Secukinumab vs Guselkumab: side effects in FDA adverse event reports
At a glance
| Secukinumab | Guselkumab | |
|---|---|---|
| Drug class | Interleukin-17A Antagonist | Interleukin-23 Antagonist |
| Brand names | Cosentyx | Tremfya |
| FAERS reports | 160,389 | 35,198 |
| Serious | 40% | 26% |
| Death outcome | 8,611 | 458 |
| Boxed warning | No | No |
Signals both drugs share
| Reaction | Secukinumab | Guselkumab | Label screen (A / B) |
|---|---|---|---|
| Psoriatic arthropathy | 10,208 · PRR 44.3 | 723 · PRR 10.8 | Likely indication confounding / Likely indication confounding |
| Dactylitis | 288 · PRR 54.1 | 13 · PRR 7.9 | Not in label — unassessed / Not in label — unassessed |
| Nail psoriasis | 179 · PRR 53.2 | 12 · PRR 11.7 | Likely indication confounding / Likely indication confounding |
Labeled signals distinctive to Secukinumab
- None stood out among the strongest labeled signals.
Labeled signals distinctive to Guselkumab
- Latent tuberculosis — n=33, PRR 9.5 Labeled (related wording)
Common questions
Which has more reported side effects, Secukinumab or Guselkumab?
Secukinumab has 160,389 FAERS reports and Guselkumab 35,198. More reports does not mean more dangerous: volume follows how widely and how long a drug has been used, prescription vs over-the-counter status, and publicity. The seriousness share (40% vs 26%) is a better like-for-like signal of the kind of problems reported.
Which side effects do Secukinumab and Guselkumab share?
Both drugs carry disproportionality signals for psoriatic arthropathy, dactylitis, nail psoriasis. Shared signals often reflect a shared drug class or the condition both are used for.
Is Secukinumab or Guselkumab safer?
FAERS cannot answer that: it has no denominator and no comparator. Use this page to see which risks are already on each label and which signals are unlabeled, then check the prescribing information and your clinician for your situation.
Sources: openFDA FAERS pair statistics (OpenPV build 2026-09-14), FDA labels via openFDA, openFDA count queries for seriousness and deaths. Pair chosen because it is a commonly searched comparison. Generated 2026-10-08.