OpenPV Signal Explorer
FAERS disproportionality dashboard
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Drug

Vonoprazan Fumarate

299 flagged reaction(s) · 12,039 total co-reports · max PRR 11.4
Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.
Reaction Co-reports (a) PRR ROR Signal
1 Interstitial Lung Disease 193 11.4 11.7 signal
2 Cerebral Infarction 96 11.2 11.4 signal
3 Hepatic Function Abnormal 144 11.1 11.3 signal
4 Adrenal Insufficiency 44 10.5 10.6 signal
5 Pneumonia Aspiration 85 9.7 9.9 signal
6 Cytokine Release Syndrome 64 9.6 9.7 signal
7 Gastrooesophageal Reflux Disease 265 9.4 9.8 signal
8 Pneumocystis Jirovecii Pneumonia 33 9.4 9.5 signal
9 Altered State Of Consciousness 69 9.1 9.2 signal
10 Drug Eruption 56 9.1 9.1 signal
11 Disseminated Intravascular Coagulation 43 8.7 8.7 signal
12 Oesophagitis 32 8.4 8.4 signal
13 Liver Disorder 103 6.6 6.7 signal
14 Hypomagnesaemia 31 6.4 6.4 signal
15 Incorrect Product Administration Duration 45 6.3 6.4 signal
16 Iron Deficiency Anaemia 20 6.2 6.2 signal
17 Neutrophil Count Decreased 87 6.1 6.2 signal
18 Drug-induced Liver Injury 64 5.9 6.0 signal
19 Gastric Ulcer 39 5.8 5.9 signal
20 Ileus 25 5.8 5.8 signal
21 Covid-19 Pneumonia 24 5.8 5.8 signal
22 Renal Impairment 167 5.7 5.8 signal
23 Cholecystitis 23 5.5 5.5 signal
24 Erythema Multiforme 18 5.5 5.5 signal
25 Hiatus Hernia 25 5.5 5.5 signal
26 Cardiac Failure 150 5.3 5.4 signal
27 Hypophagia 46 5.2 5.2 signal
28 Feeding Disorder 36 5.2 5.2 signal
29 Bacteraemia 21 5.1 5.1 signal
30 Pharyngeal Swelling 17 5.1 5.1 signal
31 Inappropriate Antidiuretic Hormone Secretion 18 5.0 5.1 signal
32 Gastric Cancer 45 5.0 5.0 signal
33 Hypocalcaemia 33 5.0 5.0 signal
34 Gastric Haemorrhage 20 4.9 4.9 signal
35 Pulmonary Arterial Hypertension 25 4.9 4.9 signal
36 Eructation 32 4.8 4.8 signal
37 Thirst 29 4.6 4.7 signal
38 Hepatic Encephalopathy 15 4.6 4.6 signal
39 Febrile Neutropenia 106 4.6 4.6 signal
40 Ascites 47 4.6 4.6 signal
41 Dyspepsia 155 4.5 4.6 signal
42 C-reactive Protein Increased 57 4.5 4.5 signal
43 Cytomegalovirus Infection 26 4.5 4.5 signal
44 Renal Pain 16 4.3 4.3 signal
45 Illness 152 4.3 4.4 signal
46 Hypothyroidism 48 4.3 4.3 signal
47 Multiple Organ Dysfunction Syndrome 42 4.3 4.3 signal
48 Myocarditis 17 4.3 4.3 signal
49 Haematemesis 38 4.3 4.3 signal
50 Lymphocyte Count Decreased 26 4.2 4.2 signal
51 Abdominal Distension 152 4.2 4.2 signal
52 Hyperkalaemia 51 4.2 4.2 signal
53 Gastritis 37 4.0 4.0 signal
54 Gastrointestinal Pain 15 3.9 3.9 signal
55 Faeces Discoloured 29 3.8 3.8 signal
56 Diabetic Ketoacidosis 32 3.8 3.8 signal
57 Hypokalaemia 61 3.8 3.8 signal
58 Toxic Epidermal Necrolysis 20 3.8 3.8 signal
59 Prescribed Underdose 26 3.7 3.7 signal
60 Stevens-johnson Syndrome 29 3.7 3.7 signal
61 Aspiration 14 3.7 3.7 signal
62 Melaena 28 3.6 3.6 signal
63 Throat Irritation 56 3.6 3.6 signal
64 Device Related Infection 19 3.5 3.5 signal
65 Hepatic Cirrhosis 23 3.5 3.5 signal
66 Tubulointerstitial Nephritis 23 3.5 3.5 signal
67 Septic Shock 53 3.5 3.5 signal
68 Blood Pressure Decreased 80 3.4 3.5 signal
69 Taste Disorder 24 3.4 3.4 signal
70 Subdural Haematoma 17 3.4 3.4 signal
71 Platelet Count Decreased 126 3.4 3.4 signal
72 Proteinuria 22 3.3 3.3 signal
73 Flatulence 65 3.3 3.3 signal
74 Clostridium Difficile Colitis 12 3.2 3.2 signal
75 Decreased Appetite 258 3.2 3.3 signal
76 Hyperthyroidism 16 3.2 3.2 signal
77 Ventricular Tachycardia 18 3.1 3.1 signal
78 Gastrointestinal Disorder 96 3.1 3.1 signal
79 Metastases To Liver 19 3.1 3.1 signal
80 Oral Candidiasis 14 3.1 3.1 signal
81 Myelosuppression 36 3.0 3.0 signal
82 Hypercalcaemia 13 3.0 3.0 signal
83 Anaphylactic Shock 27 3.0 3.0 signal
84 Pleural Effusion 64 3.0 3.0 signal
85 Hyponatraemia 59 3.0 3.0 signal
86 Acute Myocardial Infarction 31 3.0 3.0 signal
87 Metastases To Bone 17 3.0 3.0 signal
88 Abdominal Pain Upper 213 3.0 3.0 signal
89 Myelodysplastic Syndrome 15 3.0 3.0 signal
90 Decreased Immune Responsiveness 10 2.9 2.9 signal
91 Delirium 35 2.9 2.9 signal
92 Jaundice 27 2.9 2.9 signal
93 Blood Creatine Phosphokinase Increased 29 2.8 2.8 signal
94 Ventricular Fibrillation 11 2.8 2.8 signal
95 Pancytopenia 55 2.8 2.8 signal
96 Pancreatitis Acute 22 2.8 2.8 signal
97 Aspartate Aminotransferase Increased 52 2.8 2.8 signal
98 Appendicitis 9 2.8 2.8 signal
99 Blood Urea Increased 16 2.7 2.7 signal
100 Anaemia 181 2.7 2.7 signal
101 Upper Gastrointestinal Haemorrhage 16 2.7 2.7 signal
102 Gamma-glutamyltransferase Increased 21 2.7 2.7 signal
103 Blood Lactate Dehydrogenase Increased 15 2.7 2.7 signal
104 Palmar-plantar Erythrodysaesthesia Syndrome 22 2.7 2.7 signal
105 Colon Cancer 14 2.7 2.7 signal
106 Stomatitis 56 2.6 2.6 signal
107 Peritonitis 19 2.6 2.6 signal
108 Malignant Neoplasm Progression 93 2.6 2.6 signal
109 Acute Respiratory Distress Syndrome 16 2.6 2.6 signal
110 Toxic Skin Eruption 9 2.5 2.5 signal
111 Face Oedema 15 2.5 2.5 signal
112 Helicobacter Infection 9 2.5 2.5 signal
113 Subarachnoid Haemorrhage 9 2.5 2.5 signal
114 Myocardial Ischaemia 10 2.5 2.5 signal
115 Pollakiuria 36 2.5 2.5 signal
116 Alanine Aminotransferase Increased 53 2.5 2.5 signal
117 Impaired Gastric Emptying 11 2.5 2.5 signal
118 Metastases To Central Nervous System 11 2.4 2.5 signal
119 White Blood Cell Count Decreased 93 2.4 2.5 signal
120 Hypoxia 30 2.4 2.4 signal
121 Blood Bilirubin Increased 23 2.4 2.4 signal
122 Urinary Retention 28 2.4 2.4 signal
123 Dehydration 112 2.4 2.4 signal
124 Lymphoma 13 2.4 2.4 signal
125 Shock 19 2.4 2.4 signal
126 Glomerular Filtration Rate Decreased 10 2.4 2.4 signal
127 Gastroenteritis 12 2.3 2.3 signal
128 Brain Fog 12 2.3 2.3 signal
129 Unevaluable Event 61 2.3 2.3 signal
130 Therapeutic Product Effect Incomplete 57 2.3 2.3 signal
131 Bladder Disorder 8 2.3 2.3 signal
132 Hyperglycaemia 29 2.3 2.3 signal
133 Blood Potassium Decreased 24 2.3 2.3 signal
134 Renal Disorder 37 2.3 2.3 signal
135 Metastases To Lung 9 2.2 2.2 signal
136 Oedema 42 2.2 2.2 signal
137 Femur Fracture 24 2.2 2.2 signal
138 Pulmonary Hypertension 16 2.2 2.2 signal
139 Hypoglycaemia 37 2.2 2.2 signal
140 Depressed Level Of Consciousness 30 2.2 2.2 signal
141 Pulmonary Congestion 10 2.2 2.2 signal
142 Cytopenia 9 2.1 2.1 signal
143 Fungal Infection 25 2.1 2.1 signal
144 Flank Pain 7 2.1 2.1 no signal
145 Decreased Activity 8 2.1 2.1 no signal
146 Abdominal Discomfort 124 2.1 2.1 signal
147 Fracture 14 2.1 2.1 signal
148 Herpes Zoster 42 2.1 2.1 signal
149 Cardiomegaly 9 2.1 2.1 no signal
150 Diarrhoea 466 2.1 2.1 signal
151 Drug Level Increased 12 2.1 2.1 signal
152 Thrombotic Microangiopathy 7 2.1 2.1 no signal
153 Oral Discomfort 10 2.0 2.0 signal
154 Acute Myeloid Leukaemia 11 2.0 2.0 signal
155 Pneumothorax 11 2.0 2.0 no signal
156 Pyrexia 240 2.0 2.0 no signal
157 Dry Throat 7 2.0 2.0 no signal
158 Diverticulitis 19 2.0 2.0 no signal
159 Constipation 147 1.9 2.0 no signal
160 Prescribed Overdose 13 1.9 1.9 no signal
161 Cerebral Haemorrhage 24 1.9 1.9 no signal
162 Choking 13 1.9 1.9 no signal
163 Cardio-respiratory Arrest 28 1.9 1.9 no signal
164 Colitis 25 1.9 1.9 no signal
165 Acute Hepatic Failure 9 1.9 1.9 no signal
166 Hepatic Failure 20 1.9 1.9 no signal
167 Nocturia 8 1.9 1.9 no signal
168 Sudden Death 7 1.9 1.9 no signal
169 Retinal Detachment 6 1.9 1.9 no signal
170 Infusion Related Reaction 43 1.9 1.9 no signal
171 Malaise 286 1.9 1.9 no signal
172 Blood Thyroid Stimulating Hormone Increased 6 1.9 1.9 no signal
173 Body Height Decreased 7 1.8 1.8 no signal
174 Product Dose Omission Issue 184 1.8 1.9 no signal
175 Sepsis 72 1.8 1.8 no signal
176 Pharyngitis 8 1.8 1.8 no signal
177 Palpitations 74 1.8 1.8 no signal
178 Blood Urine Present 12 1.8 1.8 no signal
179 Underdose 46 1.8 1.8 no signal
180 Autoimmune Disorder 6 1.8 1.8 no signal
181 Rhabdomyolysis 26 1.8 1.8 no signal
182 Dysuria 23 1.8 1.8 no signal
183 Urinary Tract Infection 106 1.8 1.8 no signal
184 Lactic Acidosis 20 1.8 1.8 no signal
185 Chromaturia 14 1.8 1.8 no signal
186 Covid-19 109 1.8 1.8 no signal
187 Internal Haemorrhage 7 1.7 1.7 no signal
188 Electrocardiogram Qt Prolonged 22 1.7 1.7 no signal
189 Therapeutic Product Effect Decreased 27 1.7 1.7 no signal
190 Osteomyelitis 11 1.7 1.7 no signal
191 Splenomegaly 7 1.7 1.7 no signal
192 Blood Creatinine Increased 39 1.7 1.7 no signal
193 Cystitis 19 1.7 1.7 no signal
194 Throat Tightness 16 1.7 1.7 no signal
195 Eyelid Ptosis 6 1.7 1.7 no signal
196 Epilepsy 18 1.7 1.7 no signal
197 Angina Pectoris 17 1.7 1.7 no signal
198 Movement Disorder 19 1.7 1.7 no signal
199 Ear Discomfort 6 1.7 1.7 no signal
200 Drug Interaction 92 1.7 1.7 no signal
201 Heart Rate Irregular 13 1.6 1.6 no signal
202 Skin Disorder 19 1.6 1.6 no signal
203 Glaucoma 11 1.6 1.6 no signal
204 Abdominal Pain 132 1.6 1.6 no signal
205 Drug Effect Less Than Expected 8 1.6 1.6 no signal
206 Osteoporosis 23 1.6 1.6 no signal
207 Lung Neoplasm Malignant 23 1.6 1.6 no signal
208 Paraesthesia Oral 8 1.6 1.6 no signal
209 Chest Pain 103 1.6 1.6 no signal
210 Pneumonitis 15 1.6 1.6 no signal
211 Blood Potassium Increased 9 1.6 1.6 no signal
212 Brain Oedema 7 1.6 1.6 no signal
213 Product Prescribing Error 13 1.6 1.6 no signal
214 Dysphonia 32 1.6 1.6 no signal
215 Nausea 430 1.6 1.6 no signal
216 Off Label Use 472 1.6 1.6 no signal
217 Middle Insomnia 10 1.5 1.5 no signal
218 Cellulitis 27 1.5 1.5 no signal
219 Gastrointestinal Haemorrhage 45 1.5 1.5 no signal
220 Intestinal Obstruction 20 1.5 1.5 no signal
221 Circulatory Collapse 9 1.5 1.5 no signal
222 Arrhythmia 25 1.5 1.5 no signal
223 Posterior Reversible Encephalopathy Syndrome 5 1.5 1.5 no signal
224 Diabetes Mellitus 40 1.5 1.5 no signal
225 Blood Pressure Increased 80 1.5 1.5 no signal
226 Uveitis 7 1.5 1.5 no signal
227 Dysphagia 49 1.5 1.5 no signal
228 Irritable Bowel Syndrome 11 1.5 1.5 no signal
229 Post Procedural Haemorrhage 6 1.5 1.5 no signal
230 Ejection Fraction Decreased 8 1.5 1.5 no signal
231 Muscle Spasms 94 1.5 1.5 no signal
232 Blood Iron Decreased 6 1.5 1.5 no signal
233 Haematochezia 28 1.4 1.4 no signal
234 Haemoptysis 14 1.4 1.4 no signal
235 Inappropriate Schedule Of Product Administration 88 1.4 1.4 no signal
236 Oropharyngeal Pain 46 1.4 1.4 no signal
237 Dysgeusia 37 1.4 1.4 no signal
238 Muscle Tightness 8 1.4 1.4 no signal
239 Sluggishness 5 1.4 1.4 no signal
240 Poor Quality Product Administered 5 1.4 1.4 no signal
241 Hospitalisation 74 1.4 1.4 no signal
242 Hyperbilirubinaemia 5 1.4 1.4 no signal
243 Transfusion 5 1.4 1.4 no signal
244 Clostridium Difficile Infection 10 1.3 1.3 no signal
245 Blood Pressure Systolic Increased 9 1.3 1.3 no signal
246 Deep Vein Thrombosis 30 1.3 1.3 no signal
247 Cold Sweat 8 1.3 1.3 no signal
248 Disease Progression 53 1.3 1.3 no signal
249 Hunger 6 1.3 1.3 no signal
250 Dyskinesia 18 1.3 1.3 no signal
251 Chest Discomfort 45 1.3 1.3 no signal
252 Intentional Dose Omission 12 1.3 1.3 no signal
253 Brain Neoplasm 4 1.2 1.2 no signal
254 Sensory Disturbance 7 1.2 1.2 no signal
255 Cardiac Failure Congestive 35 1.2 1.2 no signal
256 Dementia 12 1.2 1.2 no signal
257 Vasculitis 5 1.2 1.2 no signal
258 Diarrhoea Haemorrhagic 4 1.2 1.2 no signal
259 Pain In Jaw 12 1.2 1.2 no signal
260 Cholestasis 8 1.2 1.2 no signal
261 Hepatitis C 5 1.2 1.2 no signal
262 Bone Pain 24 1.2 1.2 no signal
263 Colitis Ulcerative 18 1.2 1.2 no signal
264 Ageusia 10 1.1 1.1 no signal
265 Feeling Abnormal 93 1.1 1.1 no signal
266 Burning Sensation 27 1.1 1.1 no signal
267 Eczema 19 1.1 1.1 no signal
268 Sars-cov-2 Test Positive 5 1.1 1.1 no signal
269 Increased Appetite 7 1.1 1.1 no signal
270 Lip Swelling 12 1.0 1.0 no signal
271 Osteonecrosis Of Jaw 9 1.0 1.0 no signal
272 Respiratory Arrest 10 1.0 1.0 no signal
273 Pancreatic Carcinoma 10 1.0 1.0 no signal
274 Pemphigus 4 0.9 0.9 no signal
275 Personality Change 3 0.9 0.9 no signal
276 Neoplasm Progression 11 0.9 0.9 no signal
277 Inflammatory Bowel Disease 3 0.9 0.9 no signal
278 Osteonecrosis 10 0.9 0.9 no signal
279 Neoplasm Malignant 20 0.9 0.9 no signal
280 Hereditary Angioedema 3 0.8 0.8 no signal
281 Diabetes Mellitus Inadequate Control 5 0.8 0.8 no signal
282 Wrong Technique In Product Usage Process 57 0.8 0.8 no signal
283 Glycosylated Haemoglobin Increased 7 0.8 0.8 no signal
284 Drug Reaction With Eosinophilia And Systemic Symptoms 7 0.8 0.8 no signal
285 Neuroleptic Malignant Syndrome 3 0.7 0.7 no signal
286 Oesophageal Carcinoma 7 0.7 0.7 no signal
287 Injection Site Induration 3 0.7 0.7 no signal
288 Product Taste Abnormal 3 0.6 0.6 no signal
289 Prostate Cancer 16 0.6 0.6 no signal
290 Skin Burning Sensation 12 0.5 0.5 no signal
291 Hepatic Cancer 4 0.5 0.5 no signal
292 Injury Associated With Device 3 0.4 0.4 no signal
293 Dermatitis Atopic 7 0.4 0.4 no signal
294 Exposure Via Skin Contact 3 0.4 0.4 no signal
295 Injection Site Swelling 10 0.4 0.4 no signal
296 Multiple Sclerosis Relapse 9 0.4 0.4 no signal
297 Breast Cancer 12 0.4 0.4 no signal
298 Gynaecomastia 3 0.3 0.3 no signal
299 Bladder Cancer 3 0.1 0.1 no signal