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Sleep Disorder Due To General Medical Condition, Insomnia Type reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 6,355 reports · 234 co-occurring drugs

As of the last recalculation, Sleep Disorder Due To General Medical Condition, Insomnia Type appears in 6,355 FAERS reports alongside 234 co-occurring drug terms. The strongest observed disproportionality signal is DESOXIMETASONE (PRR 714.4).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Desoximetasone	2,514	714.4	823.5
Pseudoephedrine Hydrochloride	1,383	563.2	651.2
Pseudoephedrine Hcl	1,383	525.2	600.9
Cortisone Acetate	1,503	521.9	594.6
Diclofenac Potassium, Film Coated	1,049	488.8	558.7
Diclofenac Potassium Tablets	1,049	488.5	558.3
Chlorhexidine Gluconate	989	419.7	470.8
Diclofenac Potassium	1,049	380.6	421.7
Cetirizine Hydrochloride Allergy	1,864	284.8	303.6
Cetirizine Hydrochloride Tablets	1,864	284.8	303.5
Acetaminophen And Codeine	841	260.4	279.8
Naproxen Sodium Tablet, Coated	850	237.2	253.1
Naproxen Sodium, Coated Tablets	850	237.2	253.1
Naproxen Sodium 220Mg	850	236.9	252.7
Diclofenac Sodium 1%	1,762	223.1	234.7
Diclofenac Sodium Topical	1,762	223.1	234.7
Diclofenac Sodium Topical Gel, 1%	1,762	222.7	234.2
Sulfasalazine	2,798	208.5	216.2
Cetirizine	2,758	204.9	212.5
Tofacitinib Citrate	720	202.7	214.5
Golimumab	2,885	201.0	208.0
Cetiirizine	1,834	199.0	208.0
Leflunomide	3,116	190.4	196.2
Tocilizumab	3,133	176.4	181.4
Diclofenac	2,594	166.0	171.1
Oxycodone And Acetaminophen Tablets	521	155.9	163.0
Certolizumab Pegol	2,918	149.9	153.8
Hydrocortisone Sodium Succinate	382	141.5	147.5
Aprepitant	708	141.2	146.9
Alendronate Sodium	2,559	138.4	142.0
Hydroxychloroquine Sulfate	2,401	138.1	141.9
Hydroxychloroquine	2,081	135.3	139.1
Abatacept	2,944	128.9	131.7
Calcium Gluconate	433	126.2	130.9
Sarilumab	859	123.0	127.1
Fosaprepitant Dimeglumine	466	119.7	123.9
Pantoprazole Sodium In 0.9% Sodium Chloride	1,640	116.4	119.6
Pantoprazole Sodium Injection	1,640	116.4	119.6
Adalimumab-Fkjp	1,231	107.7	110.6
Adalimumab-Aaty	1,231	105.4	108.2
Adalimumab-Adaz	1,332	104.3	107.0
Isopropyl Alcohol	905	102.1	104.9
Cetirizine Hydrochloride	2,782	97.5	99.2
Diclofenac Sodium	2,635	97.3	99.0
Diltiazem Hydrochloride Extended-Release Tablets	306	92.5	95.0
Alcohol	902	88.5	90.6
Doxyclycline Hyclate	428	88.2	90.5
Quetiapine Fumarate	652	80.5	82.3
Oxycodone And Acetaminophen	522	79.8	81.7
Oxycodone	2,636	78.2	79.3
Hydrocortisone Acetate	1,351	77.0	78.5
Tofacitinib	2,554	75.1	76.2
Rituximab	2,715	72.7	73.6
Ustekinumab	1,632	69.9	71.1
Infliximab	2,692	69.3	70.2
Triamcinolone Acetonide Ointment Usp, 0.05%	457	68.8	70.2
Antacid	855	68.0	69.2
Acetaminophen Tablet Extended Release	2,774	62.4	63.1
Pain Reliever	2,774	62.4	63.1
Acetaminophen 500Mg	2,774	62.4	63.1
Calcium Carbonate	1,056	61.6	62.5
Hydrocortisone	1,305	60.0	60.9
Folic Acid	2,604	57.3	57.9
Ibuprofen Capsule	2,217	55.4	56.0
Ibuprofen Tablet, Film Coated	2,217	55.4	56.0
Ibupfrofen	2,217	55.4	56.0
Ibuprofen Tablets Usp, 200Mg	2,217	55.4	56.0
Ibuprofen Oral	2,217	55.4	56.0
Ibuprofen Capsules 200 Mg	2,217	55.3	56.0
Ibuprofen 200 Mg	2,217	55.3	55.9
Ibuprofen 200Mg	2,217	55.3	55.9
Tramadol Hydrochloride	561	53.4	54.2
Pantoprazole	2,489	52.3	52.8
Triamcinolone Acetonide	456	52.0	52.8
Anti-Itch	912	51.9	52.6
Anti-Pruritic	912	51.9	52.6
Antipruritic (Anti-Itch)	912	51.9	52.6
Cool Relief Gel With Aloe	912	51.9	52.6
Drs. Hydrocortisone	912	51.9	52.6
Hydrocortisone Continuous Spray	912	51.9	52.6
Hydrocortisone Spray	912	51.9	52.6
Anti-Itch Cream	912	51.8	52.6
Hydrocortisone Lotion	912	51.8	52.6
Hydrocortisone Cream 1%	912	51.8	52.5
Hydrocortisone Cream 1/2%	912	51.8	52.5
Hydrocortisone 1%	912	51.8	52.5
Hydrocortisone Cream	912	51.6	52.3
Doxycycline Hyclate	893	50.3	50.9
Doxycycline	892	49.6	50.3
Pantoprazole Sodium	1,666	49.5	50.1
Risedronate Sodium	431	48.6	49.3
Sulfamethoxazole And Trimethoprim	1,017	46.8	47.4
Vitamin C	1,086	46.5	47.0
Methotrexate	3,056	44.9	45.2
Ibuprofen	2,296	42.8	43.1
Methotrexate Sodium	3,191	42.2	42.5
Ascorbic Acid	286	42.1	42.6
Acetaminophen	2,974	40.0	40.3
Moxifloxacin Hydrochloride	233	39.0	39.5
Moxifloxacin	162	38.6	39.1
Diphenhydramine Hydrochloride Capsule, Liquid Filled	240	38.2	38.6
Acetaminophen, Guaifenesin, And Phenylephrine Hydrochloride	1,439	37.8	38.1
Secukinumab	1,435	37.3	37.7
Prednisone	3,038	37.0	37.2
Etanercept	3,315	36.8	37.0
Methylprednisolone Sodium Succinate	460	34.9	35.2
Naproxen Sodium	1,215	34.2	34.5
Celecoxib	1,072	31.9	32.1
Apremilast	1,166	31.7	32.0
Mycophenolate Mofetil Hydrochloride	1,094	31.6	31.9
Mycophenolate Mofetil	1,080	31.2	31.4
Diltiazem Hydrochloride	312	31.0	31.3
Trimethoprim	102	28.8	29.0
Erythromycin	150	26.8	27.0
Meloxicam	443	26.8	27.0
Naproxen	566	25.8	26.0
Ramipril	846	25.7	25.8
Fish Oil	590	23.5	23.6
Oxycodone Hydrochloride And Acetaminophen	627	22.9	23.1
Adalimumab	2,787	22.2	22.3
Indomethacin	86	21.5	21.7
Oxycodone Hydrochloride	1,165	21.3	21.4
Magnesium	493	21.2	21.3
Icosapent Ethyl	54	20.9	21.1
Alendronate Sodium Tablet	116	20.9	21.0
Lorazepam	914	19.3	19.4
Quetiapine	956	19.0	19.0
Minocycline	65	18.4	18.5
Lansoprazole	835	17.5	17.6
Cyanocobalamin	171	17.4	17.5
Liothyronine Sodium	46	17.4	17.5
Calcium	635	15.4	15.5
Tretinoin	36	14.6	14.7
Azathioprine	370	14.5	14.6
Abemaciclib	83	13.8	13.8
Pregabalin	977	13.7	13.8
Botulinum Toxin Type A	51	13.6	13.6
Ergocalciferol	1,266	13.2	13.2
Dexamethasone Sodium Phosphate	39	12.6	12.7
Levothyroxine Sodium Anhydrous	364	12.6	12.6
Vedolizumab	310	12.3	12.4
Prednisolone	565	11.2	11.2
Prednisolone Oral	565	11.2	11.2
Prednisolone Oral Solution	565	11.2	11.2
Mesalamine	184	11.0	11.1
Morphine	231	10.5	10.5
Lisinopril	800	9.6	9.7
Atomoxetine Hydrochloride	60	8.3	8.3
Esomeprazole Magnesium Capsule, Delayed Release	36	8.2	8.2
Esomeprazole Magnesium Delayed Release Capsules	36	8.2	8.2
Esomeprazole Magnesium Dihydrate	36	8.1	8.1
Infliximab-Dyyb	69	7.8	7.8
Methylprednisolone Acetate	19	7.8	7.8
Mometasone	42	7.5	7.6
Albuterol	261	7.4	7.4
Tirzepatide	344	7.3	7.3
Diphenhydramine Hydrochloride	352	7.3	7.3
Methylprednisolone	287	7.1	7.1
Ibuprofen Sodium	87	6.7	6.7
Thiamine Hydrochloride, Riboflavin 5 Phosphate Sodium, Dexpanthenol And Niacinamide	61	6.6	6.7
Candesartan	71	6.6	6.6
Ibuprofen Tablets, Coated	83	6.5	6.5
Erenumab-Aooe	102	6.1	6.2
Cyclosporine	195	5.9	5.9
Esomeprazole Magnesium	386	5.7	5.7
Sodium Bicarbonate	39	5.5	5.5
Sodium Bicarbonate Injection,	39	5.5	5.5
Loperamide Hydrochloride Oral	17	5.5	5.5
Goserelin	22	5.4	5.4
Thiamine Hydrochloride	20	5.3	5.3
Fluticasone Furoate	19	5.1	5.2
Magnesium Hydroxide	21	5.1	5.1
Temazepam	58	5.1	5.1
Prednisolone Acetate	16	5.1	5.1
Diphenhydramine	95	5.0	5.0
Trazodone Hydrochloride	23	4.8	4.8
Mirabegron	55	4.7	4.7
Levothyroxine Sodium	426	4.7	4.7
Bupropion	60	4.4	4.4
Upadacitinib	108	4.4	4.4
Loperamide Hcl	17	4.3	4.3
Mometasone Furoate	53	4.2	4.2
Mepolizumab	63	4.2	4.2
Anastrozole Tablets	27	4.1	4.1
Albuterol Sulfate	358	4.1	4.1
Salicylic Acid	65	4.1	4.1
Tacrolimus Ointment 0.1%	149	4.0	4.0
Tacrolimus Extended-Release Capsules	149	4.0	4.0
Bupivacaine	11	3.9	3.9
Naltrexone Hydrochloride And Bupropion Hydrochloride	10	3.8	3.8
Tacrolimus	180	3.8	3.8
Dulaglutide	96	3.6	3.6
Dexamethasone 1.5 Mg	290	3.3	3.4
Teriparatide	113	3.3	3.3
Dexamethasone	290	3.3	3.3
Candesartan Cilexetil	26	3.2	3.2
Anastrozole	36	3.2	3.2
Budesonide	57	3.2	3.2
Cyclobenzaprine	47	3.1	3.1
Morphine Sulfate	109	3.0	3.0
Budesonide And Formoterol Fumarate Dihydrate	85	2.9	2.9
Esomeprazole	53	2.8	2.8
Topiramate	75	2.7	2.7
Fluticasone Propionate Nasal	24	2.6	2.6
Ticagrelor	25	2.6	2.6
Montelukast	65	2.6	2.6
Montelukast Sodium	94	2.6	2.6
Estradiol Gel 0.1%	33	2.4	2.4
Estradiol Transdermal	33	2.4	2.4
Indapamide	13	2.4	2.4
Clonidine	37	2.4	2.4
Anakinra	12	2.4	2.4
Benralizumab	14	2.3	2.3
Letrozole Tablets	33	2.3	2.3
Buprenorphine	63	2.2	2.2
Leucovorin Calcium	13	2.2	2.2
Apixaban	44	2.2	2.2
Cetirizine Hcl	6	2.1	2.1
Lisinopril And Hydrochlorothiazide Tablets	5	2.1	2.1
Galcanezumab-Gnlm	20	2.1	2.1
Ranitidine Hydrochloride	31	1.9	1.9
Ixekizumab	21	1.9	1.9
Azelastine	10	1.8	1.8
Evolocumab	84	1.7	1.7
Romosozumab-Aqqg	7	1.7	1.7
Denosumab	102	1.7	1.7
Insulin Lispro	68	1.6	1.6
Budesonide, Glycopyrrolate, And Formoterol Fumarate	5	1.6	1.6
Orlistat	12	1.5	1.5
Crisaborole	4	1.4	1.4
Naltrexone	12	1.3	1.3
Dupilumab	162	1.1	1.1
Lifitegrast	4	0.8	0.8
Nirmatrelvir And Ritonavir	7	0.4	0.4

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.