Drug

Tenapanor Hydrochloride

61 flagged reaction(s) · 4,858 total co-reports · max PRR 74.6

Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.

	Reaction	Co-reports (a)	PRR	ROR	Signal
1	Insurance Issue	184	74.6	78.7	signal
2	Therapy Interrupted	292	25.3	27.5	signal
3	Inability To Afford Medication	35	21.2	21.4	signal
4	Prescribed Underdose	68	20.3	20.7	signal
5	Product Use Issue	430	13.7	15.5	signal
6	Flatulence	130	13.7	14.2	signal
7	Abdominal Distension	234	13.4	14.3	signal
8	Inappropriate Schedule Of Product Administration	391	13.2	14.7	signal
9	Diarrhoea	1,239	11.5	17.2	signal
10	Intentional Dose Omission	50	10.9	11.0	signal
11	Underdose	123	10.0	10.4	signal
12	Product Dose Omission In Error	38	8.4	8.5	signal
13	Frequent Bowel Movements	35	7.7	7.8	signal
14	Haemorrhoids	24	7.3	7.4	signal
15	Impaired Gastric Emptying	15	7.0	7.0	signal
16	Unevaluable Event	83	6.5	6.7	signal
17	Drug Effect Less Than Expected	15	6.3	6.4	signal
18	Product Use In Unapproved Indication	250	6.1	6.5	signal
19	Illness	87	5.2	5.3	signal
20	Brain Fog	12	4.9	4.9	signal
21	Gastrointestinal Pain	9	4.9	4.9	signal
22	Cholecystectomy	9	4.7	4.7	signal
23	Therapeutic Product Effect Decreased	35	4.7	4.7	signal
24	Product Prescribing Issue	16	4.7	4.7	signal
25	Abdominal Pain Upper	159	4.6	4.8	signal
26	Blood Sodium Decreased	14	4.4	4.4	signal
27	Therapy Change	7	4.3	4.3	signal
28	Spinal Operation	8	3.9	3.9	signal
29	Feeding Disorder	13	3.9	3.9	signal
30	Peritonitis	13	3.7	3.7	signal
31	Therapy Cessation	32	3.7	3.8	signal
32	Adverse Drug Reaction	55	3.7	3.7	signal
33	Irritable Bowel Syndrome	13	3.6	3.6	signal
34	Faeces Discoloured	13	3.6	3.6	signal
35	Abdominal Pain	134	3.4	3.5	signal
36	Cerebral Infarction	14	3.4	3.4	signal
37	Dehydration	76	3.4	3.4	signal
38	Abdominal Pain Lower	14	3.3	3.3	signal
39	Product Availability Issue	12	3.2	3.2	signal
40	Hospitalisation	81	3.2	3.2	signal
41	Abdominal Discomfort	87	3.1	3.2	signal
42	Rectal Haemorrhage	21	2.9	2.9	signal
43	Surgery	28	2.9	2.9	signal
44	Accidental Underdose	7	2.9	2.9	signal
45	Wrong Technique In Product Usage Process	93	2.7	2.8	signal
46	Treatment Noncompliance	25	2.7	2.8	signal
47	Intestinal Obstruction	17	2.7	2.7	signal
48	Melaena	10	2.7	2.7	signal
49	Thirst	8	2.7	2.7	signal
50	Circumstance Or Information Capable Of Leading To Medication Error	15	2.7	2.7	signal
51	Diverticulitis	12	2.6	2.6	signal
52	Eructation	7	2.2	2.2	no signal
53	Inflammatory Bowel Disease	3	1.8	1.8	no signal
54	Complication Associated With Device	4	1.8	1.8	no signal
55	Drug Effective For Unapproved Indication	8	1.6	1.6	no signal
56	Product Dispensing Error	5	1.4	1.4	no signal
57	Dysmenorrhoea	3	1.4	1.4	no signal
58	Exposure Via Skin Contact	4	1.1	1.1	no signal
59	No Adverse Event	31	1.0	1.0	no signal
60	Dermatitis Atopic	5	0.6	0.6	no signal
61	Device Expulsion	3	0.3	0.3	no signal