OpenPV Signal Explorer
FAERS disproportionality dashboard
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Drug

Pyridoxine Hydrochloride

292 flagged reaction(s) · 20,472 total co-reports · max PRR 204.4
Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.
Reaction Co-reports (a) PRR ROR Signal
1 Appendicitis 234 204.4 224.1 signal
2 Ventricular Fibrillation 190 137.4 147.9 signal
3 Cardiogenic Shock 225 126.8 138.5 signal
4 Folliculitis 104 80.5 83.7 signal
5 Bursitis 111 73.5 76.7 signal
6 Incorrect Route Of Product Administration 143 67.9 71.7 signal
7 Helicobacter Infection 84 65.8 67.9 signal
8 Ascites 242 65.7 72.2 signal
9 Pemphigus 101 64.8 67.4 signal
10 Multiple Organ Dysfunction Syndrome 217 62.0 67.5 signal
11 Pericarditis 126 60.3 63.3 signal
12 Wound Infection 80 58.7 60.5 signal
13 Bacterial Infection 121 51.9 54.3 signal
14 Joint Range Of Motion Decreased 87 51.9 53.6 signal
15 Hand Deformity 81 49.3 50.8 signal
16 Obesity 88 43.9 45.4 signal
17 Synovitis 99 43.7 45.3 signal
18 Hyperlipidaemia 65 43.2 44.2 signal
19 Taste Disorder 107 42.5 44.2 signal
20 Blood Cholesterol Increased 233 39.7 43.5 signal
21 Neuralgia 113 37.0 38.7 signal
22 Irritable Bowel Syndrome 93 34.6 35.8 signal
23 Hyponatraemia 238 33.7 36.9 signal
24 Glossodynia 87 30.9 31.9 signal
25 Pneumonia Aspiration 96 30.6 31.7 signal
26 Red Blood Cell Sedimentation Rate Increased 42 30.1 30.6 signal
27 Back Injury 41 30.1 30.5 signal
28 End Stage Renal Disease 68 29.3 30.1 signal
29 Liver Injury 89 29.2 30.2 signal
30 Gout 66 29.2 29.9 signal
31 Epilepsy 112 29.2 30.4 signal
32 Fibromyalgia 89 29.1 30.1 signal
33 Micturition Urgency 41 28.7 29.2 signal
34 Ulcer 56 27.9 28.5 signal
35 Wound 97 27.7 28.7 signal
36 Blood Test Abnormal 48 27.2 27.6 signal
37 Head Discomfort 59 26.6 27.2 signal
38 Osteoarthritis 142 26.5 28.0 signal
39 Hypercholesterolaemia 31 25.7 26.0 signal
40 Lower Respiratory Tract Infection 146 25.6 27.0 signal
41 Nocturia 39 25.6 25.9 signal
42 Dry Mouth 260 25.5 28.2 signal
43 Toxic Epidermal Necrolysis 48 25.3 25.7 signal
44 General Physical Health Deterioration 360 24.9 28.6 signal
45 Stress 217 24.0 26.0 signal
46 Gastrooesophageal Reflux Disease 239 23.7 25.9 signal
47 Psoriatic Arthropathy 119 23.5 24.5 signal
48 Night Sweats 95 23.4 24.3 signal
49 Systemic Lupus Erythematosus 102 22.9 23.8 signal
50 Impaired Healing 94 22.7 23.5 signal
51 Abdominal Distension 290 22.1 24.7 signal
52 Contraindicated Product Administered 81 21.3 22.0 signal
53 Blood Potassium Increased 43 21.0 21.4 signal
54 Sleep Disorder 180 20.4 21.8 signal
55 Swelling 239 20.3 22.2 signal
56 Ataxia 30 20.0 20.2 signal
57 Cyst 30 19.2 19.4 signal
58 Chronic Obstructive Pulmonary Disease 125 19.0 19.9 signal
59 Type 2 Diabetes Mellitus 79 18.6 19.1 signal
60 Muscle Spasticity 29 18.5 18.7 signal
61 Aspiration 25 18.3 18.5 signal
62 Drug Intolerance 222 18.3 19.9 signal
63 Inflammation 117 18.1 18.9 signal
64 Liver Function Test Increased 47 17.5 17.8 signal
65 Stomatitis 132 17.3 18.1 signal
66 Sepsis 242 17.2 18.8 signal
67 Musculoskeletal Pain 113 17.0 17.7 signal
68 Lung Disorder 103 16.7 17.3 signal
69 Osteopenia 32 16.6 16.8 signal
70 C-reactive Protein Increased 76 16.6 17.0 signal
71 Wheezing 123 16.5 17.2 signal
72 Coma 99 16.5 17.1 signal
73 Neck Pain 116 16.4 17.1 signal
74 Arthropathy 113 16.1 16.7 signal
75 Central Nervous System Lesion 27 15.5 15.6 signal
76 Infusion Related Reaction 125 15.0 15.7 signal
77 Blister 103 14.6 15.1 signal
78 Deformity 17 14.4 14.5 signal
79 Frequent Bowel Movements 48 14.1 14.4 signal
80 Autoimmune Disorder 17 14.1 14.2 signal
81 Migraine 166 13.9 14.7 signal
82 Diabetes Mellitus 131 13.6 14.2 signal
83 Rash Papular 38 13.4 13.6 signal
84 Pulmonary Fibrosis 31 12.9 13.0 signal
85 Full Blood Count Abnormal 17 12.8 12.9 signal
86 Thrombosis 130 12.8 13.4 signal
87 Laryngitis 17 12.4 12.5 signal
88 Hepatic Enzyme Increased 105 12.2 12.7 signal
89 Blood Creatinine Increased 100 12.1 12.6 signal
90 Sputum Discoloured 14 11.7 11.8 signal
91 Maternal Exposure During Pregnancy 127 11.4 11.9 signal
92 Obstructive Airways Disorder 16 11.4 11.4 signal
93 Pulmonary Mass 21 11.2 11.3 signal
94 Intentional Product Misuse 122 11.1 11.6 signal
95 Skin Lesion 37 10.8 10.9 signal
96 Somnolence 272 10.7 11.8 signal
97 Abdominal Pain 314 10.7 12.0 signal
98 Vitamin D Deficiency 13 10.6 10.6 signal
99 Constipation 284 10.4 11.5 signal
100 Musculoskeletal Stiffness 115 10.4 10.8 signal
101 Iron Deficiency Anaemia 12 10.4 10.4 signal
102 Sleep Disorder Due To A General Medical Condition 21 10.3 10.4 signal
103 Rheumatoid Arthritis 145 10.2 10.7 signal
104 Blood Pressure Systolic Increased 25 10.1 10.2 signal
105 Pulmonary Embolism 119 9.9 10.3 signal
106 Rash Erythematous 58 9.8 10.0 signal
107 Hepatic Steatosis 23 9.8 9.9 signal
108 Memory Impairment 170 9.8 10.4 signal
109 Ear Pain 24 9.8 9.9 signal
110 Mobility Decreased 87 9.6 9.9 signal
111 Aspartate Aminotransferase Increased 60 9.0 9.1 signal
112 Feeling Hot 69 8.9 9.1 signal
113 Exposure During Pregnancy 69 8.8 9.0 signal
114 Drug Hypersensitivity 215 8.8 9.5 signal
115 Hypoaesthesia 164 8.7 9.2 signal
116 Dysarthria 41 8.6 8.8 signal
117 Erectile Dysfunction 28 8.6 8.7 signal
118 Therapeutic Product Effect Decreased 48 8.6 8.7 signal
119 Transaminases Increased 24 8.6 8.6 signal
120 Sciatica 17 8.5 8.5 signal
121 Gait Inability 35 8.4 8.5 signal
122 Eructation 20 8.3 8.4 signal
123 Paraesthesia 164 8.2 8.7 signal
124 Anaemia 198 8.2 8.8 signal
125 Prescribed Overdose 20 8.2 8.2 signal
126 Condition Aggravated 310 8.1 9.1 signal
127 Prescribed Underdose 20 7.9 8.0 signal
128 Joint Swelling 120 7.9 8.2 signal
129 Hepatotoxicity 22 7.9 7.9 signal
130 Abdominal Pain Upper 202 7.8 8.4 signal
131 Osteoporosis 40 7.7 7.8 signal
132 Movement Disorder 31 7.6 7.7 signal
133 Weight Fluctuation 10 7.6 7.6 signal
134 Rash Maculo-papular 21 7.5 7.6 signal
135 Peripheral Swelling 144 7.4 7.8 signal
136 Pleural Effusion 57 7.4 7.6 signal
137 Treatment Failure 76 7.3 7.5 signal
138 Hepatic Cirrhosis 17 7.2 7.2 signal
139 Body Temperature Decreased 9 7.2 7.2 signal
140 Adverse Reaction 12 7.2 7.2 signal
141 Joint Stiffness 23 6.9 7.0 signal
142 Oedema Peripheral 107 6.9 7.2 signal
143 Blood Pressure Fluctuation 21 6.9 7.0 signal
144 Vomiting 408 6.9 8.0 signal
145 Diverticulitis 24 6.9 6.9 signal
146 Oedema 47 6.9 7.0 signal
147 Respiratory Disorder 26 6.9 6.9 signal
148 Tuberculosis 11 6.8 6.8 signal
149 Diarrhoea Haemorrhagic 8 6.8 6.8 signal
150 Urticaria 142 6.8 7.1 signal
151 Dry Eye 41 6.7 6.8 signal
152 Musculoskeletal Chest Pain 13 6.6 6.7 signal
153 Red Blood Cell Count Decreased 24 6.6 6.7 signal
154 Lower Limb Fracture 16 6.6 6.7 signal
155 Dizziness Postural 8 6.6 6.6 signal
156 Haemoptysis 23 6.5 6.6 signal
157 Injury 58 6.5 6.6 signal
158 Foot Deformity 9 6.4 6.4 signal
159 Product Use In Unapproved Indication 196 6.4 6.8 signal
160 Blood Calcium Decreased 9 6.3 6.3 signal
161 Joint Injury 17 6.3 6.3 signal
162 Hypomagnesaemia 11 6.3 6.3 signal
163 Motor Dysfunction 8 6.3 6.3 signal
164 Confusional State 128 6.3 6.5 signal
165 Haemoglobin Decreased 81 6.2 6.4 signal
166 Hypertension 165 6.2 6.5 signal
167 Poor Venous Access 8 6.1 6.2 signal
168 Oral Candidiasis 10 6.1 6.1 signal
169 Blood Iron Decreased 9 6.0 6.1 signal
170 Gastrointestinal Disorder 67 6.0 6.1 signal
171 Neuropathy Peripheral 71 5.9 6.1 signal
172 Premature Delivery 12 5.9 6.0 signal
173 Pollakiuria 30 5.7 5.8 signal
174 Upper Respiratory Tract Infection 33 5.7 5.7 signal
175 Abdominal Discomfort 119 5.6 5.9 signal
176 Underdose 52 5.6 5.7 signal
177 Status Epilepticus 8 5.6 5.6 signal
178 Haematocrit Decreased 14 5.6 5.6 signal
179 Vaginal Discharge 7 5.5 5.5 signal
180 Muscle Spasms 126 5.4 5.7 signal
181 Sleep Apnoea Syndrome 13 5.4 5.4 signal
182 Discomfort 41 5.4 5.4 signal
183 Nasopharyngitis 123 5.3 5.5 signal
184 Delirium 23 5.3 5.3 signal
185 Joint Dislocation 7 5.3 5.3 signal
186 Bradycardia 35 5.2 5.3 signal
187 Hypophagia 16 5.0 5.0 signal
188 Nerve Injury 7 5.0 5.0 signal
189 Paraesthesia Oral 9 5.0 5.0 signal
190 Apathy 9 4.9 4.9 signal
191 Hypersensitivity 113 4.8 5.0 signal
192 Decreased Appetite 137 4.7 4.9 signal
193 Blood Bilirubin Increased 16 4.7 4.7 signal
194 Alopecia 116 4.7 4.8 signal
195 Macular Degeneration 7 4.7 4.7 signal
196 Rectal Haemorrhage 25 4.6 4.6 signal
197 Asthenia 218 4.6 4.9 signal
198 Renal Impairment 48 4.5 4.6 signal
199 Pain 351 4.5 5.1 signal
200 Faeces Discoloured 12 4.4 4.4 signal
201 Balance Disorder 47 4.3 4.4 signal
202 Cardiomyopathy 8 4.3 4.3 signal
203 Product Quality Issue 72 4.2 4.3 signal
204 Tooth Infection 7 4.2 4.2 signal
205 Nausea 418 4.2 4.8 signal
206 Hypocalcaemia 10 4.2 4.2 signal
207 Heart Rate Irregular 12 4.2 4.2 signal
208 Coronary Artery Disease 16 4.2 4.2 signal
209 Therapeutic Product Effect Incomplete 37 4.1 4.2 signal
210 Dyspepsia 51 4.1 4.2 signal
211 Sinus Bradycardia 5 4.1 4.1 signal
212 Off Label Use 446 4.1 4.7 signal
213 Lymphadenopathy 18 4.0 4.0 signal
214 Depression 114 4.0 4.1 signal
215 Weight Increased 110 3.9 4.0 signal
216 Inappropriate Antidiuretic Hormone Secretion 5 3.9 3.9 signal
217 Asthma 55 3.9 3.9 signal
218 Back Pain 114 3.9 4.0 signal
219 Thinking Abnormal 9 3.8 3.8 signal
220 Headache 300 3.8 4.2 signal
221 Immunodeficiency 7 3.8 3.8 signal
222 Fluid Retention 24 3.7 3.8 signal
223 Colitis Ulcerative 21 3.7 3.8 signal
224 Paranoia 8 3.7 3.7 signal
225 Arthralgia 191 3.7 3.9 signal
226 Hip Arthroplasty 7 3.6 3.7 signal
227 Oropharyngeal Pain 42 3.6 3.6 signal
228 Delusion 7 3.6 3.6 signal
229 Eye Haemorrhage 6 3.6 3.6 signal
230 Multiple Sclerosis Relapse 31 3.6 3.6 signal
231 Visual Impairment 55 3.5 3.6 signal
232 Amnesia 29 3.5 3.5 signal
233 Knee Arthroplasty 9 3.4 3.4 signal
234 Road Traffic Accident 18 3.4 3.4 signal
235 Vasculitis 5 3.4 3.4 signal
236 Rash Pruritic 23 3.4 3.4 signal
237 Covid-19 Pneumonia 5 3.3 3.3 signal
238 Polyneuropathy 5 3.3 3.3 signal
239 Limb Discomfort 13 3.3 3.3 signal
240 Muscle Rigidity 5 3.3 3.3 signal
241 Therapy Change 4 3.3 3.3 signal
242 Hyperthyroidism 6 3.3 3.3 signal
243 Localised Infection 10 3.3 3.3 signal
244 Parkinsonism 4 3.2 3.3 signal
245 Coeliac Disease 4 3.2 3.2 signal
246 Adverse Event 37 3.2 3.2 signal
247 Flushing 41 3.2 3.2 signal
248 Eosinophilia 7 3.2 3.2 signal
249 Sluggishness 4 3.1 3.1 no signal
250 Cardiovascular Disorder 10 3.1 3.1 signal
251 Inappropriate Schedule Of Product Administration 68 3.0 3.1 signal
252 Transfusion 4 3.0 3.0 no signal
253 Breast Cancer Metastatic 4 3.0 3.0 no signal
254 Akathisia 5 2.9 2.9 signal
255 Drug Effect Less Than Expected 5 2.8 2.8 signal
256 Upper Limb Fracture 7 2.8 2.8 signal
257 Full Blood Count Decreased 7 2.7 2.8 signal
258 Pregnancy 7 2.7 2.7 signal
259 Foetal Exposure During Pregnancy 28 2.7 2.7 signal
260 Procedural Pain 9 2.6 2.6 signal
261 Injection Site Irritation 4 2.5 2.5 no signal
262 Product Physical Issue 6 2.4 2.4 no signal
263 Cytomegalovirus Infection 5 2.4 2.4 no signal
264 Toxic Skin Eruption 3 2.4 2.4 no signal
265 Influenza Like Illness 24 2.3 2.3 signal
266 Rebound Effect 3 2.1 2.1 no signal
267 Sexual Dysfunction 3 2.0 2.0 no signal
268 Caesarean Section 3 2.0 2.0 no signal
269 Schizophrenia 3 2.0 2.0 no signal
270 Hepatic Cytolysis 3 1.9 1.9 no signal
271 Injection Site Warmth 5 1.9 1.9 no signal
272 Peritonitis 5 1.9 1.9 no signal
273 Glycosylated Haemoglobin Increased 6 1.9 1.9 no signal
274 Drug Reaction With Eosinophilia And Systemic Symptoms 6 1.9 1.9 no signal
275 Neoplasm Progression 8 1.8 1.8 no signal
276 Drug Toxicity 3 1.7 1.7 no signal
277 Palmar-plantar Erythrodysaesthesia Syndrome 5 1.7 1.7 no signal
278 Premature Baby 6 1.6 1.6 no signal
279 Injection Site Swelling 15 1.6 1.6 no signal
280 Injection Site Rash 6 1.6 1.6 no signal
281 Injection Site Mass 7 1.5 1.5 no signal
282 Drug Effect Decreased 10 1.4 1.5 no signal
283 Injection Site Erythema 22 1.4 1.4 no signal
284 Needle Issue 5 1.4 1.4 no signal
285 Drug Effective For Unapproved Indication 5 1.4 1.4 no signal
286 Withdrawal Syndrome 7 1.3 1.3 no signal
287 Injection Site Reaction 11 1.3 1.3 no signal
288 Product Complaint 4 1.3 1.3 no signal
289 Circumstance Or Information Capable Of Leading To Medication Error 5 1.2 1.2 no signal
290 Injection Site Pruritus 9 1.1 1.1 no signal
291 Injection Site Urticaria 3 1.0 1.0 no signal
292 Device Dislocation 5 0.9 0.9 no signal