Reaction

Device Mechanical Issue reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 12,736 reports · 350 co-occurring drugs

As of the last recalculation, Device Mechanical Issue appears in 12,736 FAERS reports alongside 350 co-occurring drug terms. The strongest observed disproportionality signal is SOMATROPIN (PRR 429.5).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Somatropin	7,685	429.5	479.9
Adalimumab-Afzb	117	73.5	76.9
Adalimumab-Adbm	8	61.1	63.4
Budesonide And Formoterol Fumarate	43	56.0	58.0
Somatrogon-Ghla	36	48.4	49.9
Pegfilgrastim-Jmdb	8	29.7	30.2
Insulin Glargine-Yfgn	309	23.6	24.0
Filgrastim-Aafi	8	20.3	20.5
Olopatadine Hydrochloride And Mometasone Furoate	20	16.4	16.5
Insulin Glargine And Lixisenatide	26	11.9	12.0
Glatiramer Acetate Injection	29	10.2	10.2
Glatiramer	29	9.7	9.7
Gaunfacine	20	9.0	9.1
Insulin Degludec And Liraglutide	9	9.0	9.0
Insulin Aspart Injection	12	7.5	7.5
Guanfacine Hydrochloride	20	7.2	7.3
Insulin Glargine	964	6.8	6.9
Fluticasone Propionate And Salmeterol	166	6.6	6.6
Dalteparin Sodium	41	6.4	6.4
Albuterol	450	6.3	6.3
Ertugliflozin	4	6.0	6.0
Albuterol Sulfate And Budesonide	5	5.9	5.9
Copper	120	4.6	4.6
Alprostadil	10	4.5	4.5
Guselkumab	98	4.5	4.5
Glatiramer Acetate	162	4.5	4.5
Epoetin Alfa-Epbx	6	4.5	4.5
Guanfacine	21	4.4	4.4
Albuterol Sulfate	688	3.9	4.0
Cyproheptadine Hydrochloride	10	3.7	3.7
Glycopyrrolate And Formoterol Fumarate	4	3.3	3.4
Insulin Aspart	132	3.3	3.3
Dexmethylphenidate Hydrochloride	8	3.1	3.1
Triptorelin	6	3.0	3.0
Adalimumab-Adaz	89	2.8	2.8
Abaloparatide	49	2.7	2.7
Lanreotide Acetate	13	2.7	2.7
Medroxyprogesterone Acetate	82	2.7	2.7
Pegvisomant	6	2.4	2.4
Estradiol, Folliculinum, Oophorinum (Suis)	3	2.2	2.2
Budesonide, Glycopyrrolate, And Formoterol Fumarate	13	2.0	2.0
Oral Semaglutide	88	2.0	2.0
Liraglutide	56	1.9	1.9
Insulin Degludec	26	1.8	1.8
Golimumab	94	1.8	1.8
Adalimumab-Fkjp	48	1.7	1.7
Ofatumumab	30	1.5	1.5
Anastrozole Tablets	19	1.4	1.4
Dapagliflozin And Metformin Hydrochloride	3	1.4	1.4
Testosterone	20	1.4	1.4
Peginterferon Beta-1A	11	1.4	1.4
Clindamycin Hydrochloride	3	1.4	1.4
Lisdexamfetamine Dimesylate	27	1.3	1.3
Adalimumab-Aaty	38	1.3	1.3
Tiotropium Bromide And Olodaterol	4	1.3	1.3
Sumatriptan Succinate	20	1.3	1.3
Tiotropium Bromide	107	1.3	1.3
Anti-Itch	51	1.2	1.2
Anti-Pruritic	51	1.2	1.2
Antipruritic (Anti-Itch)	51	1.2	1.2
Cool Relief Gel With Aloe	51	1.2	1.2
Drs. Hydrocortisone	51	1.2	1.2
Hydrocortisone Continuous Spray	51	1.2	1.2
Hydrocortisone Spray	51	1.2	1.2
Anti-Itch Cream	51	1.2	1.2
Hydrocortisone Lotion	51	1.2	1.2
Hydrocortisone Cream 1%	51	1.2	1.2
Hydrocortisone Cream 1/2%	51	1.2	1.2
Hydrocortisone 1%	51	1.2	1.2
Hydrocortisone Cream	51	1.2	1.2
Insulin Lispro	101	1.2	1.2
Hydrocortisone Acetate	53	1.2	1.2
Tiotropium Bromide Inhalation Spray	8	1.2	1.2
Hydrocortisone	63	1.2	1.2
Fremanezumab-Vfrm	8	1.1	1.1
Insulin Glulisine	7	1.1	1.1
Pegfilgrastim	67	1.1	1.1
Metformin Er 500 Mg	200	1.1	1.1
Metformin Er 750 Mg	200	1.1	1.1
Tezepelumab-Ekko	4	1.0	1.0
Empagliflozin	41	1.0	1.0
Methylphenidate	17	1.0	1.0
Metformin	207	0.9	0.9
Glipizide	35	0.9	0.9
Anastrozole	21	0.9	0.9
Human Insulin	7	0.9	0.9
Methylphenidate Hydrochloride	32	0.9	0.9
Glimepiride	18	0.8	0.8
Secukinumab	66	0.7	0.7
Filgrastim	15	0.7	0.7
Budesonide And Formoterol Fumarate Dihydrate	38	0.6	0.6
Fluticasone Furoate, Umeclidinium Bromide And Vilanterol Trifenatate	16	0.6	0.6
Chlorthalidone	4	0.6	0.6
Losartan	60	0.6	0.6
Nebivolol	5	0.5	0.5
Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, And Amphetamine Sulfate	11	0.5	0.5
Etanercept	188	0.5	0.5
Levocetirizine Dihydrochloride	7	0.5	0.5
Tocilizumab	33	0.5	0.5
Abatacept	40	0.5	0.5
Alendronate Sodium Tablet	5	0.4	0.4
Lisinopril	82	0.4	0.4
Dextroamphetamine Sulfate, Dextroamphetamine Saccharate, Amphetamine Sulfate And Amphetamine Aspartate	11	0.4	0.4
Felodipine Extended-Release Tablets	3	0.4	0.4
Felodipine	3	0.4	0.4
Montelukast	22	0.4	0.4
Melatonin	14	0.4	0.4
Pioglitazone	11	0.4	0.4
Benralizumab	5	0.4	0.4
Estradiol Gel 0.1%	11	0.4	0.4
Estradiol,	11	0.4	0.4
Estradiol Transdermal	11	0.4	0.4
Dulaglutide	21	0.4	0.4
Sitagliptin And Metformin Hydrochloride	5	0.4	0.4
Epinephrine	15	0.4	0.4
Exenatide	12	0.4	0.4
Labetalol	3	0.4	0.4
Dapagliflozin	7	0.4	0.4
Metoprolol Tartrate Injection	42	0.4	0.4
Progesterone	5	0.4	0.4
Methotrexate	93	0.4	0.4
Cetiirizine	9	0.3	0.3
Atomoxetine Hydrochloride	5	0.3	0.3
Iron	14	0.3	0.3
Rifampin	3	0.3	0.3
Fluticasone Propionate	26	0.3	0.3
Ropinirole	3	0.3	0.3
Clonidine	10	0.3	0.3
Teriparatide	22	0.3	0.3
Adrenalinum	8	0.3	0.3
Mometasone Furoate And Formoterol Fumarate Dihydrate	3	0.3	0.3
Metoprolol	48	0.3	0.3
Fluticasone Propionate And Salmeterol Xinafoate	11	0.3	0.3
Acetaminophen, Chlorpheniramine Maleate, Phenylephrine Hcl	9	0.3	0.3
Sulfasalazine	14	0.3	0.3
Hydrochlorothiazide	26	0.3	0.3
Metoprolol Tartrate	48	0.3	0.3
Amlodipine	47	0.3	0.3
Fluoxetine Hydrochloride	22	0.3	0.3
Oxybutynin	5	0.3	0.3
Indapamide	3	0.3	0.3
Azelastine	3	0.3	0.3
Linagliptin	3	0.3	0.3
Mometasone	3	0.3	0.3
Estradiol	14	0.3	0.3
Leucovorin Calcium	3	0.3	0.3
Irbesartan	7	0.3	0.3
Folic Acid	39	0.3	0.3
Escitslopram	9	0.3	0.3
Sertraline	18	0.2	0.2
Cetirizine Hydrochloride	25	0.2	0.2
Rosuvastatin	31	0.2	0.2
Fluoxetine	10	0.2	0.2
Calcitriol Capsules 0.25 Mcg	3	0.2	0.2
Calcitriol Capsules 0.5 Mcg	3	0.2	0.2
Nebivolol Hydrochloride	5	0.2	0.2
Calcitriol	3	0.2	0.2
Carvedilol	20	0.2	0.2
Hydroxyzine	7	0.2	0.2
Mometasone Furoate	6	0.2	0.2
Duloxetine	10	0.2	0.2
Levothyroxine Sodium	45	0.2	0.2
Cetirizine	11	0.2	0.2
Fenofibrate	5	0.2	0.2
Omalizumab	12	0.2	0.2
Escitalopram Oxalate	10	0.2	0.2
Ustekinumab	14	0.2	0.2
Celecoxib	18	0.2	0.2
Hydroxychloroquine	10	0.2	0.2
Finasteride	8	0.2	0.2
Methocarbamol	3	0.2	0.2
Fluticasone Propionate Nasal	4	0.2	0.2
Leuprolide Acetate	10	0.2	0.2
Losartan Potassium	10	0.2	0.2
Tizanidine	3	0.2	0.2
Sucralfate	3	0.2	0.2
Sitagliptin	9	0.2	0.2
Oxcarbazepine	4	0.2	0.2
Metformin Hydrochloride Tablets	7	0.2	0.2
Metformin Hydrochloride Extended-Release Tablets	7	0.2	0.2
Metformin Hydrochloride Tablet	7	0.2	0.2
Minoxidil Foam 5% (Womens)	4	0.2	0.2
Torsemide	4	0.2	0.2
Cyclobenzaprine	6	0.2	0.2
Ibuprofen Capsule	24	0.2	0.2
Ibuprofen Tablet, Film Coated	24	0.2	0.2
Ibuprofen Tablet, Film-Coated	24	0.2	0.2
Ibupfrofen	24	0.2	0.2
Ibuprofen Tablets Usp, 200Mg	24	0.2	0.2
Ibuprofen Oral	24	0.2	0.2
Ibuprofen Capsules 200 Mg	24	0.2	0.2
Ibuprofen 200 Mg	24	0.2	0.2
Ibuprofen 200Mg	24	0.2	0.2
Ferrous Sulfate	6	0.2	0.2
Metformin Hydrochloride	7	0.2	0.2
Sertraline Hydrochloride	14	0.2	0.2
Ibuprofen	32	0.2	0.2
Ergocalciferol	45	0.2	0.2
Dupilumab	56	0.2	0.2
Escitalopram	16	0.2	0.2
Linaclotide	3	0.2	0.2
Bupropion	5	0.2	0.2
Ipratropium Bromide	4	0.2	0.2
Fluticasone Furoate And Vilanterol Trifenatate	4	0.2	0.2
Enalapril	6	0.2	0.2
Calcium	16	0.2	0.2
Topiramate	10	0.2	0.2
Ezetimibe	8	0.2	0.2
Nifedipine	5	0.2	0.2
Acetaminophen, Guaifenesin, And Phenylephrine Hydrochloride	17	0.2	0.2
Clindamycin	3	0.2	0.2
Meloxicam	6	0.2	0.2
Pantoprazole	26	0.2	0.2
Bupropion Hydrochloride	10	0.2	0.2
Insulin Human	4	0.2	0.2
Azithromycin	4	0.2	0.2
Clopidogrel Bisulfate	10	0.2	0.2
Omeprazole	34	0.2	0.2
Magnesium	8	0.2	0.2
Biotin	3	0.2	0.2
Azithromycin Monohydrate	4	0.2	0.2
Ibuprofen Tablets, Coated	4	0.2	0.2
Ibuprofen Sodium	4	0.2	0.2
Famotidine	11	0.2	0.2
Loratadine Tablet	5	0.2	0.2
Docusate Sodium - Sennosides	3	0.2	0.2
Modafinil	3	0.2	0.2
Loratadine	10	0.2	0.2
Cyanocobalamin	3	0.1	0.1
Metoroprolol Tartrate	6	0.1	0.1
Paroxetine Hydrochloride Hemihydrate	3	0.1	0.1
Montelukast Sodium	11	0.1	0.1
Clindamycin Phosphate	3	0.1	0.1
Aripiprazole	11	0.1	0.1
Gabapentin	33	0.1	0.1
Minoxidil	4	0.1	0.1
Doxycycline Hyclate	6	0.1	0.1
Fish Oil	8	0.1	0.1
Paroxetine	3	0.1	0.1
Doxycycline	6	0.1	0.1
Clarithromycin	3	0.1	0.1
Simvastatin	22	0.1	0.1
Mirtazapine	8	0.1	0.1
Vitamin C	8	0.1	0.1
Enoxaparin Sodium	5	0.1	0.1
Divalproex Sodium	4	0.1	0.1
Diclofenac Sodium 1%	3	0.1	0.1
Diclofenac Sodium Topical	3	0.1	0.1
Diclofenac Sodium Topical Gel, 1%	3	0.1	0.1
Lamotirigine	6	0.1	0.1
Lamotrigine Extended-Release	6	0.1	0.1
Lamotrigine Chewable Dispersible	6	0.1	0.1
Omeprazole Magnesium	38	0.1	0.1
Aspirin 325 Mg	43	0.1	0.1
Aspirin 81 Mg	43	0.1	0.1
Atenolol	11	0.1	0.1
Prednisone	42	0.1	0.1
Loratadine Oral	4	0.1	0.1
Baclofen	7	0.1	0.1
Duloxetine Hydrochloride	15	0.1	0.1
Sumatriptan	3	0.1	0.1
Diazepam Oral Solution (Concentrate)	7	0.1	0.1
Diazepam Oral	7	0.1	0.1
Aspirin	43	0.1	0.1
Methotrexate Sodium	38	0.1	0.1
Naproxen	6	0.1	0.1
Clopidogrel	15	0.1	0.1
Amlodipine Besylate	11	0.1	0.1
Risankizumab-Rzaa	6	0.1	0.1
Citalopram	10	0.1	0.1
Erenumab-Aooe	4	0.1	0.1
Aripiprazole Oral	3	0.1	0.1
Aripiprazole Orally Disintegrating	3	0.1	0.1
Magnesium Oxide	3	0.1	0.1
Spironolactone	10	0.1	0.1
Tacrolimus	11	0.1	0.1
Venlafaxine	5	0.1	0.1
Docusate Sodium	4	0.1	0.1
Alendronate Sodium	7	0.1	0.1
Azithromycin Dihydrate	4	0.1	0.1
Budesonide	4	0.1	0.1
Risperidone	9	0.1	0.1
Levetiracetam	9	0.1	0.1
Diazepam	8	0.1	0.1
Citalopram Hydrobromide	7	0.1	0.1
Potassium Chloride, Dextrose Monohydrate	6	0.1	0.1
Potassium Chloride Oral	6	0.1	0.1
Potassium Chloride Extended-Release	6	0.1	0.1
Pantoprazole Sodium In 0.9% Sodium Chloride	4	0.1	0.1
Pantoprazole Sodium Injection	4	0.1	0.1
Metoprolol Succinate Er Tablets	4	0.1	0.1
Adalimumab	45	0.1	0.1
Tirzepatide	10	0.1	0.1
Diclofenac	5	0.1	0.1
Metoprolol Succinate	5	0.1	0.1
Azathioprine	5	0.1	0.1
Atorvastatin Calcium	14	0.1	0.1
Tacrolimus Ointment 0.1%	7	0.1	0.1
Nitroglycerin	3	0.1	0.1
Tacrolimus Extended-Release Capsules	7	0.1	0.1
Propranolol Hydrochloride	4	0.1	0.1
Lamotrigine	7	0.1	0.1
Venlafaxine Hydrochloride	7	0.1	0.1
Potassium Chloride	6	0.1	0.1
Amoxicillin	4	0.1	0.1
Pregabalin	14	0.1	0.1
Allopurinol	8	0.1	0.1
Sodium Chloride	4	0.1	0.1
Clonazepam	8	0.1	0.1
Ondansetron Hydrochloride	6	0.1	0.1
Esomeprazole	3	0.1	0.1
Rivaroxaban	10	0.1	0.1
Pantoprazole Sodium	7	0.1	0.1
Diclofenac Sodium	7	0.1	0.1
Ondansetron	5	0.1	0.1
Ondansetron Tablets	5	0.1	0.1
Lansoprazole	8	0.1	0.1
Zolpidem Tartrate	6	0.1	0.1
Bisoprolol Fumarate	6	0.1	0.1
Acetaminophen	20	0.1	0.1
Paroxetine Hydrochloride	4	0.1	0.1
Hydroxychloroquine Sulfate	4	0.1	0.1
Hydromorphone Hydrochloride	4	0.1	0.1
Naproxen Sodium	6	0.1	0.1
Digoxin	3	0.1	0.1
Polyethylene Glycol 3350	4	0.1	0.1
Furosemide	17	0.1	0.1
Quetiapine	8	0.1	0.1
Sodium Chloride Tablet	3	0.1	0.1
Sodium Chloride Tablets	3	0.1	0.1
Morphine	3	0.1	0.1
Fluorouracil Cream, 0.5%	3	0.1	0.1
Fluorouracil	3	0.1	0.1
Diphenhydramine Hydrochloride	6	0.1	0.1
Vedolizumab	3	0.1	0.1
Levothyroxine Sodium Anhydrous	3	0.0	0.0
Levonorgestrel	6	0.0	0.0
Mycophenolate Mofetil	4	0.0	0.0
Mycophenolate Mofetil Hydrochloride	4	0.0	0.0
Leflunomide	3	0.0	0.0
Olanzapine	3	0.0	0.0
Cyclosporine	3	0.0	0.0
Alprazolam	5	0.0	0.0
Clozapine	3	0.0	0.0
Warfarin	3	0.0	0.0
Esomeprazole Magnesium	5	0.0	0.0
Lorazepam	3	0.0	0.0
Denosumab	3	0.0	0.0
Dexamethasone 1.5 Mg	3	0.0	0.0
Dexamethasone	3	0.0	0.0

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.