Pantoprazole vs Esomeprazole: side effects in FDA adverse event reports
At a glance
| Pantoprazole | Esomeprazole | |
|---|---|---|
| Drug class | – | Proton Pump Inhibitor |
| Brand names | – | – |
| FAERS reports | 251,540 | 232,620 |
| Serious | 83% | 72% |
| Death outcome | 28,518 | 19,443 |
| Boxed warning | No | No |
Signals both drugs share
| Reaction | Pantoprazole | Esomeprazole | Label screen (A / B) |
|---|---|---|---|
| End stage renal disease | 2,897 · PRR 15.4 | 10,300 · PRR 115.0 | Not in label — unassessed / Not in label — unassessed |
| Nephrogenic anaemia | 835 · PRR 17.9 | 2,916 · PRR 151.0 | Not in label — unassessed / Not in label — unassessed |
| Hypertensive nephropathy | 277 · PRR 28.6 | 429 · PRR 59.3 | Not in label — unassessed / Not in label — unassessed |
| Adjustment disorder | 231 · PRR 17.8 | 294 · PRR 26.0 | Not in label — unassessed / Not in label — unassessed |
Labeled signals distinctive to Pantoprazole
- Glossodynia — n=3,951, PRR 17.7 Labeled (related wording)
- Sleep disorder due to general medical condition, insomnia type — n=2,489, PRR 52.3 Labeled (related wording)
- Systemic infection — n=457, PRR 31.3 Labeled (related wording)
- Subcutaneous drug absorption impaired — n=222, PRR 57.1 Labeled (related wording)
Labeled signals distinctive to Esomeprazole
- Tubulointerstitial nephritis — n=4,232, PRR 26.1 Labeled adverse reaction
- Pruritus genital — n=399, PRR 18.5 Labeled (related wording)
- Gastric polyps — n=339, PRR 15.7 Labeled (related wording)
- Calcium deficiency — n=325, PRR 29.7 Labeled (related wording)
Common questions
Which has more reported side effects, Pantoprazole or Esomeprazole?
Pantoprazole has 251,540 FAERS reports and Esomeprazole 232,620. More reports does not mean more dangerous: volume follows how widely and how long a drug has been used, prescription vs over-the-counter status, and publicity. The seriousness share (83% vs 72%) is a better like-for-like signal of the kind of problems reported.
Which side effects do Pantoprazole and Esomeprazole share?
Both drugs carry disproportionality signals for end stage renal disease, nephrogenic anaemia, hypertensive nephropathy, adjustment disorder. Shared signals often reflect a shared drug class or the condition both are used for.
Is Pantoprazole or Esomeprazole safer?
FAERS cannot answer that: it has no denominator and no comparator. Use this page to see which risks are already on each label and which signals are unlabeled, then check the prescribing information and your clinician for your situation.
Sources: openFDA FAERS pair statistics (OpenPV build 2026-09-14), FDA labels via openFDA, openFDA count queries for seriousness and deaths. Pair chosen because it is a commonly searched comparison. Generated 2026-10-08.