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Expected pharmacological effect
Causality assessment · Expected pharmacological effect
Oxazepam and Drug Abuse: is the FAERS signal real?
A written Bradford Hill assessment of one drug–event pair. The grade is a judgement about the signal, not a statement that this drug causes this event in any one person; FAERS counts are reports, not rates.
Oxazepam ↔ Drug Abuse
n=1,522 co-reports · PRR 18.2 · ROR 19.5
Rifampicin is a first-line antitubercular agent. Drug resistance is the expected consequence of selective pressure: M. tuberculosis rpoB mutations reduce rifampicin binding while maintaining RNA polymerase function. 100 co-reports (PRR 36.4) reflect TB-treated populations. Resistance is a known class effect documented in TB literature.
TB resistance literature: J. Infect Dis 2019, PMID: 31187644.
| Bradford Hill viewpoint | Status | Note |
|---|---|---|
| Temporality (necessary) | met | Documented in TB literature |
| Strength | met | PRR 36.4 with 100 co-reports |
| Consistency | met | Reproduced across antitubercular class |
| Specificity | partial | Specific to RNA polymerase inhibitors |
| Biological gradient | met | Resistance increases with monotherapy |
| Plausibility | met | Known rpoB mutation mechanism |
| Coherence | met | Coherent with bacterial evolution |
| Experiment | n/a | Measured in TB studies |
| Analogy | met | Other TB drugs show resistance |
This table is this page's own qualitative read of the literature cited above, not an automated or citation-gated assessment — see the note at the bottom of this page.
✗ No ClinicalTrials.gov results-posting trial in the top search hits for Oxazepam captured drug abuse as a tracked adverse event in a usable structure. Drug resistance is measured in TB surveillance studies, not RCT AE tables.