Which FAERS drug signals hold up?

Every card takes one drug–reaction pair with a strong FAERS signal and asks whether it survives the FDA label, the reporting-over-time pattern, the trial record and Bradford Hill's viewpoints. Grades: well established (the association is accepted and labelled), expected effect (follows from the drug's pharmacology or indication), contested (evidence conflicts), coding artifact (the signal is a reporting or coding pattern, not a harm). The single-page version has every card in one document.

• Abacavir ↔ Hypersensitivity reactionCausality: well establishedn=200 co-reports · PRR 3.8 · ROR 3.9
• Acarbose ↔ Gastrointestinal disorderExpected pharmacological effectn=68 co-reports · PRR 4.2 · ROR 4.3
• Acetaminophen ↔ Infusion Related ReactionCausality: well establishedn=13,947 co-reports · PRR 12.4 · ROR 12.8
• Acetaminophen (paracetamol) ↔ Liver injury / hepatotoxicityCausality: well establishedn=4,238 co-reports · PRR 9.8 · ROR 9.9
• Acetazolamide ↔ Metabolic acidosisCausality: well establishedn=206 co-reports · PRR 23.1 · ROR 23.9
• Acyclovir ↔ Acute kidney injuryCausality: well establishedn=2,499 co-reports · PRR 3.1 · ROR 3.1
• Adalimumab ↔ Rheumatoid ArthritisCoding artifact: the indication reported back as the "reaction"n=36,065 co-reports · PRR 13.6 · ROR 14.3
• Adefovir Dipivoxil ↔ Drug ResistanceCausality: well establishedn=275 co-reports · PRR 178.6 · ROR 227.6
• Adenosine ↔ BronchospasmExpected pharmacological effectn=41 co-reports · PRR 37.6 · ROR 38.6
• Alendronate (bisphosphonates) ↔ Atypical femoral fractureCausality: well establishedn=11,361 co-reports · PRR 120.9 · ROR 136.2
• Aliskiren ↔ HyperkalaemiaCausality: well establishedn=76 co-reports · PRR 20.2 · ROR 20.9
• Allopurinol ↔ DRESS syndrome (drug reaction with eosinophilia and systemic symptoms)Causality: well establishedn=2,952 co-reports · PRR 17.5 · ROR 17.8
• Allopurinol ↔ Toxic epidermal necrolysisCausality: well establishedn=1,170 co-reports · PRR 11.3 · ROR 11.3
• Alosetron Hydrochloride ↔ ConstipationCausality: well establishedn=128 co-reports · PRR 14.9 · ROR 17.4
• Alprazolam ↔ Drug AbuseExpected pharmacological effectn=11,121 co-reports · PRR 15.6 · ROR 16.4
• Alprazolam (benzodiazepines) ↔ Drug dependence / abuseCausality: well establishedn=11,121 co-reports · PRR 15.6 · ROR 16.4
• Alteplase ↔ Cerebral haemorrhageCausality: well establishedn=819 co-reports · PRR 32.9 · ROR 34.8
• Amantadine ↔ Livedo reticularisCausality: well establishedn=50 co-reports · PRR 33.5 · ROR 33.6
• Ambrisentan ↔ Fluid retentionExpected pharmacological effectn=5,470 co-reports · PRR 20.3 · ROR 21.2
• Amiodarone ↔ Pulmonary fibrosis (interstitial lung disease)Causality: well establishedn=395 co-reports · PRR 39.7 · ROR 41.1
• Amitriptyline ↔ TachycardiaExpected pharmacological effectn=579 co-reports · PRR 7.9 · ROR 8.1
• Amitriptyline Hydrochloride ↔ Cognitive DisorderCausality: well establishedn=955 co-reports · PRR 25.2 · ROR 26.6
• Amlodipine (dihydropyridine CCBs) ↔ Peripheral oedemaExpected pharmacological effectn=4,541 co-reports · PRR 3.0 · ROR 3.0
• Amoxicillin–clavulanate ↔ Cholestatic liver injuryCausality: well establishedn=563 co-reports · PRR 23.6 · ROR 24.0
• Amphetamine ↔ Drug AbuseExpected pharmacological effectn=1,733 co-reports · PRR 53.9 · ROR 68.0
• Amphotericin B ↔ Acute kidney injuryCausality: well establishedn=436 co-reports · PRR 4.8 · ROR 5.0
• Amphotericin B ↔ Hypokalaemia / electrolyte wastingExpected pharmacological effectn=288 co-reports · PRR 10.6 · ROR 10.9
• Apixaban ↔ Gastrointestinal bleedingCausality: well establishedn=1,649 co-reports · PRR 6.3 · ROR 6.4
• Argatroban ↔ HaemorrhageExpected pharmacological effectn=80 co-reports · PRR 10.7 · ROR 11.3
• Aripiprazole ↔ Weight IncreasedExpected pharmacological effectn=7,848 co-reports · PRR 6.3 · ROR 6.6
• Aripiprazole (antipsychotics) ↔ AkathisiaCausality: well establishedn=3,031 co-reports · PRR 49.1 · ROR 50.3
• Atomoxetine ↔ HypertensionExpected pharmacological effectn=400 co-reports · PRR 11.2 · ROR 12.4
• Atorvastatin (statins) ↔ Type 2 diabetes mellitusContested: small, real but modest effectn=11,260 co-reports · PRR 42.4 · ROR 44.4
• Axicabtagene Ciloleucel ↔ Cytokine Release SyndromeCausality: well establishedn=4,499 co-reports · PRR 663.0 · ROR 1223.7
• Azathioprine ↔ Bone-marrow suppression (pancytopenia)Causality: well establishedn=1,126 co-reports · PRR 4.9 · ROR 5.0
• Azathioprine ↔ PancytopeniaExpected pharmacological effectn=1,126 co-reports · PRR 4.9 · ROR 5.0
• Azithromycin (macrolides) ↔ QT prolongation / torsadesCausality: well establishedn=522 co-reports · PRR 7.7 · ROR 7.8
• Baclofen ↔ SomnolenceExpected pharmacological effectn=2,765 co-reports · PRR 3.4 · ROR 3.5
• Benzocaine ↔ MethaemoglobinaemiaCausality: well establishedn=35 co-reports · PRR 46.5 · ROR 48.2
• Benztropine ↔ Dry mouthExpected pharmacological effectn=89 co-reports · PRR 3.2 · ROR 3.2
• Bevacizumab ↔ HypertensionCausality: well establishedn=5,851 co-reports · PRR 4.8 · ROR 5.0
• Bevacizumab ↔ HypertensionExpected pharmacological effectn=5,851 co-reports · PRR 4.8 · ROR 5.0
• Bivalirudin ↔ HaemorrhageExpected pharmacological effectn=87 co-reports · PRR 18.2 · ROR 19.9
• Bleomycin ↔ Interstitial lung diseaseCausality: well establishedn=146 co-reports · PRR 8.6 · ROR 8.7
• Bleomycin ↔ Pulmonary fibrosisCausality: well establishedn=139 co-reports · PRR 20.7 · ROR 21.1
• Bortezomib ↔ Peripheral neuropathyCausality: well establishedn=6,473 co-reports · PRR 17.3 · ROR 18.6
• Bortezomib (proteasome inhibitors) ↔ Peripheral neuropathyCausality: well establishedn=6,473 co-reports · PRR 17.3 · ROR 18.6
• Bosentan ↔ HepatotoxicityCausality: well establishedn=258 co-reports · PRR 2.9 · ROR 2.9
• Brexpiprazole ↔ Weight IncreasedExpected pharmacological effectn=1,702 co-reports · PRR 9.8 · ROR 10.8
• Brexucabtagene Autoleucel ↔ Cytokine Release SyndromeCausality: well establishedn=917 co-reports · PRR 511.7 · ROR 916.8
• Brivaracetam ↔ AggressionExpected pharmacological effectn=297 co-reports · PRR 14.0 · ROR 14.4
• Bupropion ↔ SeizuresCausality: well establishedn=1,664 co-reports · PRR 7.0 · ROR 7.2
• Bupropion Hydrochloride ↔ Suicidal IdeationExpected pharmacological effectn=2,547 co-reports · PRR 6.1 · ROR 6.2
• Buspirone ↔ Serotonin syndromeCausality: well establishedn=119 co-reports · PRR 12.0 · ROR 12.1
• Cabazitaxel ↔ Febrile NeutropeniaCausality: well establishedn=248 co-reports · PRR 22.7 · ROR 24.4
• Cabergoline ↔ Pleural effusionCausality: well establishedn=77 co-reports · PRR 5.5 · ROR 5.6
• Canagliflozin ↔ AmputationContested: signal not confirmed by large randomized trialsn=2,195 co-reports · PRR 535.9 · ROR 578.5
• Capecitabine ↔ Palmar-plantar erythrodysaesthesia (hand-foot syndrome)Expected pharmacological effectn=6,675 co-reports · PRR 92.1 · ROR 99.3
• Capecitabine ↔ Palmar-Plantar Erythrodysaesthesia SyndromeCausality: well establishedn=— co-reports · PRR — · ROR —
• Carbamazepine ↔ AgranulocytosisCausality: well establishedn=184 co-reports · PRR 3.2 · ROR 3.2
• Carbamazepine ↔ HyponatraemiaCausality: well establishedn=1,446 co-reports · PRR 8.3 · ROR 8.4
• Carbamazepine ↔ HyponatraemiaCausality: well establishedn=1,446 co-reports · PRR 8.3 · ROR 8.4
• Carbamazepine ↔ Stevens-Johnson syndromeCausality: well establishedn=920 co-reports · PRR 13.5 · ROR 13.7
• Carbamazepine ↔ Stevens–Johnson syndrome / TENCausality: well establishedn=920 co-reports · PRR 13.5 · ROR 13.7
• Cenobamate ↔ EosinophiliaCausality: well establishedn=32 co-reports · PRR 4.6 · ROR 4.6
• Certolizumab Pegol ↔ Rheumatoid ArthritisCoding artifact: the indication reported back as the "reaction"n=19,803 co-reports · PRR 38.1 · ROR 45.7
• Cetuximab ↔ HypomagnesaemiaCausality: well establishedn=596 co-reports · PRR 30.2 · ROR 30.8
• Cetuximab ↔ RashExpected pharmacological effectn=2,273 co-reports · PRR 3.5 · ROR 3.7
• Chlorpromazine ↔ Neuroleptic malignant syndromeCausality: well establishedn=294 co-reports · PRR 74.9 · ROR 78.1
• Ciltacabtagene Autoleucel ↔ Cytokine Release SyndromeCausality: well establishedn=813 co-reports · PRR 159.1 · ROR 184.5
• Cinacalcet ↔ HypocalcaemiaExpected pharmacological effectn=273 co-reports · PRR 65.8 · ROR 69.8
• Ciprofloxacin (fluoroquinolones) ↔ Tendon rupture / tendinitisCausality: well establishedTendon rupture: n=1,254 · PRR 25.8 · ROR 26.2
• Cisplatin ↔ Acute kidney injuryExpected pharmacological effectn=1,863 co-reports · PRR 3.3 · ROR 3.4
• Cisplatin ↔ Ototoxicity (hearing loss)Causality: well establishedn=415 co-reports · PRR 4.3 · ROR 4.3
• Cisplatin ↔ Peripheral neuropathyCausality: well establishedn=1,228 co-reports · PRR 3.5 · ROR 3.6
• Citalopram ↔ QT prolongationCausality: well establishedn=1,712 co-reports · PRR 7.7 · ROR 7.7
• Clindamycin ↔ Clostridioides difficile colitisCausality: well establishedn=409 co-reports · PRR 14.3 · ROR 14.5
• Clonidine ↔ Blood pressure increased (rebound)Causality: well establishedn=1,733 co-reports · PRR 4.7 · ROR 4.8
• Clonidine ↔ Rebound hypertension / withdrawal syndromeCausality: well establishedn=741 co-reports · PRR 3.5 · ROR 3.5
• Clopidogrel ↔ Gastrointestinal haemorrhageCausality: well establishedn=8,285 co-reports · PRR 11.5 · ROR 12.0
• Clopidogrel ↔ Thrombotic thrombocytopenic purpuraCausality: well establishedn=456 co-reports · PRR 15.7 · ROR 15.7
• Clorazepate Dipotassium ↔ Drug AbuseExpected pharmacological effectn=77 co-reports · PRR 9.9 · ROR 10.3
• Clozapine ↔ Agranulocytosis / severe neutropeniaCausality: well establishedAgranulocytosis: n=2,074 · PRR 21.1 · ROR 21.5
• Clozapine ↔ MyocarditisCausality: well establishedn=2,231 co-reports · PRR 41.1 · ROR 41.8
• Clozapine ↔ MyocarditisCausality: well establishedn=2,231 co-reports · PRR 41.1 · ROR 41.8
• Colchicine ↔ MyopathyExpected pharmacological effectn=220 co-reports · PRR 20.8 · ROR 21.0
• Colchicine ↔ PancytopeniaCausality: well establishedn=400 co-reports · PRR 5.8 · ROR 5.9
• Colchicine ↔ RhabdomyolysisCausality: well establishedn=519 co-reports · PRR 10.1 · ROR 10.3
• Conjugated Estrogens And Medroxyprogesterone Acetate ↔ Breast CancerCoding artifact: the indication reported back as the "reaction"n=7,888 co-reports · PRR 81.8 · ROR 122.7
• Copper ↔ Foreign Body In Reproductive TractCausality: well establishedn=8,693 co-reports · PRR 89124.5 · ROR 111803.9
• Copper intrauterine device ↔ Foreign body in reproductive tractCoding artifact: the device named as the "reaction"n=8,693 co-reports · PRR 89,124.5 · ROR 111,803.9
• Corticosteroids (prednisolone) ↔ Avascular necrosis of boneCausality: well establishedn=1,064 co-reports · PRR 3.8 · ROR 3.9
• Corticosteroids (prednisolone) ↔ Hyperglycaemia / steroid diabetesExpected pharmacological effectn=1,068 co-reports · PRR 3.5 · ROR 3.5
• Cyclophosphamide ↔ Haemorrhagic cystitisCausality: well establishedn=1,125 co-reports · PRR 46.1 · ROR 46.4
• Cyclophosphamide ↔ Haemorrhagic cystitisCausality: well establishedn=1,125 co-reports · PRR 46.1 · ROR 46.4
• Cyclosporine ↔ Acute kidney injuryExpected pharmacological effectn=1,777 co-reports · PRR 2.2 · ROR 2.2
• Cyclosporine ↔ Gingival hypertrophyCausality: well establishedn=231 co-reports · PRR 34.4 · ROR 34.4
• Cyclosporine ↔ NephrotoxicityCausality: well establishedn=2,159 co-reports · PRR 5.0 · ROR 5.1
• Dabigatran ↔ Gastrointestinal bleedingCausality: well establishedn=8,281 co-reports · PRR 29.6 · ROR 33.0
• Danazol ↔ Hepatic enzyme increasedCausality: well establishedn=110 co-reports · PRR 12.1 · ROR 12.6
• Dapagliflozin ↔ Genital infectionExpected pharmacological effectn=130 co-reports · PRR 5.3 · ROR 5.3
• Dapsone ↔ DRESS syndrome (eosinophilia)Causality: well establishedn=354 co-reports · PRR 27.7 · ROR 28.7
• Dapsone ↔ Haemolytic anaemiaCausality: well establishedn=165 co-reports · PRR 36.9 · ROR 37.5
• Dapsone ↔ MethaemoglobinaemiaCausality: well establishedn=480 co-reports · PRR 522.3 · ROR 547.0
• Dapsone ↔ Methaemoglobinaemia / haemolysisCausality: well establishedn=480 co-reports · PRR 522.3 · ROR 547.0
• Daptomycin ↔ Myopathy / rhabdomyolysisCausality: well establishedn=370 co-reports · PRR 20.5 · ROR 21.3
• Deferiprone ↔ AgranulocytosisCausality: well establishedn=158 co-reports · PRR 60.2 · ROR 63.5
• Denosumab ↔ HypocalcaemiaExpected pharmacological effectn=3,338 co-reports · PRR 22.2 · ROR 22.6
• Denosumab ↔ Osteonecrosis of the jawCausality: well establishedn=8,645 co-reports · PRR 55.1 · ROR 57.6
• Diazepam ↔ Drug AbuseExpected pharmacological effectn=7,212 co-reports · PRR 16.3 · ROR 17.2
• Digoxin ↔ Bradycardia / AV blockExpected pharmacological effectn=2,533 co-reports · PRR 14.7 · ROR 15.2
• Diltiazem (non-dihydropyridine CCBs) ↔ Bradycardia / AV blockExpected pharmacological effectn=540 co-reports · PRR 6.3 · ROR 6.3
• Dimethyl fumarate ↔ LymphopeniaExpected pharmacological effectn=80 co-reports · PRR 36.4 · ROR 37.2
• Disulfiram ↔ Drug-induced liver injuryCausality: well establishedn=40 co-reports · PRR 24.2 · ROR 25.1
• Docetaxel ↔ Febrile neutropeniaExpected pharmacological effectn=3,074 co-reports · PRR 15.2 · ROR 15.9
• Docetaxel (taxanes) ↔ AlopeciaExpected pharmacological effectn=16,970 co-reports · PRR 29.5 · ROR 39.1
• Docetaxel Anhydrous ↔ AlopeciaCausality: well establishedn=16,970 co-reports · PRR 29.5 · ROR 39.1
• Dofetilide ↔ Prolonged QT intervalCausality: well establishedn=445 co-reports · PRR 25.1 · ROR 26.2
• Donepezil (cholinesterase inhibitors) ↔ Bradycardia / syncopeCausality: well establishedn=1,014 co-reports · PRR 11.2 · ROR 11.5
• Doxorubicin ↔ CardiotoxicityCausality: well establishedn=1,221 co-reports · PRR 37.7 · ROR 38.2
• Doxorubicin (anthracyclines) ↔ Cardiotoxicity / cardiomyopathyCausality: well establishedn=1,221 co-reports · PRR 37.7 · ROR 38.2
• Doxycycline (tetracyclines) ↔ Photosensitivity reactionCausality: well establishedn=427 co-reports · PRR 8.2 · ROR 8.3
• Dronedarone ↔ Atrial FibrillationCausality: well establishedn=1,424 co-reports · PRR 30.6 · ROR 35.5
• Droperidol ↔ QT prolongationCausality: well establishedn=39 co-reports · PRR 14.1 · ROR 14.4
• Drospirenone/ethinyl estradiol ↔ Pulmonary embolism (venous thromboembolism)Causality: well establishedn=9,171 co-reports · PRR 50.7 · ROR 63.8
• Duloxetine ↔ Completed suicideContested: signal not confirmed by large randomized trialsn=2,204 co-reports · PRR 8.1 · ROR 8.4
• Ecallantide ↔ Hereditary AngioedemaCausality: well establishedn=779 co-reports · PRR 903.6 · ROR 1553.4
• Edoxaban ↔ Gastrointestinal haemorrhageExpected pharmacological effectn=195 co-reports · PRR 7.4 · ROR 7.6
• Efavirenz ↔ Depression / neuropsychiatric effectsCausality: well establishedn=461 co-reports · PRR 3.8 · ROR 3.9
• Efavirenz ↔ Suicidal depressionCausality: well establishedn=36 co-reports · PRR 19.9 · ROR 19.9
• Elranatamab-Bcmm ↔ Cytokine Release SyndromeCausality: well establishedn=184 co-reports · PRR 197.2 · ROR 239.5
• Elvitegravir, Cobicistat, Emtricitabine, And Tenofovir Disoproxil Fumarate ↔ Bone Density DecreasedCausality: well establishedn=4,593 co-reports · PRR 398.0 · ROR 816.3
• Empagliflozin ↔ Necrotising fasciitis (Fournier's gangrene)Causality: well establishedn=251 co-reports · PRR 24.0 · ROR 24.1
• Empagliflozin (SGLT2 inhibitors) ↔ Diabetic ketoacidosisCausality: well establishedn=3,864 co-reports · PRR 60.2 · ROR 63.8
• Emtricitabine And Tenofovir Disoproxil Fumarate ↔ Chronic Kidney DiseaseCausality: well establishedn=10,383 co-reports · PRR 72.5 · ROR 93.7
• Enoxaparin (low-molecular-weight heparins) ↔ Heparin-induced thrombocytopenia (HIT)Causality: well establishedn=637 co-reports · PRR 54.1 · ROR 54.7
• Entacapone ↔ DyskinesiaExpected pharmacological effectn=481 co-reports · PRR 60.6 · ROR 68.4
• Epcoritamab-Bysp ↔ Cytokine Release SyndromeCausality: well establishedn=450 co-reports · PRR 398.8 · ROR 616.6
• Epirubicin Hydrochloride ↔ MyelosuppressionCoding artifact: the indication reported back as the "reaction"n=695 co-reports · PRR 69.0 · ROR 77.4
• Eplerenone (MR antagonists) ↔ HyperkalaemiaExpected pharmacological effectn=413 co-reports · PRR 19.7 · ROR 20.3
• Epoprostenol ↔ HeadacheExpected pharmacological effectn=2,295 co-reports · PRR 5.9 · ROR 7.0
• Eptifibatide ↔ ThrombocytopeniaCausality: well establishedn=65 co-reports · PRR 16.0 · ROR 17.4
• Erlotinib ↔ Interstitial lung diseaseCausality: well establishedn=95 co-reports · PRR 4.3 · ROR 4.3
• Erythropoiesis-stimulating agents (darbepoetin alfa) ↔ Mortality / cardiovascular riskCausality: well establishedDarbepoetin alfa ↔ Death: n=16,130 · PRR 7.5 · ROR 10.2
• Escitalopram ↔ QT prolongationCausality: well establishedn=1,236 co-reports · PRR 5.3 · ROR 5.4
• Escitalopram ↔ Suicidal IdeationExpected pharmacological effectn=3,196 co-reports · PRR 5.4 · ROR 5.5
• Escitslopram ↔ Suicidal IdeationExpected pharmacological effectn=1,320 co-reports · PRR 5.3 · ROR 5.4
• Estradiol, ↔ Breast Cancer FemaleCausality: well establishedn=1,709 co-reports · PRR 31.6 · ROR 32.8
• Estradiol/Norethindrone Acetate ↔ Breast CancerCoding artifact: the indication reported back as the "reaction"n=281 co-reports · PRR 32.7 · ROR 38.2
• Estrogen + medroxyprogesterone acetate ↔ Breast cancerCausality: well establishedn=9,771 co-reports · PRR 242.8 · ROR 302.2
• Estrogens, Conjugated ↔ Breast CancerCoding artifact: the indication reported back as the "reaction"n=9,643 co-reports · PRR 40.5 · ROR 48.2
• Eszopiclone ↔ AmnesiaExpected pharmacological effectn=270 co-reports · PRR 3.4 · ROR 3.5
• Etanercept ↔ Rheumatoid ArthritisCoding artifact: the indication reported back as the "reaction"n=46,770 co-reports · PRR 24.4 · ROR 26.4
• Ethiodized Oil ↔ Pulmonary EmbolismCausality: well establishedn=48 co-reports · PRR 8.2 · ROR 8.5
• Etoposide ↔ Febrile neutropeniaExpected pharmacological effectn=7,715 co-reports · PRR 37.8 · ROR 42.1
• Exenatide ↔ PancreatitisCausality: well establishedn=2,012 co-reports · PRR 15.8 · ROR 16.4
• Fam-Trastuzumab Deruxtecan-Nxki ↔ Interstitial Lung DiseaseCausality: well establishedn=1,020 co-reports · PRR 45.1 · ROR 50.1
• Febuxostat ↔ GoutCoding artifact: the indication reported back as the "reaction"n=698 co-reports · PRR 50.9 · ROR 53.0
• Fentanyl ↔ Drug AbuseExpected pharmacological effectn=10,770 co-reports · PRR 31.6 · ROR 35.3
• Fentanyl (opioids) ↔ Respiratory depressionExpected pharmacological effectn=920 co-reports · PRR 17.3 · ROR 17.5
• Finasteride ↔ Sexual dysfunctionCausality: well establishedn=2,398 co-reports · PRR 90.4 · ROR 94.1
• Fingolimod ↔ BradycardiaExpected pharmacological effectn=34 co-reports · PRR 3.0 · ROR 3.1
• Flecainide ↔ ProarrhythmiaCausality: well establishedn=99 co-reports · PRR 8.3 · ROR 8.5
• Fluconazole ↔ QT prolongation / torsadesCausality: well establishedn=568 co-reports · PRR 4.8 · ROR 4.8
• Fluorouracil ↔ NeutropeniaExpected pharmacological effectn=5,175 co-reports · PRR 10.8 · ROR 11.5
• Fluoxetine ↔ Serotonin syndromeCausality: well establishedn=1,720 co-reports · PRR 31.2 · ROR 32.0
• Fluoxetine Hydrochloride ↔ Suicidal IdeationExpected pharmacological effectn=3,701 co-reports · PRR 6.9 · ROR 7.1
• Flurazepam Hydrochloride ↔ Drug AbuseExpected pharmacological effectn=65 co-reports · PRR 41.3 · ROR 49.2
• Flutamide ↔ Hepatic function abnormalCausality: well establishedn=24 co-reports · PRR 13.8 · ROR 14.1
• Fluvoxamine ↔ Serotonin syndromeCausality: well establishedn=81 co-reports · PRR 37.3 · ROR 38.6
• Fondaparinux ↔ ThrombocytopeniaCausality: well establishedn=263 co-reports · PRR 6.2 · ROR 6.3
• Fosphenytoin ↔ HypotensionExpected pharmacological effectn=114 co-reports · PRR 4.7 · ROR 4.8
• Furosemide (loop diuretics) ↔ HypokalaemiaExpected pharmacological effectn=5,325 co-reports · PRR 6.8 · ROR 6.9
• Ganciclovir ↔ NeutropeniaExpected pharmacological effectn=531 co-reports · PRR 8.1 · ROR 8.5
• Ganciclovir ↔ Neutropenia / bone-marrow suppressionExpected pharmacological effectn=531 co-reports · PRR 8.1 · ROR 8.5
• Gentamicin ↔ OtotoxicityCausality: well establishedn=94 co-reports · PRR 86.1 · ROR 86.7
• Gentamicin (aminoglycosides) ↔ Ototoxicity (hearing/balance)Causality: well establishedn=94 co-reports · PRR 86.1 · ROR 86.7
• Gentamicin Sulfate ↔ Renal FailureCausality: well establishedn=705 co-reports · PRR 7.1 · ROR 7.4
• Glipizide (sulfonylureas) ↔ HypoglycaemiaExpected pharmacological effectn=1,332 co-reports · PRR 9.7 · ROR 9.9
• Glofitamab ↔ Cytokine Release SyndromeCausality: well establishedn=747 co-reports · PRR 359.2 · ROR 522.7
• Golimumab ↔ Rheumatoid ArthritisCoding artifact: the indication reported back as the "reaction"n=14,419 co-reports · PRR 35.9 · ROR 43.0
• Haloperidol ↔ HyperprolactinaemiaExpected pharmacological effectn=255 co-reports · PRR 35.4 · ROR 35.8
• Haloperidol ↔ Neuroleptic malignant syndromeCausality: well establishedn=1,630 co-reports · PRR 138.0 · ROR 147.9
• Haloperidol ↔ Prolonged QT intervalCausality: well establishedn=653 co-reports · PRR 16.0 · ROR 16.4
• Haloperidol ↔ QT prolongation / torsadesCausality: well establishedn=653 co-reports · PRR 16.0 · ROR 16.4
• Haloperidol ↔ Tardive dyskinesiaCausality: well establishedn=378 co-reports · PRR 11.7 · ROR 11.8
• Haloperidol Decanoate ↔ Weight IncreasedExpected pharmacological effectn=272 co-reports · PRR 9.4 · ROR 10.3
• Heparin ↔ Heparin-induced thrombocytopenia (HIT)Causality: well establishedn=1,273 co-reports · PRR 533.2 · ROR 587.8
• Hydralazine ↔ Drug-induced lupusCausality: well establishedn=52 co-reports · PRR 11.8 · ROR 12.0
• Hydrochlorothiazide (thiazides) ↔ HyponatraemiaExpected pharmacological effectn=2,897 co-reports · PRR 7.8 · ROR 8.0
• Hydrocodone Bitartrate And Acetaminophen ↔ Drug DependenceExpected pharmacological effectn=33,295 co-reports · PRR 96.4 · ROR 236.1
• Hydromorphone ↔ Drug dependenceCausality: well establishedn=35,112 co-reports · PRR 63.1 · ROR 101.7
• Hydromorphone Hydrochloride ↔ Drug DependenceExpected pharmacological effectn=35,112 co-reports · PRR 63.1 · ROR 101.7
• Hydroxychloroquine ↔ QT prolongationCausality: well establishedn=921 co-reports · PRR 7.4 · ROR 7.5
• Hydroxychloroquine ↔ RetinopathyCausality: well establishedn=290 co-reports · PRR 23.7 · ROR 23.8
• Hydroxyurea ↔ Febrile neutropeniaExpected pharmacological effectn=426 co-reports · PRR 6.5 · ROR 6.6
• Ibuprofen (NSAIDs) ↔ Gastrointestinal bleedingCausality: well establishedn=2,645 co-reports · PRR 2.5 · ROR 2.5
• Idecabtagene Vicleucel ↔ Cytokine Release SyndromeCausality: well establishedn=696 co-reports · PRR 651.3 · ROR 1513.5
• Imatinib ↔ Fluid retention / oedemaCausality: well establishedn=287 co-reports · PRR 28.5 · ROR 29.0
• Indapamide ↔ HyponatraemiaCausality: well establishedn=1,318 co-reports · PRR 28.2 · ROR 30.4
• Infliximab ↔ Infusion Related ReactionCausality: well establishedn=19,073 co-reports · PRR 39.0 · ROR 42.7
• Infliximab (TNF inhibitors) ↔ Tuberculosis reactivationCausality: well establishedn=2,003 co-reports · PRR 17.7 · ROR 17.8
• Insulin glargine ↔ Hypoglycaemia (blood glucose decreased)Expected pharmacological effectn=10,511 co-reports · PRR 23.6 · ROR 24.7
• Interferon beta-1a ↔ Influenza-like illnessExpected pharmacological effectn=13,251 co-reports · PRR 20.7 · ROR 22.2
• Iodixanol ↔ Contrast-induced nephropathyExpected pharmacological effectn=40 co-reports · PRR 21.5 · ROR 21.7
• Ipilimumab (checkpoint inhibitors) ↔ Immune-mediated colitisCausality: well establishedn=2,316 co-reports · PRR 32.0 · ROR 33.7
• Irinotecan ↔ DiarrhoeaExpected pharmacological effectn=1,721 co-reports · PRR 4.4 · ROR 4.9
• Irinotecan Hydrochloride ↔ MyelosuppressionCoding artifact: the indication reported back as the "reaction"n=686 co-reports · PRR 33.7 · ROR 35.6
• Isoniazid ↔ Drug-induced liver injuryCausality: well establishedn=862 co-reports · PRR 37.4 · ROR 39.5
• Isoniazid ↔ Peripheral neuropathyCausality: well establishedn=227 co-reports · PRR 3.1 · ROR 3.2
• Isotretinoin ↔ Inflammatory bowel diseaseContested: signal not confirmed by large randomized trialsn=5,252 co-reports · PRR 494.6 · ROR 553.6
• Isotretinoin (Accutane) ↔ Depression / suicidal ideationContested / confounded by indicationDepression: n=5,803 · PRR 11.1 · ROR 12.4
• Itraconazole ↔ Heart failureCausality: well establishedn=153 co-reports · PRR 3.4 · ROR 3.5
• Ivabradine ↔ BradycardiaCausality: well establishedn=256 co-reports · PRR 14.9 · ROR 15.4
• Ivermectin ↔ NeurotoxicityCausality: well establishedn=246 co-reports · PRR 17.3 · ROR 17.9
• Ketamine ↔ CystitisCausality: well establishedn=83 co-reports · PRR 11.3 · ROR 11.4
• Ketoconazole ↔ HepatotoxicityCausality: well establishedn=64 co-reports · PRR 3.5 · ROR 3.5
• Ketoconazole (oral) ↔ HepatotoxicityCausality: well establishedn=64 co-reports · PRR 3.5 · ROR 3.5
• Ketorolac Tromethamine ↔ Drug HypersensitivityCausality: well establishedn=329 co-reports · PRR 6.4 · ROR 6.7
• Lacosamide ↔ BradycardiaExpected pharmacological effectn=402 co-reports · PRR 4.3 · ROR 4.4
• Lamotrigine ↔ Stevens-Johnson syndromeCausality: well establishedn=2,615 co-reports · PRR 21.2 · ROR 21.6
• Lamotrigine ↔ Stevens–Johnson syndrome / toxic epidermal necrolysisCausality: well establishedn=2,615 co-reports · PRR 21.2 · ROR 21.6
• Leflunomide ↔ HepatotoxicityCausality: well establishedn=1,297 co-reports · PRR 10.7 · ROR 10.8
• Leflunomide ↔ Interstitial lung diseaseCausality: well establishedn=1,346 co-reports · PRR 5.7 · ROR 5.8
• Lenalidomide ↔ Deep vein thrombosisCausality: well establishedn=4,404 co-reports · PRR 3.5 · ROR 3.6
• Lenalidomide (IMiDs) ↔ Venous thromboembolismCausality: well establishedn=7,546 co-reports · PRR 5.1 · ROR 5.1
• Levodopa ↔ DyskinesiaCausality: well establishedn=760 co-reports · PRR 33.3 · ROR 35.5
• Levodopa ↔ HallucinationExpected pharmacological effectn=656 co-reports · PRR 15.4 · ROR 16.2
• Levofloxacin (fluoroquinolones) ↔ Aortic aneurysm / dissectionCausality: well establishedn=113 co-reports · PRR 5.2 · ROR 5.2
• Linagliptin ↔ PancreatitisCausality: well establishedn=331 co-reports · PRR 7.3 · ROR 7.4
• Linezolid ↔ Lactic acidosisExpected pharmacological effectn=1,018 co-reports · PRR 23.2 · ROR 24.0
• Linezolid ↔ Serotonin syndromeCausality: well establishedn=917 co-reports · PRR 35.6 · ROR 36.8
• Linezolid ↔ ThrombocytopeniaCausality: well establishedn=2,199 co-reports · PRR 14.2 · ROR 15.3
• Liraglutide ↔ Impaired gastric emptyingExpected pharmacological effectn=592 co-reports · PRR 20.7 · ROR 21.0
• Lisinopril (ACE inhibitors) ↔ AngioedemaCausality: well establishedn=6,693 co-reports · PRR 12.2 · ROR 12.4
• Lisocabtagene Maraleucel ↔ Cytokine Release SyndromeCausality: well establishedn=352 co-reports · PRR 466.6 · ROR 798.3
• Lithium ↔ HypothyroidismCausality: well establishedn=224 co-reports · PRR 5.9 · ROR 6.0
• Lithium ↔ HypothyroidismCausality: well establishedn=224 co-reports · PRR 5.9 · ROR 6.0
• Lithium ↔ Nephrogenic diabetes insipidusCausality: well establishedn=304 co-reports · PRR 301.3 · ROR 305.0
• Lithium ↔ Nephrogenic diabetes insipidusCausality: well establishedn=304 co-reports · PRR 301.3 · ROR 305.0
• Lithium ↔ TremorCausality: well establishedn=1,509 co-reports · PRR 7.7 · ROR 8.1
• Lomustine ↔ ThrombocytopeniaCoding artifact: the indication reported back as the "reaction"n=180 co-reports · PRR 13.4 · ROR 14.3
• Loperamide ↔ QT prolongationContested: signal not confirmed by large randomized trialsn=274 co-reports · PRR 3.6 · ROR 3.6
• Losartan ↔ Renal failureExpected pharmacological effectn=3,053 co-reports · PRR 2.8 · ROR 2.8
• Mannitol ↔ Renal failureExpected pharmacological effectn=592 co-reports · PRR 19.0 · ROR 21.4
• Medroxyprogesterone Acetate ↔ Breast Cancer FemaleCausality: well establishedn=9,771 co-reports · PRR 242.8 · ROR 302.2
• Medroxyprogesterone acetate ↔ MeningiomaEmerging: progestogen class effect, under reviewn=11,275 co-reports · PRR 1,443.2 · ROR 1,868.2
• Memantine ↔ Confusional stateExpected pharmacological effectn=739 co-reports · PRR 7.1 · ROR 7.4
• Meperidine ↔ ConvulsionCausality: well establishedn=77 co-reports · PRR 3.0 · ROR 3.1
• Mesalamine ↔ PancreatitisCausality: well establishedn=636 co-reports · PRR 4.6 · ROR 4.6
• Metformin ↔ Lactic acidosisCausality: well establishedn=17,141 co-reports · PRR 67.6 · ROR 71.0
• Metformin ↔ Vitamin B12 deficiencyCausality: well establishedn=630 co-reports · PRR 10.8 · ROR 10.8
• Metformin Hydrochloride ↔ Lactic AcidosisCausality: well establishedn=4,538 co-reports · PRR 58.7 · ROR 63.5
• Methadone ↔ QT prolongation / torsadesCausality: well establishedn=862 co-reports · PRR 12.1 · ROR 12.3
• Methamphetamine Hydrochloride ↔ Drug AbuseExpected pharmacological effectn=238 co-reports · PRR 55.7 · ROR 71.3
• Methimazole ↔ AgranulocytosisCausality: well establishedn=259 co-reports · PRR 38.2 · ROR 39.4
• Methimazole ↔ AgranulocytosisCausality: well establishedn=259 co-reports · PRR 38.2 · ROR 39.4
• Methotrexate ↔ HepatotoxicityCausality: well establishedn=2,128 co-reports · PRR 5.2 · ROR 5.2
• Methotrexate ↔ PancytopeniaExpected pharmacological effectn=5,955 co-reports · PRR 5.9 · ROR 6.0
• Methotrexate ↔ Pneumonitis / pulmonary fibrosisCausality: well establishedn=3,464 co-reports · PRR 10.9 · ROR 11.0
• Methotrexate Sodium ↔ Rheumatoid ArthritisCoding artifact: the indication reported back as the "reaction"n=42,466 co-reports · PRR 25.7 · ROR 28.1
• Methyldopa ↔ Drug-induced liver injuryCausality: well establishedn=75 co-reports · PRR 10.6 · ROR 10.7
• Methylene Blue ↔ Serotonin SyndromeCausality: well establishedn=469 co-reports · PRR 340.1 · ROR 487.2
• Methylphenidate ↔ Hallucination, visualCausality: well establishedn=117 co-reports · PRR 4.1 · ROR 4.1
• Metoclopramide ↔ Tardive dyskinesiaCausality: well establishedn=13,206 co-reports · PRR 335.0 · ROR 441.6
• Metoclopramide ↔ Tardive dyskinesiaCausality: well establishedn=13,206 co-reports · PRR 335.0 · ROR 441.6
• Metoclopramide Hydrochloride ↔ Tardive DyskinesiaCausality: well establishedn=16,218 co-reports · PRR 366.3 · ROR 464.3
• Metronidazole ↔ Drug HypersensitivityCausality: well establishedn=3,150 co-reports · PRR 5.4 · ROR 5.7
• Metronidazole ↔ Peripheral neuropathyCausality: well establishedn=899 co-reports · PRR 3.2 · ROR 3.2
• Minocycline ↔ DRESS (eosinophilia and systemic symptoms)Causality: well establishedn=279 co-reports · PRR 20.0 · ROR 20.4
• Minocycline ↔ Drug-induced lupusCausality: well establishedn=569 co-reports · PRR 29.6 · ROR 31.0
• Minocycline ↔ Skin hyperpigmentationCausality: well establishedn=188 co-reports · PRR 40.6 · ROR 41.2
• Minoxidil (oral) ↔ Pericardial effusionCausality: well establishedn=142 co-reports · PRR 2.9 · ROR 2.9
• Mirtazapine ↔ Suicidal IdeationExpected pharmacological effectn=2,410 co-reports · PRR 6.2 · ROR 6.3
• Misoprostol ↔ Abortion IncompleteCausality: well establishedn=1,159 co-reports · PRR 3517.3 · ROR 3995.5
• Mitotane ↔ Adrenal InsufficiencyCausality: well establishedn=132 co-reports · PRR 131.2 · ROR 141.6
• Modafinil ↔ Suicidal ideationContested: signal not confirmed by large randomized trialsn=654 co-reports · PRR 4.7 · ROR 4.8
• Montelukast ↔ Neuropsychiatric eventsCausality: well establishedn=2,210 co-reports · PRR 27.3 · ROR 27.8
• Montelukast Sodium ↔ AsthmaCoding artifact: the indication reported back as the "reaction"n=14,958 co-reports · PRR 26.6 · ROR 30.2
• Morphine (opioids) ↔ Overdose / respiratory depressionCausality: well establishedn=23,522 co-reports · PRR 21.1 · ROR 26.0
• Mosunetuzumab ↔ Cytokine Release SyndromeCausality: well establishedn=213 co-reports · PRR 258.8 · ROR 336.9
• Mycophenolate Mofetil Hydrochloride ↔ Cytomegalovirus InfectionCausality: well establishedn=4,935 co-reports · PRR 65.3 · ROR 67.8
• Naltrexone ↔ Drug withdrawal syndromeCausality: well establishedn=595 co-reports · PRR 9.8 · ROR 9.9
• Natalizumab ↔ Progressive multifocal leukoencephalopathyCausality: well establishedn=2,127 co-reports · PRR 40.1 · ROR 40.6
• Nevirapine ↔ HepatotoxicityCausality: well establishedn=170 co-reports · PRR 18.1 · ROR 18.4
• Nevirapine ↔ HepatotoxicityCausality: well establishedn=170 co-reports · PRR 18.1 · ROR 18.4
• Nevirapine ↔ Stevens-Johnson syndromeCausality: well establishedn=192 co-reports · PRR 20.3 · ROR 20.7
• Nifedipine (dihydropyridine CCBs) ↔ Peripheral oedemaExpected pharmacological effectn=1,063 co-reports · PRR 3.9 · ROR 4.0
• Nirmatrelvir And Ritonavir ↔ Covid-19Coding artifact: the indication reported back as the "reaction"n=— co-reports · PRR — · ROR —
• Nirmatrelvir/ritonavir (Paxlovid) ↔ COVID-19 recurrence ("Paxlovid rebound")Causality: well establishedDisease recurrence: n=20,103 · PRR 285.7 · ROR 455.4
• Nitrofurantoin ↔ Peripheral neuropathyCausality: well establishedn=207 co-reports · PRR 2.8 · ROR 2.8
• Nitrofurantoin ↔ Pulmonary fibrosis / interstitial lung diseaseCausality: well establishedn=147 co-reports · PRR 9.9 · ROR 10.0
• Nitroglycerin ↔ HypotensionExpected pharmacological effectn=2,299 co-reports · PRR 4.6 · ROR 4.7
• Nivolumab (checkpoint inhibitors) ↔ Immune-mediated colitisCausality: well establishedn=2,268 co-reports · PRR 13.9 · ROR 14.2
• Nortriptyline ↔ QT prolongationExpected pharmacological effectn=24 co-reports · PRR 2.4 · ROR 2.4
• Octreotide ↔ CholelithiasisExpected pharmacological effectn=68 co-reports · PRR 7.8 · ROR 7.9
• Octreotide (somatostatin analogues) ↔ Gallstones (cholelithiasis)Causality: well establishedn=68 co-reports · PRR 7.8 · ROR 7.9
• Olanzapine ↔ Diabetes mellitusExpected pharmacological effectn=5,404 co-reports · PRR 14.8 · ROR 15.6
• Olanzapine ↔ Weight gainExpected pharmacological effectn=6,832 co-reports · PRR 6.2 · ROR 6.5
• Olanzapine (antipsychotics) ↔ Weight gain / metabolic syndromeExpected pharmacological effectn=6,832 co-reports · PRR 6.2 · ROR 6.5
• Omeprazole (proton-pump inhibitors) ↔ Chronic kidney diseaseContested: signal present, magnitude disputedn=36,748 co-reports · PRR 43.0 · ROR 46.8
• Onabotulinumtoxina ↔ Product Preparation ErrorCausality: well establishedn=3,647 co-reports · PRR 58.4 · ROR 61.2
• Ondansetron ↔ Prolonged QT intervalCausality: well establishedn=1,167 co-reports · PRR 6.4 · ROR 6.5
• Ondansetron (5-HT3 antagonists) ↔ QT prolongation / torsadesCausality: well establishedn=1,167 co-reports · PRR 6.4 · ROR 6.5
• Oseltamivir ↔ Neuropsychiatric eventsContested: signal not confirmed by large randomized trialsn=66 co-reports · PRR 5.1 · ROR 5.1
• Oxaliplatin ↔ Peripheral neuropathyCausality: well establishedn=4,317 co-reports · PRR 13.6 · ROR 14.3
• Oxazepam ↔ Drug AbuseExpected pharmacological effectn=1,522 co-reports · PRR 18.2 · ROR 19.5
• Oxcarbazepine ↔ HyponatraemiaCausality: well establishedn=1,305 co-reports · PRR 15.4 · ROR 16.0
• Oxycodone ↔ Drug dependence / withdrawal syndromeCausality: well establishedDrug dependence: n=100,436 · PRR 158.4 · ROR 295.3
• Oxycodone Hydrochloride ↔ Drug DependenceExpected pharmacological effectn=100,436 co-reports · PRR 158.4 · ROR 295.3
• Oxymorphone Hydrochloride ↔ DependenceExpected pharmacological effectn=4,904 co-reports · PRR 175.2 · ROR 302.9
• Paclitaxel ↔ Peripheral neuropathyCausality: well establishedn=3,933 co-reports · PRR 9.2 · ROR 9.5
• Paroxetine (SSRIs) ↔ Discontinuation (withdrawal) syndromeCausality: well establishedn=554 co-reports · PRR 3.9 · ROR 3.9
• Pembrolizumab (checkpoint inhibitors) ↔ HypothyroidismCausality: well establishedn=2,917 co-reports · PRR 20.1 · ROR 20.7
• Penicillamine ↔ ProteinuriaCausality: well establishedn=65 co-reports · PRR 78.6 · ROR 84.5
• Penicillamine ↔ Proteinuria / membranous nephropathyCausality: well establishedn=65 co-reports · PRR 78.6 · ROR 84.5
• Perampanel ↔ AggressionExpected pharmacological effectn=499 co-reports · PRR 28.0 · ROR 29.9
• Perphenazine ↔ Weight IncreasedExpected pharmacological effectn=224 co-reports · PRR 10.2 · ROR 11.3
• Phenelzine ↔ Serotonin syndromeCausality: well establishedn=36 co-reports · PRR 25.3 · ROR 25.9
• Phenelzine Sulfate ↔ Weight IncreasedExpected pharmacological effectn=122 co-reports · PRR 7.4 · ROR 7.9
• Phenobarbital ↔ Stevens-Johnson syndromeCausality: well establishedn=88 co-reports · PRR 5.8 · ROR 5.8
• Phentermine ↔ TachycardiaExpected pharmacological effectn=21 co-reports · PRR 4.9 · ROR 4.9
• Phenytoin ↔ Gingival hypertrophyCausality: well establishedn=85 co-reports · PRR 60.6 · ROR 60.9
• Phenytoin ↔ Stevens-Johnson syndromeCausality: well establishedn=771 co-reports · PRR 36.2 · ROR 37.6
• Phenytoin ↔ Stevens–Johnson syndrome / TENCausality: well establishedn=771 co-reports · PRR 36.2 · ROR 37.6
• Pimavanserin Tartrate ↔ HallucinationCausality: well establishedn=12,702 co-reports · PRR 77.8 · ROR 100.9
• Pimozide ↔ Prolonged QT intervalCausality: well establishedn=23 co-reports · PRR 28.5 · ROR 29.9
• Pioglitazone ↔ Bladder cancerContested: label-warned, evidence disputedn=8,739 co-reports · PRR 83.9 · ROR 105.0
• Pioglitazone ↔ Fracture (ankle)Causality: well establishedn=94 co-reports · PRR 3.0 · ROR 3.0
• Pioglitazone ↔ Oedema peripheralExpected pharmacological effectn=1,008 co-reports · PRR 4.0 · ROR 4.1
• Pioglitazone Hydrochloride ↔ Cardiac FailureCausality: well establishedn=37 co-reports · PRR 7.8 · ROR 8.0
• Polymyxin B Sulfate ↔ Drug HypersensitivityCausality: well establishedn=250 co-reports · PRR 17.3 · ROR 20.4
• Pomalidomide ↔ Plasma Cell MyelomaCausality: well establishedn=8,060 co-reports · PRR 53.2 · ROR 57.7
• Pramipexole ↔ HypersexualityExpected pharmacological effectn=115 co-reports · PRR 92.0 · ROR 92.7
• Pramipexole ↔ SomnolenceCausality: well establishedn=557 co-reports · PRR 3.8 · ROR 3.9
• Pramipexole (dopamine agonists) ↔ Impulse-control disorderCausality: well establishedn=195 co-reports · PRR 144.0 · ROR 145.8
• Pregabalin ↔ Oedema peripheralExpected pharmacological effectn=5,399 co-reports · PRR 3.5 · ROR 3.6
• Propofol ↔ Infusion syndromeCausality: well establishedn=910 co-reports · PRR 12.9 · ROR 13.2
• Propranolol (beta-blockers) ↔ Bradycardia / bronchospasmExpected pharmacological effectn=1,448 co-reports · PRR 8.2 · ROR 8.3
• Propylthiouracil ↔ AgranulocytosisCausality: well establishedn=60 co-reports · PRR 33.3 · ROR 34.3
• Propylthiouracil ↔ Hepatotoxicity / acute liver failureCausality: well establishedn=46 co-reports · PRR 34.7 · ROR 35.5
• Pyrazinamide ↔ Drug-induced liver injuryCausality: well establishedn=655 co-reports · PRR 48.7 · ROR 52.3
• Quetiapine ↔ HypotensionExpected pharmacological effectn=4,265 co-reports · PRR 2.4 · ROR 2.4
• Quetiapine (antipsychotics) ↔ Diabetes mellitusCausality: well establishedn=8,357 co-reports · PRR 13.3 · ROR 13.9
• Quetiapine Fumarate ↔ Weight IncreasedExpected pharmacological effectn=2,075 co-reports · PRR 6.7 · ROR 7.1
• Quinine ↔ ThrombocytopeniaCausality: well establishedn=172 co-reports · PRR 3.8 · ROR 3.9
• Quinine Sulfate ↔ Renal FailureCausality: well establishedn=179 co-reports · PRR 7.9 · ROR 8.3
• Ranitidine (Zantac) ↔ Cancer (breast, prostate, bladder, colorectal, renal)Causality: well establishedBreast cancer: n=24,854 · PRR 37.9
• Ranolazine ↔ QT prolongationCausality: well establishedn=99 co-reports · PRR 5.6 · ROR 5.6
• Ribavirin ↔ Haemolytic anaemiaExpected pharmacological effectn=8,367 co-reports · PRR 15.0 · ROR 17.1
• Ribavirin ↔ Haemolytic anaemiaExpected pharmacological effectn=339 co-reports · PRR 12.8 · ROR 12.9
• Rifampicin ↔ Drug-induced liver injuryCausality: well establishedn=346 co-reports · PRR 16.4 · ROR 16.8
• Riociguat ↔ HypotensionExpected pharmacological effectn=3,401 co-reports · PRR 11.2 · ROR 12.4
• Risperidone ↔ GynaecomastiaCausality: well establishedn=24,650 · PRR 614.0 · ROR 754.5
• Risperidone ↔ Neuroleptic malignant syndromeCausality: well establishedn=2,246 co-reports · PRR 36.8 · ROR 37.4
• Risperidone ↔ Weight gainCausality: well establishedn=9,452 co-reports · PRR 513.3 · ROR 552.8
• Rituximab ↔ Progressive multifocal leukoencephalopathyCausality: well establishedn=1,797 co-reports · PRR 27.6 · ROR 27.8
• Rituximab ↔ Serious infectionCausality: well establishedn=11,043 co-reports · PRR 8.2 · ROR 8.6
• Rivaroxaban ↔ Gastrointestinal bleedingCausality: well establishedn=21,636 co-reports · PRR 34.9 · ROR 38.9
• Rivaroxaban ↔ Gastrointestinal HaemorrhageCausality: well establishedn=21,636 co-reports · PRR 34.9 · ROR 38.9
• Rivastigmine ↔ VomitingExpected pharmacological effectn=907 co-reports · PRR 2.2 · ROR 2.2
• Ropinirole ↔ HallucinationExpected pharmacological effectn=747 co-reports · PRR 13.8 · ROR 14.5
• Ropinirole (dopamine agonists) ↔ Impulse-control disorderCausality: well establishedn=92 co-reports · PRR 64.2 · ROR 64.6
• Rufinamide ↔ ConvulsionCausality: well establishedn=76 co-reports · PRR 10.7 · ROR 11.0
• Sacituzumab Govitecan ↔ NeutropeniaCoding artifact: the indication reported back as the "reaction"n=510 co-reports · PRR 17.5 · ROR 19.6
• Salmeterol Xinafoate ↔ AsthmaCoding artifact: the indication reported back as the "reaction"n=910 co-reports · PRR 20.0 · ROR 22.3
• Semaglutide ↔ Impaired gastric emptyingExpected pharmacological effectn=3,558 co-reports · PRR 111.3 · ROR 117.0
• Sertraline (SSRIs) ↔ Upper gastrointestinal bleedingCausality: well establishedn=361 co-reports · PRR 3.9 · ROR 3.9
• Sertraline Hydrochloride ↔ Suicidal IdeationExpected pharmacological effectn=2,770 co-reports · PRR 5.5 · ROR 5.6
• Sildenafil (PDE5 inhibitors) ↔ Non-arteritic anterior ischaemic optic neuropathy (NAION)Causality: well establishedn=90 co-reports · PRR 9.4 · ROR 9.4
• Simvastatin (statins) ↔ RhabdomyolysisCausality: well establishedn=5,389 co-reports · PRR 12.4 · ROR 12.7
• Sirolimus ↔ Interstitial lung diseaseCausality: well establishedn=92 co-reports · PRR 3.0 · ROR 3.0
• Sitagliptin ↔ Pancreatic cancerContested: signal not confirmed by large randomized trialsn=1,670 co-reports · PRR 17.8 · ROR 18.2
• Sitagliptin (DPP-4 inhibitors) ↔ PancreatitisContested: signal not confirmed by large randomized trialsn=2,226 co-reports · PRR 12.8 · ROR 13.2
• Sofosbuvir ↔ Hepatitis CCoding artifact: the indication reported back as the "reaction"n=1,736 co-reports · PRR 177.3 · ROR 194.4
• Sofosbuvir, Velpatasvir, And Voxilaprevir ↔ Hepatitis CCoding artifact: the indication reported back as the "reaction"n=91 co-reports · PRR 145.2 · ROR 158.4
• Sorafenib ↔ HypertensionExpected pharmacological effectn=1,148 co-reports · PRR 5.5 · ROR 5.8
• Sotalol ↔ Prolonged QT intervalCausality: well establishedn=446 co-reports · PRR 15.9 · ROR 16.3
• Sotalol ↔ QT prolongation / torsadesCausality: well establishedn=446 co-reports · PRR 15.9 · ROR 16.3
• Spironolactone ↔ HyperkalaemiaExpected pharmacological effectn=5,027 co-reports · PRR 25.1 · ROR 26.0
• Stiripentol ↔ SomnolenceExpected pharmacological effectn=230 co-reports · PRR 11.2 · ROR 12.4
• Tacrolimus ↔ Acute kidney injuryExpected pharmacological effectn=6,153 co-reports · PRR 5.6 · ROR 5.8
• Tacrolimus ↔ NephrotoxicityCausality: well establishedn=6,153 co-reports · PRR 5.6 · ROR 5.8
• Talquetamab ↔ Cytokine Release SyndromeCausality: well establishedn=489 co-reports · PRR 270.0 · ROR 354.5
• Tamoxifen ↔ Venous thromboembolismCausality: well establishedn=112 co-reports · PRR 4.3 · ROR 4.4
• Tapentadol Hydrochloride ↔ Drug AbuseExpected pharmacological effectn=1,552 co-reports · PRR 11.9 · ROR 12.4
• Tebentafusp ↔ Cytokine Release SyndromeCausality: well establishedn=115 co-reports · PRR 219.1 · ROR 273.0
• Teclistamab-Cqyv ↔ Cytokine Release SyndromeCausality: well establishedn=508 co-reports · PRR 271.1 · ROR 356.3
• Temazepam ↔ Drug AbuseExpected pharmacological effectn=859 co-reports · PRR 5.8 · ROR 5.9
• Temozolomide ↔ ThrombocytopeniaExpected pharmacological effectn=1,572 co-reports · PRR 14.3 · ROR 15.4
• Tenofovir Disoproxil Fumarate ↔ Bone Density DecreasedCausality: well establishedn=10,686 co-reports · PRR 326.5 · ROR 483.4
• Tenofovir disoproxil fumarate ↔ Bone lossCausality: well establishedn=7,079 co-reports · PRR 563.0 · ROR 717.3
• Terbinafine ↔ Hepatic enzyme increasedCausality: well establishedn=62 co-reports · PRR 2.7 · ROR 2.7
• Terbinafine ↔ Taste disturbance (ageusia/dysgeusia)Causality: well establishedn=273 co-reports · PRR 32.5 · ROR 33.7
• Teriparatide ↔ HypercalcaemiaExpected pharmacological effectn=551 co-reports · PRR 8.7 · ROR 8.7
• Testosterone Undecanoate ↔ CoughCausality: well establishedn=153 co-reports · PRR 6.0 · ROR 6.4
• Thalidomide ↔ Abnormal/increased blood hCGMonitoring-protocol artifact, not a drug effecthCG increased: n=113 · PRR 633.2
• Thalidomide ↔ Peripheral neuropathyCausality: well establishedn=1,823 co-reports · PRR 11.3 · ROR 11.8
• Ticagrelor ↔ DyspnoeaCausality: well establishedn=4,009 co-reports · PRR 4.7 · ROR 5.3
• Tisagenlecleucel ↔ Cytokine Release SyndromeCausality: well establishedn=1,757 co-reports · PRR 467.9 · ROR 760.9
• Tizanidine ↔ HypotensionExpected pharmacological effectn=509 co-reports · PRR 2.2 · ROR 2.3
• TNF-inhibitors (adalimumab) ↔ Drug-induced lupusCausality: well establishedAdalimumab ↔ Systemic lupus erythematosus: n=13,702 · PRR 18.4
• Tocilizumab ↔ Gastrointestinal perforationExpected pharmacological effectn=5,011 co-reports · PRR 406.8 · ROR 425.5
• Tocilizumab ↔ Rheumatoid ArthritisCoding artifact: the indication reported back as the "reaction"n=22,731 co-reports · PRR 46.4 · ROR 57.8
• Tofacitinib ↔ ArthralgiaCausality: well establishedn=19,961 co-reports · PRR 5.7 · ROR 6.3
• Topiramate ↔ Acute angle-closure glaucomaCausality: well establishedn=597 co-reports · PRR 68.7 · ROR 69.2
• Topiramate ↔ Metabolic acidosisCausality: well establishedn=638 co-reports · PRR 4.6 · ROR 4.7
• Topiramate ↔ NephrolithiasisExpected pharmacological effectn=1,504 co-reports · PRR 7.7 · ROR 7.8
• Topotecan ↔ NeutropeniaCoding artifact: the indication reported back as the "reaction"n=484 co-reports · PRR 12.4 · ROR 13.4
• Tramadol ↔ SeizuresCausality: well establishedn=467 co-reports · PRR 2.3 · ROR 2.3
• Tramadol ↔ Serotonin syndromeCausality: well establishedn=624 co-reports · PRR 18.9 · ROR 19.2
• Tramadol Hydrochloride ↔ DependenceExpected pharmacological effectn=7,827 co-reports · PRR 91.9 · ROR 116.0
• Trastuzumab ↔ Cardiotoxicity / heart failureCausality: well establishedn=1,080 co-reports · PRR 4.2 · ROR 4.2
• Trastuzumab ↔ Ejection fraction decreasedCausality: well establishedn=2,048 co-reports · PRR 46.5 · ROR 47.9
• Trazodone ↔ PriapismCausality: well establishedn=34 co-reports · PRR 13.3 · ROR 13.4
• Treprostinil ↔ HeadacheExpected pharmacological effectn=17,283 co-reports · PRR 4.7 · ROR 5.3
• Triazolam ↔ Drug AbuseExpected pharmacological effectn=336 co-reports · PRR 21.2 · ROR 23.1
• Trihexyphenidyl ↔ HallucinationExpected pharmacological effectn=36 co-reports · PRR 10.1 · ROR 10.5
• Trimethoprim (and co-trimoxazole) ↔ HyperkalaemiaCausality: well establishedn=213 co-reports · PRR 11.0 · ROR 11.2
• Ursodiol ↔ PruritusExpected pharmacological effectn=1,299 co-reports · PRR 3.3 · ROR 3.5
• Valacyclovir ↔ Acute kidney injuryExpected pharmacological effectn=1,170 co-reports · PRR 3.9 · ROR 4.0
• Valproate ↔ Acute pancreatitisCausality: well establishedn=120 co-reports · PRR 5.5 · ROR 5.5
• Valproate ↔ HepatotoxicityCausality: well establishedn=175 co-reports · PRR 5.3 · ROR 5.3
• Valproate ↔ HepatotoxicityCausality: well establishedn=65 co-reports · PRR 3.0 · ROR 3.0
• Valproate ↔ HyperammonaemiaCausality: well establishedn=298 co-reports · PRR 64.7 · ROR 65.7
• Valproate ↔ Hyperammonaemia / encephalopathyExpected pharmacological effectn=624 co-reports · PRR 95.6 · ROR 97.5
• Valproate ↔ ThrombocytopeniaCausality: well establishedn=455 co-reports · PRR 4.2 · ROR 4.2
• Valsartan ↔ Acute kidney injuryExpected pharmacological effectn=3,260 co-reports · PRR 4.4 · ROR 4.5
• Vancomycin ↔ Acute kidney injuryCausality: well establishedn=4,892 co-reports · PRR 10.6 · ROR 11.4
• Vancomycin ↔ DRESS (eosinophilia and systemic symptoms)Causality: well establishedn=2,386 co-reports · PRR 37.5 · ROR 39.1
• Vancomycin ↔ NeutropeniaCausality: well establishedn=1,361 co-reports · PRR 3.7 · ROR 3.8
• Varenicline ↔ NauseaExpected pharmacological effectn=582 co-reports · PRR 2.6 · ROR 2.7
• Varenicline (Chantix) ↔ Suicidal ideation / depressionSignal detected, later overturned by randomized trialSuicidal ideation: n=218 · PRR 8.3 · ROR 8.5
• Venlafaxine (serotonergic antidepressants) ↔ Serotonin syndromeCausality: well establishedn=2,520 co-reports · PRR 24.1 · ROR 24.5
• Venlafaxine Hydrochloride ↔ Suicidal IdeationExpected pharmacological effectn=4,167 co-reports · PRR 7.5 · ROR 7.8
• Verapamil (non-dihydropyridine CCBs) ↔ Bradycardia / AV blockExpected pharmacological effectn=213 co-reports · PRR 19.9 · ROR 20.9
• Vigabatrin ↔ Visual field defectCausality: well establishedn=141 co-reports · PRR 28.8 · ROR 29.1
• Vincristine ↔ Peripheral neuropathyCausality: well establishedn=645 co-reports · PRR 4.9 · ROR 5.0
• Vincristine (vinca alkaloids) ↔ Peripheral neuropathyCausality: well establishedn=645 co-reports · PRR 4.9 · ROR 5.0
• Voriconazole ↔ HallucinationExpected pharmacological effectn=704 co-reports · PRR 6.6 · ROR 6.7
• Vortioxetine ↔ Suicidal IdeationExpected pharmacological effectn=942 co-reports · PRR 12.9 · ROR 13.6
• Warfarin ↔ INR increasedMonitoring-protocol artifact, not a drug effectn=10,358 co-reports · PRR 93.4 · ROR 101.7
• Warfarin ↔ Skin necrosisCausality: well establishedn=345 co-reports · PRR 11.7 · ROR 11.7
• Warfarin ↔ Warfarin-induced skin necrosisCausality: well establishedn=345 co-reports · PRR 11.7 · ROR 11.7
• Zidovudine ↔ Anaemia / bone-marrow suppressionCausality: well establishedn=935 co-reports · PRR 7.8 · ROR 8.3
• Ziprasidone ↔ QT prolongationCausality: well establishedn=265 co-reports · PRR 8.9 · ROR 9.0
• Ziprasidone ↔ Weight IncreasedExpected pharmacological effectn=1,180 co-reports · PRR 6.4 · ROR 6.8
• Zoledronic acid ↔ HypocalcaemiaExpected pharmacological effectn=610 co-reports · PRR 17.5 · ROR 17.8
• Zoledronic acid ↔ Osteonecrosis of the jawCausality: well establishedn=2,708 co-reports · PRR 64.0 · ROR 68.6
• Zoledronic acid (bisphosphonates) ↔ Osteonecrosis of the jawCausality: well establishedn=2,708 co-reports · PRR 64.0 · ROR 68.6
• Zolpidem ↔ AmnesiaCausality: well establishedn=2,881 co-reports · PRR 7.2 · ROR 7.3
• Zonisamide ↔ NephrolithiasisCausality: well establishedn=189 co-reports · PRR 5.9 · ROR 6.0