OpenPV Signal Explorer
FAERS disproportionality dashboard
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Drug

Phenylephrine

268 flagged reaction(s) · 8,087 total co-reports · max PRR 30.7
Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.
Reaction Co-reports (a) PRR ROR Signal
1 Premature Delivery 100 30.7 31.4 signal
2 Vitreous Floaters 51 25.7 26.0 signal
3 Cardiogenic Shock 65 22.3 22.6 signal
4 Premature Baby 118 19.1 19.6 signal
5 Metabolic Acidosis 90 13.9 14.2 signal
6 Respiratory Depression 34 13.5 13.6 signal
7 Serotonin Syndrome 53 13.5 13.7 signal
8 Bradycardia 145 13.3 13.8 signal
9 Shock 60 12.8 13.0 signal
10 Cardiomyopathy 38 12.5 12.6 signal
11 Maternal Exposure During Pregnancy 216 12.0 12.5 signal
12 Ventricular Fibrillation 27 11.8 11.9 signal
13 Posterior Reversible Encephalopathy Syndrome 23 11.8 11.9 signal
14 Drug Level Increased 40 11.8 11.9 signal
15 Circulatory Collapse 41 11.7 11.8 signal
16 Mydriasis 30 11.4 11.5 signal
17 Renal Tubular Necrosis 23 11.4 11.5 signal
18 Status Epilepticus 26 11.2 11.3 signal
19 Hypothermia 23 11.1 11.1 signal
20 Encephalopathy 55 11.0 11.1 signal
21 Hypoxia 78 10.9 11.0 signal
22 Hepatotoxicity 48 10.6 10.7 signal
23 Helicobacter Infection 22 10.5 10.6 signal
24 Exposure During Pregnancy 132 10.4 10.7 signal
25 Acute Respiratory Failure 40 10.2 10.3 signal
26 Lactic Acidosis 66 10.0 10.2 signal
27 Blood Calcium Decreased 23 10.0 10.0 signal
28 Multiple Organ Dysfunction Syndrome 54 9.4 9.6 signal
29 Hypotension 379 9.2 10.0 signal
30 Visual Acuity Reduced 63 9.2 9.3 signal
31 Mitral Valve Incompetence 21 9.1 9.1 signal
32 Cardiac Arrest 149 8.8 9.1 signal
33 Intentional Overdose 112 8.6 8.8 signal
34 Atelectasis 17 8.6 8.6 signal
35 Acute Respiratory Distress Syndrome 31 8.6 8.6 signal
36 Ventricular Tachycardia 29 8.5 8.6 signal
37 Foetal Exposure During Pregnancy 136 8.2 8.4 signal
38 Folliculitis 17 8.0 8.1 signal
39 Hand Deformity 21 7.8 7.9 signal
40 Bursitis 19 7.7 7.7 signal
41 Haemorrhage Intracranial 23 7.5 7.5 signal
42 Electrocardiogram Qt Prolonged 55 7.5 7.5 signal
43 Therapy Non-responder 68 7.4 7.5 signal
44 Depressed Level Of Consciousness 60 7.4 7.5 signal
45 Sinus Tachycardia 21 7.2 7.3 signal
46 Septic Shock 63 7.1 7.2 signal
47 Joint Range Of Motion Decreased 19 6.9 7.0 signal
48 Disseminated Intravascular Coagulation 20 6.9 6.9 signal
49 Ejection Fraction Decreased 22 6.9 6.9 signal
50 Pulmonary Oedema 62 6.7 6.8 signal
51 Pemphigus 16 6.3 6.3 signal
52 Respiratory Failure 92 6.2 6.3 signal
53 Acute Hepatic Failure 17 6.1 6.1 signal
54 Myocardial Ischaemia 14 6.0 6.0 signal
55 Retinal Detachment 11 5.8 5.8 signal
56 Wound Infection 13 5.8 5.8 signal
57 Post Procedural Complication 23 5.8 5.9 signal
58 Bronchospasm 17 5.8 5.8 signal
59 Tachycardia 105 5.8 5.9 signal
60 Intraocular Pressure Increased 15 5.7 5.7 signal
61 Eye Inflammation 11 5.7 5.7 signal
62 Pneumonia Aspiration 29 5.7 5.7 signal
63 Acute Kidney Injury 177 5.7 5.9 signal
64 Generalised Tonic-clonic Seizure 18 5.4 5.4 signal
65 Feeling Jittery 21 5.4 5.4 signal
66 Brain Injury 11 5.3 5.4 signal
67 Multi-organ Failure 19 5.3 5.3 signal
68 Joint Injury 23 5.2 5.3 signal
69 Photophobia 20 5.2 5.2 signal
70 Incorrect Route Of Product Administration 18 5.2 5.2 signal
71 Schizophrenia 13 5.2 5.2 signal
72 Deformity 10 5.2 5.2 signal
73 Leukocytosis 19 5.1 5.1 signal
74 Hypercholesterolaemia 10 5.1 5.1 signal
75 Anaphylactic Reaction 57 5.1 5.1 signal
76 Sinus Bradycardia 10 5.0 5.0 signal
77 End Stage Renal Disease 19 5.0 5.0 signal
78 Post Procedural Haemorrhage 12 5.0 5.0 signal
79 Pericarditis 17 5.0 5.0 signal
80 Acute Myocardial Infarction 30 4.9 5.0 signal
81 Delirium 35 4.9 5.0 signal
82 Mental Status Changes 28 4.9 4.9 signal
83 Unresponsive To Stimuli 25 4.7 4.8 signal
84 Drug Ineffective For Unapproved Indication 54 4.7 4.8 signal
85 Flank Pain 9 4.7 4.7 signal
86 Liver Injury 23 4.6 4.7 signal
87 Autoimmune Disorder 9 4.6 4.6 signal
88 Toxic Epidermal Necrolysis 14 4.5 4.5 signal
89 Fibromyalgia 22 4.4 4.4 signal
90 Coagulopathy 15 4.4 4.4 signal
91 Drug Interaction 143 4.4 4.5 signal
92 Hypertensive Crisis 10 4.4 4.4 signal
93 Contraindicated Product Administered 27 4.4 4.4 signal
94 Ileus 11 4.4 4.4 signal
95 Fluid Overload 13 4.3 4.3 signal
96 Obesity 14 4.3 4.3 signal
97 Tenderness 9 4.2 4.2 signal
98 Type 2 Diabetes Mellitus 29 4.2 4.2 signal
99 Caesarean Section 10 4.1 4.2 signal
100 Glossodynia 19 4.1 4.2 signal
101 Cytokine Release Syndrome 16 4.1 4.1 signal
102 Supraventricular Tachycardia 8 4.1 4.1 signal
103 Eye Pain 45 4.0 4.0 signal
104 Tachypnoea 11 4.0 4.0 signal
105 Therapeutic Product Effect Decreased 36 4.0 4.0 signal
106 Cardiomegaly 10 3.9 3.9 signal
107 Intestinal Perforation 9 3.9 3.9 signal
108 Renal Injury 24 3.9 3.9 signal
109 Liver Function Test Increased 17 3.9 3.9 signal
110 Toxicity To Various Agents 133 3.9 4.0 signal
111 Anaphylactic Shock 20 3.8 3.8 signal
112 Coma 37 3.8 3.8 signal
113 Synovitis 14 3.8 3.8 signal
114 Blood Bilirubin Increased 21 3.8 3.8 signal
115 Pallor 21 3.8 3.8 signal
116 Rash Maculo-papular 17 3.7 3.8 signal
117 Nodule 10 3.7 3.7 signal
118 Pulmonary Hypertension 16 3.7 3.7 signal
119 Hemiparesis 13 3.7 3.7 signal
120 Joint Stiffness 20 3.7 3.7 signal
121 Macular Degeneration 9 3.7 3.7 signal
122 Tubulointerstitial Nephritis 14 3.6 3.7 signal
123 No Therapeutic Response 9 3.5 3.6 signal
124 Product Preparation Error 15 3.5 3.5 signal
125 Blood Pressure Decreased 48 3.5 3.6 signal
126 Hyperkalaemia 25 3.5 3.5 signal
127 Brain Oedema 9 3.5 3.5 signal
128 Blindness Unilateral 10 3.5 3.5 signal
129 Product Use Complaint 11 3.5 3.5 signal
130 Irritable Bowel Syndrome 15 3.4 3.4 signal
131 Renal Failure Acute 30 3.4 3.4 signal
132 Cerebral Infarction 17 3.4 3.4 signal
133 Sciatica 11 3.4 3.4 signal
134 Blindness 28 3.4 3.4 signal
135 Subarachnoid Haemorrhage 7 3.3 3.3 signal
136 Ear Discomfort 7 3.3 3.3 signal
137 Musculoskeletal Pain 36 3.3 3.3 signal
138 Ataxia 8 3.3 3.3 signal
139 Myoclonus 8 3.3 3.3 signal
140 Quality Of Life Decreased 9 3.3 3.3 signal
141 Uveitis 9 3.2 3.3 signal
142 Cardio-respiratory Arrest 28 3.2 3.3 signal
143 International Normalised Ratio Increased 19 3.2 3.2 signal
144 Renal Failure 88 3.2 3.3 signal
145 Generalised Oedema 8 3.2 3.2 signal
146 Wound 18 3.2 3.2 signal
147 Seizure 74 3.1 3.2 signal
148 Wheezing 38 3.1 3.2 signal
149 Nephropathy Toxic 7 3.1 3.1 signal
150 Fear 17 3.1 3.1 signal
151 Obstructive Airways Disorder 7 3.1 3.1 signal
152 Systemic Lupus Erythematosus 22 3.0 3.0 signal
153 Renal Impairment 51 3.0 3.0 signal
154 Treatment Failure 49 2.9 2.9 signal
155 Vision Blurred 81 2.9 2.9 signal
156 Arthropathy 33 2.9 2.9 signal
157 Eyelid Ptosis 6 2.9 2.9 signal
158 Eye Discharge 6 2.9 2.9 signal
159 Muscle Rigidity 7 2.9 2.9 signal
160 Hyperbilirubinaemia 6 2.8 2.8 signal
161 Skin Ulcer 15 2.8 2.8 signal
162 Impaired Healing 19 2.8 2.8 signal
163 Neuralgia 14 2.8 2.8 signal
164 Rhabdomyolysis 24 2.8 2.8 signal
165 Accidental Overdose 21 2.8 2.8 signal
166 Chronic Kidney Disease 44 2.8 2.8 signal
167 Dialysis 8 2.7 2.7 signal
168 Subdural Haematoma 8 2.7 2.7 signal
169 Paralysis 8 2.7 2.7 signal
170 Disability 11 2.7 2.7 signal
171 Back Injury 6 2.7 2.7 signal
172 Ocular Discomfort 6 2.7 2.7 signal
173 Conjunctivitis 10 2.7 2.7 signal
174 Angioedema 24 2.7 2.7 signal
175 Heart Rate Decreased 19 2.6 2.6 signal
176 Haematoma 14 2.6 2.6 signal
177 Therapeutic Product Effect Incomplete 38 2.6 2.6 signal
178 Poisoning Deliberate 5 2.6 2.6 no signal
179 Dry Eye 26 2.6 2.6 signal
180 Chromaturia 12 2.6 2.6 signal
181 Hepatic Failure 16 2.6 2.6 signal
182 Anhedonia 14 2.6 2.6 signal
183 Suicide Attempt 32 2.6 2.6 signal
184 Injury 37 2.6 2.6 signal
185 Eye Haemorrhage 7 2.6 2.6 signal
186 Economic Problem 8 2.5 2.5 signal
187 Neurotoxicity 9 2.5 2.5 signal
188 Drug Dispensing Error 8 2.5 2.5 signal
189 Cyanosis 8 2.5 2.5 signal
190 Drug Toxicity 7 2.5 2.5 signal
191 Inflammation 26 2.5 2.5 signal
192 Ischaemic Stroke 9 2.5 2.5 signal
193 Cerebral Haemorrhage 18 2.5 2.5 signal
194 Drug Ineffective 662 2.5 2.7 signal
195 Ulcer 8 2.4 2.5 signal
196 Glomerular Filtration Rate Decreased 6 2.4 2.4 no signal
197 Transaminases Increased 11 2.4 2.4 signal
198 Hypoglycaemia 24 2.4 2.4 signal
199 Motor Dysfunction 5 2.4 2.4 no signal
200 Ocular Hyperaemia 23 2.4 2.4 signal
201 Cataract 29 2.4 2.4 signal
202 Cholelithiasis 16 2.4 2.4 signal
203 Impaired Quality Of Life 7 2.4 2.4 signal
204 Drug-induced Liver Injury 15 2.4 2.4 signal
205 Psychotic Disorder 14 2.3 2.3 signal
206 Haematemesis 12 2.3 2.3 signal
207 Visual Impairment 58 2.3 2.3 signal
208 Infusion Related Reaction 31 2.3 2.3 signal
209 Lacrimation Increased 14 2.3 2.3 signal
210 Musculoskeletal Stiffness 41 2.3 2.3 signal
211 Impaired Work Ability 10 2.3 2.3 signal
212 Prescribed Overdose 9 2.3 2.3 signal
213 Nerve Injury 5 2.2 2.2 no signal
214 Blood Creatine Phosphokinase Increased 13 2.2 2.2 signal
215 Lung Infection 7 2.2 2.2 no signal
216 Gastric Haemorrhage 5 2.1 2.1 no signal
217 Product Packaging Issue 4 2.1 2.1 no signal
218 Eye Irritation 24 2.1 2.1 signal
219 Eyelid Oedema 5 2.1 2.1 no signal
220 Overdose 90 2.0 2.0 signal
221 Coeliac Disease 4 2.0 2.0 no signal
222 Product Administration Error 8 2.0 2.0 no signal
223 Medication Error 22 1.9 1.9 no signal
224 Toxic Skin Eruption 4 1.9 1.9 no signal
225 Neoplasm Malignant 26 1.9 1.9 no signal
226 Pelvic Pain 7 1.9 1.9 no signal
227 Road Traffic Accident 16 1.9 1.9 no signal
228 Bone Density Decreased 12 1.8 1.8 no signal
229 Adverse Reaction 5 1.8 1.8 no signal
230 Product Dispensing Error 8 1.8 1.8 no signal
231 Eye Pruritus 12 1.8 1.8 no signal
232 Respiratory Arrest 10 1.8 1.8 no signal
233 Device Occlusion 5 1.8 1.8 no signal
234 Psoriatic Arthropathy 14 1.7 1.7 no signal
235 Sedation 9 1.7 1.7 no signal
236 Product Prescribing Issue 7 1.7 1.7 no signal
237 Polyneuropathy 4 1.6 1.6 no signal
238 Cytopenia 4 1.6 1.6 no signal
239 Blood Thyroid Stimulating Hormone Increased 3 1.6 1.6 no signal
240 Drug Exposure During Pregnancy 11 1.6 1.6 no signal
241 Erectile Dysfunction 8 1.5 1.5 no signal
242 Complication Associated With Device 4 1.5 1.5 no signal
243 Convulsion 17 1.4 1.4 no signal
244 Lung Neoplasm Malignant 12 1.4 1.4 no signal
245 Central Nervous System Lesion 4 1.4 1.4 no signal
246 Prostatic Specific Antigen Increased 4 1.4 1.4 no signal
247 Emotional Distress 35 1.4 1.4 no signal
248 Rheumatoid Arthritis 32 1.4 1.4 no signal
249 Dystonia 5 1.3 1.3 no signal
250 Sleep Disorder Due To A General Medical Condition 4 1.2 1.2 no signal
251 Peritonitis 5 1.2 1.2 no signal
252 Expired Product Administered 8 1.2 1.2 no signal
253 Myocardial Infarction 42 1.2 1.2 no signal
254 Poisoning 3 1.2 1.2 no signal
255 Product Quality Issue 31 1.1 1.1 no signal
256 Device Delivery System Issue 6 1.1 1.1 no signal
257 Circumstance Or Information Capable Of Leading To Medication Error 7 1.0 1.0 no signal
258 Device Failure 3 1.0 1.0 no signal
259 Pregnancy 4 1.0 1.0 no signal
260 Incorrect Route Of Drug Administration 7 0.9 0.9 no signal
261 Completed Suicide 15 0.9 0.9 no signal
262 Drug Effective For Unapproved Indication 5 0.8 0.8 no signal
263 Extra Dose Administered 6 0.7 0.7 no signal
264 Intentional Self-injury 3 0.7 0.7 no signal
265 Drug Abuse 12 0.7 0.7 no signal
266 Incorrect Dose Administered By Device 3 0.6 0.6 no signal
267 Drug Withdrawal Syndrome 10 0.5 0.5 no signal
268 Accidental Exposure To Product 10 0.5 0.5 no signal