Drug

Estradiol And Levonorgestrel

50 flagged reaction(s) · 3,228 total co-reports · max PRR 199.3

Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.

	Reaction	Co-reports (a)	PRR	ROR	Signal
1	Product Adhesion Issue	668	199.3	297.2	signal
2	Product Physical Issue	329	174.2	207.8	signal
3	Device Adhesion Issue	245	169.9	193.2	signal
4	Application Site Rash	189	144.1	158.8	signal
5	Application Site Irritation	89	74.7	78.1	signal
6	Application Site Pruritus	107	49.1	51.8	signal
7	Application Site Erythema	98	38.8	40.7	signal
8	Hot Flush	226	31.2	35.0	signal
9	Metrorrhagia	51	30.7	31.4	signal
10	Genital Haemorrhage	31	24.9	25.3	signal
11	Device Breakage	92	24.4	25.5	signal
12	Device Use Issue	30	18.0	18.3	signal
13	Vaginal Haemorrhage	73	17.8	18.4	signal
14	Wrong Technique In Device Usage Process	71	16.1	16.7	signal
15	Device Defective	25	16.1	16.2	signal
16	Application Site Pain	31	14.6	14.8	signal
17	Breast Pain	15	14.6	14.7	signal
18	Night Sweats	43	13.9	14.2	signal
19	Wrong Technique In Product Usage Process	259	13.3	15.1	signal
20	Product Packaging Issue	11	12.3	12.4	signal
21	Product Prescribing Issue	21	10.7	10.8	signal
22	Product Quality Issue	134	10.3	11.0	signal
23	Product Availability Issue	20	9.3	9.3	signal
24	Poor Quality Product Administered	9	9.1	9.2	signal
25	Dermatitis Contact	9	8.2	8.3	signal
26	Abdominal Pain Lower	17	7.0	7.0	signal
27	Mood Swings	18	5.9	5.9	signal
28	Middle Insomnia	10	5.6	5.6	signal
29	Incorrect Drug Administration Duration	15	5.5	5.5	signal
30	Drug Dose Omission	87	5.4	5.6	signal
31	Affect Lability	5	5.4	5.4	signal
32	Mood Altered	13	5.0	5.0	signal
33	Incorrect Dose Administered By Device	12	4.9	4.9	signal
34	Vaginal Discharge	4	4.1	4.1	signal
35	Skin Irritation	18	4.1	4.1	signal
36	Amenorrhoea	6	3.7	3.7	signal
37	Menorrhagia	7	3.6	3.7	signal
38	Adverse Event	29	3.3	3.3	signal
39	Crying	11	3.1	3.1	signal
40	Device Use Error	10	3.0	3.1	signal
41	Drug Effect Less Than Expected	4	2.9	2.9	no signal
42	Drug Administered At Inappropriate Site	3	2.9	2.9	no signal
43	Product Packaging Quantity Issue	3	2.9	2.9	no signal
44	Inappropriate Schedule Of Drug Administration	19	2.7	2.7	signal
45	Pharmaceutical Product Complaint	6	2.4	2.4	no signal
46	No Adverse Event	36	2.1	2.1	signal
47	Complication Of Device Removal	3	1.8	1.8	no signal
48	Menstruation Irregular	3	1.2	1.2	no signal
49	Wrong Technique In Drug Usage Process	4	1.1	1.1	no signal
50	Breast Cancer	9	1.0	1.0	no signal