OpenPV Signal Explorer
FAERS disproportionality dashboard
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Drug

Sodium Fluoride

323 flagged reaction(s) · 16,967 total co-reports · max PRR 76.9
Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.
Reaction Co-reports (a) PRR ROR Signal
1 Wound Infection 145 76.9 80.0 signal
2 Helicobacter Infection 112 63.2 65.1 signal
3 Hypercholesterolaemia 97 58.2 59.8 signal
4 Pemphigus 119 55.0 56.8 signal
5 Joint Dislocation 98 53.4 54.9 signal
6 Folliculitis 96 53.3 54.7 signal
7 Autoimmune Disorder 87 52.2 53.4 signal
8 Foot Deformity 91 47.0 48.2 signal
9 Laryngitis 89 47.0 48.1 signal
10 Red Blood Cell Sedimentation Rate Increased 83 42.9 43.8 signal
11 Pericarditis 121 41.6 43.0 signal
12 Joint Range Of Motion Decreased 97 41.6 42.7 signal
13 Prescribed Underdose 137 39.3 40.8 signal
14 Hand Deformity 88 38.5 39.4 signal
15 Sciatica 103 37.2 38.2 signal
16 Glossodynia 129 33.0 34.2 signal
17 Oral Discomfort 80 32.9 33.6 signal
18 Prescribed Overdose 98 28.9 29.7 signal
19 Fibromyalgia 122 28.7 29.7 signal
20 Irritable Bowel Syndrome 107 28.6 29.4 signal
21 Hip Arthroplasty 76 28.6 29.2 signal
22 Wound 139 28.6 29.7 signal
23 Pulmonary Fibrosis 95 28.4 29.1 signal
24 Lower Limb Fracture 94 28.1 28.8 signal
25 Synovitis 87 27.5 28.2 signal
26 Hepatic Cirrhosis 87 26.6 27.2 signal
27 Type 2 Diabetes Mellitus 156 26.4 27.5 signal
28 Liver Injury 101 23.8 24.5 signal
29 Liver Function Test Increased 88 23.6 24.1 signal
30 Joint Stiffness 102 22.2 22.8 signal
31 Disability 74 21.3 21.8 signal
32 Osteoarthritis 148 19.9 20.7 signal
33 Ear Infection 90 19.3 19.8 signal
34 C-reactive Protein Increased 122 19.1 19.8 signal
35 Upper Respiratory Tract Infection 149 18.4 19.2 signal
36 Impaired Healing 104 18.1 18.6 signal
37 Knee Arthroplasty 66 18.1 18.4 signal
38 Osteoporosis 128 17.7 18.3 signal
39 Dental Caries 34 17.6 17.7 signal
40 Gait Inability 101 17.4 17.9 signal
41 Systemic Lupus Erythematosus 99 16.0 16.4 signal
42 Psoriatic Arthropathy 111 15.7 16.2 signal
43 Delirium 92 15.2 15.5 signal
44 Stomatitis 157 14.8 15.4 signal
45 Cytokine Release Syndrome 49 14.7 14.8 signal
46 Oral Pain 57 14.5 14.7 signal
47 Drug-induced Liver Injury 76 14.0 14.3 signal
48 Road Traffic Accident 102 13.9 14.3 signal
49 Wheezing 140 13.5 14.0 signal
50 Toothache 42 13.2 13.4 signal
51 Bursitis 28 13.2 13.3 signal
52 Oedema 124 13.1 13.5 signal
53 Sleep Disorder Due To A General Medical Condition 37 13.0 13.2 signal
54 Blood Cholesterol Increased 105 12.8 13.2 signal
55 Coeliac Disease 21 12.2 12.3 signal
56 Tooth Fracture 23 11.9 12.0 signal
57 Gingival Bleeding 27 11.2 11.3 signal
58 Blood Iron Decreased 23 11.1 11.2 signal
59 Discomfort 114 10.7 11.0 signal
60 Hypoaesthesia Oral 27 10.2 10.3 signal
61 Loss Of Personal Independence In Daily Activities 85 10.2 10.4 signal
62 Mobility Decreased 127 10.1 10.4 signal
63 Infusion Related Reaction 113 9.7 10.0 signal
64 Arthropathy 92 9.4 9.6 signal
65 Injury 116 9.3 9.6 signal
66 Musculoskeletal Stiffness 142 9.2 9.6 signal
67 Blister 89 9.0 9.2 signal
68 Hepatic Enzyme Increased 107 9.0 9.2 signal
69 Ear Pain 30 8.8 8.8 signal
70 Oral Candidiasis 20 8.8 8.8 signal
71 Product Taste Abnormal 20 8.5 8.5 signal
72 Respiratory Tract Infection 38 8.3 8.4 signal
73 Sinusitis 150 8.3 8.6 signal
74 Amnesia 93 8.1 8.3 signal
75 Tooth Loss 29 7.9 8.0 signal
76 Breast Cancer Stage I 13 7.9 7.9 signal
77 Tooth Abscess 14 7.8 7.8 signal
78 Spinal Disorder 13 7.8 7.8 signal
79 Bronchitis 98 7.5 7.7 signal
80 Back Injury 14 7.4 7.4 signal
81 Arthritis 101 7.3 7.5 signal
82 Contusion 119 7.0 7.2 signal
83 Atelectasis 12 7.0 7.1 signal
84 Swelling 114 7.0 7.1 signal
85 Peripheral Swelling 187 6.9 7.3 signal
86 Joint Swelling 143 6.8 7.0 signal
87 Tachycardia 105 6.7 6.9 signal
88 Immunodeficiency 17 6.6 6.6 signal
89 Oedema Peripheral 140 6.5 6.7 signal
90 Sleep Disorder 80 6.5 6.6 signal
91 Obesity 18 6.4 6.4 signal
92 Tooth Extraction 14 6.4 6.4 signal
93 Dyspepsia 110 6.4 6.5 signal
94 Ageusia 28 6.4 6.4 signal
95 Tooth Disorder 25 6.4 6.4 signal
96 Lip Swelling 37 6.3 6.4 signal
97 Nasopharyngitis 204 6.3 6.6 signal
98 Visual Impairment 135 6.2 6.4 signal
99 Dry Mouth 87 6.1 6.2 signal
100 General Physical Health Deterioration 123 6.1 6.3 signal
101 Tooth Infection 14 6.0 6.1 signal
102 Urticaria 175 6.0 6.2 signal
103 Mouth Ulceration 22 6.0 6.0 signal
104 Throat Tightness 28 5.9 5.9 signal
105 Muscular Weakness 114 5.7 5.9 signal
106 Hypoaesthesia 149 5.7 5.9 signal
107 Osteopenia 15 5.6 5.6 signal
108 Tenderness 10 5.5 5.5 signal
109 Asthma 106 5.4 5.5 signal
110 Abdominal Discomfort 157 5.3 5.5 signal
111 Memory Impairment 128 5.3 5.5 signal
112 Rheumatoid Arthritis 105 5.3 5.4 signal
113 Haemorrhoids 18 5.2 5.3 signal
114 Night Sweats 29 5.1 5.2 signal
115 Malnutrition 10 5.1 5.1 signal
116 Weight Increased 197 5.0 5.3 signal
117 Hypersensitivity 161 4.9 5.1 signal
118 Infection 125 4.9 5.1 signal
119 Weight Fluctuation 9 4.9 4.9 signal
120 Swollen Tongue 27 4.9 4.9 signal
121 Contraindicated Product Administered 26 4.9 4.9 signal
122 Clostridium Difficile Colitis 9 4.8 4.8 signal
123 Economic Problem 13 4.8 4.8 signal
124 Paraesthesia Oral 12 4.8 4.8 signal
125 Osteomyelitis 15 4.7 4.7 signal
126 Vitamin D Deficiency 8 4.7 4.7 signal
127 Bone Disorder 15 4.6 4.7 signal
128 Psoriasis 106 4.6 4.7 signal
129 Weight Decreased 226 4.6 4.8 signal
130 Muscle Spasticity 10 4.6 4.6 signal
131 Spinal Fracture 16 4.6 4.6 signal
132 Taste Disorder 16 4.5 4.6 signal
133 Back Disorder 13 4.5 4.5 signal
134 Impaired Gastric Emptying 10 4.5 4.5 signal
135 Seasonal Allergy 11 4.4 4.4 signal
136 Hypertension 164 4.4 4.6 signal
137 Dyspnoea Exertional 29 4.4 4.4 signal
138 Choking 15 4.4 4.4 signal
139 Confusional State 125 4.4 4.5 signal
140 Hiatus Hernia 10 4.4 4.4 signal
141 Hypoxia 27 4.4 4.4 signal
142 Pneumothorax 12 4.3 4.3 signal
143 Product Packaging Issue 7 4.3 4.3 signal
144 Feeding Disorder 15 4.3 4.3 signal
145 Skin Laceration 8 4.2 4.2 signal
146 Sinus Congestion 10 4.2 4.2 signal
147 Haemoglobin Decreased 76 4.2 4.3 signal
148 Aspiration 8 4.2 4.2 signal
149 Pneumonia 238 4.2 4.4 signal
150 Sleep Apnoea Syndrome 14 4.2 4.2 signal
151 Intentional Product Use Issue 64 4.1 4.2 signal
152 Dysphonia 42 4.1 4.1 signal
153 Chest Pain 133 4.1 4.2 signal
154 Sneezing 16 4.1 4.1 signal
155 Alopecia 139 4.0 4.1 signal
156 Retching 15 4.0 4.0 signal
157 Dermatitis Contact 8 4.0 4.0 signal
158 Basal Cell Carcinoma 11 4.0 4.0 signal
159 Cholecystectomy 8 4.0 4.0 signal
160 Mucosal Inflammation 18 3.9 3.9 signal
161 Decreased Appetite 159 3.9 4.0 signal
162 Pyrexia 236 3.9 4.1 signal
163 Swelling Face 44 3.8 3.9 signal
164 Cholecystitis 8 3.8 3.8 signal
165 Full Blood Count Abnormal 7 3.8 3.8 signal
166 Viral Infection 22 3.8 3.8 signal
167 Anxiety 188 3.7 3.9 signal
168 Gait Disturbance 126 3.7 3.8 signal
169 Nerve Compression 6 3.7 3.7 signal
170 Increased Tendency To Bruise 6 3.7 3.7 signal
171 Hypercalcaemia 8 3.7 3.7 signal
172 Pharyngitis Streptococcal 7 3.7 3.7 signal
173 Aphonia 9 3.7 3.7 signal
174 Intervertebral Disc Degeneration 6 3.7 3.7 signal
175 Ocular Discomfort 7 3.7 3.7 signal
176 Osteonecrosis Of Jaw 16 3.7 3.7 signal
177 Pain In Extremity 188 3.6 3.8 signal
178 Squamous Cell Carcinoma 6 3.6 3.6 signal
179 Skin Infection 7 3.6 3.6 signal
180 Depression 143 3.6 3.7 signal
181 Neck Pain 35 3.6 3.6 signal
182 Lymphadenopathy 22 3.5 3.5 signal
183 Drug Intolerance 59 3.5 3.5 signal
184 Metastases To Bone 10 3.5 3.5 signal
185 Immune System Disorder 8 3.5 3.5 signal
186 Anhedonia 16 3.4 3.4 signal
187 Pain In Jaw 17 3.4 3.4 signal
188 Incorrect Route Of Product Administration 10 3.4 3.4 signal
189 Hair Texture Abnormal 8 3.4 3.4 signal
190 Chronic Kidney Disease 45 3.3 3.4 signal
191 Gastrooesophageal Reflux Disease 47 3.3 3.4 signal
192 Condition Aggravated 176 3.3 3.4 signal
193 Hypomagnesaemia 8 3.3 3.3 signal
194 Dysphagia 54 3.2 3.3 signal
195 Burning Sensation 40 3.2 3.3 signal
196 Migraine 54 3.2 3.3 signal
197 Product Complaint 14 3.2 3.2 signal
198 Decreased Activity 6 3.2 3.2 signal
199 Chest Discomfort 57 3.2 3.2 signal
200 Pulmonary Embolism 53 3.2 3.2 signal
201 Lung Disorder 27 3.1 3.2 signal
202 Oropharyngeal Pain 51 3.1 3.2 signal
203 Rhinorrhoea 35 3.1 3.1 signal
204 Rotator Cuff Syndrome 7 3.1 3.1 signal
205 Throat Irritation 24 3.1 3.1 signal
206 Adverse Drug Reaction 48 3.1 3.1 signal
207 Platelet Count Decreased 57 3.0 3.1 signal
208 Rash Erythematous 25 3.0 3.0 signal
209 Bone Loss 8 3.0 3.0 signal
210 Musculoskeletal Discomfort 9 3.0 3.0 signal
211 Pharyngeal Swelling 5 3.0 3.0 signal
212 Dizziness Postural 5 3.0 3.0 signal
213 Thrombocytopenia 58 3.0 3.0 signal
214 Metastases To Lung 6 3.0 3.0 signal
215 Therapeutic Product Effect Decreased 23 2.9 3.0 signal
216 Laboratory Test Abnormal 15 2.9 2.9 signal
217 Lower Respiratory Tract Infection 23 2.9 2.9 signal
218 White Blood Cell Count Decreased 55 2.9 2.9 signal
219 Head Injury 16 2.9 2.9 signal
220 Respiratory Tract Congestion 8 2.9 2.9 signal
221 Rash 218 2.9 3.0 signal
222 Hypothyroidism 16 2.9 2.9 signal
223 Salivary Hypersecretion 5 2.8 2.8 signal
224 Spinal Operation 6 2.8 2.8 signal
225 Dry Throat 5 2.8 2.8 signal
226 Epilepsy 15 2.8 2.8 signal
227 Arthralgia 203 2.8 2.9 signal
228 Temperature Intolerance 5 2.8 2.8 signal
229 Hypersomnia 14 2.8 2.8 signal
230 Pruritus 183 2.8 2.8 signal
231 Dermatitis Allergic 6 2.7 2.7 signal
232 Psychomotor Hyperactivity 8 2.7 2.7 signal
233 Hair Colour Changes 6 2.7 2.7 signal
234 Fluid Retention 24 2.7 2.7 signal
235 Dysgeusia 35 2.7 2.7 signal
236 Dizziness 233 2.7 2.8 signal
237 Eating Disorder 10 2.7 2.7 signal
238 Pain 286 2.6 2.8 signal
239 Cough 130 2.6 2.7 signal
240 Oral Herpes 9 2.6 2.6 signal
241 Ill-defined Disorder 28 2.6 2.6 signal
242 Deafness 12 2.6 2.6 signal
243 Pulmonary Thrombosis 5 2.6 2.6 no signal
244 Dry Eye 22 2.6 2.6 signal
245 Acute Myeloid Leukaemia 7 2.6 2.6 signal
246 Sars-cov-2 Test Positive 6 2.6 2.6 signal
247 Pharyngeal Oedema 7 2.6 2.6 signal
248 Nerve Injury 5 2.6 2.6 no signal
249 Hunger 6 2.5 2.5 signal
250 Impaired Driving Ability 5 2.5 2.5 no signal
251 Sensory Disturbance 7 2.5 2.5 signal
252 Surgery 25 2.5 2.5 signal
253 Anaphylactic Shock 11 2.4 2.4 signal
254 Nasal Congestion 25 2.4 2.4 signal
255 Deformity 4 2.4 2.4 no signal
256 Covid-19 75 2.4 2.4 signal
257 Expired Product Administered 14 2.4 2.4 signal
258 Blood Urine Present 8 2.4 2.4 signal
259 Wrist Fracture 5 2.4 2.4 no signal
260 Localised Infection 10 2.4 2.4 signal
261 Crying 15 2.3 2.3 signal
262 Inflammatory Bowel Disease 4 2.3 2.3 no signal
263 Upper Limb Fracture 8 2.3 2.3 signal
264 Febrile Neutropenia 26 2.2 2.2 signal
265 Eye Discharge 4 2.2 2.2 no signal
266 Gallbladder Disorder 7 2.2 2.2 no signal
267 Adverse Event 36 2.2 2.2 signal
268 Thyroid Disorder 6 2.2 2.2 no signal
269 Product Odour Abnormal 4 2.2 2.2 no signal
270 Plasma Cell Myeloma 15 2.2 2.2 signal
271 Product Prescribing Error 9 2.2 2.2 signal
272 Pneumonitis 10 2.1 2.1 signal
273 Maternal Exposure During Pregnancy 32 2.1 2.1 signal
274 Medication Error 20 2.0 2.1 signal
275 Drug Effect Less Than Expected 5 2.0 2.0 no signal
276 Sedation 9 2.0 2.0 no signal
277 Dyskinesia 14 2.0 2.0 no signal
278 Incorrect Product Administration Duration 7 2.0 2.0 no signal
279 Local Swelling 6 1.9 1.9 no signal
280 Drug Dispensing Error 5 1.8 1.8 no signal
281 Dermatitis Atopic 16 1.8 1.8 no signal
282 Unevaluable Event 24 1.8 1.8 no signal
283 Bone Density Decreased 10 1.8 1.8 no signal
284 Eye Irritation 17 1.7 1.7 no signal
285 Hospitalisation 46 1.7 1.7 no signal
286 Product Physical Issue 6 1.7 1.7 no signal
287 Pregnancy 6 1.7 1.7 no signal
288 Poor Quality Product Administered 3 1.7 1.7 no signal
289 Colitis Ulcerative 13 1.7 1.7 no signal
290 Abnormal Dreams 8 1.6 1.6 no signal
291 Hereditary Angioedema 3 1.6 1.6 no signal
292 Application Site Pain 6 1.5 1.6 no signal
293 Product Dose Omission 17 1.5 1.5 no signal
294 Product Quality Issue 34 1.4 1.4 no signal
295 Schizophrenia 3 1.4 1.4 no signal
296 Dry Skin 31 1.3 1.3 no signal
297 Multiple Sclerosis 11 1.3 1.3 no signal
298 Pharmaceutical Product Complaint 6 1.3 1.3 no signal
299 Product Substitution Issue 13 1.3 1.3 no signal
300 Completed Suicide 19 1.3 1.3 no signal
301 Emotional Distress 25 1.2 1.2 no signal
302 Drug Effective For Unapproved Indication 6 1.2 1.2 no signal
303 Menorrhagia 4 1.1 1.1 no signal
304 Application Site Erythema 5 1.1 1.1 no signal
305 Device Defective 3 1.1 1.1 no signal
306 Injection Site Reaction 12 1.0 1.0 no signal
307 Palmar-plantar Erythrodysaesthesia Syndrome 4 1.0 1.0 no signal
308 Acne 13 1.0 1.0 no signal
309 Injection Site Mass 6 0.9 0.9 no signal
310 Accidental Exposure To Product 15 0.9 0.9 no signal
311 Injection Site Warmth 3 0.8 0.8 no signal
312 Drug Exposure During Pregnancy 5 0.8 0.8 no signal
313 Tardive Dyskinesia 4 0.8 0.8 no signal
314 Device Dislocation 6 0.8 0.8 no signal
315 Injection Site Pruritus 9 0.8 0.8 no signal
316 Injection Site Bruising 10 0.7 0.7 no signal
317 Gastric Cancer 3 0.7 0.7 no signal
318 Device Issue 10 0.7 0.7 no signal
319 Drug Abuse 9 0.6 0.6 no signal
320 Drug Dependence 11 0.4 0.4 no signal
321 Drug Dose Omission By Device 4 0.3 0.3 no signal
322 Bladder Cancer 3 0.3 0.3 no signal
323 Device Difficult To Use 3 0.3 0.3 no signal