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Causality: well established
Causality assessment · Causality: well established
Mycophenolate Mofetil Hydrochloride and Cytomegalovirus Infection: is the FAERS signal real?
A written Bradford Hill assessment of one drug–event pair. The grade is a judgement about the signal, not a statement that this drug causes this event in any one person; FAERS counts are reports, not rates.
Mycophenolate Mofetil Hydrochloride ↔ Cytomegalovirus Infection
n=4,935 co-reports · PRR 65.3 · ROR 67.8
Docetaxel is a taxane chemotherapy agent. Myelosuppression is expected: microtubule stabilisation disrupts mitosis. 14,506 co-reports (PRR 6.8). Label carries boxed warning.
Boxed warning: docetaxel label (myelosuppression). Taxane literature.
| Bradford Hill viewpoint | Status | Note |
|---|---|---|
| Temporality (necessary) | met | Documented in label |
| Strength | met | PRR 6.8 with 14,506 co-reports |
| Consistency | met | Reproduced across taxane class |
| Specificity | partial | Specific to microtubule-stabilising agents |
| Biological gradient | met | Correlates with dose |
| Plausibility | met | Known mitotic arrest mechanism |
| Coherence | met | Coherent with pharmacology |
| Experiment | met | RCTs confirm |
| Analogy | met | Analogous to paclitaxel |
This table is this page's own qualitative read of the literature cited above, not an automated or citation-gated assessment — see the note at the bottom of this page.
✗ No ClinicalTrials.gov results-posting trial in the top search hits for Mycophenolate captured cytomegalovirus infection as a tracked adverse event in a usable structure. Myelosuppression is a standard haematological endpoint in all chemotherapy trials.