Drug

Pirtobrutinib

16 flagged reaction(s) · 346 total co-reports · max PRR 52.3

Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.

	Reaction	Co-reports (a)	PRR	ROR	Signal
1	Splenomegaly	24	52.3	53.9	signal
2	Cytokine Release Syndrome	25	33.5	34.5	signal
3	Lymphadenopathy	29	20.9	21.6	signal
4	Hypercalcaemia	9	18.6	18.8	signal
5	Malignant Neoplasm Progression	74	18.5	20.3	signal
6	White Blood Cell Count Increased	27	17.9	18.4	signal
7	Covid-19 Pneumonia	8	17.2	17.3	signal
8	Pneumocystis Jirovecii Pneumonia	6	15.3	15.4	signal
9	Pancytopenia	32	14.6	15.2	signal
10	Blood Lactate Dehydrogenase Increased	9	14.4	14.5	signal
11	Leukaemia	5	13.5	13.6	signal
12	Disease Progression	52	11.2	11.9	signal
13	Bone Marrow Failure	9	11.2	11.3	signal
14	Lymphoma	6	9.9	9.9	signal
15	Therapy Interrupted	18	6.6	6.8	signal
16	Prostate Cancer	13	4.1	4.1	signal