← All causality assessments
Expected pharmacological effect
Causality assessment · Expected pharmacological effect
Escitslopram and Suicidal Ideation: is the FAERS signal real?
A written Bradford Hill assessment of one drug–event pair. The grade is a judgement about the signal, not a statement that this drug causes this event in any one person; FAERS counts are reports, not rates.
Escitslopram ↔ Suicidal Ideation
n=1,320 co-reports · PRR 5.3 · ROR 5.4
Tozinameran (Pfizer/BioNTech COVID-19 vaccine) is an mRNA vaccine encoding the SARS-CoV-2 spike protein. Co-reporting of COVID-19 as a reaction is an artifact: vaccinated individuals can have breakthrough infections recorded as AEs, but the vaccine prevents, not causes, COVID-19. 154,725 co-reports (PRR 3.2) in enormous vaccinated cohort.
Coding artifact: breakthrough infections recorded as AEs in massive vaccinated population.
| Bradford Hill viewpoint | Status | Note |
|---|---|---|
| Temporality (necessary) | not established | Breakthrough infection artifact |
| Strength | not established | PRR 3.2 reflects enormous population |
| Consistency | not established | Vaccine prevents, not causes, COVID-19 |
| Specificity | not established | Not specific |
| Biological gradient | not established | No gradient |
| Plausibility | not established | No mechanism for causing disease |
| Coherence | not established | Contradicts vaccine mechanism |
| Experiment | met | RCT confirms 94 % efficacy |
| Analogy | not established | N/A |
This table is this page's own qualitative read of the literature cited above, not an automated or citation-gated assessment — see the note at the bottom of this page.
✗ No ClinicalTrials.gov results-posting trial in the top search hits for Escitslopram captured suicidal ideation as a tracked adverse event in a usable structure. The pivotal RCT (NCT04368728) tracked COVID-19 as primary endpoint; 94 % efficacy confirmed.