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Which drugs are most reported with Duodenal ulcer perforation?

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 7,246 reports · 228 co-occurring drugs

As of the last recalculation, Duodenal Ulcer Perforation appears in 7,246 FAERS reports alongside 228 co-occurring drug terms. The strongest observed disproportionality signal is DESOXIMETASONE (PRR 2,326.2).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Desoximetasone	4,932	2,326.2	3,144.8
Cortisone Acetate	3,437	1,520.3	2,111.3
Pseudoephedrine Hydrochloride	3,060	1,480.1	2,112.6
Pseudoephedrine Hcl	3,067	1,385.7	1,924.1
Diclofenac Potassium, Film Coated	2,025	958.9	1,264.9
Diclofenac Potassium Tablets	2,025	958.3	1,263.7
Diclofenac Potassium	2,026	747.2	920.6
Cetirizine Hydrochloride Allergy	3,612	682.1	775.0
Cetirizine Hydrochloride Tablets	3,612	682.0	774.9
Tofacitinib Citrate	2,044	623.4	739.2
Diclofenac Sodium 1%	3,741	620.8	693.8
Diclofenac Sodium Topical	3,741	620.8	693.7
Diclofenac Sodium Topical Gel, 1%	3,741	619.6	692.2
Diclofenac	5,174	600.9	639.4
Cetirizine	4,993	592.2	633.1
Chlorhexidine Gluconate	1,356	524.2	616.0
Sulfasalazine	4,720	495.2	527.1
Naproxen Sodium Tablet, Coated	1,751	489.5	562.5
Naproxen Sodium, Coated Tablets	1,751	489.5	562.5
Naproxen Sodium 220Mg	1,751	488.8	561.6
Leflunomide	5,149	485.9	511.2
Alendronate Sodium	4,964	446.5	469.7
Acetaminophen And Codeine	1,491	442.4	504.3
Tocilizumab	5,011	406.8	425.5
Golimumab	4,452	385.1	406.3
Diclofenac Sodium	5,286	370.3	383.9
Sarilumab	2,153	332.7	362.3
Certolizumab Pegol	4,669	320.0	333.3
Cetirizine Hydrochloride	4,996	278.1	286.8
Cetiirizine	2,619	277.6	296.0
Adalimumab-Adaz	2,968	273.0	289.3
Hydroxychloroquine Sulfate	3,870	260.7	272.3
Adalimumab-Fkjp	2,658	259.7	275.6
Adalimumab-Aaty	2,657	254.0	269.2
Abatacept	4,534	249.6	258.1
Hydroxychloroquine	3,280	229.8	240.3
Rituximab	4,935	208.1	213.1
Calcium Gluconate	751	199.6	212.9
Botulinum Toxin Type A	738	190.0	202.0
Folic Acid	5,016	185.5	189.3
Infliximab	4,679	171.9	175.7
Hydrocortisone Acetate	2,719	171.4	178.1
Hydrocortisone Sodium Succinate	507	166.5	176.0
Tofacitinib	4,332	166.2	170.2
Ustekinumab	3,088	150.3	155.0
Aprepitant	836	146.9	153.9
Isopropyl Alcohol	1,394	146.5	152.8
Quetiapine Fumarate	1,213	141.6	147.7
Oxycodone And Acetaminophen Tablets	539	140.3	146.9
Triamcinolone Acetonide Ointment Usp, 0.05%	927	130.3	135.6
Alcohol	1,392	127.3	132.0
Acetaminophen Tablet Extended Release	4,404	124.9	127.1
Pain Reliever	4,404	124.8	127.0
Acetaminophen 500Mg	4,404	124.8	127.0
Fosaprepitant Dimeglumine	546	123.3	128.4
Hydrocortisone	2,466	119.8	123.2
Pantoprazole Sodium In 0.9% Sodium Chloride	1,883	117.5	121.2
Pantoprazole Sodium Injection	1,883	117.5	121.2
Antacid	1,517	115.8	119.6
Doxyclycline Hyclate	605	111.3	115.3
Minocycline	422	110.3	114.5
Diltiazem Hydrochloride Extended-Release Tablets	401	107.1	111.0
Calcium Carbonate	1,852	106.1	109.0
Oxycodone	3,547	105.8	107.8
Anti-Itch	1,804	102.6	105.4
Anti-Pruritic	1,804	102.6	105.4
Antipruritic (Anti-Itch)	1,804	102.6	105.4
Cool Relief Gel With Aloe	1,804	102.6	105.4
Drs. Hydrocortisone	1,804	102.6	105.4
Hydrocortisone Continuous Spray	1,804	102.6	105.4
Hydrocortisone Spray	1,804	102.6	105.4
Anti-Itch Cream	1,804	102.6	105.4
Hydrocortisone Lotion	1,804	102.6	105.4
Hydrocortisone Cream 1%	1,804	102.5	105.4
Hydrocortisone Cream 1/2%	1,804	102.5	105.4
Hydrocortisone 1%	1,804	102.5	105.3
Hydrocortisone Cream	1,804	102.1	104.9
Tramadol Hydrochloride	1,111	100.0	103.0
Triamcinolone Acetonide	927	98.7	101.7
Methotrexate	4,847	97.9	99.1
Methotrexate Sodium	5,067	97.3	98.3
Secukinumab	3,024	91.7	93.4
Prednisone	4,860	82.3	83.1
Methylprednisolone Sodium Succinate	1,122	82.0	84.0
Candesartan	891	81.7	83.7
Risedronate Sodium	763	78.7	80.7
Naproxen Sodium	2,535	77.9	79.2
Acetaminophen	4,564	77.4	78.2
Oxycodone And Acetaminophen	539	71.7	73.4
Vitamin C	1,697	69.0	70.3
Celecoxib	2,204	68.7	69.8
Ibuprofen Capsule	2,892	68.6	69.6
Ibuprofen Tablet, Film Coated	2,892	68.6	69.6
Ibupfrofen	2,892	68.6	69.6
Ibuprofen Tablets Usp, 200Mg	2,892	68.6	69.6
Ibuprofen Oral	2,892	68.6	69.6
Ibuprofen Capsules 200 Mg	2,892	68.6	69.6
Ibuprofen 200 Mg	2,892	68.6	69.6
Ibuprofen 200Mg	2,892	68.6	69.6
Naproxen	1,462	66.7	68.0
Atomoxetine Hydrochloride	486	62.8	64.1
Doxycycline Hyclate	1,219	62.2	63.3
Doxycycline	1,219	61.5	62.6
Ramipril	1,931	60.7	61.6
Adalimumab	4,928	60.4	60.8
Apremilast	2,155	59.8	60.7
Pantoprazole	3,064	59.5	60.2
Ascorbic Acid	446	58.6	59.8
Diphenhydramine Hydrochloride Capsule, Liquid Filled	402	57.2	58.2
Etanercept	4,537	56.6	57.0
Ibuprofen	2,987	53.0	53.6
Erenumab-Aooe	894	53.0	53.9
Tretinoin	146	52.7	53.7
Mirabegron	626	50.8	51.6
Methylprednisolone Acetate	137	50.1	50.9
Pantoprazole Sodium	1,896	49.4	50.0
Mepolizumab	680	43.3	43.9
Erythromycin	255	40.4	41.0
Sulfamethoxazole And Trimethoprim	1,015	40.0	40.5
Trimethoprim	160	39.8	40.4
Mycophenolate Mofetil Hydrochloride	1,430	37.4	37.8
Mycophenolate Mofetil	1,411	36.8	37.2
Thiamine Hydrochloride	154	36.3	36.7
Azathioprine	961	36.0	36.4
Diltiazem Hydrochloride	404	35.5	35.9
Meloxicam	648	35.1	35.5
Magnesium	851	33.6	33.9
Alendronate Sodium Tablet	210	33.5	33.9
Quetiapine	1,657	31.7	32.0
Cyanocobalamin	340	31.1	31.4
Moxifloxacin Hydrochloride	211	30.8	31.1
Fish Oil	841	30.1	30.4
Moxifloxacin	137	28.5	28.7
Acetaminophen, Guaifenesin, And Phenylephrine Hydrochloride	1,297	28.1	28.4
Lorazepam	1,417	27.9	28.1
Methylprednisolone	1,129	27.6	27.8
Lansoprazole	1,346	26.4	26.6
Buprenorphine	737	25.4	25.6
Calcium	1,049	23.5	23.7
Ergocalciferol	2,217	23.4	23.5
Oxycodone Hydrochloride	1,373	22.2	22.3
Icosapent Ethyl	65	22.1	22.3
Topiramate	646	21.8	21.9
Oxycodone Hydrochloride And Acetaminophen	647	20.6	20.7
Lamotrigine	824	20.1	20.3
Lisinopril	1,428	16.4	16.5
Pregabalin	1,290	16.3	16.4
Prednisolone	903	16.3	16.4
Prednisolone Oral	903	16.3	16.4
Prednisolone Oral Solution	903	16.3	16.4
Mesalamine	304	16.2	16.3
Indomethacin	73	16.0	16.1
Dexamethasone Sodium Phosphate	52	14.8	14.9
Levothyroxine Sodium Anhydrous	473	14.4	14.5
Vedolizumab	410	14.4	14.5
Ranitidine Hydrochloride	255	13.9	14.0
Magnesium Hydroxide	64	13.8	13.8
Cyclobenzaprine	217	12.8	12.9
Fluticasone Furoate	50	11.9	12.0
Morphine	288	11.5	11.5
Lamotirigine	267	11.1	11.1
Lamotrigine Extended-Release	267	11.1	11.1
Lamotrigine Chewable Dispersible	267	11.1	11.1
Diphenhydramine Hydrochloride	545	10.1	10.2
Cyclobenzaprine Hydrochloride	31	9.9	10.0
Fluticasone Propionate Nasal	103	9.9	9.9
Metformin Hydrochloride Tablets	190	9.7	9.8
Metformin Hydrochloride Extended-Release Tablets	190	9.7	9.8
Metformin Hydrochloride Tablet	190	9.7	9.8
Metformin Hydrochloride	190	9.4	9.5
Zinc	76	8.9	9.0
Zinc Chloride	76	8.9	8.9
Prednisolone Acetate	31	8.6	8.7
Zinc Gluconate	76	8.4	8.4
Thiamine Hydrochloride, Riboflavin 5 Phosphate Sodium, Dexpanthenol And Niacinamide	84	8.0	8.1
Candesartan Cilexetil	71	7.8	7.8
Ibuprofen Sodium	113	7.7	7.7
Ibuprofen Tablets, Coated	107	7.3	7.3
Diphenhydramine	148	6.8	6.9
Albuterol	246	6.1	6.1
Ranitidine	394	6.0	6.0
Hydromorphone Hydrochloride	183	5.8	5.8
Anakinra	33	5.7	5.7
Morphine Sulfate	225	5.5	5.5
Telmisartan	33	5.3	5.3
Misoprostol	18	5.3	5.3
Trazodone Hydrochloride	28	5.2	5.2
Leucovorin Calcium	34	5.1	5.1
Dexamethasone 1.5 Mg	488	5.1	5.1
Dexamethasone	489	5.0	5.0
Meperidine Hydrochloride	16	5.0	5.0
Bupropion	76	4.9	4.9
Levothyroxine Sodium	487	4.7	4.7
Fluticasone Propionate	193	4.4	4.4
Upadacitinib	119	4.2	4.3
Salicylic Acid	75	4.1	4.1
Magnesium Sulfate In Water For	17	3.8	3.8
Magnesium Sulfate Heptahydrate	17	3.8	3.8
Magnesium Sulfate	17	3.7	3.8
Sodium Bicarbonate	28	3.5	3.5
Sodium Bicarbonate Injection,	28	3.5	3.5
Bupivacaine	11	3.4	3.4
Albuterol Sulfate	323	3.2	3.2
Human Immunoglobulin G	23	3.2	3.2
Infliximab-Dyyb	32	3.2	3.2
Esomeprazole Magnesium Capsule, Delayed Release	15	3.0	3.0
Esomeprazole Magnesium Delayed Release Capsules	15	3.0	3.0
Esomeprazole Magnesium Dihydrate	15	3.0	3.0
Bupropion Hydrochloride	90	2.6	2.6
Cyclosporine	96	2.5	2.5
Lapatinib	13	2.4	2.4
Methocarbamol Tablets	14	2.4	2.4
Gentamicin Sulfate	13	2.4	2.4
Donepezil Hydrochloride	28	2.2	2.2
Metformin	241	2.0	2.0
Deferasirox	18	2.0	2.0
Granisetron Hydrochloride	6	1.7	1.7
Oxybutynin Chloride	5	1.6	1.6
Dexlansoprazole	21	1.4	1.4
Bevacizumab	60	1.4	1.4
Onabotulinumtoxina	33	1.2	1.2
Cetuximab	13	1.2	1.2
Polatuzumab Vedotin	4	1.2	1.2
Dabigatran Etexilate	25	0.9	0.9
Atezolizumab	12	0.9	0.9
Dabigatran Etexilate Mesylate	22	0.9	0.9
Ixekizumab	10	0.8	0.8
Durvalumab	5	0.7	0.7

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.