Drug

Estradiol Acetate

25 flagged reaction(s) · 518 total co-reports · max PRR 57.9

Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.

	Reaction	Co-reports (a)	PRR	ROR	Signal
1	Therapeutic Product Effect Decreased	93	57.9	65.8	signal
2	Hot Flush	123	45.0	53.5	signal
3	Vaginal Discharge	11	30.2	30.6	signal
4	Night Sweats	33	28.3	29.5	signal
5	Device Expulsion	58	24.5	26.5	signal
6	Product Physical Issue	17	23.5	24.0	signal
7	Vaginal Haemorrhage	35	22.7	23.7	signal
8	Breast Pain	7	18.1	18.3	signal
9	Ovarian Cyst	6	16.4	16.6	signal
10	Fungal Infection	18	14.9	15.2	signal
11	Product Odour Abnormal	5	13.3	13.4	signal
12	Drug Effect Incomplete	16	12.0	12.2	signal
13	Mood Swings	13	11.2	11.4	signal
14	Device Defective	6	10.2	10.3	signal
15	Drug Prescribing Error	7	9.9	10.0	signal
16	Drug Effect Less Than Expected	5	9.8	9.8	signal
17	Metrorrhagia	6	9.6	9.6	signal
18	Crying	11	8.3	8.4	signal
19	Complication Of Device Removal	5	8.1	8.2	signal
20	Drug Effect Decreased	11	5.5	5.6	signal
21	Complication Of Device Insertion	3	4.5	4.5	signal
22	Breast Cancer	13	3.8	3.9	signal
23	Device Difficult To Use	8	3.3	3.4	signal
24	Device Dislocation	5	3.2	3.2	signal
25	Device Breakage	3	2.1	2.1	no signal