OpenPV Signal Explorer
FAERS disproportionality dashboard
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Drug

Megestrol Acetate

272 flagged reaction(s) · 7,039 total co-reports · max PRR 29.8
Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.
Reaction Co-reports (a) PRR ROR Signal
1 Adrenal Insufficiency 65 29.8 30.3 signal
2 Atelectasis 23 13.0 13.0 signal
3 Economic Problem 32 11.4 11.4 signal
4 End Stage Renal Disease 33 9.8 9.9 signal
5 Prostatic Specific Antigen Increased 24 9.5 9.5 signal
6 Hospice Care 17 9.4 9.5 signal
7 Deep Vein Thrombosis 106 8.9 9.1 signal
8 Malnutrition 16 7.9 7.9 signal
9 Metastases To Bone 23 7.7 7.7 signal
10 Meningioma 20 7.4 7.5 signal
11 Metastases To Lung 15 7.1 7.1 signal
12 Mental Status Changes 36 7.1 7.1 signal
13 Hyperbilirubinaemia 13 6.9 6.9 signal
14 Supraventricular Tachycardia 12 6.9 6.9 signal
15 Oral Candidiasis 16 6.7 6.7 signal
16 Breast Cancer Metastatic 13 6.6 6.6 signal
17 Dehydration 161 6.6 6.8 signal
18 Bacteraemia 14 6.5 6.5 signal
19 Decreased Appetite 275 6.5 6.9 signal
20 Emphysema 12 6.5 6.5 signal
21 Metastases To Central Nervous System 15 6.4 6.4 signal
22 Osteonecrosis Of Jaw 29 6.4 6.4 signal
23 Renal Failure Acute 49 6.2 6.3 signal
24 Cardiomegaly 14 6.2 6.2 signal
25 Hypokalaemia 51 6.1 6.1 signal
26 Pleural Effusion 67 6.0 6.1 signal
27 Anhedonia 29 6.0 6.0 signal
28 Hypomagnesaemia 15 5.9 5.9 signal
29 Pneumothorax 17 5.9 5.9 signal
30 Anorexia 14 5.9 5.9 signal
31 Arteriosclerosis 10 5.8 5.8 signal
32 Generalised Oedema 13 5.8 5.8 signal
33 Haematocrit Decreased 21 5.7 5.8 signal
34 Pulmonary Embolism 100 5.7 5.8 signal
35 Electrolyte Imbalance 12 5.7 5.7 signal
36 Upper Gastrointestinal Haemorrhage 17 5.5 5.5 signal
37 Ileus 12 5.3 5.3 signal
38 Mitral Valve Incompetence 11 5.3 5.3 signal
39 Unresponsive To Stimuli 25 5.3 5.3 signal
40 Metastases To Liver 17 5.3 5.3 signal
41 Hepatic Failure 29 5.2 5.3 signal
42 Hypocalcaemia 18 5.2 5.2 signal
43 Malignant Neoplasm Progression 97 5.2 5.3 signal
44 Blood Urea Increased 16 5.2 5.2 signal
45 Full Blood Count Decreased 19 5.1 5.2 signal
46 Dementia 26 5.1 5.1 signal
47 Blood Potassium Decreased 28 5.1 5.1 signal
48 Pericardial Effusion 21 5.0 5.0 signal
49 Hyponatraemia 51 5.0 5.0 signal
50 Febrile Neutropenia 60 4.9 5.0 signal
51 Ovarian Cyst 9 4.9 4.9 signal
52 Product Taste Abnormal 12 4.9 4.9 signal
53 Hypercalcaemia 11 4.9 4.9 signal
54 Acute Respiratory Failure 17 4.8 4.9 signal
55 Tooth Abscess 9 4.8 4.8 signal
56 Cardiomyopathy 13 4.8 4.8 signal
57 Anaemia 167 4.8 5.0 signal
58 Pulmonary Mass 13 4.8 4.8 signal
59 Night Sweats 28 4.7 4.8 signal
60 Neoplasm 10 4.7 4.7 signal
61 Hot Flush 65 4.7 4.8 signal
62 Hyperkalaemia 30 4.7 4.7 signal
63 Flank Pain 8 4.7 4.7 signal
64 Clostridium Difficile Colitis 9 4.6 4.6 signal
65 Sinus Tachycardia 12 4.6 4.6 signal
66 Hyperlipidaemia 10 4.6 4.6 signal
67 Hypophagia 21 4.5 4.5 signal
68 Nocturia 10 4.5 4.5 signal
69 Pneumonitis 22 4.4 4.5 signal
70 Neutropenia 110 4.4 4.5 signal
71 Ventricular Fibrillation 9 4.4 4.4 signal
72 Red Blood Cell Count Decreased 23 4.4 4.4 signal
73 Orthostatic Hypotension 14 4.4 4.4 signal
74 Oral Pain 18 4.4 4.4 signal
75 Gastritis 21 4.4 4.4 signal
76 Abasia 20 4.4 4.4 signal
77 Blood Sodium Decreased 15 4.4 4.4 signal
78 Hypoaesthesia Oral 12 4.4 4.4 signal
79 Stomatitis 48 4.3 4.4 signal
80 Pulmonary Oedema 35 4.3 4.3 signal
81 Poor Venous Access 8 4.2 4.2 signal
82 Mucosal Inflammation 20 4.2 4.2 signal
83 Brain Neoplasm 7 4.2 4.2 signal
84 Pneumonia 246 4.2 4.4 signal
85 Urosepsis 7 4.1 4.2 signal
86 Ovarian Cancer 7 4.1 4.1 signal
87 Incontinence 8 4.1 4.1 signal
88 Grand Mal Convulsion 7 4.1 4.1 signal
89 Pancytopenia 41 4.0 4.1 signal
90 Hypercholesterolaemia 7 4.0 4.0 signal
91 Gingival Bleeding 10 4.0 4.0 signal
92 International Normalised Ratio Increased 21 4.0 4.0 signal
93 Dizziness Postural 7 4.0 4.0 signal
94 Sepsis 81 4.0 4.0 signal
95 Tooth Extraction 9 3.9 4.0 signal
96 Asthenia 271 3.9 4.2 signal
97 Dyspnoea Exertional 27 3.9 3.9 signal
98 Candida Infection 12 3.9 3.9 signal
99 Oedema Peripheral 87 3.9 4.0 signal
100 Eating Disorder 15 3.8 3.8 signal
101 Lung Infection 11 3.8 3.8 signal
102 Productive Cough 33 3.8 3.8 signal
103 Weight Decreased 192 3.8 3.9 signal
104 Disease Progression 81 3.8 3.8 signal
105 Gastroenteritis 10 3.7 3.8 signal
106 Hypoxia 24 3.7 3.8 signal
107 Rib Fracture 14 3.7 3.7 signal
108 Ascites 20 3.7 3.7 signal
109 Chronic Obstructive Pulmonary Disease 35 3.7 3.7 signal
110 Septic Shock 29 3.7 3.7 signal
111 Delirium 23 3.6 3.6 signal
112 Osteopenia 10 3.6 3.6 signal
113 Sudden Death 7 3.6 3.6 signal
114 Musculoskeletal Chest Pain 10 3.5 3.5 signal
115 Intervertebral Disc Degeneration 6 3.5 3.5 signal
116 Oesophagitis 7 3.5 3.5 signal
117 Musculoskeletal Discomfort 11 3.5 3.5 signal
118 Chronic Kidney Disease 49 3.5 3.5 signal
119 Thrombocytopenia 71 3.5 3.5 signal
120 Hyperglycaemia 23 3.5 3.5 signal
121 Haemoglobin Decreased 65 3.4 3.5 signal
122 Respiratory Failure 46 3.4 3.5 signal
123 Peritonitis 13 3.4 3.4 signal
124 Impaired Gastric Emptying 8 3.4 3.4 signal
125 Infusion Site Pain 8 3.4 3.4 signal
126 Constipation 135 3.4 3.5 signal
127 Leukopenia 31 3.4 3.4 signal
128 Hiatus Hernia 8 3.4 3.4 signal
129 Respiratory Distress 17 3.4 3.4 signal
130 Bone Pain 36 3.4 3.4 signal
131 Renal Tubular Necrosis 6 3.3 3.3 signal
132 Leukocytosis 11 3.3 3.3 signal
133 Osteomyelitis 11 3.3 3.3 signal
134 Osteoporosis 25 3.3 3.3 signal
135 Dysphagia 57 3.3 3.3 signal
136 Coagulopathy 10 3.3 3.3 signal
137 Bone Disorder 11 3.3 3.3 signal
138 Epistaxis 44 3.2 3.2 signal
139 Blood Count Abnormal 9 3.2 3.2 signal
140 Gastric Ulcer 11 3.2 3.2 signal
141 Urinary Incontinence 17 3.1 3.1 signal
142 Lethargy 33 3.1 3.2 signal
143 Platelet Count Decreased 61 3.1 3.2 signal
144 Urinary Retention 19 3.1 3.1 signal
145 Gastrointestinal Haemorrhage 48 3.1 3.1 signal
146 Small Intestinal Obstruction 7 3.1 3.1 signal
147 Haemorrhoids 11 3.1 3.1 signal
148 Thrombosis 45 3.0 3.1 signal
149 Cardiac Failure Congestive 45 3.0 3.1 signal
150 Blood Potassium Increased 9 3.0 3.0 signal
151 Toothache 10 3.0 3.0 signal
152 Diarrhoea 351 3.0 3.2 signal
153 Multiple Fractures 9 3.0 3.0 signal
154 Rotator Cuff Syndrome 7 3.0 3.0 signal
155 Fluid Overload 8 3.0 3.0 signal
156 Glossodynia 12 2.9 2.9 signal
157 Haemoptysis 15 2.9 2.9 signal
158 Lymphadenopathy 19 2.9 2.9 signal
159 Hepatic Encephalopathy 5 2.9 2.9 signal
160 Fistula 6 2.9 2.9 signal
161 Proteinuria 10 2.9 2.9 signal
162 Pain In Jaw 15 2.9 2.9 signal
163 Sputum Discoloured 5 2.9 2.9 signal
164 Blood Urine Present 10 2.9 2.9 signal
165 Haematuria 18 2.9 2.9 signal
166 Hypersomnia 15 2.9 2.9 signal
167 Device Related Infection 8 2.8 2.8 signal
168 Retching 11 2.8 2.8 signal
169 Palmar-plantar Erythrodysaesthesia Syndrome 12 2.8 2.8 signal
170 Rectal Haemorrhage 22 2.8 2.8 signal
171 Intestinal Obstruction 19 2.8 2.8 signal
172 Drug Toxicity 7 2.8 2.8 signal
173 Intervertebral Disc Protrusion 11 2.7 2.7 signal
174 Mass 7 2.7 2.7 signal
175 Cardio-respiratory Arrest 21 2.7 2.7 signal
176 Hypotonia 5 2.7 2.7 no signal
177 White Blood Cell Count Decreased 54 2.7 2.7 signal
178 Neutrophil Count Decreased 20 2.7 2.7 signal
179 Dialysis 7 2.7 2.7 signal
180 Inappropriate Antidiuretic Hormone Secretion 5 2.7 2.7 no signal
181 No Therapeutic Response 6 2.6 2.6 signal
182 Myelodysplastic Syndrome 7 2.6 2.6 signal
183 Cyst 6 2.6 2.6 signal
184 Tubulointerstitial Nephritis 9 2.6 2.6 signal
185 Disorientation 19 2.6 2.6 signal
186 Mouth Ulceration 10 2.6 2.6 signal
187 Laboratory Test Abnormal 14 2.6 2.6 signal
188 Metabolic Acidosis 15 2.6 2.6 signal
189 Acute Myocardial Infarction 14 2.6 2.6 signal
190 Death 406 2.6 2.8 signal
191 Mood Swings 15 2.6 2.6 signal
192 Hernia 9 2.6 2.6 signal
193 Body Height Decreased 5 2.5 2.5 no signal
194 Laryngitis 5 2.5 2.5 no signal
195 Coronary Artery Disease 14 2.5 2.5 signal
196 Pulmonary Thrombosis 5 2.5 2.5 no signal
197 Pollakiuria 19 2.5 2.5 signal
198 Neoplasm Progression 16 2.5 2.5 signal
199 Melaena 10 2.5 2.5 signal
200 Feeding Disorder 9 2.5 2.5 signal
201 Joint Range Of Motion Decreased 6 2.5 2.5 no signal
202 Nerve Injury 5 2.4 2.4 no signal
203 Activities Of Daily Living Impaired 9 2.4 2.4 signal
204 Jaundice 12 2.4 2.4 signal
205 Head Injury 14 2.4 2.4 signal
206 Chromaturia 10 2.4 2.4 signal
207 Bone Density Decreased 14 2.4 2.4 signal
208 Ageusia 11 2.4 2.4 signal
209 Shock 10 2.4 2.4 signal
210 Increased Tendency To Bruise 4 2.4 2.4 no signal
211 Oral Discomfort 6 2.4 2.4 no signal
212 Tooth Loss 9 2.4 2.4 signal
213 Feeling Cold 12 2.3 2.4 signal
214 Carpal Tunnel Syndrome 6 2.3 2.3 no signal
215 Deformity 4 2.3 2.3 no signal
216 Covid-19 Pneumonia 5 2.3 2.3 no signal
217 Posterior Reversible Encephalopathy Syndrome 4 2.3 2.3 no signal
218 Laceration 4 2.3 2.3 no signal
219 Subdural Haematoma 6 2.3 2.3 no signal
220 Blood Pressure Fluctuation 10 2.3 2.3 signal
221 Dysgeusia 31 2.3 2.3 signal
222 Spinal Operation 5 2.3 2.3 no signal
223 Hip Fracture 13 2.2 2.2 signal
224 Hepatic Function Abnormal 15 2.2 2.2 signal
225 Tooth Disorder 9 2.2 2.2 signal
226 Colon Cancer 6 2.2 2.2 no signal
227 Haemorrhage Intracranial 6 2.2 2.2 no signal
228 Gallbladder Disorder 7 2.1 2.1 no signal
229 Neoplasm Malignant 26 2.1 2.1 signal
230 Delusion 6 2.1 2.1 no signal
231 Lung Neoplasm Malignant 16 2.1 2.1 signal
232 Hallucination 29 2.1 2.1 signal
233 Plasma Cell Myeloma 15 2.1 2.1 signal
234 Injury 27 2.1 2.1 signal
235 Haematochezia 21 2.1 2.1 signal
236 Transfusion 4 2.1 2.1 no signal
237 Thinking Abnormal 7 2.0 2.0 no signal
238 Musculoskeletal Disorder 7 2.0 2.0 no signal
239 Osteonecrosis 12 2.0 2.0 no signal
240 Dystonia 7 2.0 2.0 no signal
241 Impaired Driving Ability 4 1.9 1.9 no signal
242 Gastric Haemorrhage 4 1.9 1.9 no signal
243 Cytopenia 4 1.8 1.8 no signal
244 Agranulocytosis 6 1.8 1.8 no signal
245 Drug Dispensing Error 5 1.8 1.8 no signal
246 Lymphoma 5 1.8 1.8 no signal
247 Personality Change 3 1.8 1.8 no signal
248 Eczema 16 1.7 1.7 no signal
249 Convulsion 18 1.7 1.7 no signal
250 Pancreatic Carcinoma 9 1.7 1.7 no signal
251 Malignant Melanoma 4 1.6 1.6 no signal
252 Myelosuppression 10 1.6 1.6 no signal
253 Euphoric Mood 3 1.6 1.6 no signal
254 Pelvic Pain 5 1.5 1.5 no signal
255 Pharmaceutical Product Complaint 7 1.5 1.5 no signal
256 Emotional Distress 32 1.4 1.4 no signal
257 Pain Of Skin 7 1.4 1.4 no signal
258 Vaginal Haemorrhage 11 1.4 1.4 no signal
259 Acute Myeloid Leukaemia 4 1.4 1.4 no signal
260 Madarosis 3 1.4 1.4 no signal
261 Tardive Dyskinesia 7 1.3 1.3 no signal
262 Hair Colour Changes 3 1.3 1.3 no signal
263 Tuberculosis 3 1.3 1.3 no signal
264 Hair Texture Abnormal 3 1.2 1.2 no signal
265 Bone Loss 3 1.1 1.1 no signal
266 Prostate Cancer 14 0.9 0.9 no signal
267 Breast Cancer 12 0.7 0.7 no signal
268 Extrapyramidal Disorder 3 0.7 0.7 no signal
269 Gynaecomastia 3 0.5 0.5 no signal
270 Product Adhesion Issue 3 0.5 0.5 no signal
271 Bladder Cancer 4 0.4 0.4 no signal
272 Device Expulsion 3 0.3 0.3 no signal