Lamotrigine vs Lithium Bromatum: side effects in FDA adverse event reports
At a glance
| Lamotrigine | Lithium Bromatum | |
|---|---|---|
| Drug class | Anti-epileptic Agent, Mood Stabilizer | – |
| Brand names | – | Lithium |
| FAERS reports | 130,963 | 25,059 |
| Serious | 72% | 78% |
| Death outcome | 11,279 | 2,094 |
| Boxed warning | Yes SERIOUS SKIN RASHES Lamotrigine can cause serious rashes requiring hospitalization and discontinuation of treatment. The incidence of these rashes, which have i | No |
Signals both drugs share
| Reaction | Lamotrigine | Lithium Bromatum | Label screen (A / B) |
|---|---|---|---|
| Pleurothotonus | 94 · PRR 18.3 | 62 · PRR 61.0 | Not in label — unassessed / No label text to screen |
Labeled signals distinctive to Lamotrigine
- Epilepsy — n=3,415, PRR 20.1 Labeled — boxed warning
- Stevens-johnson syndrome — n=2,615, PRR 21.2 Labeled — boxed warning
- Duodenal ulcer perforation — n=824, PRR 20.1 Labeled (related wording)
- Petit mal epilepsy — n=696, PRR 25.3 Labeled (related wording)
- Peripheral venous disease — n=638, PRR 30.3 Labeled (related wording)
- Complex partial seizures — n=173, PRR 28.9 Labeled (related wording)
- Seizure cluster — n=92, PRR 20.6 Labeled adverse reaction
- Change in seizure presentation — n=86, PRR 24.0 Labeled (related wording)
Labeled signals distinctive to Lithium Bromatum
- None stood out among the strongest labeled signals.
Common questions
Which has more reported side effects, Lamotrigine or Lithium Bromatum?
Lamotrigine has 130,963 FAERS reports and Lithium Bromatum 25,059. More reports does not mean more dangerous: volume follows how widely and how long a drug has been used, prescription vs over-the-counter status, and publicity. The seriousness share (72% vs 78%) is a better like-for-like signal of the kind of problems reported.
Which side effects do Lamotrigine and Lithium Bromatum share?
Both drugs carry disproportionality signals for pleurothotonus. Shared signals often reflect a shared drug class or the condition both are used for.
Is Lamotrigine or Lithium Bromatum safer?
FAERS cannot answer that: it has no denominator and no comparator. Use this page to see which risks are already on each label and which signals are unlabeled, then check the prescribing information and your clinician for your situation.
Sources: openFDA FAERS pair statistics (OpenPV build 2026-09-14), FDA labels via openFDA, openFDA count queries for seriousness and deaths. Pair chosen because it is a commonly searched comparison. Generated 2026-10-08.