OpenPV Signal Explorer
FAERS disproportionality dashboard
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Drug

Trametinib

1,066 flagged reaction(s) · 72,432 total co-reports · max PRR 721.6
Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.
Reaction Co-reports (a) PRR ROR Signal
1 Braf V600e Mutation Positive 26 721.6 722.4 signal
2 Anaplastic Thyroid Cancer 44 491.6 492.5 signal
3 Ganglioglioma 12 286.8 286.9 signal
4 Metastatic Malignant Melanoma 486 235.0 239.9 signal
5 Malignant Melanoma Stage Iv 56 214.1 214.6 signal
6 Braf Gene Mutation 16 188.6 188.7 signal
7 Jejunal Ulcer Perforation 8 181.1 181.2 signal
8 Malignant Mesenteric Neoplasm 10 132.4 132.4 signal
9 Optic Glioma 13 130.1 130.1 signal
10 Melanoma Recurrent 54 129.1 129.3 signal
11 Astrocytoma, Low Grade 22 127.9 128.0 signal
12 Vogt-koyanagi-harada Disease 25 115.0 115.1 signal
13 Serous Retinopathy 12 113.5 113.5 signal
14 Neurofibrosarcoma 11 105.2 105.2 signal
15 Histiocytic Sarcoma 8 101.2 101.3 signal
16 Panniculitis Lobular 9 95.6 95.6 signal
17 Glioma 49 72.2 72.3 signal
18 Brain Stem Glioma 10 61.9 61.9 signal
19 Astrocytoma 25 59.4 59.5 signal
20 Serous Retinal Detachment 49 57.3 57.4 signal
21 Intestinal Metastasis 21 55.4 55.5 signal
22 Malignant Melanoma Stage Iii 12 54.6 54.7 signal
23 Lung Adenocarcinoma Stage Iv 21 51.0 51.1 signal
24 Panniculitis 129 49.3 49.6 signal
25 Sarcoid-like Reaction 12 47.6 47.6 signal
26 Haemangioma Of Bone 10 47.5 47.6 signal
27 Acute Polyneuropathy 14 45.8 45.8 signal
28 Metastases To Stomach 19 45.3 45.3 signal
29 Anaplastic Astrocytoma 8 43.8 43.9 signal
30 Non-small Cell Lung Cancer Recurrent 13 42.9 42.9 signal
31 Metastases To Abdominal Wall 8 37.8 37.8 signal
32 Detachment Of Retinal Pigment Epithelium 35 36.5 36.6 signal
33 Leukoderma 8 36.4 36.4 signal
34 Metastases To Heart 12 35.8 35.9 signal
35 Creatine Kinase Increased 17 35.7 35.7 signal
36 Metastases To Spleen 16 34.9 34.9 signal
37 Metastases To Central Nervous System 487 34.5 35.2 signal
38 Chorioretinopathy 51 32.0 32.1 signal
39 Malignant Melanoma 434 29.2 29.7 signal
40 Procalcitonin Increased 37 28.9 28.9 signal
41 Small Cell Carcinoma 11 28.9 28.9 signal
42 Metastases To The Mediastinum 13 28.2 28.2 signal
43 Dermatitis Acneiform 182 27.0 27.2 signal
44 Metastases To Skin 30 26.3 26.3 signal
45 Metastases To Meninges 63 25.2 25.3 signal
46 Non-small Cell Lung Cancer Stage Iv 10 24.9 24.9 signal
47 Ureteral Disorder 11 23.8 23.8 signal
48 Metastases To Adrenals 24 23.4 23.4 signal
49 Cutaneous Sarcoidosis 11 23.3 23.3 signal
50 Tumour Invasion 12 22.4 22.5 signal
51 Skin Toxicity 134 21.5 21.6 signal
52 Paronychia 103 21.3 21.3 signal
53 Autoimmune Colitis 15 20.8 20.8 signal
54 Ocular Toxicity 24 20.2 20.3 signal
55 Metastases To Peritoneum 54 19.2 19.3 signal
56 Erythema Nodosum 72 18.3 18.4 signal
57 Malignant Neoplasm Progression 2,040 17.8 19.4 signal
58 Non-small Cell Lung Cancer Metastatic 17 17.6 17.6 signal
59 Ovarian Cancer Metastatic 16 16.9 16.9 signal
60 Hyperpyrexia 76 16.3 16.3 signal
61 Uveitis 236 15.5 15.6 signal
62 Hilar Lymphadenopathy 15 15.3 15.3 signal
63 Granulomatous Liver Disease 12 15.1 15.1 signal
64 Peritoneal Disorder 11 14.9 14.9 signal
65 Non-small Cell Lung Cancer 78 14.6 14.7 signal
66 Ejection Fraction Decreased 255 14.5 14.7 signal
67 Xerosis 20 14.5 14.5 signal
68 Abdominal Lymphadenopathy 14 14.5 14.5 signal
69 Acquired Gene Mutation 21 14.1 14.1 signal
70 Metastases To Bone Marrow 8 14.1 14.1 signal
71 Metastasis 110 13.6 13.6 signal
72 Second Primary Malignancy 123 13.1 13.2 signal
73 Keratoacanthoma 10 13.0 13.0 signal
74 Metastases To Lymph Nodes 98 12.9 13.0 signal
75 Angular Cheilitis 10 12.9 12.9 signal
76 Demyelinating Polyneuropathy 15 12.9 12.9 signal
77 Brain Cancer Metastatic 10 12.8 12.8 signal
78 Metastases To Pleura 15 12.7 12.7 signal
79 Ovarian Cancer Recurrent 23 12.7 12.7 signal
80 Metastases To Lung 162 12.4 12.5 signal
81 Brain Neoplasm 121 11.6 11.7 signal
82 Cataract Subcapsular 8 11.6 11.6 signal
83 Iridocyclitis 41 11.6 11.6 signal
84 Central Serous Chorioretinopathy 8 11.4 11.4 signal
85 Hypophysitis 26 11.4 11.4 signal
86 Intracranial Mass 12 11.2 11.3 signal
87 Gastrointestinal Wall Thickening 18 10.7 10.7 signal
88 Ileal Perforation 8 10.6 10.6 signal
89 Amylase Increased 44 10.6 10.6 signal
90 Pyrexia 4,068 10.4 12.3 signal
91 Haemophagocytic Lymphohistiocytosis 84 10.3 10.3 signal
92 Product Temperature Excursion Issue 55 10.2 10.2 signal
93 Metastatic Neoplasm 49 10.0 10.0 signal
94 Retinopathy 42 9.9 9.9 signal
95 Immune-mediated Hepatitis 22 9.9 9.9 signal
96 Chills 1,293 9.7 10.2 signal
97 Pseudomonas Test Positive 9 9.6 9.6 signal
98 Blood Creatine Phosphokinase Increased 318 9.6 9.7 signal
99 Recurrent Cancer 43 9.3 9.4 signal
100 Tumour Haemorrhage 30 9.3 9.3 signal
101 Gouty Arthritis 8 8.8 8.8 signal
102 Lung Adenocarcinoma 29 8.5 8.5 signal
103 Erysipelas 48 8.4 8.4 signal
104 Adrenal Suppression 8 8.3 8.3 signal
105 Glioblastoma 15 7.9 7.9 signal
106 Metastases To Liver 157 7.9 7.9 signal
107 Ejection Fraction Abnormal 11 7.9 7.9 signal
108 Pancreatic Enzymes Increased 13 7.9 7.9 signal
109 Cholangiocarcinoma 13 7.7 7.7 signal
110 Cardiac Dysfunction 32 7.7 7.7 signal
111 Vitiligo 20 7.6 7.6 signal
112 Lipase Increased 66 7.6 7.6 signal
113 Metastases To Spine 29 7.6 7.6 signal
114 Lymphangiosis Carcinomatosa 9 7.6 7.6 signal
115 Concomitant Disease Aggravated 53 7.5 7.6 signal
116 Nail Infection 12 7.4 7.4 signal
117 Retinal Detachment 77 7.4 7.4 signal
118 Therapy Partial Responder 126 7.4 7.4 signal
119 Malignant Pleural Effusion 14 7.3 7.3 signal
120 Blood Lactate Dehydrogenase Increased 130 7.2 7.2 signal
121 Hyperkeratosis 45 7.1 7.2 signal
122 Left Ventricular Dysfunction 53 7.0 7.0 signal
123 Hyperthermia 60 7.0 7.0 signal
124 Peripheral Motor Neuropathy 11 6.9 6.9 signal
125 Febrile Infection 9 6.9 6.9 signal
126 Body Temperature Fluctuation 16 6.7 6.8 signal
127 Ingrowing Nail 18 6.7 6.7 signal
128 Acrochordon 10 6.7 6.7 signal
129 Papillary Thyroid Cancer 13 6.6 6.6 signal
130 Small Intestinal Perforation 14 6.5 6.5 signal
131 Retinal Vein Occlusion 21 6.5 6.5 signal
132 Aspartate Aminotransferase Abnormal 11 6.4 6.4 signal
133 Neoplasm 83 6.3 6.3 signal
134 Lymphoedema 49 6.2 6.2 signal
135 Concomitant Disease Progression 14 6.2 6.2 signal
136 Immune-mediated Enterocolitis 24 6.0 6.0 signal
137 Dermatitis Exfoliative Generalised 23 5.9 5.9 signal
138 Adenovirus Infection 19 5.8 5.8 signal
139 Neurological Decompensation 15 5.8 5.8 signal
140 Squamous Cell Carcinoma 62 5.8 5.8 signal
141 Systemic Inflammatory Response Syndrome 25 5.8 5.8 signal
142 Sarcoidosis 31 5.7 5.7 signal
143 Ventricular Hypokinesia 21 5.7 5.7 signal
144 Neoplasm Skin 10 5.6 5.6 signal
145 Metastases To Bone 105 5.6 5.7 signal
146 Lymphadenopathy Mediastinal 12 5.5 5.5 signal
147 Immune-mediated Lung Disease 11 5.5 5.5 signal
148 Skin Papilloma 25 5.5 5.5 signal
149 Brain Neoplasm Malignant 28 5.5 5.5 signal
150 Lymphadenitis 15 5.4 5.4 signal
151 Fibrin D Dimer Increased 22 5.4 5.4 signal
152 Papilloedema 28 5.4 5.4 signal
153 Ovarian Cancer 57 5.4 5.4 signal
154 Retinal Disorder 16 5.4 5.4 signal
155 Cholestatic Liver Injury 13 5.3 5.3 signal
156 Cell Death 12 5.3 5.3 signal
157 Thyroid Cancer 73 5.3 5.3 signal
158 Hepatic Lesion 26 5.3 5.3 signal
159 C-reactive Protein Increased 217 5.2 5.3 signal
160 Hypoalbuminaemia 45 5.2 5.2 signal
161 Spleen Disorder 10 5.2 5.2 signal
162 Alanine Aminotransferase Abnormal 12 5.0 5.0 signal
163 Thyroiditis 17 5.0 5.0 signal
164 Acute Febrile Neutrophilic Dermatosis 13 4.9 4.9 signal
165 Hyperaemia 11 4.9 4.9 signal
166 Body Temperature Increased 113 4.8 4.9 signal
167 Pneumonitis 149 4.8 4.9 signal
168 No Therapeutic Response 67 4.7 4.8 signal
169 Impetigo 8 4.7 4.7 signal
170 Ventricular Dysfunction 14 4.7 4.7 signal
171 Brain Oedema 68 4.7 4.7 signal
172 Pigmentation Disorder 33 4.7 4.7 signal
173 Lung Consolidation 15 4.7 4.7 signal
174 Pneumatosis Intestinalis 15 4.6 4.6 signal
175 Adrenocortical Insufficiency Acute 10 4.6 4.6 signal
176 Macular Oedema 29 4.5 4.5 signal
177 Vitreous Detachment 11 4.5 4.5 signal
178 Visual Impairment 625 4.5 4.5 signal
179 Hepatic Cytolysis 62 4.4 4.5 signal
180 Protein Total Decreased 19 4.4 4.4 signal
181 Melanocytic Naevus 22 4.4 4.4 signal
182 Cardiotoxicity 44 4.3 4.4 signal
183 Erythema Multiforme 46 4.3 4.3 signal
184 Basal Cell Carcinoma 77 4.3 4.3 signal
185 Vitreous Floaters 48 4.3 4.3 signal
186 Rash Pustular 36 4.3 4.3 signal
187 Blood Alkaline Phosphatase Increased 122 4.3 4.3 signal
188 Pancreatic Carcinoma Metastatic 14 4.3 4.3 signal
189 Hepatotoxicity 108 4.3 4.3 signal
190 Nephritis 16 4.2 4.2 signal
191 Facial Paralysis 41 4.2 4.2 signal
192 Skin Mass 32 4.2 4.2 signal
193 Pustule 11 4.2 4.2 signal
194 Rash Maculo-papular 104 4.1 4.1 signal
195 Gamma-glutamyltransferase Increased 104 4.1 4.1 signal
196 Hepatitis 120 4.1 4.1 signal
197 Intestinal Perforation 52 4.1 4.1 signal
198 Blood Chloride Decreased 12 4.0 4.0 signal
199 Serum Ferritin Increased 24 4.0 4.0 signal
200 General Physical Condition Abnormal 31 4.0 4.0 signal
201 Small Intestinal Haemorrhage 9 3.9 3.9 signal
202 Product Use In Unapproved Indication 1,088 3.9 4.0 signal
203 Neoplasm Recurrence 15 3.9 3.9 signal
204 Liver Function Test Increased 93 3.8 3.8 signal
205 Metamorphopsia 8 3.8 3.8 signal
206 Myositis 39 3.8 3.8 signal
207 Central Nervous System Lesion 60 3.8 3.8 signal
208 Body Temperature Abnormal 8 3.8 3.8 signal
209 Squamous Cell Carcinoma Of Skin 26 3.8 3.8 signal
210 Blood Albumin Decreased 34 3.8 3.8 signal
211 Adenocarcinoma Of Colon 8 3.7 3.7 signal
212 Hospice Care 42 3.7 3.7 signal
213 Folliculitis 44 3.7 3.7 signal
214 Disease Progression 496 3.7 3.7 signal
215 Hypovolaemic Shock 20 3.7 3.7 signal
216 Guillain-barre Syndrome 20 3.6 3.6 signal
217 Aspartate Aminotransferase Increased 218 3.6 3.6 signal
218 Eye Oedema 10 3.6 3.6 signal
219 Embolism 34 3.6 3.6 signal
220 Polyneuropathy 48 3.5 3.5 signal
221 Drug Resistance 103 3.5 3.5 signal
222 Rash 1,736 3.5 3.7 signal
223 Adenocarcinoma 9 3.5 3.5 signal
224 Small Intestine Carcinoma 9 3.5 3.5 signal
225 Brain Operation 9 3.5 3.5 signal
226 Hepatic Neoplasm 13 3.5 3.5 signal
227 Bacterial Sepsis 13 3.5 3.5 signal
228 Neoplasm Progression 139 3.5 3.5 signal
229 Death 3,392 3.4 3.9 signal
230 Colorectal Cancer Metastatic 9 3.4 3.4 signal
231 Aphthous Ulcer 30 3.4 3.4 signal
232 Cheilitis 21 3.4 3.4 signal
233 Lung Opacity 10 3.4 3.4 signal
234 Blood Sodium Decreased 73 3.4 3.4 signal
235 Bone Lesion 14 3.4 3.4 signal
236 Lymphadenopathy 137 3.4 3.4 signal
237 Faeces Hard 15 3.4 3.4 signal
238 Paraplegia 11 3.3 3.3 signal
239 Meningitis Aseptic 17 3.3 3.3 signal
240 Hepatocellular Injury 54 3.3 3.3 signal
241 Photosensitivity Reaction 62 3.3 3.3 signal
242 Product Storage Error 324 3.3 3.3 signal
243 Cholangitis 23 3.3 3.3 signal
244 Cholestasis 71 3.3 3.3 signal
245 Cachexia 19 3.2 3.2 signal
246 Pulmonary Mass 55 3.2 3.2 signal
247 Mucosal Inflammation 96 3.2 3.2 signal
248 Rhabdomyolysis 152 3.2 3.2 signal
249 Renal Cyst 29 3.2 3.2 signal
250 Performance Status Decreased 17 3.2 3.2 signal
251 Hepatic Enzyme Abnormal 18 3.2 3.2 signal
252 Disseminated Intravascular Coagulation 51 3.2 3.2 signal
253 Intracranial Pressure Increased 20 3.1 3.1 signal
254 Duodenal Ulcer 25 3.1 3.1 signal
255 Dermatitis 73 3.1 3.1 signal
256 Blood Creatinine Decreased 11 3.1 3.1 signal
257 Hydrocephalus 19 3.1 3.1 signal
258 Skin Lesion 95 3.1 3.1 signal
259 Neoplasm Malignant 230 3.0 3.0 signal
260 Rhinovirus Infection 13 3.0 3.0 signal
261 Palmar-plantar Erythrodysaesthesia Syndrome 80 3.0 3.0 signal
262 Cushingoid 11 3.0 3.0 signal
263 Stridor 10 3.0 3.0 signal
264 Abdominal Mass 9 2.9 2.9 signal
265 Intra-abdominal Haemorrhage 8 2.9 2.9 signal
266 Alanine Aminotransferase Increased 205 2.9 2.9 signal
267 Acne 254 2.9 2.9 signal
268 Colitis 125 2.9 2.9 signal
269 Skin Infection 37 2.9 2.9 signal
270 Keratitis 10 2.9 2.9 signal
271 Enteritis 21 2.9 2.9 signal
272 Lip Blister 9 2.9 2.9 signal
273 Ulcerative Keratitis 9 2.9 2.9 signal
274 Transaminases Increased 73 2.9 2.9 signal
275 Myocarditis 37 2.9 2.9 signal
276 Localised Oedema 15 2.8 2.8 signal
277 Feeling Of Despair 15 2.8 2.8 signal
278 Hypernatraemia 16 2.8 2.8 signal
279 Nodule 42 2.8 2.8 signal
280 Investigation 10 2.8 2.8 signal
281 Hyperreflexia 11 2.7 2.7 signal
282 Pyelonephritis 27 2.7 2.7 signal
283 Cerebral Disorder 23 2.7 2.7 signal
284 General Physical Health Deterioration 354 2.7 2.7 signal
285 Night Sweats 99 2.7 2.7 signal
286 Tenderness 32 2.7 2.7 signal
287 Actinic Keratosis 8 2.7 2.7 signal
288 Epigastric Discomfort 12 2.7 2.7 signal
289 Incorrect Dosage Administered 15 2.7 2.7 signal
290 Dehydration 403 2.6 2.7 signal
291 Abdominal Tenderness 15 2.6 2.6 signal
292 Neutrophil Count Increased 31 2.6 2.6 signal
293 Thrombocytosis 11 2.6 2.6 signal
294 Hepatic Function Abnormal 111 2.6 2.6 signal
295 Hypophosphataemia 22 2.6 2.6 signal
296 Urine Output Decreased 26 2.6 2.6 signal
297 Cerebral Haemorrhage 105 2.6 2.6 signal
298 B-cell Lymphoma 10 2.6 2.6 signal
299 Multiple-drug Resistance 9 2.5 2.5 signal
300 Partial Seizures 15 2.5 2.5 signal
301 Red Cell Distribution Width Increased 12 2.5 2.5 signal
302 Toxic Skin Eruption 29 2.5 2.5 signal
303 Photopsia 18 2.5 2.5 signal
304 Pulmonary Toxicity 20 2.5 2.5 signal
305 Tubulointerstitial Nephritis 53 2.5 2.5 signal
306 Escherichia Urinary Tract Infection 12 2.5 2.5 signal
307 Rebound Effect 32 2.5 2.5 signal
308 Feeding Disorder 56 2.5 2.5 signal
309 Therapy Change 27 2.4 2.4 signal
310 Dysphagia 265 2.4 2.5 signal
311 Oedema 151 2.4 2.4 signal
312 Blepharitis 11 2.4 2.4 signal
313 Staphylococcal Bacteraemia 12 2.4 2.4 signal
314 Encephalitis 19 2.4 2.4 signal
315 Monocyte Count Increased 10 2.4 2.4 signal
316 Autoimmune Hepatitis 19 2.4 2.4 signal
317 Major Depression 20 2.4 2.4 signal
318 Vision Blurred 370 2.4 2.4 signal
319 Stomatitis 164 2.4 2.4 signal
320 Rash Vesicular 13 2.4 2.4 signal
321 Tonsillitis 14 2.3 2.3 signal
322 Adrenal Insufficiency 32 2.3 2.3 signal
323 Eating Disorder 57 2.3 2.3 signal
324 Product Administered To Patient Of Inappropriate Age 16 2.3 2.3 signal
325 Lymphocyte Count Decreased 47 2.3 2.3 signal
326 Histiocytosis Haematophagic 8 2.3 2.3 signal
327 Inflammatory Marker Increased 13 2.3 2.3 signal
328 Cardiomyopathy 39 2.3 2.3 signal
329 Embolism Venous 8 2.3 2.3 signal
330 Iritis 8 2.3 2.3 signal
331 Skin Reaction 37 2.3 2.3 signal
332 Bowel Movement Irregularity 20 2.3 2.3 signal
333 Onychoclasis 18 2.3 2.3 signal
334 Granuloma 9 2.3 2.3 signal
335 Aortic Valve Incompetence 11 2.3 2.3 signal
336 Decreased Appetite 596 2.2 2.3 signal
337 Skin Abrasion 12 2.2 2.2 signal
338 Hyponatraemia 144 2.2 2.2 signal
339 Prostatomegaly 10 2.2 2.2 signal
340 Hyperaesthesia 21 2.2 2.2 signal
341 Venous Thrombosis 10 2.2 2.2 signal
342 Terminal State 17 2.2 2.2 signal
343 Liver Disorder 111 2.2 2.2 signal
344 Blood Phosphorus Decreased 9 2.2 2.2 signal
345 Hepatic Enzyme Increased 168 2.2 2.2 signal
346 Large Intestine Perforation 17 2.1 2.1 signal
347 Papule 17 2.1 2.1 signal
348 Pemphigoid 18 2.1 2.1 signal
349 Staphylococcal Sepsis 12 2.1 2.1 signal
350 Hyperthyroidism 35 2.1 2.1 signal
351 Oral Pain 54 2.1 2.1 signal
352 Lung Neoplasm Malignant 99 2.1 2.1 signal
353 Urosepsis 22 2.1 2.1 signal
354 Hordeolum 10 2.1 2.1 signal
355 Mass 33 2.1 2.1 signal
356 Hepatic Pain 10 2.0 2.0 signal
357 Hypothyroidism 74 2.0 2.0 signal
358 Functional Gastrointestinal Disorder 8 2.0 2.0 no signal
359 Splenomegaly 27 2.0 2.0 signal
360 Chapped Lips 10 2.0 2.0 signal
361 Vomiting 1,071 2.0 2.0 no signal
362 Pleural Effusion 137 2.0 2.0 no signal
363 Aphasia 68 2.0 2.0 no signal
364 Pancreatic Disorder 11 2.0 2.0 no signal
365 Peripheral Sensory Neuropathy 13 1.9 1.9 no signal
366 Melaena 49 1.9 1.9 no signal
367 Visual Field Defect 16 1.9 1.9 no signal
368 Speech Disorder 116 1.9 1.9 no signal
369 Hyperglycaemia 80 1.9 1.9 no signal
370 Hypertransaminasaemia 15 1.9 1.9 no signal
371 Gingival Bleeding 30 1.9 1.9 no signal
372 Blood Bilirubin Increased 59 1.9 1.9 no signal
373 Ascites 64 1.9 1.9 no signal
374 Hemiparesis 37 1.9 1.9 no signal
375 Type 1 Diabetes Mellitus 13 1.9 1.9 no signal
376 Hemiplegia 18 1.9 1.9 no signal
377 Pneumothorax 34 1.9 1.9 no signal
378 Dry Skin 280 1.9 1.9 no signal
379 Gastrointestinal Toxicity 10 1.9 1.9 no signal
380 Proteinuria 40 1.9 1.9 no signal
381 Peripheral Swelling 324 1.8 1.9 no signal
382 Leukopenia 105 1.8 1.8 no signal
383 Skin Disorder 70 1.8 1.8 no signal
384 Seizure 241 1.8 1.8 no signal
385 Pancreatitis 111 1.8 1.8 no signal
386 Epilepsy 64 1.8 1.8 no signal
387 Interstitial Lung Disease 101 1.8 1.8 no signal
388 Electrocardiogram Qt Prolonged 75 1.8 1.8 no signal
389 Myopathy 18 1.8 1.8 no signal
390 Sepsis 231 1.8 1.8 no signal
391 Atrioventricular Block First Degree 9 1.8 1.8 no signal
392 Lymphopenia 29 1.8 1.8 no signal
393 Bone Cancer 9 1.8 1.8 no signal
394 Therapy Cessation 105 1.8 1.8 no signal
395 Drug Eruption 36 1.8 1.8 no signal
396 White Blood Cell Count Abnormal 13 1.8 1.8 no signal
397 Visual Acuity Reduced 68 1.8 1.8 no signal
398 Rash Generalised 53 1.8 1.8 no signal
399 Liver Function Test Abnormal 59 1.8 1.8 no signal
400 Face Oedema 34 1.8 1.8 no signal
401 Diarrhoea 1,288 1.7 1.8 no signal
402 Post Transplant Lymphoproliferative Disorder 10 1.7 1.7 no signal
403 Drug Intolerance 191 1.7 1.7 no signal
404 Product Supply Issue 14 1.7 1.7 no signal
405 Asthenia 737 1.7 1.7 no signal
406 Fatigue 1,516 1.7 1.8 no signal
407 Hyperuricaemia 8 1.7 1.7 no signal
408 Blood Calcium Decreased 22 1.7 1.7 no signal
409 Altered State Of Consciousness 42 1.7 1.7 no signal
410 Pulmonary Embolism 186 1.7 1.7 no signal
411 Intestinal Haemorrhage 11 1.7 1.7 no signal
412 Dermatitis Bullous 14 1.7 1.7 no signal
413 Hypercalcaemia 24 1.7 1.7 no signal
414 Meningitis 13 1.7 1.7 no signal
415 Mitral Valve Incompetence 22 1.7 1.7 no signal
416 Septic Shock 84 1.7 1.7 no signal
417 Cytokine Release Syndrome 37 1.7 1.7 no signal
418 Haemorrhage Intracranial 29 1.7 1.7 no signal
419 Pancreatitis Acute 43 1.7 1.7 no signal
420 Rash Macular 67 1.7 1.7 no signal
421 Epistaxis 144 1.7 1.7 no signal
422 Yellow Skin 9 1.7 1.7 no signal
423 Pulmonary Haemorrhage 15 1.7 1.7 no signal
424 Nasal Dryness 12 1.7 1.7 no signal
425 Electrolyte Imbalance 22 1.7 1.7 no signal
426 Eye Inflammation 18 1.7 1.7 no signal
427 Chromaturia 43 1.7 1.7 no signal
428 Multiple Organ Dysfunction Syndrome 53 1.7 1.7 no signal
429 Nephrotic Syndrome 13 1.7 1.7 no signal
430 Nausea 1,496 1.7 1.7 no signal
431 Thrombocytopenia 210 1.6 1.7 no signal
432 Hypovolaemia 11 1.6 1.6 no signal
433 Ileus 23 1.6 1.6 no signal
434 Extrasystoles 13 1.6 1.6 no signal
435 Hepatic Failure 56 1.6 1.6 no signal
436 Taste Disorder 37 1.6 1.6 no signal
437 Cardiac Failure 148 1.6 1.6 no signal
438 Blood Urea Increased 31 1.6 1.6 no signal
439 Organising Pneumonia 9 1.6 1.6 no signal
440 Venoocclusive Liver Disease 9 1.6 1.6 no signal
441 Hair Colour Changes 23 1.6 1.6 no signal
442 Pericardial Effusion 42 1.6 1.6 no signal
443 Photophobia 34 1.6 1.6 no signal
444 Illness 182 1.6 1.6 no signal
445 Mouth Ulceration 38 1.6 1.6 no signal
446 Viral Infection 60 1.6 1.6 no signal
447 Incorrect Product Storage 24 1.6 1.6 no signal
448 Anal Incontinence 16 1.6 1.6 no signal
449 Nephropathy Toxic 20 1.6 1.6 no signal
450 Eczema 90 1.6 1.6 no signal
451 Hypothermia 18 1.5 1.6 no signal
452 Tricuspid Valve Incompetence 14 1.5 1.5 no signal
453 Oedema Peripheral 216 1.5 1.5 no signal
454 Hypokalaemia 81 1.5 1.5 no signal
455 Drug Reaction With Eosinophilia And Systemic Symptoms 45 1.5 1.5 no signal
456 Platelet Count Increased 23 1.5 1.5 no signal
457 Feeling Cold 49 1.5 1.5 no signal
458 Haemoptysis 49 1.5 1.5 no signal
459 Enterocolitis 10 1.5 1.5 no signal
460 Ocular Discomfort 19 1.5 1.5 no signal
461 Cellulitis 88 1.5 1.5 no signal
462 Blindness 71 1.5 1.5 no signal
463 Decreased Immune Responsiveness 17 1.5 1.5 no signal
464 Mouth Swelling 10 1.5 1.5 no signal
465 Muscle Strain 15 1.5 1.5 no signal
466 Inflammation 89 1.5 1.5 no signal
467 Cerebral Ischaemia 9 1.5 1.5 no signal
468 Bundle Branch Block Right 8 1.5 1.5 no signal
469 Ischaemia 8 1.5 1.5 no signal
470 Blood Creatinine Increased 113 1.5 1.5 no signal
471 Infection 249 1.5 1.5 no signal
472 Metabolic Disorder 10 1.5 1.5 no signal
473 Hepatomegaly 17 1.5 1.5 no signal
474 Blindness Unilateral 24 1.5 1.5 no signal
475 Cholecystitis 20 1.5 1.5 no signal
476 Constipation 364 1.5 1.5 no signal
477 Intestinal Obstruction 63 1.5 1.5 no signal
478 Anaemia 319 1.5 1.5 no signal
479 Neutropenia 225 1.5 1.5 no signal
480 Drug-induced Liver Injury 51 1.4 1.4 no signal
481 Hypoacusis 71 1.4 1.4 no signal
482 Hyperbilirubinaemia 17 1.4 1.4 no signal
483 Coronavirus Infection 11 1.4 1.4 no signal
484 Pulmonary Thrombosis 18 1.4 1.4 no signal
485 Myalgia 280 1.4 1.4 no signal
486 Gastroenteritis 24 1.4 1.4 no signal
487 Gastric Haemorrhage 19 1.4 1.4 no signal
488 Therapy Interrupted 113 1.4 1.4 no signal
489 Colitis Ischaemic 11 1.4 1.4 no signal
490 Oral Disorder 12 1.4 1.4 no signal
491 Ulcer 26 1.4 1.4 no signal
492 Inflammatory Bowel Disease 16 1.4 1.4 no signal
493 Ulcer Haemorrhage 11 1.4 1.4 no signal
494 Sensory Loss 13 1.4 1.4 no signal
495 Influenza Like Illness 133 1.4 1.4 no signal
496 Neutrophil Count Decreased 65 1.4 1.4 no signal
497 Dry Mouth 129 1.4 1.4 no signal
498 Cholecystitis Acute 9 1.4 1.4 no signal
499 Hypomagnesaemia 22 1.4 1.4 no signal
500 Neutrophilia 9 1.4 1.4 no signal
501 Coronary Artery Stenosis 8 1.4 1.4 no signal
502 Hypotension 316 1.4 1.4 no signal
503 Oral Mucosal Blistering 10 1.4 1.4 no signal
504 Endocarditis 8 1.4 1.4 no signal
505 Eye Disorder 51 1.4 1.4 no signal
506 Oesophagitis 17 1.4 1.4 no signal
507 Encephalopathy 38 1.4 1.4 no signal
508 Benign Prostatic Hyperplasia 8 1.3 1.3 no signal
509 Generalised Oedema 19 1.3 1.3 no signal
510 Aspergillus Infection 10 1.3 1.3 no signal
511 Diplopia 40 1.3 1.3 no signal
512 Haemorrhagic Stroke 12 1.3 1.3 no signal
513 Acute Kidney Injury 231 1.3 1.3 no signal
514 Clostridium Difficile Colitis 16 1.3 1.3 no signal
515 Confusional State 243 1.3 1.3 no signal
516 Arthropod Bite 11 1.3 1.3 no signal
517 Flank Pain 14 1.3 1.3 no signal
518 Haematemesis 38 1.3 1.3 no signal
519 Lung Disorder 73 1.3 1.3 no signal
520 Pancytopenia 83 1.3 1.3 no signal
521 Syncope 149 1.3 1.3 no signal
522 Malaise 653 1.3 1.3 no signal
523 Gingivitis 8 1.3 1.3 no signal
524 Blood Calcium Increased 13 1.3 1.3 no signal
525 Mental Status Changes 41 1.3 1.3 no signal
526 Laryngeal Oedema 9 1.3 1.3 no signal
527 Haematuria 50 1.3 1.3 no signal
528 Lip Dry 13 1.3 1.3 no signal
529 Cyst 18 1.3 1.3 no signal
530 Dry Eye 70 1.3 1.3 no signal
531 Coagulopathy 24 1.3 1.3 no signal
532 Bacteraemia 17 1.3 1.3 no signal
533 Urinary Retention 48 1.3 1.3 no signal
534 Blood Potassium Decreased 43 1.2 1.2 no signal
535 Ataxia 17 1.2 1.2 no signal
536 Blood Test Abnormal 20 1.2 1.2 no signal
537 Cytopenia 17 1.2 1.2 no signal
538 Gastrointestinal Haemorrhage 119 1.2 1.2 no signal
539 Status Epilepticus 16 1.2 1.2 no signal
540 Rash Erythematous 66 1.2 1.2 no signal
541 Urinary Tract Infection 238 1.2 1.2 no signal
542 Intervertebral Disc Degeneration 13 1.2 1.2 no signal
543 Neuropathy Peripheral 132 1.2 1.2 no signal
544 Stevens-johnson Syndrome 31 1.2 1.2 no signal
545 Atrial Fibrillation 135 1.2 1.2 no signal
546 Emphysema 14 1.2 1.2 no signal
547 Tumour Lysis Syndrome 12 1.2 1.2 no signal
548 Groin Pain 12 1.2 1.2 no signal
549 Supraventricular Tachycardia 13 1.2 1.2 no signal
550 Abdominal Pain 316 1.2 1.2 no signal
551 Skin Ulcer 35 1.2 1.2 no signal
552 Muscle Atrophy 17 1.2 1.2 no signal
553 Renal Impairment 113 1.2 1.2 no signal
554 Hiccups 11 1.2 1.2 no signal
555 Escherichia Infection 11 1.2 1.2 no signal
556 Abnormal Faeces 11 1.2 1.2 no signal
557 Atelectasis 13 1.2 1.2 no signal
558 Sinus Tachycardia 19 1.2 1.2 no signal
559 Colon Cancer 20 1.2 1.2 no signal
560 Dysarthria 50 1.2 1.2 no signal
561 Arthralgia 550 1.2 1.2 no signal
562 Skin Fissures 25 1.2 1.2 no signal
563 Scab 15 1.2 1.2 no signal
564 Gastric Ulcer 25 1.1 1.1 no signal
565 Internal Haemorrhage 15 1.1 1.1 no signal
566 Dyspnoea Exertional 49 1.1 1.1 no signal
567 Pneumonia 421 1.1 1.1 no signal
568 Cough 364 1.1 1.1 no signal
569 Blood Thyroid Stimulating Hormone Increased 12 1.1 1.1 no signal
570 Secretion Discharge 16 1.1 1.1 no signal
571 Bacterial Infection 24 1.1 1.1 no signal
572 Tremor 214 1.1 1.1 no signal
573 Platelet Count Decreased 137 1.1 1.1 no signal
574 Acute Myeloid Leukaemia 20 1.1 1.1 no signal
575 Plasma Cell Myeloma 50 1.1 1.1 no signal
576 Blood Magnesium Decreased 11 1.1 1.1 no signal
577 White Blood Cell Count Increased 49 1.1 1.1 no signal
578 Lung Infection 20 1.1 1.1 no signal
579 Staphylococcal Infection 42 1.1 1.1 no signal
580 Electrocardiogram Abnormal 10 1.1 1.1 no signal
581 Renal Failure 168 1.1 1.1 no signal
582 Conjunctivitis 23 1.1 1.1 no signal
583 Haemoglobin Abnormal 8 1.1 1.1 no signal
584 Faeces Discoloured 27 1.1 1.1 no signal
585 Nervous System Disorder 39 1.1 1.1 no signal
586 Alopecia 245 1.1 1.1 no signal
587 Thrombosis 100 1.1 1.1 no signal
588 Gastrointestinal Disorder 109 1.1 1.1 no signal
589 Appetite Disorder 8 1.1 1.1 no signal
590 Circulatory Collapse 21 1.1 1.1 no signal
591 Incontinence 13 1.1 1.1 no signal
592 Product Use Issue 229 1.1 1.1 no signal
593 Hypophagia 31 1.1 1.1 no signal
594 Polyuria 10 1.1 1.1 no signal
595 Hypocalcaemia 23 1.1 1.1 no signal
596 Headache 761 1.1 1.1 no signal
597 Decreased Activity 13 1.1 1.1 no signal
598 Skin Cancer 26 1.1 1.1 no signal
599 Blood Pressure Decreased 80 1.1 1.1 no signal
600 Hydronephrosis 9 1.1 1.1 no signal
601 Product Availability Issue 27 1.1 1.1 no signal
602 Pharyngitis 15 1.1 1.1 no signal
603 Pulmonary Fibrosis 23 1.1 1.1 no signal
604 Haematocrit Decreased 24 1.0 1.0 no signal
605 Back Injury 13 1.0 1.0 no signal
606 Skin Discolouration 55 1.0 1.0 no signal
607 Spinal Pain 14 1.0 1.0 no signal
608 Limb Discomfort 37 1.0 1.0 no signal
609 Joint Swelling 144 1.0 1.0 no signal
610 Spinal Compression Fracture 10 1.0 1.0 no signal
611 Weight Decreased 332 1.0 1.0 no signal
612 Gastrointestinal Pain 13 1.0 1.0 no signal
613 Skin Plaque 10 1.0 1.0 no signal
614 Tachypnoea 16 1.0 1.0 no signal
615 Diffuse Large B-cell Lymphoma 9 1.0 1.0 no signal
616 Gastritis 31 1.0 1.0 no signal
617 Arteriosclerosis 11 1.0 1.0 no signal
618 Sputum Discoloured 11 1.0 1.0 no signal
619 Hyperhidrosis 150 1.0 1.0 no signal
620 Rash Papular 26 1.0 1.0 no signal
621 Delirium 40 1.0 1.0 no signal
622 Jaundice 31 1.0 1.0 no signal
623 Gait Inability 38 1.0 1.0 no signal
624 Haemoglobin Decreased 118 1.0 1.0 no signal
625 Erythema 233 1.0 1.0 no signal
626 Cold Sweat 20 1.0 1.0 no signal
627 Wound 31 1.0 1.0 no signal
628 Urinary Incontinence 33 1.0 1.0 no signal
629 Shock Haemorrhagic 9 1.0 1.0 no signal
630 Adverse Drug Reaction 99 1.0 1.0 no signal
631 Decubitus Ulcer 9 1.0 1.0 no signal
632 Blood Iron Decreased 13 1.0 1.0 no signal
633 Inappropriate Schedule Of Product Administration 194 1.0 1.0 no signal
634 Optic Neuritis 10 1.0 1.0 no signal
635 Brain Injury 11 1.0 1.0 no signal
636 Pneumonia Bacterial 10 1.0 1.0 no signal
637 Gastrointestinal Carcinoma 10 1.0 1.0 no signal
638 Ill-defined Disorder 66 0.9 0.9 no signal
639 Hypoxia 38 0.9 0.9 no signal
640 Muscular Weakness 123 0.9 0.9 no signal
641 Malnutrition 12 0.9 0.9 no signal
642 White Blood Cell Count Decreased 117 0.9 0.9 no signal
643 Blister 60 0.9 0.9 no signal
644 Pulmonary Oedema 48 0.9 0.9 no signal
645 Kidney Infection 21 0.9 0.9 no signal
646 Diarrhoea Haemorrhagic 10 0.9 0.9 no signal
647 Increased Appetite 20 0.9 0.9 no signal
648 Swelling Face 69 0.9 0.9 no signal
649 Lethargy 61 0.9 0.9 no signal
650 Dysstasia 31 0.9 0.9 no signal
651 Tachycardia 94 0.9 0.9 no signal
652 Rash Pruritic 57 0.9 0.9 no signal
653 Adverse Reaction 14 0.9 0.9 no signal
654 Respiratory Failure 77 0.9 0.9 no signal
655 Cardiac Disorder 99 0.9 0.9 no signal
656 Spinal Fracture 21 0.9 0.9 no signal
657 Abdominal Discomfort 176 0.9 0.9 no signal
658 Shock 24 0.9 0.9 no signal
659 Posterior Reversible Encephalopathy Syndrome 10 0.9 0.9 no signal
660 Eye Pain 58 0.9 0.9 no signal
661 Diabetes Mellitus 80 0.9 0.9 no signal
662 Renal Pain 11 0.9 0.9 no signal
663 Device Related Infection 16 0.9 0.9 no signal
664 Liver Injury 25 0.9 0.9 no signal
665 Sinus Bradycardia 10 0.9 0.9 no signal
666 Dysuria 38 0.9 0.9 no signal
667 Deafness 27 0.9 0.9 no signal
668 Vasculitis 12 0.9 0.9 no signal
669 Gastrointestinal Inflammation 8 0.9 0.9 no signal
670 Lip Swelling 34 0.9 0.9 no signal
671 Upper Respiratory Tract Infection 47 0.9 0.9 no signal
672 Myasthenia Gravis 8 0.9 0.9 no signal
673 Product Distribution Issue 9 0.9 0.9 no signal
674 Aspiration 11 0.9 0.9 no signal
675 Peritonitis 21 0.9 0.9 no signal
676 Laryngitis 11 0.9 0.9 no signal
677 Furuncle 8 0.9 0.9 no signal
678 Arrhythmia 48 0.9 0.9 no signal
679 Labelled Drug-drug Interaction Medication Error 9 0.9 0.9 no signal
680 Gastrointestinal Infection 9 0.9 0.9 no signal
681 Aphonia 14 0.9 0.9 no signal
682 Respiratory Tract Infection 26 0.9 0.9 no signal
683 Cystitis 32 0.9 0.9 no signal
684 Skin Exfoliation 83 0.9 0.9 no signal
685 Pancreatic Carcinoma 29 0.9 0.9 no signal
686 Swelling 93 0.9 0.9 no signal
687 Flatulence 56 0.9 0.9 no signal
688 Ventricular Fibrillation 11 0.9 0.9 no signal
689 Retching 21 0.9 0.9 no signal
690 Cardiogenic Shock 14 0.9 0.9 no signal
691 Iron Deficiency Anaemia 9 0.9 0.9 no signal
692 Asphyxia 8 0.9 0.9 no signal
693 Small Intestinal Obstruction 12 0.9 0.9 no signal
694 Skin Haemorrhage 14 0.8 0.8 no signal
695 Hepatic Steatosis 18 0.8 0.8 no signal
696 Renal Disorder 45 0.8 0.8 no signal
697 Hypokinesia 14 0.8 0.8 no signal
698 Petechiae 10 0.8 0.8 no signal
699 Blood Pressure Abnormal 19 0.8 0.8 no signal
700 Pain In Extremity 283 0.8 0.8 no signal
701 Off Label Use 831 0.8 0.8 no signal
702 Loss Of Consciousness 122 0.8 0.8 no signal
703 Presyncope 23 0.8 0.8 no signal
704 Lower Respiratory Tract Infection 43 0.8 0.8 no signal
705 Abdominal Pain Upper 194 0.8 0.8 no signal
706 Gait Disturbance 181 0.8 0.8 no signal
707 Red Blood Cell Count Decreased 27 0.8 0.8 no signal
708 Ocular Hyperaemia 44 0.8 0.8 no signal
709 Acute Respiratory Failure 18 0.8 0.8 no signal
710 Pharyngeal Swelling 9 0.8 0.8 no signal
711 Febrile Neutropenia 62 0.8 0.8 no signal
712 Glaucoma 18 0.8 0.8 no signal
713 Amnesia 61 0.8 0.8 no signal
714 Scar 16 0.8 0.8 no signal
715 Haematochezia 51 0.8 0.8 no signal
716 Hypertension 196 0.8 0.8 no signal
717 Nail Disorder 8 0.8 0.8 no signal
718 Wound Infection 10 0.8 0.8 no signal
719 Pruritus 345 0.8 0.8 no signal
720 Dysgeusia 68 0.8 0.8 no signal
721 Localised Infection 22 0.8 0.8 no signal
722 Nocturia 11 0.8 0.8 no signal
723 Dysphonia 53 0.8 0.8 no signal
724 Body Temperature Decreased 9 0.8 0.8 no signal
725 Disorientation 36 0.8 0.8 no signal
726 Bone Pain 53 0.8 0.8 no signal
727 Product Use Complaint 14 0.8 0.8 no signal
728 Candida Infection 15 0.8 0.8 no signal
729 Lung Infiltration 8 0.8 0.8 no signal
730 Drug Ineffective For Unapproved Indication 50 0.8 0.8 no signal
731 Haemorrhage 93 0.8 0.8 no signal
732 Cardiomegaly 11 0.8 0.8 no signal
733 Leukocytosis 16 0.8 0.8 no signal
734 Eyelid Ptosis 9 0.8 0.8 no signal
735 Pneumonia Aspiration 22 0.8 0.8 no signal
736 Sciatica 14 0.8 0.8 no signal
737 Disease Recurrence 42 0.8 0.8 no signal
738 Ageusia 22 0.8 0.8 no signal
739 Clostridium Difficile Infection 19 0.8 0.8 no signal
740 Depressed Mood 46 0.8 0.8 no signal
741 Myocardial Ischaemia 10 0.8 0.8 no signal
742 Hospitalisation 132 0.8 0.8 no signal
743 Agranulocytosis 16 0.8 0.8 no signal
744 Haematotoxicity 8 0.8 0.8 no signal
745 Toxic Epidermal Necrolysis 13 0.8 0.8 no signal
746 Cataract 51 0.8 0.7 no signal
747 Intraocular Pressure Increased 11 0.7 0.7 no signal
748 Fear 23 0.7 0.7 no signal
749 Acute Respiratory Distress Syndrome 15 0.7 0.7 no signal
750 Feeling Hot 52 0.7 0.7 no signal
751 Full Blood Count Decreased 17 0.7 0.7 no signal
752 Sudden Death 9 0.7 0.7 no signal
753 Thirst 15 0.7 0.7 no signal
754 Eye Swelling 31 0.7 0.7 no signal
755 Dyspnoea 474 0.7 0.7 no signal
756 Glomerular Filtration Rate Decreased 10 0.7 0.7 no signal
757 Eye Haemorrhage 11 0.7 0.7 no signal
758 Oropharyngeal Pain 76 0.7 0.7 no signal
759 Pain 504 0.7 0.7 no signal
760 Cerebral Infarction 20 0.7 0.7 no signal
761 Cognitive Disorder 38 0.7 0.7 no signal
762 Abscess 13 0.7 0.7 no signal
763 Pain Of Skin 22 0.7 0.7 no signal
764 Therapeutic Response Decreased 49 0.7 0.7 no signal
765 Depressed Level Of Consciousness 32 0.7 0.7 no signal
766 Hypertensive Crisis 9 0.7 0.7 no signal
767 Muscle Tightness 13 0.7 0.7 no signal
768 Mental Disorder 35 0.7 0.7 no signal
769 Peripheral Coldness 11 0.7 0.7 no signal
770 Deep Vein Thrombosis 52 0.7 0.7 no signal
771 Micturition Urgency 9 0.7 0.7 no signal
772 Discomfort 48 0.7 0.7 no signal
773 Motor Dysfunction 8 0.7 0.7 no signal
774 Sluggishness 8 0.7 0.7 no signal
775 Blood Urine Present 15 0.7 0.7 no signal
776 Cardiac Arrest 65 0.7 0.7 no signal
777 Temperature Intolerance 8 0.7 0.7 no signal
778 Movement Disorder 25 0.7 0.7 no signal
779 Lymphoma 12 0.7 0.7 no signal
780 Incorrect Dose Administered 174 0.7 0.7 no signal
781 Gastroenteritis Viral 14 0.7 0.7 no signal
782 Dizziness 383 0.7 0.7 no signal
783 Hypersomnia 22 0.7 0.7 no signal
784 Hypersensitivity 142 0.7 0.7 no signal
785 Pulmonary Hypertension 16 0.7 0.7 no signal
786 Dyspepsia 75 0.7 0.7 no signal
787 Back Pain 177 0.7 0.7 no signal
788 Productive Cough 36 0.7 0.7 no signal
789 Immune System Disorder 10 0.7 0.7 no signal
790 Diverticulitis 21 0.7 0.7 no signal
791 Pulmonary Congestion 10 0.7 0.7 no signal
792 Bradycardia 40 0.7 0.7 no signal
793 Influenza 84 0.7 0.7 no signal
794 Abdominal Pain Lower 19 0.7 0.7 no signal
795 Sars-cov-2 Test Positive 10 0.7 0.7 no signal
796 Quality Of Life Decreased 10 0.6 0.6 no signal
797 Nephrolithiasis 34 0.6 0.6 no signal
798 Memory Impairment 102 0.6 0.6 no signal
799 Head Discomfort 13 0.6 0.6 no signal
800 Vertigo 45 0.6 0.6 no signal
801 Local Swelling 13 0.6 0.6 no signal
802 Myelosuppression 25 0.6 0.6 no signal
803 Neck Pain 41 0.6 0.6 no signal
804 Toxicity To Various Agents 122 0.6 0.6 no signal
805 Respiratory Distress 20 0.6 0.6 no signal
806 Thrombotic Microangiopathy 7 0.6 0.6 no signal
807 Dermatitis Allergic 9 0.6 0.6 no signal
808 Cytomegalovirus Infection 12 0.6 0.6 no signal
809 Oral Herpes 14 0.6 0.6 no signal
810 Skin Irritation 33 0.6 0.6 no signal
811 Vitamin D Deficiency 7 0.6 0.6 no signal
812 Therapy Non-responder 32 0.6 0.6 no signal
813 Hip Fracture 23 0.6 0.6 no signal
814 Hyperkalaemia 25 0.6 0.6 no signal
815 Incorrect Route Of Product Administration 12 0.6 0.6 no signal
816 Musculoskeletal Chest Pain 11 0.6 0.6 no signal
817 Neuralgia 17 0.6 0.6 no signal
818 Musculoskeletal Pain 37 0.6 0.6 no signal
819 Erectile Dysfunction 18 0.6 0.6 no signal
820 Hypotonia 7 0.6 0.6 no signal
821 Somnolence 140 0.6 0.6 no signal
822 Paralysis 10 0.6 0.6 no signal
823 Rectal Haemorrhage 30 0.6 0.6 no signal
824 Hypoaesthesia 104 0.6 0.6 no signal
825 Neurotoxicity 12 0.6 0.6 no signal
826 Product Dispensing Error 15 0.6 0.6 no signal
827 Dry Throat 7 0.6 0.6 no signal
828 Inappropriate Antidiuretic Hormone Secretion 7 0.6 0.6 no signal
829 Eosinophilia 12 0.6 0.6 no signal
830 Fracture 13 0.6 0.6 no signal
831 Nervousness 36 0.6 0.6 no signal
832 Arthritis 54 0.6 0.6 no signal
833 Urticaria 114 0.6 0.6 no signal
834 Tooth Abscess 7 0.6 0.6 no signal
835 Fall 227 0.6 0.6 no signal
836 Tooth Infection 9 0.6 0.6 no signal
837 Sensory Disturbance 11 0.6 0.6 no signal
838 Lower Limb Fracture 13 0.6 0.6 no signal
839 Blood Potassium Increased 11 0.6 0.6 no signal
840 Nasopharyngitis 125 0.6 0.6 no signal
841 Scratch 7 0.6 0.6 no signal
842 Generalised Tonic-clonic Seizure 11 0.6 0.6 no signal
843 Macular Degeneration 8 0.6 0.6 no signal
844 Hunger 9 0.6 0.6 no signal
845 Frequent Bowel Movements 18 0.6 0.6 no signal
846 Full Blood Count Abnormal 7 0.6 0.6 no signal
847 Abdominal Distension 69 0.6 0.6 no signal
848 Osteomyelitis 12 0.6 0.6 no signal
849 Paraesthesia 104 0.6 0.6 no signal
850 Balance Disorder 57 0.6 0.6 no signal
851 Product Administration Error 13 0.6 0.6 no signal
852 Fluid Retention 33 0.6 0.6 no signal
853 Pollakiuria 27 0.6 0.6 no signal
854 Muscle Spasms 119 0.6 0.6 no signal
855 Cerebrovascular Accident 110 0.6 0.6 no signal
856 Product Packaging Issue 6 0.6 0.6 no signal
857 Osteonecrosis 21 0.6 0.6 no signal
858 Head Injury 20 0.6 0.6 no signal
859 Accidental Overdose 23 0.5 0.5 no signal
860 Obstructive Airways Disorder 7 0.5 0.5 no signal
861 Pallor 17 0.5 0.5 no signal
862 Transient Ischaemic Attack 21 0.5 0.5 no signal
863 Apathy 9 0.5 0.5 no signal
864 Choking 12 0.5 0.5 no signal
865 Toothache 11 0.5 0.5 no signal
866 Contusion 58 0.5 0.5 no signal
867 Treatment Failure 49 0.5 0.5 no signal
868 Heart Rate Increased 59 0.5 0.5 no signal
869 Lactic Acidosis 19 0.5 0.5 no signal
870 Covid-19 Pneumonia 7 0.5 0.5 no signal
871 Acute Hepatic Failure 8 0.5 0.5 no signal
872 Accident 7 0.5 0.5 no signal
873 Rib Fracture 12 0.5 0.5 no signal
874 Thyroid Disorder 9 0.5 0.5 no signal
875 Feeling Abnormal 140 0.5 0.5 no signal
876 Poor Venous Access 6 0.5 0.5 no signal
877 Drug Dispensing Error 9 0.5 0.5 no signal
878 Emotional Disorder 18 0.5 0.5 no signal
879 Haematoma 15 0.5 0.5 no signal
880 Orthostatic Hypotension 10 0.5 0.5 no signal
881 Burning Sensation 40 0.5 0.5 no signal
882 Blood Triglycerides Increased 10 0.5 0.5 no signal
883 Haemorrhoids 11 0.5 0.5 no signal
884 Breast Cancer Metastatic 6 0.5 0.5 no signal
885 Drug Interaction 88 0.5 0.5 no signal
886 Product Prescribing Error 13 0.5 0.5 no signal
887 Femur Fracture 17 0.5 0.5 no signal
888 Coma 26 0.5 0.5 no signal
889 Dental Caries 6 0.5 0.5 no signal
890 Acute Myocardial Infarction 16 0.5 0.5 no signal
891 Blood Glucose Abnormal 10 0.5 0.5 no signal
892 Eye Infection 6 0.5 0.5 no signal
893 Upper Gastrointestinal Haemorrhage 9 0.5 0.5 no signal
894 Fistula 6 0.5 0.5 no signal
895 Hot Flush 40 0.5 0.5 no signal
896 Blood Pressure Increased 81 0.5 0.5 no signal
897 Cardio-respiratory Arrest 22 0.5 0.5 no signal
898 Autoimmune Disorder 5 0.5 0.5 no signal
899 Post Procedural Complication 10 0.5 0.5 no signal
900 Oxygen Saturation Decreased 29 0.5 0.5 no signal
901 Hair Texture Abnormal 7 0.5 0.5 no signal
902 Limb Injury 14 0.5 0.5 no signal
903 Mobility Decreased 37 0.5 0.4 no signal
904 Delusion 8 0.5 0.5 no signal
905 Hypoglycaemia 25 0.4 0.4 no signal
906 Covid-19 91 0.4 0.4 no signal
907 Post Procedural Haemorrhage 6 0.4 0.4 no signal
908 Drug Effective For Unapproved Indication 15 0.4 0.4 no signal
909 Eyelid Oedema 6 0.4 0.4 no signal
910 Drug Ineffective 672 0.4 0.4 no signal
911 Laboratory Test Abnormal 15 0.4 0.4 no signal
912 Blood Glucose Increased 96 0.4 0.4 no signal
913 Hallucination 38 0.4 0.4 no signal
914 Ischaemic Stroke 9 0.4 0.4 no signal
915 Oral Discomfort 7 0.4 0.4 no signal
916 Dementia 14 0.4 0.4 no signal
917 Respiratory Disorder 15 0.4 0.4 no signal
918 Coordination Abnormal 7 0.4 0.4 no signal
919 Ovarian Cyst 5 0.4 0.4 no signal
920 Mental Impairment 12 0.4 0.4 no signal
921 Restlessness 18 0.4 0.4 no signal
922 Helicobacter Infection 5 0.4 0.4 no signal
923 Ear Infection 13 0.4 0.4 no signal
924 Bone Disorder 9 0.4 0.4 no signal
925 Subarachnoid Haemorrhage 5 0.4 0.4 no signal
926 Subdural Haematoma 7 0.4 0.4 no signal
927 Angina Pectoris 14 0.4 0.4 no signal
928 Abasia 12 0.4 0.4 no signal
929 Nasal Congestion 28 0.4 0.4 no signal
930 Eructation 9 0.4 0.4 no signal
931 Weight Increased 105 0.4 0.4 no signal
932 Insurance Issue 7 0.4 0.4 no signal
933 Musculoskeletal Disorder 9 0.4 0.4 no signal
934 Lacrimation Increased 14 0.4 0.4 no signal
935 Tuberculosis 6 0.4 0.4 no signal
936 Musculoskeletal Discomfort 8 0.4 0.4 no signal
937 Ear Pain 9 0.4 0.4 no signal
938 Impaired Healing 15 0.4 0.4 no signal
939 Cardiac Failure Congestive 37 0.4 0.4 no signal
940 Red Blood Cell Sedimentation Rate Increased 5 0.4 0.4 no signal
941 Fungal Infection 15 0.4 0.4 no signal
942 Tendonitis 7 0.4 0.4 no signal
943 Gastrooesophageal Reflux Disease 36 0.4 0.4 no signal
944 Nerve Injury 5 0.4 0.4 no signal
945 Product Dose Omission Issue 127 0.4 0.4 no signal
946 Bronchitis 33 0.4 0.4 no signal
947 Sleep Disorder 31 0.4 0.4 no signal
948 Heart Rate Irregular 10 0.4 0.4 no signal
949 Intentional Dose Omission 12 0.4 0.4 no signal
950 Osteoporosis 18 0.4 0.4 no signal
951 Anaphylactic Reaction 24 0.4 0.4 no signal
952 Glycosylated Haemoglobin Increased 11 0.4 0.4 no signal
953 Coronary Artery Occlusion 6 0.4 0.4 no signal
954 Intentional Product Use Issue 38 0.4 0.4 no signal
955 Respiratory Arrest 12 0.4 0.4 no signal
956 Chest Pain 80 0.4 0.4 no signal
957 Eye Irritation 24 0.4 0.4 no signal
958 Cardiovascular Disorder 11 0.4 0.4 no signal
959 Thinking Abnormal 8 0.4 0.4 no signal
960 Heart Rate Decreased 15 0.4 0.4 no signal
961 Condition Aggravated 127 0.4 0.4 no signal
962 Palpitations 49 0.4 0.4 no signal
963 Wrist Fracture 5 0.4 0.4 no signal
964 Inappropriate Schedule Of Drug Administration 30 0.4 0.4 no signal
965 Intervertebral Disc Protrusion 9 0.4 0.4 no signal
966 Myocardial Infarction 72 0.4 0.4 no signal
967 Blood Pressure Systolic Increased 8 0.4 0.4 no signal
968 Meningioma 6 0.4 0.4 no signal
969 Agitation 30 0.4 0.4 no signal
970 Depression 93 0.4 0.4 no signal
971 Mood Altered 11 0.4 0.4 no signal
972 Upper Limb Fracture 8 0.3 0.3 no signal
973 Surgery 23 0.3 0.3 no signal
974 Tinnitus 18 0.3 0.3 no signal
975 Muscle Twitching 9 0.3 0.3 no signal
976 Wrong Technique In Product Usage Process 78 0.3 0.3 no signal
977 Chronic Obstructive Pulmonary Disease 20 0.3 0.3 no signal
978 Herpes Zoster 22 0.3 0.3 no signal
979 Breast Pain 4 0.3 0.3 no signal
980 Disturbance In Attention 20 0.3 0.3 no signal
981 Cholelithiasis 12 0.3 0.3 no signal
982 Procedural Pain 10 0.3 0.3 no signal
983 Device Occlusion 5 0.3 0.3 no signal
984 Colitis Ulcerative 16 0.3 0.3 no signal
985 Extra Dose Administered 14 0.3 0.3 no signal
986 Anxiety 100 0.3 0.3 no signal
987 Insomnia 93 0.3 0.3 no signal
988 Stress 25 0.3 0.3 no signal
989 International Normalised Ratio Increased 10 0.3 0.3 no signal
990 Pulmonary Arterial Hypertension 5 0.3 0.3 no signal
991 Musculoskeletal Stiffness 30 0.3 0.3 no signal
992 Bone Marrow Failure 7 0.3 0.3 no signal
993 Fluid Overload 5 0.3 0.3 no signal
994 Migraine 32 0.3 0.3 no signal
995 Hepatitis C 4 0.3 0.3 no signal
996 Type 2 Diabetes Mellitus 11 0.3 0.3 no signal
997 Blood Count Abnormal 5 0.3 0.3 no signal
998 Libido Decreased 4 0.3 0.3 no signal
999 Leukaemia 3 0.3 0.3 no signal
1000 Chest Discomfort 32 0.3 0.3 no signal
1001 Anaphylactic Shock 8 0.3 0.3 no signal
1002 Sinusitis 32 0.3 0.3 no signal
1003 Coeliac Disease 3 0.3 0.3 no signal
1004 Arthropathy 17 0.3 0.3 no signal
1005 Product Physical Issue 6 0.3 0.3 no signal
1006 Renal Injury 9 0.3 0.3 no signal
1007 Product Taste Abnormal 4 0.3 0.3 no signal
1008 Rhinorrhoea 19 0.3 0.3 no signal
1009 Angioedema 13 0.3 0.3 no signal
1010 Anger 10 0.3 0.3 no signal
1011 Flushing 30 0.3 0.3 no signal
1012 Blood Glucose Decreased 14 0.3 0.3 no signal
1013 Hepatic Cancer 7 0.3 0.3 no signal
1014 Swollen Tongue 9 0.3 0.3 no signal
1015 Gastric Disorder 10 0.3 0.3 no signal
1016 Vaginal Haemorrhage 12 0.2 0.2 no signal
1017 Device Dislocation 12 0.2 0.2 no signal
1018 Anosmia 4 0.2 0.2 no signal
1019 Pelvic Pain 5 0.2 0.2 no signal
1020 Adverse Event 25 0.2 0.2 no signal
1021 Coronary Artery Disease 8 0.2 0.2 no signal
1022 Drug Hypersensitivity 50 0.2 0.2 no signal
1023 Blood Cholesterol Increased 12 0.2 0.2 no signal
1024 Mood Swings 8 0.2 0.2 no signal
1025 Multiple Sclerosis 12 0.2 0.2 no signal
1026 No Adverse Event 44 0.2 0.2 no signal
1027 Crying 9 0.2 0.2 no signal
1028 Osteonecrosis Of Jaw 6 0.2 0.2 no signal
1029 Gastric Cancer 6 0.2 0.2 no signal
1030 Loss Of Personal Independence In Daily Activities 11 0.2 0.2 no signal
1031 Colorectal Cancer 11 0.2 0.2 no signal
1032 Therapeutic Product Effect Incomplete 16 0.2 0.2 no signal
1033 Skin Burning Sensation 16 0.2 0.2 no signal
1034 Drug Dose Omission 37 0.2 0.2 no signal
1035 Prostatic Specific Antigen Increased 3 0.2 0.2 no signal
1036 Product Dose Omission 14 0.2 0.2 no signal
1037 Diabetic Ketoacidosis 5 0.2 0.2 no signal
1038 Drug Prescribing Error 4 0.2 0.2 no signal
1039 Throat Irritation 9 0.2 0.2 no signal
1040 Therapeutic Response Unexpected 9 0.2 0.2 no signal
1041 Bone Loss 3 0.2 0.2 no signal
1042 Dyskinesia 8 0.2 0.2 no signal
1043 Drug Administration Error 6 0.2 0.2 no signal
1044 Convulsion 11 0.2 0.2 no signal
1045 Wheezing 11 0.2 0.2 no signal
1046 Unevaluable Event 14 0.2 0.2 no signal
1047 Circumstance Or Information Capable Of Leading To Medication Error 6 0.2 0.2 no signal
1048 Prostate Cancer 14 0.2 0.1 no signal
1049 Irritability 10 0.1 0.1 no signal
1050 Medication Error 9 0.1 0.1 no signal
1051 Breast Cancer 15 0.1 0.1 no signal
1052 Injury 11 0.1 0.1 no signal
1053 Overdose 33 0.1 0.1 no signal
1054 Menstruation Irregular 4 0.1 0.1 no signal
1055 Menorrhagia 3 0.1 0.1 no signal
1056 Intentional Product Misuse 13 0.1 0.1 no signal
1057 Psoriasis 19 0.1 0.1 no signal
1058 Rheumatoid Arthritis 16 0.1 0.1 no signal
1059 Underdose 10 0.1 0.1 no signal
1060 Multiple Sclerosis Relapse 9 0.1 0.1 no signal
1061 Chronic Kidney Disease 9 0.1 0.1 no signal
1062 Bladder Cancer 6 0.1 0.1 no signal
1063 Dermatitis Atopic 5 0.1 0.1 no signal
1064 Oesophageal Carcinoma 3 0.1 0.1 no signal
1065 Emotional Distress 9 0.1 0.1 no signal
1066 Asthma 8 0.1 0.1 no signal