OpenPV Signal Explorer
FAERS disproportionality dashboard
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Drug

Gaunfacine

191 flagged reaction(s) · 4,997 total co-reports · max PRR 29.6
Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.
Reaction Co-reports (a) PRR ROR Signal
1 Sinus Bradycardia 49 29.6 30.0 signal
2 Aggression 185 21.6 22.7 signal
3 Psychomotor Hyperactivity 61 21.4 21.7 signal
4 Serotonin Syndrome 52 15.9 16.1 signal
5 Intentional Overdose 148 13.6 14.1 signal
6 Bradycardia 121 13.3 13.7 signal
7 Abnormal Behaviour 88 12.9 13.2 signal
8 Intentional Self-injury 44 12.7 12.9 signal
9 Dystonia 41 12.3 12.4 signal
10 Anger 71 12.2 12.4 signal
11 Sedation 50 11.2 11.3 signal
12 Neuroleptic Malignant Syndrome 22 10.8 10.9 signal
13 Electrocardiogram Qt Prolonged 66 10.7 10.9 signal
14 Respiratory Depression 22 10.5 10.5 signal
15 Affect Lability 17 10.3 10.3 signal
16 Product Substitution Issue 99 10.0 10.3 signal
17 Irritability 98 9.5 9.7 signal
18 Mania 26 9.2 9.3 signal
19 Agitation 115 9.1 9.4 signal
20 Device Mechanical Issue 20 9.0 9.1 signal
21 Therapy Change 14 8.5 8.5 signal
22 Orthostatic Hypotension 25 8.4 8.4 signal
23 Generalised Tonic-clonic Seizure 20 7.1 7.2 signal
24 Rebound Effect 13 6.7 6.7 signal
25 Hallucination, Auditory 18 6.6 6.6 signal
26 Emotional Disorder 35 6.6 6.6 signal
27 Toxicity To Various Agents 179 6.2 6.5 signal
28 Increased Appetite 20 6.2 6.2 signal
29 Posterior Reversible Encephalopathy Syndrome 10 6.1 6.1 signal
30 Mood Swings 33 6.0 6.1 signal
31 Lethargy 59 6.0 6.1 signal
32 Muscle Rigidity 12 5.9 5.9 signal
33 Salivary Hypersecretion 10 5.8 5.8 signal
34 Blindness Unilateral 14 5.8 5.8 signal
35 Sinus Tachycardia 14 5.8 5.8 signal
36 Impaired Quality Of Life 14 5.7 5.7 signal
37 Inability To Afford Medication 9 5.3 5.3 signal
38 Bipolar Disorder 10 5.3 5.3 signal
39 Drug Level Increased 15 5.3 5.3 signal
40 Product Physical Issue 18 5.3 5.3 signal
41 Coma 43 5.3 5.3 signal
42 Somnolence 180 5.2 5.4 signal
43 Treatment Failure 73 5.2 5.3 signal
44 Suicidal Ideation 80 5.1 5.2 signal
45 Suicide Attempt 53 5.1 5.1 signal
46 Mydriasis 11 5.0 5.0 signal
47 Dysarthria 32 5.0 5.0 signal
48 Gynaecomastia 26 4.8 4.9 signal
49 Akathisia 11 4.7 4.7 signal
50 Drug Interaction 127 4.7 4.8 signal
51 Status Epilepticus 9 4.6 4.6 signal
52 Hypotension 158 4.6 4.8 signal
53 Depressed Level Of Consciousness 31 4.6 4.6 signal
54 Completed Suicide 64 4.4 4.5 signal
55 Disturbance In Attention 41 4.4 4.5 signal
56 Withdrawal Syndrome 32 4.4 4.4 signal
57 Obesity 12 4.4 4.4 signal
58 Paranoia 13 4.4 4.4 signal
59 Presyncope 18 4.3 4.4 signal
60 Restlessness 27 4.3 4.3 signal
61 Mood Altered 20 4.3 4.3 signal
62 Therapy Partial Responder 11 4.3 4.3 signal
63 Parkinsonism 7 4.2 4.2 signal
64 Seizure 79 4.0 4.1 signal
65 Apathy 10 4.0 4.0 signal
66 Brain Fog 10 4.0 4.0 signal
67 Tachycardia 60 3.9 4.0 signal
68 Product Availability Issue 15 3.9 3.9 signal
69 Drug Ineffective For Unapproved Indication 37 3.9 3.9 signal
70 End Stage Renal Disease 12 3.8 3.8 signal
71 Thinking Abnormal 12 3.7 3.7 signal
72 Device Breakage 25 3.7 3.7 signal
73 Brain Oedema 8 3.7 3.7 signal
74 Impaired Gastric Emptying 8 3.7 3.7 signal
75 Dizziness Postural 6 3.6 3.6 signal
76 Intentional Dose Omission 17 3.6 3.6 signal
77 Blood Triglycerides Increased 11 3.6 3.6 signal
78 Prescribed Overdose 12 3.6 3.6 signal
79 Insurance Issue 9 3.5 3.5 signal
80 Product Taste Abnormal 8 3.5 3.5 signal
81 Hypersomnia 17 3.5 3.5 signal
82 Hypothermia 6 3.4 3.5 signal
83 Euphoric Mood 6 3.4 3.4 signal
84 Delusion 9 3.4 3.4 signal
85 Pulmonary Oedema 26 3.4 3.4 signal
86 Application Site Irritation 7 3.3 3.3 signal
87 Abnormal Weight Gain 7 3.3 3.3 signal
88 Gastroenteritis Viral 10 3.2 3.2 signal
89 Product Dispensing Error 12 3.2 3.2 signal
90 Crying 20 3.2 3.2 signal
91 Hallucination 41 3.2 3.2 signal
92 Dyskinesia 22 3.2 3.2 signal
93 Therapy Non-responder 24 3.1 3.2 signal
94 Product Adhesion Issue 19 3.1 3.1 signal
95 Encephalopathy 13 3.1 3.1 signal
96 Dermatitis Contact 6 3.1 3.1 signal
97 Hallucination, Visual 11 3.1 3.1 signal
98 Accidental Overdose 19 3.0 3.0 signal
99 Retching 11 3.0 3.0 signal
100 Product Use Complaint 8 3.0 3.0 signal
101 Sexual Dysfunction 6 3.0 3.0 signal
102 Urinary Retention 17 3.0 3.0 signal
103 Drug Dose Omission By Device 39 3.0 3.0 signal
104 Psychotic Disorder 15 3.0 3.0 signal
105 Product Administration Error 10 2.9 2.9 signal
106 Anxiety 142 2.9 3.0 signal
107 Device Leakage 21 2.9 2.9 signal
108 Glomerular Filtration Rate Decreased 6 2.9 2.9 signal
109 Sleep Disorder Due To A General Medical Condition 8 2.9 2.9 signal
110 Cognitive Disorder 23 2.9 2.9 signal
111 Sluggishness 5 2.9 2.9 signal
112 Cardiogenic Shock 7 2.9 2.9 signal
113 Initial Insomnia 5 2.9 2.9 signal
114 Nightmare 17 2.9 2.9 signal
115 Insomnia 130 2.8 2.9 signal
116 Paralysis 7 2.8 2.8 signal
117 Middle Insomnia 9 2.8 2.8 signal
118 Drug Prescribing Error 9 2.7 2.7 signal
119 Application Site Erythema 12 2.7 2.7 signal
120 Depressed Mood 24 2.7 2.7 signal
121 Mental Impairment 11 2.6 2.6 signal
122 Thirst 8 2.6 2.6 signal
123 Treatment Noncompliance 24 2.6 2.6 signal
124 Application Site Pruritus 10 2.6 2.6 signal
125 Product Quality Issue 59 2.6 2.6 signal
126 Lactic Acidosis 14 2.5 2.5 signal
127 Mental Disorder 19 2.5 2.5 signal
128 Sensory Disturbance 7 2.5 2.5 signal
129 Poisoning Deliberate 4 2.5 2.5 no signal
130 Drug Effect Less Than Expected 6 2.5 2.5 no signal
131 Feeling Jittery 8 2.4 2.4 signal
132 Altered State Of Consciousness 9 2.4 2.4 signal
133 Pallor 11 2.3 2.4 signal
134 Neurotoxicity 7 2.3 2.4 signal
135 Brain Injury 4 2.3 2.3 no signal
136 Product Dose Omission 26 2.3 2.3 signal
137 Therapy Cessation 20 2.3 2.3 signal
138 Poor Venous Access 4 2.3 2.3 no signal
139 Nervous System Disorder 12 2.2 2.2 signal
140 Overdose 83 2.2 2.3 signal
141 Device Use Error 13 2.2 2.2 signal
142 Hunger 5 2.2 2.2 no signal
143 Hypertensive Crisis 4 2.1 2.1 no signal
144 Wrong Technique In Drug Usage Process 13 2.1 2.1 signal
145 Product Prescribing Issue 7 2.0 2.0 no signal
146 Spinal Operation 4 1.9 1.9 no signal
147 Device Adhesion Issue 5 1.9 1.9 no signal
148 Blood Thyroid Stimulating Hormone Increased 3 1.9 1.9 no signal
149 Libido Decreased 4 1.9 1.9 no signal
150 Tardive Dyskinesia 9 1.8 1.8 no signal
151 Therapeutic Product Effect Decreased 14 1.8 1.8 no signal
152 Therapeutic Response Shortened 10 1.8 1.8 no signal
153 Drug Effect Decreased 17 1.8 1.8 no signal
154 Device Issue 27 1.8 1.8 no signal
155 Wrong Technique In Device Usage Process 14 1.8 1.8 no signal
156 Dermatitis Atopic 15 1.7 1.8 no signal
157 Incorrect Product Administration Duration 6 1.7 1.7 no signal
158 Application Site Rash 4 1.7 1.7 no signal
159 Hereditary Angioedema 3 1.7 1.7 no signal
160 Extrapyramidal Disorder 7 1.6 1.6 no signal
161 Incorrect Dose Administered By Device 7 1.6 1.6 no signal
162 Product Administered At Inappropriate Site 5 1.6 1.6 no signal
163 Product Packaging Quantity Issue 3 1.6 1.6 no signal
164 Device Delivery System Issue 7 1.6 1.6 no signal
165 Drug Withdrawal Syndrome Neonatal 4 1.6 1.6 no signal
166 Emotional Distress 32 1.5 1.5 no signal
167 No Adverse Event 46 1.5 1.5 no signal
168 Sickle Cell Anaemia With Crisis 4 1.5 1.5 no signal
169 Wrong Technique In Product Usage Process 50 1.4 1.4 no signal
170 Device Defective 4 1.4 1.4 no signal
171 Product Complaint 6 1.4 1.4 no signal
172 Application Site Pain 5 1.3 1.3 no signal
173 Pain Of Skin 6 1.3 1.3 no signal
174 Drug Effect Incomplete 8 1.3 1.3 no signal
175 Drug Effective For Unapproved Indication 6 1.2 1.2 no signal
176 Extra Dose Administered 8 1.2 1.2 no signal
177 Glycosylated Haemoglobin Increased 5 1.2 1.2 no signal
178 Drug Dispensing Error 3 1.1 1.1 no signal
179 Incorrect Drug Administration Duration 5 1.0 1.0 no signal
180 Drug Withdrawal Syndrome 15 1.0 1.0 no signal
181 Device Difficult To Use 11 1.0 1.0 no signal
182 Injection Site Reaction 10 0.8 0.8 no signal
183 Product Preparation Error 3 0.8 0.8 no signal
184 Accidental Exposure To Product 14 0.8 0.8 no signal
185 Needle Issue 4 0.8 0.8 no signal
186 Injection Site Mass 5 0.8 0.8 no signal
187 Exposure Via Skin Contact 3 0.8 0.8 no signal
188 Injection Site Urticaria 3 0.7 0.7 no signal
189 Device Malfunction 8 0.7 0.7 no signal
190 Injection Site Pruritus 7 0.6 0.6 no signal
191 Drug Dependence 9 0.3 0.3 no signal