Drug

Selpercatinib

30 flagged reaction(s) · 633 total co-reports · max PRR 24.4

Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.

	Reaction	Co-reports (a)	PRR	ROR	Signal
1	Hepatotoxicity	34	24.4	25.0	signal
2	Hepatic Cytolysis	17	22.1	22.4	signal
3	Liver Function Test Increased	29	21.6	22.1	signal
4	Hepatic Function Abnormal	48	20.6	21.3	signal
5	Ascites	38	20.5	21.1	signal
6	Malignant Neoplasm Progression	130	20.3	22.4	signal
7	Nephropathy Toxic	14	20.0	20.2	signal
8	Electrocardiogram Qt Prolonged	39	17.2	17.7	signal
9	Drug-induced Liver Injury	25	12.9	13.1	signal
10	Aspartate Aminotransferase Increased	40	12.0	12.3	signal
11	Therapy Partial Responder	11	11.6	11.7	signal
12	Hypercalcaemia	9	11.6	11.7	signal
13	Alanine Aminotransferase Increased	40	10.3	10.6	signal
14	Proteinuria	12	10.1	10.2	signal
15	Inappropriate Antidiuretic Hormone Secretion	6	9.4	9.4	signal
16	Drug Resistance	15	9.3	9.4	signal
17	Pericardial Effusion	13	9.0	9.0	signal
18	Hypocalcaemia	10	8.4	8.5	signal
19	Hepatic Failure	16	8.4	8.5	signal
20	Therapy Change	5	8.2	8.3	signal
21	Disseminated Intravascular Coagulation	7	7.9	7.9	signal
22	Mucosal Inflammation	11	6.7	6.7	signal
23	Thrombotic Microangiopathy	4	6.6	6.6	signal
24	Metastases To Central Nervous System	5	6.2	6.2	signal
25	Myelosuppression	13	6.1	6.1	signal
26	Pneumonitis	10	5.9	5.9	signal
27	Myocarditis	4	5.6	5.6	signal
28	Brain Neoplasm	3	5.2	5.2	signal
29	Haematotoxicity	3	5.1	5.1	signal
30	Therapy Interrupted	22	5.1	5.1	signal