pulmonary Thrombosis 4 1.3 1.3 no signal
112 Mania 6 1.3 1.3 no signal
113 Expired Product Administered 12 1.3 1.3 no signal
114 Amenorrhoea 6 1.3 1.3 no signal
115 Drug Prescribing Error 7 1.3 1.3 no signal
116 Menorrhagia 7 1.3 1.3 no signal
117 Menstruation Irregular 9 1.2 1.2 no signal
118 Incorrect Dose Administered 74 1.2 1.2 no signal
119 Impaired Work Ability 7 1.2 1.2 no signal
120 Brain Neoplasm 3 1.2 1.2 no signal
121 Glycosylated Haemoglobin Increased 8 1.2 1.2 no signal
122 Neoplasm Malignant 21 1.1 1.1 no signal
123 Exposure During Pregnancy 19 1.1 1.1 no signal
124 Vaginal Haemorrhage 13 1.1 1.1 no signal
125 Visual Acuity Reduced 10 1.1 1.1 no signal
126 Hair Texture Abnormal 4 1.1 1.1 no signal
127 Menstruation Delayed 3 1.0 1.0 no signal
128 Abnormal Behaviour 11 1.0 1.0 no signal
129 Intentional Self-injury 5 0.9 0.9 no signal
130 Breast Cancer 21 0.8 0.8 no signal
131 Blood Glucose Decreased 10 0.8 0.8 no signal
132 Abortion Spontaneous 8 0.7 0.7 no signal
133 Drug Withdrawal Syndrome 12 0.5 0.5 no signal