Drug

Rasburicase

109 flagged reaction(s) · 2,840 total co-reports · max PRR 58.8

Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.

	Reaction	Co-reports (a)	PRR	ROR	Signal
1	Cytokine Release Syndrome	128	58.8	62.1	signal
2	Multiple Organ Dysfunction Syndrome	87	27.2	28.2	signal
3	Febrile Neutropenia	202	26.6	29.0	signal
4	Hyperbilirubinaemia	30	25.4	25.7	signal
5	Disseminated Intravascular Coagulation	38	23.5	23.8	signal
6	Hypercalcaemia	23	16.3	16.4	signal
7	Toxic Epidermal Necrolysis	26	15.0	15.2	signal
8	Hepatocellular Injury	24	14.7	14.8	signal
9	Hyperkalaemia	57	14.2	14.6	signal
10	Blood Lactate Dehydrogenase Increased	26	14.2	14.4	signal
11	Ventricular Fibrillation	18	14.1	14.2	signal
12	Lymphopenia	21	13.0	13.1	signal
13	Hypoxia	52	12.9	13.2	signal
14	Neurotoxicity	25	12.5	12.7	signal
15	Blood Potassium Increased	23	12.3	12.5	signal
16	Acute Myeloid Leukaemia	21	11.7	11.8	signal
17	Respiratory Failure	91	10.9	11.2	signal
18	Mucosal Inflammation	32	10.7	10.8	signal
19	Bacteraemia	14	10.4	10.4	signal
20	Toxic Skin Eruption	12	10.3	10.4	signal
21	Haematotoxicity	11	10.3	10.4	signal
22	Encephalopathy	29	10.3	10.4	signal
23	Posterior Reversible Encephalopathy Syndrome	11	10.1	10.1	signal
24	Septic Shock	49	9.9	10.1	signal
25	Clostridium Difficile Colitis	12	9.8	9.9	signal
26	Cytopenia	13	9.5	9.5	signal
27	Pancytopenia	60	9.4	9.6	signal
28	Cardiogenic Shock	15	9.2	9.2	signal
29	Multi-organ Failure	18	8.9	9.0	signal
30	Candida Infection	17	8.9	8.9	signal
31	Neutropenia	132	8.5	8.9	signal
32	Electrolyte Imbalance	11	8.3	8.4	signal
33	Acute Kidney Injury	142	8.1	8.6	signal
34	Sinus Tachycardia	13	8.0	8.0	signal
35	Sepsis	102	8.0	8.3	signal
36	Hypocalcaemia	16	7.4	7.4	signal
37	Subdural Haematoma	12	7.3	7.3	signal
38	Respiratory Distress	23	7.3	7.3	signal
39	Hepatic Failure	25	7.2	7.3	signal
40	Hepatotoxicity	18	7.1	7.1	signal
41	Blood Creatinine Increased	52	6.9	7.1	signal
42	Neutrophil Count Decreased	32	6.9	7.0	signal
43	Metabolic Acidosis	25	6.9	6.9	signal
44	Blood Test Abnormal	11	6.8	6.8	signal
45	Nervous System Disorder	24	6.7	6.7	signal
46	Tachypnoea	10	6.4	6.4	signal
47	Cholestasis	14	6.4	6.4	signal
48	Acute Respiratory Failure	14	6.4	6.4	signal
49	Coagulopathy	12	6.3	6.3	signal
50	Leukopenia	36	6.3	6.4	signal
51	Blood Calcium Decreased	8	6.2	6.2	signal
52	Thrombocytopenia	79	6.2	6.3	signal
53	Bacterial Infection	13	6.1	6.1	signal
54	Tubulointerstitial Nephritis	13	6.0	6.1	signal
55	Splenomegaly	8	5.9	6.0	signal
56	Product Preparation Error	14	5.9	5.9	signal
57	Covid-19 Pneumonia	8	5.9	5.9	signal
58	Chromaturia	15	5.8	5.8	signal
59	Appendicitis	6	5.6	5.6	signal
60	Blood Bilirubin Increased	17	5.5	5.5	signal
61	Renal Tubular Necrosis	6	5.3	5.3	signal
62	Infusion Related Reaction	40	5.3	5.3	signal
63	Pericarditis	10	5.2	5.2	signal
64	Clostridium Difficile Infection	13	5.2	5.2	signal
65	Bone Marrow Failure	12	5.1	5.1	signal
66	Gamma-glutamyltransferase Increased	13	5.1	5.1	signal
67	Drug Resistance	15	5.1	5.1	signal
68	Petechiae	6	5.0	5.0	signal
69	Hypomagnesaemia	8	5.0	5.0	signal
70	Renal Failure	77	5.0	5.1	signal
71	Staphylococcal Infection	19	5.0	5.0	signal
72	Lymphocyte Count Decreased	10	4.9	4.9	signal
73	Aphasia	17	4.9	4.9	signal
74	Pleural Effusion	34	4.9	4.9	signal
75	Cardio-respiratory Arrest	23	4.8	4.8	signal
76	Fluid Overload	8	4.7	4.7	signal
77	Skin Disorder	18	4.7	4.7	signal
78	Renal Failure Acute	23	4.7	4.7	signal
79	Upper Gastrointestinal Haemorrhage	9	4.6	4.7	signal
80	Circulatory Collapse	9	4.6	4.6	signal
81	Sinus Bradycardia	5	4.5	4.5	signal
82	Plasma Cell Myeloma	20	4.5	4.5	signal
83	Acute Respiratory Distress Syndrome	9	4.4	4.4	signal
84	Polyneuropathy	6	4.4	4.4	signal
85	Dialysis	7	4.3	4.3	signal
86	Product Prescribing Issue	10	4.3	4.3	signal
87	White Blood Cell Count Decreased	53	4.3	4.3	signal
88	Folliculitis	5	4.2	4.2	signal
89	Cardiac Arrest	40	4.2	4.3	signal
90	Cytomegalovirus Infection	8	4.2	4.2	signal
91	Unresponsive To Stimuli	12	4.1	4.1	signal
92	Disease Progression	55	4.1	4.1	signal
93	Transaminases Increased	10	3.9	3.9	signal
94	Obstructive Airways Disorder	5	3.9	3.9	signal
95	Lung Infection	7	3.9	3.9	signal
96	Pneumonitis	11	3.5	3.6	signal
97	Hospice Care	4	3.5	3.5	signal
98	Stevens-johnson Syndrome	9	3.5	3.5	signal
99	Pneumocystis Jirovecii Pneumonia	4	3.5	3.5	signal
100	Agranulocytosis	7	3.3	3.3	signal
101	Rebound Effect	4	3.1	3.1	no signal
102	Full Blood Count Decreased	7	3.0	3.0	signal
103	Neoplasm Progression	12	3.0	3.0	signal
104	Myelosuppression	11	2.8	2.8	signal
105	Lactic Acidosis	9	2.4	2.4	signal
106	Malignant Neoplasm Progression	24	2.1	2.1	signal
107	Synovitis	3	1.4	1.4	no signal
108	Product Storage Error	13	1.3	1.3	no signal
109	Accidental Exposure To Product	10	0.9	0.9	no signal