Pantoprazole vs Famotidine: side effects in FDA adverse event reports
At a glance
| Pantoprazole | Famotidine | |
|---|---|---|
| Drug class | – | Histamine-2 Receptor Antagonist |
| Brand names | – | – |
| FAERS reports | 251,540 | 116,682 |
| Serious | 83% | 64% |
| Death outcome | 28,518 | 10,682 |
| Boxed warning | No | No |
Signals both drugs share
| Reaction | Pantoprazole | Famotidine | Label screen (A / B) |
|---|---|---|---|
| End stage renal disease | 2,897 · PRR 15.4 | 2,009 · PRR 21.9 | Not in label — unassessed / Not in label — unassessed |
| Nephrogenic anaemia | 835 · PRR 17.9 | 880 · PRR 41.5 | Not in label — unassessed / Not in label — unassessed |
Labeled signals distinctive to Pantoprazole
- Glossodynia — n=3,951, PRR 17.7 Labeled (related wording)
- Sleep disorder due to general medical condition, insomnia type — n=2,489, PRR 52.3 Labeled (related wording)
- Systemic infection — n=457, PRR 31.3 Labeled (related wording)
- Subcutaneous drug absorption impaired — n=222, PRR 57.1 Labeled (related wording)
Labeled signals distinctive to Famotidine
- Acute kidney injury — n=4,727, PRR 5.7 Labeled (related wording)
- Renal failure — n=4,119, PRR 5.7 Labeled (related wording)
- Infusion site pain — n=466, PRR 6.8 Labeled (related wording)
- Infusion site pruritus — n=129, PRR 7.7 Labeled (related wording)
Common questions
Which has more reported side effects, Pantoprazole or Famotidine?
Pantoprazole has 251,540 FAERS reports and Famotidine 116,682. More reports does not mean more dangerous: volume follows how widely and how long a drug has been used, prescription vs over-the-counter status, and publicity. The seriousness share (83% vs 64%) is a better like-for-like signal of the kind of problems reported.
Which side effects do Pantoprazole and Famotidine share?
Both drugs carry disproportionality signals for end stage renal disease, nephrogenic anaemia. Shared signals often reflect a shared drug class or the condition both are used for.
Is Pantoprazole or Famotidine safer?
FAERS cannot answer that: it has no denominator and no comparator. Use this page to see which risks are already on each label and which signals are unlabeled, then check the prescribing information and your clinician for your situation.
Sources: openFDA FAERS pair statistics (OpenPV build 2026-09-14), FDA labels via openFDA, openFDA count queries for seriousness and deaths. Pair chosen because it is a commonly searched comparison. Generated 2026-10-08.