Data ICTV MSL41 & NCBI · 31 October 2026 Methods · Changelog · Corrections

Open Source Medicine Foundation

Orthoherpesviridae

Taxonomy pass, October 2026

10 Orthoherpesviridae species with sequence evidence that they infect people, classified from ICTV.

What this page does and does not yet contain. This is the taxonomy pass. Every virus below carries its ICTV classification and the evidence that it infects people. Vaccines, antivirals, antibodies and disease-burden figures have not been searched yet — that is why the last column says so, rather than being blank or saying “none”. An empty cell would claim that nothing exists; this claims only that nobody has looked.

Taxonomy is copied by script from the ICTV Virus Metadata Resource and is never hand-edited. How a virus qualifies for this list, and which viruses are deliberately left out, is on the methods page.

Where this family sits

Ranks above family are shared by every member, copied from ICTV MSL41.v1 / VMR_MSL41.v1.20260729.xlsx.

RealmDuplodnaviria
KingdomHeunggongvirae
PhylumPeploviricota
ClassHerviviricetes
OrderHerpesvirales
FamilyOrthoherpesviridae

Genome type in this family: I — dsDNA.

Members with evidence of human infection

10 of this family’s species qualify for the index. Species with no human sequence evidence, and the commensal families left out altogether, are explained on the methods page.

Orthoherpesviridae: 10 viruses in the index.
VirusFamilyBaltimore classICTV speciesHuman infectionCountermeasures
Cercopithecine betaherpesvirus 5CeBHV5; SCMV; simian cytomegalovirus; Cytomegalovirus cercopithecinebeta5OrthoherpesviridaeI — dsDNACytomegalovirus cercopithecinebeta5Human infection recorded; pattern not classifiedNot searched yet
Epstein-Barr virusHuGHV4; EBV; human gammaherpesvirus 4; Lymphocryptovirus human gamma 4OrthoherpesviridaeI — dsDNALymphocryptovirus humangamma4Human infection recorded; pattern not classifiedVaccine: Phase 2
Herpes simplex virus 1HuAHV1; HSV1; human alphaherpesvirus 1; Simplexvirus humanalpha1OrthoherpesviridaeI — dsDNASimplexvirus humanalpha1Human infection recorded; pattern not classifiedVaccine: all 1 discontinued
Antiviral: Approved
Herpes simplex virus 2HuAHV2; HSV2; human alphaherpesvirus 2; Simplexvirus humanalpha2OrthoherpesviridaeI — dsDNASimplexvirus humanalpha2Human infection recorded; pattern not classifiedVaccine: Phase 1
Antiviral: Approved
Human cytomegalovirusHuBHV5; HCMV; human betaherpesvirus 5; Cytomegalovirus humanbeta5OrthoherpesviridaeI — dsDNACytomegalovirus humanbeta5Human infection recorded; pattern not classifiedVaccine: Phase 3
Antiviral: Approved
Human herpesvirus 6AHuBHV6A; HHV6A; human betaherpesvirus 6A; Roseolovirus humanbeta6aOrthoherpesviridaeI — dsDNARoseolovirus humanbeta6aHuman infection recorded; pattern not classifiedNot searched yet
Human herpesvirus 6BHuBHV6B; HHV6B; human betaherpesvirus 6B; Roseolovirus humanbeta6bOrthoherpesviridaeI — dsDNARoseolovirus humanbeta6bHuman infection recorded; pattern not classifiedNot searched yet
Human herpesvirus 7HuBHV7; HHV7; human betaherpesvirus 7; Roseolovirus humanbeta7OrthoherpesviridaeI — dsDNARoseolovirus humanbeta7Human infection recorded; pattern not classifiedNot searched yet
Macacine alphaherpesvirus 1McAHV1; BV; B-virus; Simplexvirus macacinealpha1OrthoherpesviridaeI — dsDNASimplexvirus macacinealpha1Human infection recorded; pattern not classifiedNot searched yet
Varicella-zoster virusHuAHV3; VZV; human alphaherpesvirus 3; Varicellovirus humanalpha3OrthoherpesviridaeI — dsDNAVaricellovirus humanalpha3Human infection recorded; pattern not classifiedVaccine: Approved
Antiviral: Approved

Countermeasures across this family

Vaccines, antivirals and antibodies have not been searched for this family yet. When they are, this section will carry the family-level summary that makes broad-spectrum candidates visible. It is empty because the work is outstanding, not because nothing exists.

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Cite this page. Orthoherpesviridae. Vaccine Data Navigator, Open Source Medicine Foundation. Built 31 October 2026 from the ICTV Virus Metadata Resource (MSL41) and NCBI Taxonomy/GenBank. https://vaccinedatanavigator.org/virus-navigator/families/orthoherpesviridae.html

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