Reaction

Medication Overuse Headache reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 844 reports · 18 co-occurring drugs

As of the last recalculation, Medication Overuse Headache appears in 844 FAERS reports alongside 18 co-occurring drug terms. The strongest observed disproportionality signal is ACETAMINOPHEN, ASPIRIN (NSAID) AND CAFFEINE (PRR 362.5).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.
DrugCo-reportsPRRROR
Acetaminophen, Aspirin (Nsaid) And Caffeine193362.5366.7
Acetaminophen, Aspirin, And Caffeine201308.4311.4
Sumatriptan Succinate130149.8150.5
Sumatriptan131100.2100.5
Rimegepant Sulfate3571.071.2
Butalbital, Acetaminophen, And Caffeine2252.252.3
Indomethacin2649.950.0
Valproate Sodium3543.543.6
Topiramate13040.540.5
Rizatriptan Benzoate1537.037.1
Fremanezumab-Vfrm1532.832.8
Erenumab-Aooe5224.724.8
Rabeprazole1921.621.6
Propranolol Hydrochloride5720.820.9
Venlafaxine5018.218.3
Galcanezumab-Gnlm2116.816.8
Valproic Acid1915.215.2
Eptinezumab-Jjmr38.28.2

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.