OpenPV Signal Explorer
FAERS disproportionality dashboard
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Drug

Desvenlafaxine

211 flagged reaction(s) · 4,495 total co-reports · max PRR 37.6
Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.
Reaction Co-reports (a) PRR ROR Signal
1 Serotonin Syndrome 120 37.6 38.9 signal
2 Completed Suicide 200 14.2 15.0 signal
3 Brain Injury 22 13.1 13.2 signal
4 Poisoning Deliberate 18 11.5 11.6 signal
5 Toxicity To Various Agents 273 9.7 10.4 signal
6 Pharyngeal Swelling 13 8.1 8.1 signal
7 Withdrawal Syndrome 53 7.5 7.6 signal
8 Suicidal Ideation 115 7.5 7.7 signal
9 Impaired Gastric Emptying 16 7.5 7.5 signal
10 Panic Attack 43 7.0 7.1 signal
11 Euphoric Mood 12 6.9 7.0 signal
12 Paranoia 20 6.9 6.9 signal
13 Paralysis 16 6.6 6.7 signal
14 Drug Interaction 175 6.6 6.9 signal
15 Blood Iron Decreased 13 6.6 6.6 signal
16 Intentional Overdose 70 6.5 6.7 signal
17 Seasonal Allergy 15 6.3 6.4 signal
18 Impaired Quality Of Life 15 6.2 6.2 signal
19 Coeliac Disease 10 6.1 6.1 signal
20 Suicide Attempt 61 6.0 6.1 signal
21 Drug Withdrawal Syndrome Neonatal 15 6.0 6.0 signal
22 Tenderness 10 5.7 5.7 signal
23 Haemorrhage Intracranial 14 5.6 5.6 signal
24 Parkinsonism 9 5.5 5.5 signal
25 Brain Fog 13 5.3 5.3 signal
26 Metabolic Acidosis 28 5.3 5.3 signal
27 Initial Insomnia 9 5.3 5.3 signal
28 Immunodeficiency 13 5.3 5.3 signal
29 Shock 20 5.2 5.2 signal
30 Scar 15 5.2 5.2 signal
31 Fibromyalgia 21 5.2 5.2 signal
32 Sedation 22 5.0 5.1 signal
33 Sleep Apnoea Syndrome 16 5.0 5.0 signal
34 Schizophrenia 10 4.9 4.9 signal
35 Bipolar Disorder 9 4.9 4.9 signal
36 Overdose 177 4.9 5.1 signal
37 Ligament Sprain 8 4.8 4.8 signal
38 Agitation 59 4.8 4.8 signal
39 Product Substitution Issue 46 4.8 4.8 signal
40 Head Discomfort 14 4.7 4.8 signal
41 Unresponsive To Stimuli 20 4.6 4.7 signal
42 Sinus Tachycardia 11 4.6 4.6 signal
43 Sexual Dysfunction 9 4.6 4.6 signal
44 Depression 172 4.5 4.7 signal
45 Mental Impairment 18 4.4 4.4 signal
46 Crying 27 4.4 4.4 signal
47 Lymphocyte Count Decreased 13 4.4 4.4 signal
48 Generalised Tonic-clonic Seizure 12 4.4 4.4 signal
49 Pericarditis 12 4.3 4.3 signal
50 Delusion 11 4.2 4.2 signal
51 Myocarditis 8 4.2 4.2 signal
52 Photophobia 13 4.1 4.2 signal
53 Hallucination, Auditory 11 4.1 4.1 signal
54 Subarachnoid Haemorrhage 7 4.1 4.1 signal
55 Insurance Issue 10 4.0 4.0 signal
56 Sinus Congestion 9 4.0 4.0 signal
57 Anxiety 189 3.9 4.1 signal
58 Dermatitis Atopic 33 3.9 4.0 signal
59 Restless Legs Syndrome 12 3.9 3.9 signal
60 Multiple Organ Dysfunction Syndrome 18 3.8 3.9 signal
61 Poisoning 8 3.8 3.8 signal
62 Accidental Overdose 23 3.8 3.8 signal
63 Sleep Disorder Due To A General Medical Condition 10 3.7 3.7 signal
64 Blood Creatine Phosphokinase Increased 18 3.7 3.7 signal
65 Inability To Afford Medication 6 3.6 3.6 signal
66 Drug Ineffective For Unapproved Indication 34 3.6 3.7 signal
67 Hyperglycaemia 22 3.6 3.6 signal
68 Disorientation 24 3.6 3.6 signal
69 Treatment Noncompliance 32 3.5 3.5 signal
70 Neuroleptic Malignant Syndrome 7 3.5 3.5 signal
71 Muscle Rigidity 7 3.5 3.5 signal
72 Spinal Operation 7 3.4 3.5 signal
73 Contraindicated Product Administered 17 3.4 3.4 signal
74 Lactic Acidosis 18 3.3 3.4 signal
75 Product Dose Omission In Error 15 3.3 3.3 signal
76 Seizure 64 3.3 3.4 signal
77 Apathy 8 3.3 3.3 signal
78 Intentional Dose Omission 15 3.3 3.3 signal
79 Cardio-respiratory Arrest 23 3.3 3.3 signal
80 Product Availability Issue 12 3.2 3.2 signal
81 Upper Gastrointestinal Haemorrhage 9 3.2 3.2 signal
82 Nervousness 28 3.2 3.2 signal
83 Irritability 32 3.2 3.2 signal
84 Hemiparesis 9 3.1 3.2 signal
85 Migraine 50 3.1 3.2 signal
86 Eructation 10 3.1 3.1 signal
87 Thyroid Disorder 8 3.1 3.1 signal
88 Depressed Mood 27 3.1 3.1 signal
89 Loss Of Personal Independence In Daily Activities 24 3.0 3.0 signal
90 Hyperhidrosis 65 3.0 3.0 signal
91 Product Administration Error 10 3.0 3.0 signal
92 Mania 8 2.9 2.9 signal
93 Neutrophil Count Increased 5 2.9 2.9 signal
94 Middle Insomnia 9 2.9 2.9 signal
95 Scratch 5 2.9 2.9 signal
96 Throat Tightness 13 2.9 2.9 signal
97 Mood Altered 13 2.9 2.9 signal
98 Hereditary Angioedema 5 2.8 2.8 signal
99 Full Blood Count Abnormal 5 2.8 2.8 signal
100 Feeling Jittery 9 2.8 2.8 signal
101 Dementia 13 2.8 2.8 signal
102 Therapy Partial Responder 7 2.8 2.8 signal
103 Drug Withdrawal Syndrome 41 2.8 2.8 signal
104 Pharyngitis Streptococcal 5 2.8 2.8 no signal
105 Tooth Infection 6 2.7 2.7 signal
106 Drug Abuse 38 2.7 2.7 signal
107 Psoriatic Arthropathy 18 2.7 2.7 signal
108 Intestinal Perforation 5 2.7 2.7 no signal
109 Akathisia 6 2.6 2.6 signal
110 Mood Swings 14 2.6 2.6 signal
111 Hip Fracture 14 2.6 2.6 signal
112 Respiratory Arrest 12 2.6 2.6 signal
113 Hallucination, Visual 9 2.6 2.6 signal
114 Therapeutic Product Effect Decreased 19 2.6 2.6 signal
115 Thinking Abnormal 8 2.5 2.5 signal
116 Spinal Pain 5 2.5 2.5 no signal
117 Treatment Failure 35 2.5 2.6 signal
118 Colitis Ulcerative 19 2.5 2.5 signal
119 Increased Appetite 8 2.5 2.5 signal
120 Drug Effect Less Than Expected 6 2.5 2.5 signal
121 Product Prescribing Error 10 2.5 2.5 signal
122 Tardive Dyskinesia 12 2.5 2.5 signal
123 Dyskinesia 17 2.5 2.5 signal
124 Affect Lability 4 2.5 2.5 no signal
125 Hypokinesia 6 2.5 2.5 no signal
126 Thrombotic Microangiopathy 4 2.5 2.5 no signal
127 Oral Herpes 8 2.5 2.5 signal
128 Hot Flush 31 2.5 2.5 signal
129 Decreased Immune Responsiveness 4 2.4 2.4 no signal
130 Circulatory Collapse 7 2.4 2.4 signal
131 Covid-19 72 2.4 2.5 signal
132 Psychotic Disorder 12 2.4 2.4 signal
133 Nightmare 14 2.4 2.4 signal
134 Disease Recurrence 19 2.4 2.4 signal
135 Product Dose Omission Issue 113 2.4 2.4 signal
136 Disturbance In Attention 21 2.3 2.3 signal
137 Hallucination 29 2.3 2.3 signal
138 Swollen Tongue 12 2.3 2.3 signal
139 Anger 13 2.3 2.3 signal
140 Illness 38 2.3 2.3 signal
141 Premature Delivery 6 2.2 2.2 no signal
142 Prostatic Specific Antigen Increased 5 2.2 2.2 no signal
143 Psychomotor Hyperactivity 6 2.1 2.1 no signal
144 Cholecystectomy 4 2.1 2.1 no signal
145 Bone Density Decreased 11 2.1 2.1 signal
146 Therapeutic Response Shortened 11 2.1 2.1 signal
147 Hyperthyroidism 5 2.1 2.1 no signal
148 Systemic Lupus Erythematosus 12 2.0 2.0 signal
149 Abnormal Behaviour 13 1.9 1.9 no signal
150 Abnormal Dreams 9 1.9 1.9 no signal
151 Product Packaging Issue 3 1.9 1.9 no signal
152 Tendon Rupture 4 1.9 1.9 no signal
153 Product Dispensing Error 7 1.9 1.9 no signal
154 Tendonitis 5 1.9 1.9 no signal
155 Diarrhoea Haemorrhagic 3 1.9 1.9 no signal
156 Hair Colour Changes 4 1.9 1.9 no signal
157 Mydriasis 4 1.9 1.9 no signal
158 Exposure During Pregnancy 19 1.8 1.8 no signal
159 Eye Pruritus 10 1.8 1.8 no signal
160 Eczema 15 1.8 1.8 no signal
161 Hunger 4 1.8 1.8 no signal
162 Toxic Skin Eruption 3 1.8 1.8 no signal
163 Hair Texture Abnormal 4 1.8 1.8 no signal
164 Maternal Exposure During Pregnancy 26 1.8 1.8 no signal
165 Angioedema 13 1.8 1.8 no signal
166 Intentional Product Misuse 25 1.7 1.7 no signal
167 Blindness Unilateral 4 1.7 1.7 no signal
168 Foetal Exposure During Pregnancy 23 1.7 1.7 no signal
169 Drug Resistance 7 1.6 1.6 no signal
170 Meningioma 4 1.6 1.6 no signal
171 Aggression 13 1.5 1.5 no signal
172 Madarosis 3 1.5 1.5 no signal
173 Psoriasis 33 1.5 1.5 no signal
174 Product Physical Issue 5 1.5 1.5 no signal
175 Multiple Sclerosis 12 1.5 1.5 no signal
176 Injection Site Urticaria 6 1.5 1.5 no signal
177 Device Defective 4 1.5 1.5 no signal
178 Incorrect Product Administration Duration 5 1.5 1.5 no signal
179 Multiple Sclerosis Relapse 17 1.5 1.5 no signal
180 Product Dose Omission 16 1.4 1.4 no signal
181 Peritonitis 5 1.4 1.4 no signal
182 Incorrect Dose Administered By Device 6 1.4 1.4 no signal
183 Injection Site Rash 7 1.4 1.4 no signal
184 Neurotoxicity 4 1.4 1.4 no signal
185 Ankylosing Spondylitis 3 1.4 1.4 no signal
186 Breast Cancer Female 6 1.3 1.3 no signal
187 Drug Effect Decreased 10 1.1 1.1 no signal
188 Multiple Fractures 3 1.1 1.1 no signal
189 Product Adhesion Issue 6 1.0 1.0 no signal
190 Premature Baby 5 1.0 1.0 no signal
191 Injection Site Pruritus 11 1.0 1.0 no signal
192 Injection Site Reaction 11 1.0 1.0 no signal
193 Intentional Self-injury 3 0.9 0.9 no signal
194 Injection Site Warmth 3 0.9 0.9 no signal
195 Product Preparation Error 3 0.9 0.9 no signal
196 Skin Burning Sensation 10 0.8 0.8 no signal
197 Injection Site Erythema 17 0.8 0.8 no signal
198 Injection Site Mass 5 0.8 0.8 no signal
199 Exposure Via Skin Contact 3 0.8 0.8 no signal
200 Injection Site Bruising 10 0.8 0.8 no signal
201 Device Issue 11 0.8 0.8 no signal
202 Injection Site Pain 38 0.7 0.7 no signal
203 Injection Site Swelling 9 0.7 0.7 no signal
204 Drug Dependence 18 0.7 0.7 no signal
205 Breast Cancer 9 0.6 0.6 no signal
206 Device Dislocation 4 0.5 0.5 no signal
207 Injection Site Haemorrhage 7 0.5 0.5 no signal
208 Device Breakage 3 0.5 0.5 no signal
209 Wrong Technique In Device Usage Process 3 0.4 0.4 no signal
210 Device Difficult To Use 4 0.4 0.4 no signal
211 Drug Dose Omission By Device 4 0.3 0.3 no signal