OpenPV Signal Explorer
FAERS disproportionality dashboard
← All drugs
Drug

Pyridostigmine Bromide

621 flagged reaction(s) · 26,539 total co-reports · max PRR 52.4
Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.
Reaction Co-reports (a) PRR ROR Signal
1 Eyelid Ptosis 185 52.4 53.7 signal
2 Diplopia 290 31.9 33.2 signal
3 Paraesthesia Oral 98 19.4 19.7 signal
4 Insurance Issue 70 13.4 13.5 signal
5 Salivary Hypersecretion 38 10.8 10.8 signal
6 Muscular Weakness 394 9.8 10.3 signal
7 Poor Venous Access 34 9.3 9.4 signal
8 Therapeutic Response Shortened 100 8.9 9.0 signal
9 Hypoaesthesia Oral 44 8.3 8.3 signal
10 Dysphagia 275 8.2 8.5 signal
11 Dysarthria 105 7.9 8.0 signal
12 Choking 53 7.7 7.8 signal
13 Therapy Change 22 6.5 6.5 signal
14 Drug Effect Less Than Expected 30 6.0 6.1 signal
15 Skin Laceration 22 5.8 5.8 signal
16 Peripheral Coldness 27 5.6 5.6 signal
17 Blood Pressure Fluctuation 47 5.5 5.6 signal
18 Blood Iron Decreased 23 5.5 5.5 signal
19 Speech Disorder 102 5.5 5.6 signal
20 Pneumonia Aspiration 48 5.5 5.5 signal
21 Pulmonary Mass 28 5.3 5.4 signal
22 Decreased Activity 20 5.3 5.3 signal
23 Dermatitis Contact 21 5.2 5.3 signal
24 Urosepsis 17 5.2 5.2 signal
25 Blood Pressure Systolic Increased 35 5.1 5.1 signal
26 Dyspnoea Exertional 67 5.1 5.1 signal
27 Brain Fog 26 5.0 5.1 signal
28 Sleep Apnoea Syndrome 34 5.0 5.1 signal
29 Autoimmune Disorder 17 5.0 5.0 signal
30 Pharyngeal Swelling 17 5.0 5.0 signal
31 Atelectasis 17 5.0 5.0 signal
32 Intentional Product Use Issue 153 4.9 5.0 signal
33 Aspiration 18 4.7 4.7 signal
34 Bursitis 20 4.7 4.7 signal
35 Infusion Site Pain 21 4.7 4.7 signal
36 Seasonal Allergy 23 4.6 4.6 signal
37 Sensory Disturbance 26 4.6 4.6 signal
38 Viral Infection 53 4.5 4.5 signal
39 Micturition Urgency 18 4.5 4.5 signal
40 Gastroenteritis 23 4.5 4.5 signal
41 Dizziness Postural 15 4.4 4.4 signal
42 Neutrophil Count Increased 16 4.4 4.4 signal
43 Asthenia 582 4.4 4.7 signal
44 Vitamin D Deficiency 15 4.4 4.4 signal
45 Dysstasia 45 4.4 4.4 signal
46 Limb Discomfort 47 4.3 4.3 signal
47 Muscle Twitching 35 4.3 4.3 signal
48 Poisoning Deliberate 14 4.3 4.3 signal
49 Diverticulitis 41 4.2 4.2 signal
50 Ear Infection 39 4.2 4.2 signal
51 Head Injury 46 4.1 4.1 signal
52 Photophobia 27 4.1 4.1 signal
53 Leukocytosis 26 4.1 4.1 signal
54 Hereditary Angioedema 15 4.0 4.1 signal
55 Incontinence 15 4.0 4.0 signal
56 Throat Tightness 38 4.0 4.0 signal
57 Respiratory Tract Infection 36 3.9 3.9 signal
58 Back Injury 15 3.9 3.9 signal
59 Motor Dysfunction 14 3.9 3.9 signal
60 Cellulitis 69 3.9 3.9 signal
61 Rib Fracture 28 3.9 3.9 signal
62 Muscle Atrophy 17 3.8 3.8 signal
63 Skin Infection 15 3.8 3.8 signal
64 Respiratory Distress 37 3.8 3.8 signal
65 Wrist Fracture 16 3.8 3.8 signal
66 Paraesthesia 210 3.8 3.9 signal
67 Inability To Afford Medication 13 3.7 3.7 signal
68 Body Temperature Decreased 13 3.7 3.7 signal
69 Bone Disorder 24 3.7 3.7 signal
70 Product Physical Issue 26 3.7 3.7 signal
71 Urinary Tract Infection 221 3.7 3.8 signal
72 Secretion Discharge 16 3.7 3.7 signal
73 Cyst 16 3.6 3.7 signal
74 Spinal Pain 15 3.6 3.6 signal
75 Temperature Intolerance 13 3.6 3.6 signal
76 Blood Pressure Increased 194 3.6 3.7 signal
77 Balance Disorder 109 3.6 3.6 signal
78 Oxygen Saturation Decreased 70 3.6 3.6 signal
79 Pharmaceutical Product Complaint 33 3.5 3.6 signal
80 Respiratory Failure 91 3.5 3.6 signal
81 Cold Sweat 22 3.5 3.5 signal
82 Coma 59 3.5 3.5 signal
83 Respiratory Disorder 37 3.5 3.5 signal
84 Neck Pain 69 3.5 3.5 signal
85 Eye Disorder 40 3.5 3.5 signal
86 Feeling Cold 34 3.5 3.5 signal
87 Hypotonia 12 3.4 3.4 signal
88 White Blood Cell Count Increased 46 3.4 3.4 signal
89 Bacterial Infection 22 3.4 3.4 signal
90 Bradycardia 62 3.3 3.3 signal
91 Product Substitution Issue 67 3.3 3.3 signal
92 Musculoskeletal Discomfort 20 3.3 3.3 signal
93 Gastroenteritis Viral 21 3.3 3.3 signal
94 Glomerular Filtration Rate Decreased 14 3.3 3.3 signal
95 Immunodeficiency 17 3.3 3.3 signal
96 Acute Respiratory Failure 22 3.3 3.3 signal
97 Mitral Valve Incompetence 13 3.3 3.3 signal
98 Urinary Incontinence 34 3.3 3.3 signal
99 Dysphonia 67 3.2 3.3 signal
100 Prescribed Overdose 22 3.2 3.2 signal
101 Fall 376 3.2 3.3 signal
102 Poor Quality Sleep 24 3.2 3.2 signal
103 Covid-19 198 3.2 3.2 signal
104 Loss Of Personal Independence In Daily Activities 53 3.2 3.2 signal
105 Blood Pressure Abnormal 22 3.1 3.2 signal
106 Upper Respiratory Tract Infection 51 3.1 3.1 signal
107 Ocular Discomfort 12 3.1 3.1 signal
108 Impaired Gastric Emptying 14 3.1 3.1 signal
109 Musculoskeletal Chest Pain 17 3.1 3.1 signal
110 Gastrointestinal Pain 12 3.1 3.1 signal
111 Gait Disturbance 210 3.1 3.2 signal
112 Infusion Related Reaction 72 3.1 3.1 signal
113 Unresponsive To Stimuli 28 3.1 3.1 signal
114 Gait Inability 36 3.1 3.1 signal
115 Nerve Compression 10 3.1 3.1 signal
116 Haematoma 28 3.0 3.1 signal
117 Oral Candidiasis 14 3.0 3.1 signal
118 Aphonia 15 3.0 3.0 signal
119 Intervertebral Disc Degeneration 10 3.0 3.0 signal
120 Product Availability Issue 24 3.0 3.0 signal
121 Hand Deformity 14 3.0 3.0 signal
122 Weight Fluctuation 11 3.0 3.0 signal
123 Gastrointestinal Disorder 93 3.0 3.0 signal
124 Muscle Spasms 193 3.0 3.0 signal
125 Psychotic Disorder 31 3.0 3.0 signal
126 Paralysis 15 3.0 3.0 signal
127 Stress 75 3.0 3.0 signal
128 Glaucoma 20 2.9 2.9 signal
129 Delusion 16 2.9 2.9 signal
130 Blood Potassium Decreased 31 2.9 2.9 signal
131 Aphasia 31 2.9 2.9 signal
132 Sinusitis 105 2.9 2.9 signal
133 Bacteraemia 12 2.9 2.9 signal
134 Platelet Count Increased 13 2.8 2.8 signal
135 Lip Swelling 33 2.8 2.8 signal
136 Gamma-glutamyltransferase Increased 22 2.8 2.8 signal
137 Localised Infection 24 2.8 2.8 signal
138 Nephrolithiasis 45 2.8 2.8 signal
139 Conjunctivitis 18 2.8 2.8 signal
140 Oral Herpes 19 2.8 2.8 signal
141 Agranulocytosis 18 2.8 2.8 signal
142 Osteoporosis 40 2.7 2.8 signal
143 Clostridium Difficile Infection 21 2.7 2.7 signal
144 Cholecystectomy 11 2.7 2.7 signal
145 Rhinorrhoea 62 2.7 2.7 signal
146 Thinking Abnormal 18 2.7 2.7 signal
147 Limb Injury 26 2.7 2.7 signal
148 Fatigue 745 2.7 2.9 signal
149 Hypokalaemia 44 2.7 2.7 signal
150 Electrolyte Imbalance 11 2.7 2.7 signal
151 Herpes Zoster 55 2.7 2.7 signal
152 Chills 112 2.7 2.7 signal
153 Upper Limb Fracture 19 2.7 2.7 signal
154 Therapeutic Product Effect Incomplete 67 2.7 2.7 signal
155 Sciatica 15 2.7 2.7 signal
156 Cataract 56 2.7 2.7 signal
157 Fluid Retention 48 2.7 2.7 signal
158 Therapy Non-responder 42 2.7 2.7 signal
159 Vision Blurred 128 2.7 2.7 signal
160 Mobility Decreased 67 2.6 2.7 signal
161 Sudden Death 10 2.6 2.6 signal
162 Respiratory Arrest 26 2.6 2.7 signal
163 Hallucination 70 2.6 2.7 signal
164 Fungal Infection 31 2.6 2.6 signal
165 Affect Lability 9 2.6 2.6 signal
166 Lymphopenia 13 2.6 2.6 signal
167 Hip Arthroplasty 14 2.6 2.6 signal
168 Migraine 87 2.6 2.6 signal
169 Orthostatic Hypotension 16 2.6 2.6 signal
170 Syringe Issue 16 2.6 2.6 signal
171 Nocturia 11 2.6 2.6 signal
172 Hypersomnia 26 2.6 2.6 signal
173 Cystitis 29 2.6 2.6 signal
174 Dyspnoea 512 2.6 2.7 signal
175 Haematocrit Decreased 18 2.6 2.6 signal
176 Red Blood Cell Sedimentation Rate Increased 10 2.6 2.6 signal
177 Urinary Retention 30 2.6 2.6 signal
178 Hypoaesthesia 135 2.6 2.6 signal
179 Generalised Oedema 11 2.5 2.5 signal
180 Eye Infection 10 2.5 2.5 signal
181 Feeling Jittery 17 2.5 2.5 signal
182 Cardiomegaly 11 2.5 2.5 signal
183 Influenza 99 2.5 2.5 signal
184 Condition Aggravated 267 2.5 2.6 signal
185 Hernia 17 2.5 2.5 signal
186 Pharyngitis 11 2.5 2.5 signal
187 Initial Insomnia 9 2.5 2.5 signal
188 Tooth Abscess 9 2.5 2.5 signal
189 Therapeutic Product Effect Decreased 39 2.5 2.5 signal
190 Heart Rate Decreased 31 2.5 2.5 signal
191 Product Dose Omission Issue 249 2.5 2.5 signal
192 Anaphylactic Reaction 48 2.5 2.5 signal
193 Lacrimation Increased 26 2.5 2.5 signal
194 Retinal Detachment 8 2.5 2.5 signal
195 Therapy Interrupted 60 2.5 2.5 signal
196 Movement Disorder 28 2.5 2.5 signal
197 Presyncope 21 2.5 2.5 signal
198 Intervertebral Disc Protrusion 19 2.5 2.5 signal
199 Neuralgia 21 2.5 2.5 signal
200 Petechiae 9 2.4 2.5 signal
201 Hyperkalaemia 30 2.4 2.4 signal
202 Abdominal Pain Upper 176 2.4 2.5 signal
203 Joint Dislocation 9 2.4 2.4 signal
204 Hepatic Enzyme Increased 58 2.4 2.4 signal
205 Hyperhidrosis 110 2.4 2.4 signal
206 Oedema 46 2.4 2.4 signal
207 Arteriosclerosis 8 2.4 2.4 signal
208 Clostridium Difficile Colitis 9 2.4 2.4 signal
209 Eating Disorder 18 2.4 2.4 signal
210 Foot Fracture 16 2.4 2.4 signal
211 Diarrhoea 541 2.4 2.5 signal
212 Covid-19 Pneumonia 10 2.4 2.4 signal
213 Polyneuropathy 10 2.4 2.4 signal
214 Lung Disorder 41 2.4 2.4 signal
215 Tendonitis 13 2.4 2.4 signal
216 Tooth Infection 11 2.4 2.4 signal
217 Glycosylated Haemoglobin Increased 21 2.4 2.4 signal
218 Bronchitis 62 2.4 2.4 signal
219 Blood Urea Increased 14 2.4 2.4 signal
220 Pulmonary Congestion 11 2.4 2.4 signal
221 Treatment Noncompliance 45 2.3 2.4 signal
222 Wound Infection 9 2.3 2.3 signal
223 Throat Irritation 37 2.3 2.3 signal
224 Arthritis 65 2.3 2.3 signal
225 Contusion 79 2.3 2.3 signal
226 Headache 513 2.3 2.4 signal
227 Staphylococcal Infection 27 2.3 2.3 signal
228 Sleep Disorder 57 2.3 2.3 signal
229 Blood Pressure Decreased 54 2.3 2.3 signal
230 Sinus Congestion 11 2.3 2.3 signal
231 Tachypnoea 11 2.3 2.3 signal
232 Ligament Sprain 8 2.3 2.3 signal
233 Illness 81 2.3 2.3 signal
234 Needle Issue 23 2.3 2.3 signal
235 Bladder Disorder 8 2.3 2.3 signal
236 C-reactive Protein Increased 29 2.3 2.3 signal
237 Toxic Epidermal Necrolysis 12 2.3 2.3 signal
238 Myocarditis 9 2.2 2.3 signal
239 Toxic Skin Eruption 8 2.2 2.2 signal
240 Ill-defined Disorder 48 2.2 2.2 signal
241 Sluggishness 8 2.2 2.2 signal
242 Blood Urine Present 15 2.2 2.2 signal
243 Vertigo 48 2.2 2.2 signal
244 Poor Quality Product Administered 8 2.2 2.2 signal
245 Inflammation 40 2.2 2.2 signal
246 Skin Ulcer 20 2.2 2.2 signal
247 Abdominal Discomfort 129 2.2 2.2 signal
248 Ear Pain 15 2.2 2.2 signal
249 Intentional Dose Omission 21 2.2 2.2 signal
250 Unevaluable Event 58 2.2 2.2 signal
251 Myalgia 130 2.2 2.2 signal
252 Musculoskeletal Stiffness 67 2.2 2.2 signal
253 Feeling Abnormal 183 2.2 2.2 signal
254 Immune System Disorder 10 2.2 2.2 signal
255 Procedural Pain 21 2.1 2.2 signal
256 Increased Tendency To Bruise 7 2.1 2.2 no signal
257 Diabetes Mellitus 58 2.1 2.2 signal
258 Hypokinesia 11 2.1 2.1 signal
259 Complication Associated With Device 10 2.1 2.1 signal
260 Visual Impairment 93 2.1 2.2 signal
261 Back Pain 175 2.1 2.2 signal
262 Hepatic Steatosis 14 2.1 2.1 signal
263 Product Administration Error 15 2.1 2.1 signal
264 Sars-cov-2 Test Positive 10 2.1 2.1 signal
265 Flank Pain 7 2.1 2.1 no signal
266 Heart Rate Irregular 17 2.1 2.1 signal
267 Eosinophilia 13 2.1 2.1 signal
268 Sepsis 83 2.1 2.1 signal
269 Hunger 10 2.1 2.1 signal
270 Abortion Induced 7 2.1 2.1 no signal
271 Leukopenia 37 2.1 2.1 signal
272 Productive Cough 35 2.1 2.1 signal
273 Weight Decreased 206 2.1 2.1 signal
274 Back Disorder 12 2.1 2.1 signal
275 Therapeutic Response Unexpected 33 2.1 2.1 signal
276 Therapeutic Response Decreased 44 2.1 2.1 signal
277 Photosensitivity Reaction 12 2.1 2.1 signal
278 Thirst 13 2.1 2.1 signal
279 Post Procedural Complication 14 2.1 2.1 signal
280 Weight Increased 162 2.1 2.1 signal
281 Nasopharyngitis 134 2.1 2.1 signal
282 Therapy Cessation 37 2.0 2.1 signal
283 Joint Stiffness 19 2.0 2.1 signal
284 Medication Error 40 2.0 2.0 signal
285 Deep Vein Thrombosis 47 2.0 2.0 signal
286 Knee Arthroplasty 15 2.0 2.0 signal
287 Neuropathy Peripheral 68 2.0 2.0 signal
288 Osteomyelitis 13 2.0 2.0 signal
289 Inappropriate Schedule Of Product Administration 127 2.0 2.1 signal
290 Nerve Injury 8 2.0 2.0 no signal
291 Hypoxia 25 2.0 2.0 signal
292 Lethargy 41 2.0 2.0 signal
293 Product Use Complaint 11 2.0 2.0 signal
294 Disability 14 2.0 2.0 signal
295 Atrial Fibrillation 69 2.0 2.0 signal
296 Drug Intolerance 68 2.0 2.0 no signal
297 Somnolence 142 2.0 2.0 no signal
298 Impaired Driving Ability 8 2.0 2.0 no signal
299 Fibromyalgia 17 2.0 2.0 no signal
300 Syncope 70 2.0 2.0 no signal
301 Red Blood Cell Count Decreased 20 2.0 2.0 no signal
302 Malaise 307 2.0 2.0 no signal
303 Cyanosis 11 2.0 2.0 no signal
304 Tremor 116 2.0 2.0 no signal
305 Injection Site Induration 9 2.0 2.0 no signal
306 Loss Of Consciousness 89 2.0 2.0 no signal
307 Abscess 11 2.0 2.0 no signal
308 Anosmia 10 2.0 2.0 no signal
309 Cognitive Disorder 32 1.9 2.0 no signal
310 Inappropriate Antidiuretic Hormone Secretion 7 1.9 1.9 no signal
311 Infection 99 1.9 2.0 no signal
312 Nasal Congestion 40 1.9 1.9 no signal
313 Wound 19 1.9 1.9 no signal
314 Night Sweats 22 1.9 1.9 no signal
315 Gastric Ulcer 13 1.9 1.9 no signal
316 Thrombosis 55 1.9 1.9 no signal
317 Muscle Tightness 11 1.9 1.9 no signal
318 Transient Ischaemic Attack 23 1.9 1.9 no signal
319 Lymphocyte Count Decreased 12 1.9 1.9 no signal
320 Dysuria 25 1.9 1.9 no signal
321 Hospitalisation 103 1.9 1.9 no signal
322 Pneumonia 218 1.9 1.9 no signal
323 Hypotension 135 1.9 1.9 no signal
324 Dizziness 335 1.9 1.9 no signal
325 Pollakiuria 28 1.9 1.9 no signal
326 Ataxia 8 1.9 1.9 no signal
327 Haematuria 23 1.9 1.9 no signal
328 Hypophagia 17 1.9 1.9 no signal
329 Product Taste Abnormal 9 1.9 1.9 no signal
330 Haemorrhage Intracranial 10 1.9 1.9 no signal
331 Cardio-respiratory Arrest 28 1.9 1.9 no signal
332 Spinal Operation 8 1.9 1.9 no signal
333 Thyroid Cancer 8 1.9 1.9 no signal
334 Off Label Use 572 1.9 1.9 no signal
335 Restless Legs Syndrome 12 1.9 1.9 no signal
336 Shock 15 1.9 1.9 no signal
337 Pyrexia 226 1.8 1.9 no signal
338 Respiratory Depression 8 1.8 1.8 no signal
339 Ileus 8 1.8 1.8 no signal
340 Blood Creatine Phosphokinase Increased 19 1.8 1.8 no signal
341 Taste Disorder 13 1.8 1.8 no signal
342 Heart Rate Increased 64 1.8 1.8 no signal
343 Dehydration 86 1.8 1.8 no signal
344 Swelling 60 1.8 1.8 no signal
345 Mass 9 1.8 1.8 no signal
346 Blood Sodium Decreased 12 1.8 1.8 no signal
347 Tooth Fracture 7 1.8 1.8 no signal
348 Fracture 12 1.8 1.8 no signal
349 Pneumothorax 10 1.8 1.8 no signal
350 Swelling Face 41 1.8 1.8 no signal
351 Cough 176 1.8 1.8 no signal
352 Lower Limb Fracture 12 1.8 1.8 no signal
353 Tooth Disorder 14 1.8 1.8 no signal
354 Rectal Haemorrhage 27 1.8 1.8 no signal
355 Head Discomfort 11 1.8 1.8 no signal
356 Blood Calcium Decreased 7 1.8 1.8 no signal
357 Anger 21 1.7 1.8 no signal
358 Vitreous Floaters 6 1.7 1.7 no signal
359 Haemorrhoids 12 1.7 1.7 no signal
360 Peripheral Swelling 94 1.7 1.7 no signal
361 Kidney Infection 12 1.7 1.7 no signal
362 Bedridden 8 1.7 1.7 no signal
363 Hospice Care 6 1.7 1.7 no signal
364 Depressed Mood 32 1.7 1.7 no signal
365 Chest Discomfort 62 1.7 1.7 no signal
366 Hyperglycaemia 22 1.7 1.7 no signal
367 Sinus Disorder 12 1.7 1.7 no signal
368 Urticaria 100 1.7 1.7 no signal
369 Pain In Extremity 177 1.7 1.7 no signal
370 Joint Range Of Motion Decreased 8 1.7 1.7 no signal
371 Palpitations 70 1.7 1.7 no signal
372 Product Dose Omission In Error 16 1.7 1.7 no signal
373 Hip Fracture 19 1.7 1.7 no signal
374 Hypothermia 6 1.7 1.7 no signal
375 Insomnia 157 1.7 1.7 no signal
376 Skin Lesion 16 1.7 1.7 no signal
377 Hemiparesis 10 1.7 1.7 no signal
378 Hepatotoxicity 13 1.7 1.7 no signal
379 Adrenal Insufficiency 7 1.7 1.7 no signal
380 Nausea 461 1.7 1.7 no signal
381 Device Related Infection 9 1.7 1.7 no signal
382 Scar 10 1.6 1.7 no signal
383 Arthralgia 241 1.6 1.7 no signal
384 Ankle Fracture 9 1.6 1.6 no signal
385 Cholelithiasis 19 1.6 1.6 no signal
386 Paranoia 10 1.6 1.6 no signal
387 Basal Cell Carcinoma 9 1.6 1.6 no signal
388 Device Occlusion 8 1.6 1.6 no signal
389 Small Intestinal Obstruction 7 1.6 1.6 no signal
390 Surgery 33 1.6 1.6 no signal
391 Skin Reaction 8 1.6 1.6 no signal
392 Retching 12 1.6 1.6 no signal
393 Bone Pain 33 1.6 1.6 no signal
394 Product Use In Unapproved Indication 137 1.6 1.6 no signal
395 Aggression 28 1.6 1.6 no signal
396 Influenza Like Illness 46 1.6 1.6 no signal
397 Chronic Obstructive Pulmonary Disease 29 1.6 1.6 no signal
398 Abdominal Pain 129 1.6 1.6 no signal
399 Blood Potassium Increased 9 1.6 1.6 no signal
400 Drug Interaction 88 1.6 1.6 no signal
401 Injection Site Irritation 7 1.6 1.6 no signal
402 Toothache 10 1.6 1.6 no signal
403 Spinal Fracture 11 1.6 1.6 no signal
404 Panic Attack 20 1.6 1.6 no signal
405 Femur Fracture 17 1.5 1.6 no signal
406 Pulmonary Embolism 52 1.5 1.5 no signal
407 Melaena 12 1.5 1.5 no signal
408 Meningioma 8 1.5 1.5 no signal
409 Depression 124 1.5 1.5 no signal
410 Fluid Overload 8 1.5 1.5 no signal
411 Rash Maculo-papular 12 1.5 1.5 no signal
412 Cardiomyopathy 8 1.5 1.5 no signal
413 Vomiting 253 1.5 1.5 no signal
414 Intestinal Perforation 6 1.5 1.5 no signal
415 Diarrhoea Haemorrhagic 5 1.5 1.5 no signal
416 Upper Gastrointestinal Haemorrhage 9 1.5 1.5 no signal
417 Increased Appetite 10 1.5 1.5 no signal
418 Chromaturia 12 1.5 1.5 no signal
419 Lactic Acidosis 17 1.5 1.5 no signal
420 Scab 6 1.5 1.5 no signal
421 Spinal Disorder 5 1.5 1.5 no signal
422 Road Traffic Accident 22 1.5 1.5 no signal
423 Haemoglobin Decreased 54 1.5 1.5 no signal
424 Memory Impairment 72 1.5 1.5 no signal
425 Quality Of Life Decreased 7 1.5 1.5 no signal
426 Pancytopenia 29 1.5 1.5 no signal
427 Dyskinesia 21 1.5 1.5 no signal
428 Seizure 59 1.5 1.5 no signal
429 Ejection Fraction Decreased 8 1.5 1.5 no signal
430 Musculoskeletal Pain 27 1.4 1.4 no signal
431 Acute Myocardial Infarction 15 1.4 1.4 no signal
432 Disorientation 20 1.4 1.4 no signal
433 Macular Degeneration 6 1.4 1.4 no signal
434 Dementia 14 1.4 1.4 no signal
435 Ulcer 8 1.4 1.4 no signal
436 Blood Test Abnormal 7 1.4 1.4 no signal
437 Coordination Abnormal 7 1.4 1.4 no signal
438 Transaminases Increased 11 1.4 1.4 no signal
439 Incorrect Product Administration Duration 10 1.4 1.4 no signal
440 Dry Throat 5 1.4 1.4 no signal
441 Hepatocellular Injury 7 1.4 1.4 no signal
442 Subarachnoid Haemorrhage 5 1.4 1.4 no signal
443 Feeling Hot 30 1.4 1.4 no signal
444 Ear Discomfort 5 1.4 1.4 no signal
445 Pain 300 1.4 1.4 no signal
446 Cardiac Failure 39 1.4 1.4 no signal
447 No Therapeutic Response 6 1.4 1.4 no signal
448 Muscle Spasticity 6 1.4 1.4 no signal
449 Frequent Bowel Movements 13 1.4 1.4 no signal
450 Tooth Extraction 6 1.4 1.4 no signal
451 Ageusia 12 1.4 1.4 no signal
452 Swollen Tongue 15 1.4 1.4 no signal
453 Joint Swelling 57 1.3 1.3 no signal
454 Pancreatitis 25 1.3 1.3 no signal
455 Colon Cancer 7 1.3 1.3 no signal
456 Circulatory Collapse 8 1.3 1.3 no signal
457 Intraocular Pressure Increased 6 1.3 1.3 no signal
458 Epistaxis 35 1.3 1.3 no signal
459 Blindness 19 1.3 1.3 no signal
460 Drug Ineffective 612 1.3 1.3 no signal
461 Oropharyngeal Pain 43 1.3 1.3 no signal
462 Drug Exposure During Pregnancy 16 1.3 1.3 no signal
463 Pharyngitis Streptococcal 5 1.3 1.3 no signal
464 Cardiac Disorder 43 1.3 1.3 no signal
465 Blood Glucose Fluctuation 5 1.3 1.3 no signal
466 Thyroid Disorder 7 1.3 1.3 no signal
467 Injection Site Urticaria 11 1.3 1.3 no signal
468 Adverse Reaction 6 1.3 1.3 no signal
469 Irritability 27 1.3 1.3 no signal
470 Agitation 33 1.3 1.3 no signal
471 Malignant Melanoma 6 1.3 1.3 no signal
472 Nervous System Disorder 14 1.3 1.3 no signal
473 Oral Pain 10 1.3 1.3 no signal
474 Uveitis 6 1.3 1.3 no signal
475 Product Prescribing Issue 9 1.3 1.3 no signal
476 Arrhythmia 21 1.2 1.3 no signal
477 Pallor 12 1.2 1.2 no signal
478 Abasia 11 1.2 1.2 no signal
479 Gingival Bleeding 6 1.2 1.2 no signal
480 Nervousness 23 1.2 1.2 no signal
481 Eye Pain 24 1.2 1.2 no signal
482 Blood Thyroid Stimulating Hormone Increased 4 1.2 1.2 no signal
483 Metastases To Lung 5 1.2 1.2 no signal
484 Oral Discomfort 6 1.2 1.2 no signal
485 Discomfort 26 1.2 1.2 no signal
486 Neoplasm Progression 15 1.2 1.2 no signal
487 Grand Mal Convulsion 4 1.2 1.2 no signal
488 Impaired Healing 14 1.2 1.2 no signal
489 Adverse Drug Reaction 38 1.2 1.2 no signal
490 Squamous Cell Carcinoma 4 1.2 1.2 no signal
491 Systemic Lupus Erythematosus 15 1.2 1.2 no signal
492 Accident 5 1.2 1.2 no signal
493 Psychomotor Hyperactivity 7 1.2 1.2 no signal
494 Myoclonus 5 1.2 1.2 no signal
495 Hypoacusis 18 1.2 1.2 no signal
496 Injection Site Bruising 33 1.2 1.2 no signal
497 Hyperthyroidism 6 1.2 1.2 no signal
498 Dry Eye 20 1.2 1.2 no signal
499 Hypoglycaemia 20 1.2 1.2 no signal
500 Mental Impairment 10 1.2 1.2 no signal
501 Pulmonary Arterial Hypertension 6 1.2 1.2 no signal
502 Flushing 42 1.2 1.2 no signal
503 Parkinsonism 4 1.2 1.2 no signal
504 Decreased Immune Responsiveness 4 1.2 1.2 no signal
505 Cerebral Infarction 10 1.2 1.2 no signal
506 Gastric Disorder 14 1.1 1.1 no signal
507 Metastases To Liver 7 1.1 1.1 no signal
508 Hot Flush 30 1.1 1.1 no signal
509 Pregnancy 8 1.1 1.1 no signal
510 Injection Site Rash 12 1.1 1.1 no signal
511 Diabetes Mellitus Inadequate Control 7 1.1 1.1 no signal
512 Mydriasis 5 1.1 1.1 no signal
513 Rotator Cuff Syndrome 5 1.1 1.1 no signal
514 Injection Site Discomfort 4 1.1 1.1 no signal
515 Drug Dispensing Error 6 1.1 1.1 no signal
516 Scratch 4 1.1 1.1 no signal
517 Burning Sensation 27 1.1 1.1 no signal
518 Pelvic Pain 7 1.1 1.1 no signal
519 Asthma 43 1.1 1.1 no signal
520 International Normalised Ratio Increased 11 1.1 1.1 no signal
521 Gastrointestinal Haemorrhage 32 1.1 1.1 no signal
522 Drug Effect Incomplete 14 1.1 1.1 no signal
523 Device Issue 33 1.1 1.1 no signal
524 Disease Recurrence 18 1.1 1.1 no signal
525 Eye Haemorrhage 5 1.1 1.1 no signal
526 Disturbance In Attention 20 1.0 1.0 no signal
527 Mood Altered 10 1.0 1.0 no signal
528 Pulmonary Thrombosis 4 1.0 1.0 no signal
529 Pruritus Generalised 8 1.0 1.0 no signal
530 Cytomegalovirus Infection 6 1.0 1.0 no signal
531 Adverse Event 33 1.0 1.0 no signal
532 Glossodynia 8 1.0 1.0 no signal
533 Dialysis 5 1.0 1.0 no signal
534 Skin Irritation 16 1.0 1.0 no signal
535 Abortion Spontaneous 14 1.0 1.0 no signal
536 Drug Effect Decreased 19 1.0 1.0 no signal
537 Rash Generalised 9 1.0 1.0 no signal
538 Eye Irritation 19 1.0 1.0 no signal
539 Caesarean Section 4 1.0 1.0 no signal
540 Muscle Rigidity 4 0.9 0.9 no signal
541 Synovitis 6 0.9 0.9 no signal
542 Withdrawal Syndrome 14 0.9 0.9 no signal
543 Hepatic Cytolysis 4 0.9 0.9 no signal
544 Product Quality Issue 44 0.9 0.9 no signal
545 Impaired Work Ability 7 0.9 0.9 no signal
546 Brain Neoplasm 3 0.9 0.9 no signal
547 Blood Count Abnormal 5 0.9 0.9 no signal
548 Skin Cancer 7 0.9 0.9 no signal
549 Product Packaging Issue 3 0.9 0.9 no signal
550 Personality Change 3 0.9 0.9 no signal
551 Eczema 16 0.9 0.9 no signal
552 Injection Site Pruritus 21 0.9 0.9 no signal
553 Metastases To Central Nervous System 4 0.9 0.9 no signal
554 Knee Operation 3 0.9 0.9 no signal
555 Incorrect Dose Administered 69 0.9 0.9 no signal
556 Coeliac Disease 3 0.9 0.9 no signal
557 Injection Site Swelling 23 0.9 0.9 no signal
558 Product Dose Omission 20 0.9 0.9 no signal
559 Pneumocystis Jirovecii Pneumonia 3 0.8 0.8 no signal
560 Sopor 4 0.8 0.8 no signal
561 Bone Marrow Failure 6 0.8 0.8 no signal
562 Euphoric Mood 3 0.8 0.8 no signal
563 Injection Site Pain 85 0.8 0.8 no signal
564 Breast Cancer Metastatic 3 0.8 0.8 no signal
565 Device Dislocation 12 0.8 0.8 no signal
566 Extra Dose Administered 11 0.8 0.8 no signal
567 Exposure During Pregnancy 17 0.8 0.8 no signal
568 Wrong Technique In Product Usage Process 55 0.8 0.8 no signal
569 Lung Neoplasm Malignant 11 0.8 0.8 no signal
570 Rheumatoid Arthritis 30 0.8 0.7 no signal
571 No Adverse Event 47 0.7 0.7 no signal
572 Underdose 19 0.7 0.7 no signal
573 Convulsion 15 0.7 0.7 no signal
574 Vaginal Haemorrhage 11 0.7 0.7 no signal
575 Dystonia 5 0.7 0.7 no signal
576 Drug Prescribing Error 5 0.7 0.7 no signal
577 Myocardial Infarction 44 0.7 0.7 no signal
578 Blood Glucose Decreased 12 0.7 0.7 no signal
579 Injection Site Reaction 17 0.7 0.7 no signal
580 Device Defective 4 0.7 0.7 no signal
581 Multiple Sclerosis Relapse 17 0.7 0.7 no signal
582 Injection Site Mass 9 0.7 0.7 no signal
583 Blood Glucose Increased 46 0.7 0.7 no signal
584 Neoplasm Malignant 16 0.7 0.7 no signal
585 Drug Abuse 20 0.7 0.7 no signal
586 Hair Colour Changes 3 0.7 0.7 no signal
587 Circumstance Or Information Capable Of Leading To Medication Error 8 0.7 0.7 no signal
588 Device Use Issue 4 0.7 0.7 no signal
589 Application Site Pain 5 0.6 0.6 no signal
590 Emotional Distress 25 0.6 0.6 no signal
591 Drug Effective For Unapproved Indication 6 0.6 0.6 no signal
592 Injection Site Erythema 25 0.6 0.6 no signal
593 Injection Site Haemorrhage 16 0.6 0.6 no signal
594 Psoriatic Arthropathy 8 0.6 0.6 no signal
595 Injury Associated With Device 4 0.6 0.6 no signal
596 Bone Loss 3 0.6 0.6 no signal
597 Product Preparation Error 4 0.5 0.5 no signal
598 Intentional Overdose 12 0.5 0.5 no signal
599 Multiple Sclerosis 8 0.5 0.5 no signal
600 Product Complaint 4 0.5 0.5 no signal
601 Device Breakage 6 0.4 0.4 no signal
602 Menstruation Irregular 4 0.4 0.4 no signal
603 Drug Dose Omission 24 0.4 0.4 no signal
604 Skin Burning Sensation 10 0.4 0.4 no signal
605 Pancreatic Carcinoma 4 0.4 0.4 no signal
606 Wrong Technique In Drug Usage Process 5 0.4 0.4 no signal
607 Exposure Via Skin Contact 3 0.4 0.4 no signal
608 Drug Dependence 21 0.4 0.4 no signal
609 Incorrect Dose Administered By Device 3 0.3 0.3 no signal
610 Gastric Cancer 3 0.3 0.3 no signal
611 Breast Cancer Female 3 0.3 0.3 no signal
612 Incorrect Route Of Drug Administration 4 0.3 0.3 no signal
613 Breast Cancer 10 0.3 0.3 no signal
614 Device Difficult To Use 7 0.3 0.3 no signal
615 Device Malfunction 7 0.3 0.3 no signal
616 Product Storage Error 9 0.3 0.3 no signal
617 Device Leakage 4 0.3 0.3 no signal
618 Device Use Error 3 0.2 0.2 no signal
619 Wrong Technique In Device Usage Process 4 0.2 0.2 no signal
620 Prostate Cancer 7 0.2 0.2 no signal
621 Drug Dose Omission By Device 6 0.2 0.2 no signal