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Which drugs are most reported with Drug withdrawal syndrome neonatal?

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 14,762 reports · 374 co-occurring drugs

As of the last recalculation, Drug Withdrawal Syndrome Neonatal appears in 14,762 FAERS reports alongside 374 co-occurring drug terms. The strongest observed disproportionality signal is METHADONE HYDROCHLORIDE (PRR 206.4).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Methadone Hydrochloride	1,431	206.4	237.9
Hydrocodone Bitartrate And Acetaminophen	2,213	65.0	67.6
Buprenorphine Hydrochloride, Naloxone Hydrochloride	913	56.8	59.0
Hydromorphone Hydrochloride	2,771	52.1	53.7
Oxycodone Hydrochloride And Acetaminophen	2,919	51.7	53.2
Buprenorphine Hydrochloride	265	51.5	53.4
Buprenorphine Hydrochloride And Naloxone Hydrochloride	82	51.1	53.0
Methadone	1,352	48.9	50.5
Hydrocodone Bitartrate	1,290	45.8	47.2
Oxycodone And Acetaminophen Tablets	369	44.7	46.1
Oxycodone Hydrochloride	4,709	44.4	45.4
Oxymorphone Hydrochloride	350	43.3	44.6
Tapentadol Hydrochloride	944	42.4	43.6
Chamomilla, Passiflora Incarnata, Valeriana Officinalis, Allium Sativum, Argentum Nitricum, Avena Sativa, Caladium Seguinum, Kali Bichromicum, Lobelia Inflata, Lycopodium Clavatum, Serotonin (Hydrochloride), Tabacum, Adrenalinum, Ammoniacum Gummi, Balsamum Peruvianum, Cactus Cacti, Selenium Metallicum	5	41.2	42.5
Oxycodone And Acetaminophen	616	38.8	39.9
Morphine Sulfate	2,602	36.5	37.3
Nicotine Polacrilex Mini	375	36.1	37.0
Nicotine Polarilex	375	36.1	37.0
Tobacco Leaf	5	32.8	33.5
Buprenorphine	1,772	30.5	31.1
Tramadol Hydrochloride	703	27.6	28.1
Fentanyl Citrate	320	25.8	26.2
Levorphanol Tartrate	6	22.9	23.3
Acetaminophen And Codeine	171	20.0	20.3
Benztropine Mesylate	34	18.0	18.2
Meperidine Hydrochloride	114	17.6	17.8
Nalxone Hydrochloride	11	16.8	17.0
Oxycodone	1,809	15.4	15.6
Hydrocodone Bitartrate And Ibuprofen	5	15.0	15.2
Buprenorphine Hcl	9	14.4	14.6
Nicotine Polacrilex	382	14.4	14.6
Nicotine	395	14.1	14.3
Buprenorphine And Naloxone	12	13.9	14.0
Chlorpromazine Hydrochloride	9	13.4	13.5
Naloxone	50	12.4	12.5
Bupropion Hydrobromide	5	12.2	12.3
Clomipramine Hydrochloride	36	11.2	11.3
Dinoprostone	6	10.5	10.6
Methamphetamine Hydrochloride	8	10.4	10.5
Gabapentin Enacarbil	21	10.4	10.5
Hydrocodone Polistirex And Chlorpheniramine Polistirex	7	10.1	10.1
Promethazine Hydrochloride And Codeine Phosphate	24	9.5	9.5
Chlorpromazine	47	9.3	9.4
Doxylamine Succinate And Pyridoxine Hydrochloride	3	8.1	8.1
Benztropine	37	7.1	7.2
Fentanyl	448	6.6	6.6
Methyldopa	22	6.4	6.4
Desvenlafaxine	15	6.0	6.0
Dexmedetomidine	13	5.4	5.4
Ethyl Alcohol	94	4.9	4.9
Clomipramine Hydrochloride Capsules	3	4.8	4.9
Clomiphene Citrate	5	4.7	4.7
Iloprost	3	4.6	4.6
Ampicillin Injection	24	4.6	4.6
Venlafaxine	221	4.4	4.4
Ampicillin	25	4.3	4.3
Ampicillin Sodium	25	4.3	4.3
Naloxone Hydrochloride	14	4.1	4.1
Morphine	209	4.0	4.0
Isopropyl Alcohol	94	3.9	3.9
Doxepin	28	3.9	3.9
Oxytocin	8	3.8	3.8
Escitslopram	153	3.7	3.7
Alcohol	94	3.4	3.4
Amphetamine	20	3.4	3.4
Fluoxetine	156	3.3	3.3
Venlafaxine Hydrochloride	300	3.2	3.2
Escitalopram Oxalate	165	3.2	3.2
Quetiapine	423	3.2	3.2
Fluoxetine Hcl	12	3.2	3.2
Doxepin Hydrochloride	28	3.1	3.1
Dimenhydrinate	23	3.0	3.1
Nicotine Transdermal System	3	2.9	2.9
Citalopram Hydrobromide	217	2.9	2.9
Caffeine	16	2.9	2.9
Phenobarbital	29	2.8	2.8
Diazepam Oral Solution (Concentrate)	177	2.8	2.8
Diazepam Oral	177	2.8	2.8
Diazepam	232	2.7	2.7
Fluoxetine Hydrochloride	236	2.6	2.6
Nitrous Oxide	4	2.6	2.6
Rabeprazole	40	2.5	2.6
Sertraline	206	2.5	2.5
Quetiapine Fumarate	52	2.5	2.5
Citalopram	237	2.5	2.5
Triazolam	7	2.5	2.5
Atomoxetine	6	2.4	2.4
Fluvoxamine Maleate	4	2.3	2.3
Naloxone Hydrochloride Nasal	6	2.2	2.2
Isoflurane	3	2.2	2.2
Paroxetine Hydrochloride Hemihydrate	51	2.2	2.2
Labetalol Hydrochloride	3	2.2	2.2
Paroxetine	51	2.1	2.1
Midazolam	37	2.1	2.1
Lithium	37	2.1	2.1
Lithium Bromatum	37	2.1	2.1
Paroxetine Hydrochloride	132	2.1	2.1
Hydroxocobalamin	6	2.0	2.0
Misoprostol	14	2.0	2.0
Lisdexamfetamine Dimesylate	47	2.0	2.0
Bupropion	63	2.0	2.0
Midazolam Hydrochloride	38	2.0	2.0
Cefotaxime	6	2.0	2.0
Cefotaxime Injection	6	2.0	2.0
Escitalopram	193	2.0	2.0
Loxapine	5	1.8	1.8
Nicotine Polacrilex Gum	8	1.8	1.8
Abacavir Sulfate, Dolutegravir Sodium, Lamivudine	8	1.8	1.8
Olanzapine	134	1.8	1.8
Labetalol	16	1.7	1.7
Olanzapine Pamoate	48	1.7	1.7
Mirtazapine	104	1.6	1.6
Sertraline Hydrochloride	132	1.6	1.6
Haloperidol	27	1.6	1.6
Gaunfacine	4	1.6	1.6
Haloperidol Lactate	27	1.5	1.5
Haloperidol Decanoate	3	1.5	1.5
Lemborexant	3	1.5	1.5
Ursosiol	21	1.5	1.5
Nortriptyline Hydrochloride	6	1.5	1.5
Promethazine Hydrochloride	19	1.4	1.4
Atazanavir Sulfate	3	1.4	1.4
Nevirapine	9	1.4	1.4
Gentamicin	13	1.4	1.4
Aripiprazole	121	1.4	1.4
Efavirenz	11	1.4	1.4
Ursodiol	21	1.4	1.4
Phytonadione	8	1.3	1.3
Aripiprazole Oral	38	1.3	1.3
Aripiprazole Orally Disintegrating	38	1.3	1.3
Lamotirigine	65	1.3	1.3
Lamotrigine Extended-Release	65	1.3	1.3
Lamotrigine Chewable Dispersible	65	1.3	1.3
Alprazolam	186	1.3	1.3
Guanfacine Hydrochloride	4	1.2	1.2
Dronabinol	7	1.2	1.2
Gabapentin	315	1.2	1.2
Lamotrigine	111	1.2	1.2
Norepinephrine	9	1.2	1.2
Oxazepam	18	1.2	1.2
Amisulpride	5	1.2	1.2
Risperidone	110	1.2	1.2
Gentamicin Sulfate	13	1.2	1.2
Levetiracetam In Sodium Chloride	62	1.1	1.1
Levetiracetam Oral	62	1.1	1.1
Levetiracetam Injection	62	1.1	1.1
Carisoprodol	15	1.1	1.1
Desvenlafaxine Succinate	21	1.1	1.1
Clonazepam	123	1.1	1.1
Magnesium Sulfate Heptahydrate	10	1.1	1.1
Norepinephrine (Bitartrate)	10	1.1	1.1
Oxybutynin	22	1.1	1.1
Butalbital, Acetaminophen, And Caffeine	8	1.1	1.1
Levetiracetam	100	1.1	1.1
Phenytoin Sodium	3	1.1	1.1
Carbamazepine	50	1.1	1.1
Clonidine	38	1.0	1.0
Nitrofurantoin	12	1.0	1.0
Nitrofurantoin (Monohydrate/Macrocrystals)	12	1.0	1.0
Nitrofurantoin Monohydrate/Macrocrystals	12	1.0	1.0
Magnesium Sulfate In Water For	9	1.0	1.0
Norepinephrine Bitartrate	10	1.0	1.0
Magnesium Sulfate	9	1.0	1.0
Nicardipine	3	1.0	1.0
Vasopressin	3	1.0	1.0
Nitric Oxide	3	0.9	0.9
Doxylamine Succinate	4	0.9	0.9
Cefazolin	6	0.9	0.9
Bupropion Hydrochloride	63	0.9	0.9
Vigabatrin	9	0.9	0.9
Ondansetron Hydrochloride	74	0.9	0.9
Duloxetine	42	0.8	0.8
Zidovudine	8	0.8	0.8
Zolpidem Tartrate	80	0.8	0.8
Valproate Sodium	12	0.8	0.8
Insulin	32	0.8	0.8
Clobazam	14	0.8	0.8
Baclofen	49	0.8	0.8
Lorazepam	102	0.8	0.8
Duloxetine Hydrochloride	106	0.8	0.8
Cephalexin	12	0.8	0.8
Biotin	17	0.8	0.8
Buspirone Hydrochloride	6	0.8	0.8
Ondansetron	59	0.8	0.8
Ondansetron Tablets	59	0.8	0.8
Methocarbamol Tablets	9	0.8	0.8
Clindamycin	15	0.7	0.7
Cefuroxime	6	0.7	0.7
Propofol	19	0.7	0.7
Guanfacine	4	0.7	0.7
Cefazolin Sodium	6	0.7	0.7
Folic Acid	122	0.7	0.7
Atazanavir	7	0.7	0.7
Rocuronium	3	0.7	0.7
Phenytoin	10	0.7	0.7
Lithium Carbonate	8	0.7	0.7
Clindamycin Phosphate	15	0.6	0.6
Valproic Acid	14	0.6	0.6
Cetiirizine	18	0.6	0.6
Rocuronium Bromide	5	0.6	0.6
Zonisamide	6	0.6	0.6
Metronidazole Topical	19	0.6	0.6
Ziprasidone	7	0.6	0.6
Methocarbamol	9	0.6	0.6
Suvorexant	5	0.5	0.5
Ritonavir	11	0.5	0.5
Propranolol Hydrochloride	26	0.5	0.5
Insulin Human	14	0.5	0.5
Cefepime	5	0.5	0.5
Lactulose	13	0.5	0.5
Methylphenidate Hydrochloride	20	0.5	0.5
Metoclopramide Hydrochloride	26	0.5	0.5
Dolutegravir Sodium	3	0.5	0.5
Metronidazole	20	0.4	0.4
Cefepime Hydrochloride	5	0.4	0.4
Alemtuzumab	6	0.4	0.4
Daspone	3	0.4	0.4
Dapsone Gel, 5%	3	0.4	0.4
Divalproex Sodium	14	0.4	0.4
Nifedipine	14	0.4	0.4
Amoxicillin And Clavulanate Potassium	8	0.4	0.4
Prochlorperazine	8	0.4	0.4
Loratadine Oral	14	0.4	0.4
Diphenhydramine	18	0.4	0.4
Hydroxyurea	6	0.4	0.4
Dapsone	3	0.4	0.4
Oxcarbazepine	9	0.4	0.4
Acetaminophen, Guaifenesin, And Phenylephrine Hydrochloride	44	0.4	0.4
Ritonavir 100 Mg	4	0.4	0.4
Pregabalin	72	0.4	0.4
Cannabidiol	6	0.4	0.4
Trazodone Hydrochloride	4	0.4	0.4
Budesonide And Formoterol Fumarate Dihydrate	24	0.3	0.3
Cetirizine	19	0.3	0.3
Esomeprazole	15	0.3	0.3
Eszopiclone	6	0.3	0.3
Amitriptyline Hydrochloride	4	0.3	0.3
Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, And Amphetamine Sulfate	8	0.3	0.3
Topiramate	21	0.3	0.3
Paliperidone Palmitate	7	0.3	0.3
Docusate Sodium - Sennosides	7	0.3	0.3
Acetaminophen	92	0.3	0.3
Fluconazole	14	0.3	0.3
Ferrous Sulfate	10	0.3	0.3
Dextroamphetamine Sulfate, Dextroamphetamine Saccharate, Amphetamine Sulfate And Amphetamine Aspartate	8	0.3	0.3
Lurasidone Hydrochloride	4	0.3	0.3
Docusate Sodium	11	0.3	0.3
Vancomycin Hydrochloride	12	0.3	0.3
Iron	12	0.3	0.3
Acetaminophen Tablet Extended Release	46	0.3	0.3
Pain Reliever	46	0.3	0.3
Acetaminophen 500Mg	46	0.3	0.3
Ibuprofen Capsule	35	0.2	0.2
Ibuprofen Tablet, Film Coated	35	0.2	0.2
Ibuprofen Tablet, Film-Coated	35	0.2	0.2
Ibupfrofen	35	0.2	0.2
Ibuprofen Tablets Usp, 200Mg	35	0.2	0.2
Ibuprofen Oral	35	0.2	0.2
Ibuprofen Capsules 200 Mg	35	0.2	0.2
Ibuprofen 200 Mg	35	0.2	0.2
Ibuprofen 200Mg	35	0.2	0.2
Vancomycin	10	0.2	0.2
Paliperidone	4	0.2	0.2
Levothyroxine Sodium Anhydrous	17	0.2	0.2
Tizanidine	4	0.2	0.2
Docusate Sodium 100Mg	4	0.2	0.2
Tizanidine Hydrochloride	3	0.2	0.2
Bictegravir Sodium, Emtricitabine, And Tenofovir Alafenamide Fumarate	3	0.2	0.2
Mometasone	3	0.2	0.2
Diphenhydramine Hydrochloride	26	0.2	0.2
Emtricitabine And Tenofovir Disoproxil Fumarate	7	0.2	0.2
Ibuprofen	41	0.2	0.2
Hydroxyzine	7	0.2	0.2
Adrenalinum	6	0.2	0.2
Lidicaine	7	0.2	0.2
Burn Relief	7	0.2	0.2
Lidocaine Hydrochloride And Epinephrine	7	0.2	0.2
Valacyclovir Hydrochloride	10	0.2	0.2
Lidocaine, Menthol	7	0.2	0.2
Diphenhydramine Hydrochloride Capsule, Liquid Filled	3	0.2	0.2
Cyclobenzaprine	7	0.2	0.2
Loratadine	15	0.2	0.2
Epinephrine	9	0.2	0.2
Azathioprine	12	0.2	0.2
Magnesium	11	0.2	0.2
Albuterol	16	0.2	0.2
Temazepam	5	0.2	0.2
Lidocaine Hydrochloride	8	0.2	0.2
Progesterone	3	0.2	0.2
Lidocaine Hydrochloride And Epinephrine Bitartrate	7	0.2	0.2
Lamivudine	4	0.2	0.2
Lidocaine 4%	7	0.2	0.2
Cetirizine Hydrochloride	21	0.2	0.2
Sucralfate	3	0.2	0.2
0Xygen	6	0.2	0.2
Oxygen	6	0.2	0.2
Metoprolol Tartrate Injection	23	0.2	0.2
Lidocaine	7	0.2	0.2
Lamivudine Oral	3	0.2	0.2
Amoxicillin	9	0.2	0.2
Omeprazole	40	0.2	0.2
Clozapine	14	0.2	0.2
Metoclopramide	6	0.2	0.2
Calcium Carbonate	7	0.1	0.1
Methylphenidate	3	0.1	0.1
Omeprazole Magnesium	46	0.1	0.1
Levothyroxine Sodium	32	0.1	0.1
Ranitidine	20	0.1	0.1
Naltrexone	3	0.1	0.1
Valacyclovir	4	0.1	0.1
Magnesium Oxide	4	0.1	0.1
Metoprolol	24	0.1	0.1
Metoprolol Tartrate	24	0.1	0.1
Esomeprazole Magnesium	20	0.1	0.1
Sildenafil Powder,	3	0.1	0.1
Antacid	4	0.1	0.1
Lacosamide	3	0.1	0.1
Albuterol Sulfate	23	0.1	0.1
Enoxaparin Sodium	4	0.1	0.1
Hydrocortisone Acetate	5	0.1	0.1
Bisoprolol Fumarate	9	0.1	0.1
Tacrolimus Ointment 0.1%	8	0.1	0.1
Tacrolimus Extended-Release Capsules	8	0.1	0.1
Acetaminophen, Chlorpheniramine Maleate, Phenylephrine Hcl	3	0.1	0.1
Anti-Itch	4	0.1	0.1
Anti-Pruritic	4	0.1	0.1
Antipruritic (Anti-Itch)	4	0.1	0.1
Cool Relief Gel With Aloe	4	0.1	0.1
Drs. Hydrocortisone	4	0.1	0.1
Hydrocortisone Continuous Spray	4	0.1	0.1
Hydrocortisone Spray	4	0.1	0.1
Anti-Itch Cream	4	0.1	0.1
Hydrocortisone Lotion	4	0.1	0.1
Hydrocortisone Cream 1%	4	0.1	0.1
Hydrocortisone Cream 1/2%	4	0.1	0.1
Hydrocortisone 1%	4	0.1	0.1
Hydrocortisone Cream	4	0.1	0.1
Hydrocortisone	5	0.1	0.1
Fish Oil	5	0.1	0.1
Melatonin	3	0.1	0.1
Polyethylene Glycol 3350	5	0.1	0.1
Sildenafil	3	0.1	0.1
Azithromycin Dihydrate	3	0.1	0.1
Famotidine	6	0.1	0.1
Tacrolimus	8	0.1	0.1
Methylprednisolone	7	0.1	0.1
Metoprolol Succinate Er Tablets	3	0.1	0.1
Calcium	7	0.1	0.1
Fluticasone Propionate	6	0.1	0.1
Rituximab	9	0.1	0.1
Ergocalciferol	14	0.1	0.1
Metoprolol Succinate	3	0.0	0.0
Acyclovir	3	0.0	0.0
Montelukast Sodium	3	0.0	0.0
Sildenafil Citrate	3	0.0	0.0
Aspirin 325 Mg	12	0.0	0.0
Aspirin 81 Mg	12	0.0	0.0
Atenolol	3	0.0	0.0
Mycophenolate Mofetil	3	0.0	0.0
Mycophenolate Mofetil Hydrochloride	3	0.0	0.0
Aspirin	12	0.0	0.0
Insulin Lispro	3	0.0	0.0
Lansoprazole	3	0.0	0.0
Prednisolone	3	0.0	0.0
Prednisolone Oral	3	0.0	0.0
Prednisolone Oral Solution	3	0.0	0.0
Metformin Er 500 Mg	5	0.0	0.0
Metformin Er 750 Mg	5	0.0	0.0
Simvastatin	4	0.0	0.0
Metformin	5	0.0	0.0
Pantoprazole	3	0.0	0.0
Lisinopril	3	0.0	0.0
Prednisone	3	0.0	0.0
Adalimumab	3	0.0	0.0

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.