Drug
Zaleplon
Important: Reactions below are the flagged terms from this drug’s
FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate
disproportionality in spontaneous reporting, not causation.
Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.
| Reaction | Co-reports (a) | PRR | ROR | Signal | |
|---|---|---|---|---|---|
| 1 | Sleep Apnoea Syndrome | 26 | 18.0 | 18.2 | signal |
| 2 | Completed Suicide | 88 | 13.8 | 14.6 | signal |
| 3 | Seasonal Allergy | 12 | 11.2 | 11.3 | signal |
| 4 | Initial Insomnia | 8 | 10.4 | 10.4 | signal |
| 5 | Ventricular Fibrillation | 8 | 9.5 | 9.5 | signal |
| 6 | Intervertebral Disc Degeneration | 6 | 8.5 | 8.5 | signal |
| 7 | Infusion Site Pain | 8 | 8.3 | 8.3 | signal |
| 8 | Chronic Kidney Disease | 46 | 7.9 | 8.1 | signal |
| 9 | Middle Insomnia | 10 | 7.1 | 7.1 | signal |
| 10 | Sedation | 14 | 7.1 | 7.1 | signal |
| 11 | Tendonitis | 8 | 6.8 | 6.8 | signal |
| 12 | Poor Quality Sleep | 11 | 6.8 | 6.8 | signal |
| 13 | Surgery | 26 | 5.9 | 6.0 | signal |
| 14 | Coeliac Disease | 4 | 5.4 | 5.4 | signal |
| 15 | Disability | 8 | 5.3 | 5.4 | signal |
| 16 | Hunger | 5 | 4.9 | 4.9 | signal |
| 17 | Renal Injury | 11 | 4.8 | 4.9 | signal |
| 18 | Bipolar Disorder | 4 | 4.8 | 4.8 | signal |
| 19 | Impaired Driving Ability | 4 | 4.6 | 4.6 | signal |
| 20 | Spinal Operation | 4 | 4.4 | 4.4 | signal |
| 21 | Hallucination, Auditory | 5 | 4.1 | 4.2 | signal |
| 22 | Suicidal Ideation | 28 | 4.0 | 4.1 | signal |
| 23 | Psychotic Disorder | 9 | 4.0 | 4.0 | signal |
| 24 | Euphoric Mood | 3 | 3.8 | 3.8 | no signal |
| 25 | Product Preparation Error | 6 | 3.8 | 3.8 | signal |
| 26 | Toxicity To Various Agents | 44 | 3.5 | 3.5 | signal |
| 27 | Abnormal Dreams | 7 | 3.3 | 3.3 | signal |
| 28 | Product Substitution Issue | 14 | 3.2 | 3.2 | signal |
| 29 | Ankylosing Spondylitis | 3 | 3.0 | 3.0 | no signal |
| 30 | Akathisia | 3 | 2.9 | 2.9 | no signal |
| 31 | Suicide Attempt | 13 | 2.8 | 2.8 | signal |
| 32 | Withdrawal Syndrome | 8 | 2.5 | 2.5 | signal |
| 33 | Intentional Overdose | 12 | 2.5 | 2.5 | signal |
| 34 | Multiple Sclerosis Relapse | 12 | 2.3 | 2.3 | signal |
| 35 | Injection Site Pruritus | 10 | 2.0 | 2.0 | no signal |
| 36 | Injection Site Warmth | 3 | 1.9 | 1.9 | no signal |
| 37 | Intentional Drug Misuse | 3 | 1.9 | 1.9 | no signal |
| 38 | Injection Site Mass | 5 | 1.8 | 1.8 | no signal |
| 39 | Device Delivery System Issue | 3 | 1.5 | 1.5 | no signal |
| 40 | Drug Withdrawal Syndrome | 10 | 1.5 | 1.5 | no signal |
| 41 | Drug Abuse | 8 | 1.3 | 1.3 | no signal |
| 42 | Product Adhesion Issue | 3 | 1.1 | 1.1 | no signal |