OpenPV Signal Explorer
FAERS disproportionality dashboard
← All drugs
Drug

Bupivacaine

1,023 flagged reaction(s) · 30,547 total co-reports · max PRR 1,670.0
Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.
Reaction Co-reports (a) PRR ROR Signal
1 Arachnoid Web 6 1,670.0 1,671.1 signal
2 Oculocardiac Reflex 5 1,012.1 1,012.7 signal
3 Manipulation 6 954.3 954.9 signal
4 Anterior Spinal Artery Syndrome 24 890.7 893.0 signal
5 Infusion Site Fibrosis 5 795.2 795.7 signal
6 Maternal Exposure During Delivery 252 793.7 815.8 signal
7 Purtscher Retinopathy 13 466.9 467.5 signal
8 Platelet Aggregation Inhibition 15 439.5 440.2 signal
9 Catheter Site Granuloma 9 417.5 417.9 signal
10 Local Anaesthetic Systemic Toxicity 160 412.8 420.0 signal
11 Acute Macular Neuroretinopathy 25 403.4 404.5 signal
12 Obstetric Procedure Complication 5 347.9 348.1 signal
13 Inspiratory Capacity Decreased 36 339.7 341.0 signal
14 Bezold-jarisch Reflex 5 337.4 337.6 signal
15 Maternal Use Of Illicit Drugs 5 337.4 337.6 signal
16 Femoral Nerve Palsy 8 323.9 324.2 signal
17 Horner's Syndrome 10 305.0 305.3 signal
18 Conus Medullaris Syndrome 7 273.4 273.7 signal
19 Foetal Exposure During Delivery 73 269.6 271.7 signal
20 Spinal Anaesthesia 8 265.9 266.1 signal
21 Arthrofibrosis 10 265.1 265.4 signal
22 Femoral Nerve Injury 7 247.4 247.6 signal
23 Parophthalmia 23 242.7 243.3 signal
24 Chondrolysis 46 242.1 243.3 signal
25 Harlequin Syndrome 7 239.8 240.0 signal
26 Vascular Resistance Systemic Decreased 12 219.0 219.3 signal
27 Anaesthetic Complication Cardiac 6 212.1 212.2 signal
28 Implant Site Extravasation 64 198.8 200.1 signal
29 Phrenic Nerve Paralysis 17 192.1 192.5 signal
30 Medical Device Site Pain 44 191.7 192.6 signal
31 Lagophthalmos 30 178.1 178.7 signal
32 Spinal Cord Infarction 31 171.7 172.3 signal
33 Post Procedural Hypotension 6 171.3 171.4 signal
34 Macular Ischaemia 10 162.5 162.7 signal
35 Pulmonary Air Leakage 10 162.5 162.7 signal
36 Medical Device Site Discharge 10 155.7 155.9 signal
37 Overlap Syndrome 44 153.8 154.5 signal
38 Medical Device Site Erythema 8 152.2 152.4 signal
39 Therapeutic Response Prolonged 6 151.8 151.9 signal
40 Brief Psychotic Disorder With Marked Stressors 9 132.7 132.8 signal
41 Urinary Retention Postoperative 9 131.0 131.1 signal
42 Anaesthetic Complication 141 125.7 127.7 signal
43 Cauda Equina Syndrome 39 119.9 120.4 signal
44 Open Globe Injury 8 118.8 118.9 signal
45 Systemic Toxicity 10 117.8 117.9 signal
46 Rhythm Idioventricular 15 109.1 109.3 signal
47 Medical Device Site Swelling 8 108.6 108.7 signal
48 Brachial Plexopathy 10 106.5 106.7 signal
49 Neuromuscular Block Prolonged 16 101.5 101.7 signal
50 Uterine Atony 11 100.8 100.9 signal
51 Therapeutic Product Effect Prolonged 18 94.5 94.7 signal
52 Bradycardia Foetal 32 91.8 92.1 signal
53 Neonatal Respiratory Acidosis 6 91.5 91.6 signal
54 Procedural Hypotension 33 90.4 90.7 signal
55 Brachial Plexus Injury 6 87.3 87.4 signal
56 Myopathy Toxic 22 86.4 86.6 signal
57 Meningitis Chemical 8 84.8 84.9 signal
58 Cardiac Output Increased 6 82.0 82.0 signal
59 Arachnoiditis 24 81.1 81.3 signal
60 Implant Site Mass 6 78.1 78.2 signal
61 Delayed Recovery From Anaesthesia 31 76.3 76.5 signal
62 Chest Tube Insertion 6 75.9 76.0 signal
63 Spinal Cord Oedema 12 75.7 75.8 signal
64 Device Damage 26 75.0 75.2 signal
65 Postoperative Ileus 18 74.4 74.5 signal
66 Neuromuscular Blockade 7 71.5 71.6 signal
67 Procedural Nausea 24 70.6 70.8 signal
68 Implant Site Haematoma 7 66.9 66.9 signal
69 Labelled Drug-drug Interaction Medication Error 249 64.8 66.5 signal
70 Extradural Haematoma 37 64.6 64.9 signal
71 Mean Arterial Pressure Decreased 7 63.9 63.9 signal
72 Paralysis Flaccid 6 63.0 63.1 signal
73 Foetal Heart Rate Deceleration Abnormality 19 62.7 62.8 signal
74 Intraocular Pressure Fluctuation 5 61.2 61.2 signal
75 Anaesthetic Complication Neurological 24 61.0 61.2 signal
76 Post Lumbar Puncture Syndrome 26 57.8 58.0 signal
77 Hyponatraemic Encephalopathy 5 57.4 57.4 signal
78 Procedural Vomiting 16 57.3 57.4 signal
79 Device Battery Issue 16 55.6 55.7 signal
80 Implant Site Discharge 8 52.5 52.6 signal
81 Implant Site Pain 87 52.0 52.5 signal
82 Conjunctival Oedema 23 51.6 51.8 signal
83 Device Infusion Issue 54 50.9 51.2 signal
84 Infusion Site Mass 23 49.7 49.8 signal
85 Diaphragmatic Paralysis 13 49.5 49.5 signal
86 Ophthalmoplegia 32 46.9 47.0 signal
87 Extradural Abscess 16 46.7 46.8 signal
88 Implant Site Erosion 6 46.6 46.6 signal
89 Hypertensive Encephalopathy 12 46.1 46.2 signal
90 Radicular Pain 7 46.0 46.0 signal
91 Ureaplasma Infection 8 45.6 45.6 signal
92 Herpes Simplex Reactivation 7 42.9 43.0 signal
93 Loss Of Proprioception 6 42.4 42.4 signal
94 Sensorimotor Disorder 9 41.6 41.6 signal
95 Apgar Score Low 23 40.8 40.9 signal
96 Nerve Block 10 39.6 39.7 signal
97 Procedural Headache 7 39.6 39.6 signal
98 Left Ventricle Outflow Tract Obstruction 6 39.4 39.4 signal
99 Catheter Related Complication 19 38.2 38.3 signal
100 Eclampsia 6 37.8 37.9 signal
101 Symmetrical Drug-related Intertriginous And Flexural Exanthema 13 37.6 37.6 signal
102 Cerebrospinal Fluid Leakage 30 37.3 37.4 signal
103 Corneal Reflex Decreased 6 36.6 36.6 signal
104 Spinal Epidural Haematoma 9 36.6 36.6 signal
105 Administration Site Swelling 5 35.3 35.4 signal
106 Paraplegia 44 34.9 35.1 signal
107 Seroma 19 34.2 34.2 signal
108 Spinal Cord Injury 26 34.1 34.2 signal
109 Medical Device Site Infection 9 33.6 33.7 signal
110 Implant Site Swelling 14 33.4 33.5 signal
111 Sphincter Of Oddi Dysfunction 6 33.4 33.4 signal
112 Implant Site Scar 9 33.0 33.0 signal
113 Anal Sphincter Atony 6 32.0 32.0 signal
114 Dose Calculation Error 8 31.1 31.2 signal
115 Brain Stem Syndrome 10 30.4 30.5 signal
116 Implant Site Infection 30 30.3 30.4 signal
117 Periprosthetic Fracture 5 30.3 30.3 signal
118 Surgical Procedure Repeated 9 30.0 30.0 signal
119 Device Alarm Issue 23 29.1 29.2 signal
120 Areflexia 34 28.9 29.0 signal
121 Drug Effect Prolonged 7 28.6 28.6 signal
122 Normal Newborn 68 28.6 28.8 signal
123 Endotracheal Intubation Complication 7 27.3 27.3 signal
124 Anastomotic Leak 8 26.2 26.3 signal
125 Tryptase Increased 8 25.9 26.0 signal
126 Vasoplegia Syndrome 18 25.4 25.5 signal
127 Incision Site Erythema 5 24.9 24.9 signal
128 Allodynia 12 24.3 24.4 signal
129 Medical Device Site Discomfort 7 24.1 24.1 signal
130 Sinus Arrest 16 23.6 23.6 signal
131 Hypercapnia 30 22.9 22.9 signal
132 Retinal Artery Occlusion 25 22.6 22.7 signal
133 Postpartum Haemorrhage 13 22.6 22.6 signal
134 Electromechanical Dissociation 8 22.5 22.5 signal
135 Exophthalmos 21 22.5 22.5 signal
136 Low Birth Weight Baby 78 22.4 22.5 signal
137 Hyperaesthesia 79 21.8 21.9 signal
138 Adrenal Suppression 8 21.6 21.6 signal
139 Respiratory Depression 116 21.5 21.8 signal
140 Incision Site Pain 11 21.3 21.3 signal
141 Unmasking Of Previously Unidentified Disease 10 21.2 21.2 signal
142 Staphylococcal Abscess 6 21.2 21.2 signal
143 Kounis Syndrome 21 21.2 21.2 signal
144 Intracranial Hypotension 6 20.8 20.9 signal
145 Myelitis 14 20.5 20.6 signal
146 Cancer Pain 23 20.4 20.4 signal
147 Myoclonus 106 20.2 20.5 signal
148 Muscle Necrosis 8 20.1 20.1 signal
149 Autonomic Nervous System Imbalance 25 19.8 19.8 signal
150 Soft Tissue Necrosis 6 19.8 19.8 signal
151 Foetal Heart Rate Abnormal 8 19.7 19.7 signal
152 Diplegia 17 19.5 19.5 signal
153 Fanconi Syndrome 12 19.4 19.5 signal
154 Myelitis Transverse 12 19.4 19.4 signal
155 Implant Site Erythema 8 19.2 19.2 signal
156 Sensory Loss 68 19.2 19.3 signal
157 Spinal Cord Compression 32 18.6 18.7 signal
158 Product Administered To Patient Of Inappropriate Age 49 18.6 18.6 signal
159 Medical Device Discomfort 25 18.5 18.6 signal
160 Paresis 18 18.3 18.3 signal
161 Foetal Distress Syndrome 17 18.2 18.3 signal
162 Apnoea 61 17.7 17.8 signal
163 Iatrogenic Injury 10 17.5 17.5 signal
164 Device Kink 25 17.1 17.1 signal
165 No Therapeutic Response 91 16.7 16.9 signal
166 Live Birth 61 16.7 16.8 signal
167 Bradyarrhythmia 12 16.6 16.6 signal
168 Paraparesis 13 16.5 16.6 signal
169 Deafness Bilateral 12 16.1 16.1 signal
170 Wound Dehiscence 24 16.1 16.1 signal
171 Postoperative Wound Complication 9 16.0 16.0 signal
172 Peroneal Nerve Palsy 40 16.0 16.1 signal
173 Granuloma 24 15.8 15.8 signal
174 Myelopathy 13 15.5 15.5 signal
175 Axillary Pain 10 15.3 15.4 signal
176 Lupus Vulgaris 8 15.3 15.3 signal
177 Spinal Cord Disorder 11 15.1 15.1 signal
178 Deep Vein Thrombosis Postoperative 13 15.1 15.1 signal
179 Respiratory Acidosis 26 15.1 15.1 signal
180 Premature Baby 200 15.0 15.4 signal
181 Premature Delivery 104 14.8 14.9 signal
182 Wrong Product Administered 42 14.4 14.4 signal
183 Catheter Site Pain 16 14.3 14.3 signal
184 Performance Status Decreased 29 14.1 14.1 signal
185 Muscle Spasticity 76 13.9 14.0 signal
186 Endotracheal Intubation 17 13.8 13.8 signal
187 Amaurosis 5 13.8 13.8 signal
188 Hypothermia 61 13.7 13.7 signal
189 Breakthrough Pain 14 13.6 13.7 signal
190 Tachyarrhythmia 15 13.6 13.6 signal
191 Device Failure 90 13.5 13.6 signal
192 Hypogonadism 6 13.4 13.4 signal
193 Blood Pressure Immeasurable 9 13.3 13.3 signal
194 Sedation Complication 14 12.7 12.7 signal
195 Post Procedural Complication 107 12.6 12.8 signal
196 C-reactive Protein 5 12.5 12.5 signal
197 Therapeutic Product Effect Variable 21 12.5 12.5 signal
198 Paralysis 79 12.5 12.6 signal
199 Arrhythmia Supraventricular 6 12.4 12.4 signal
200 Respiratory Rate Decreased 17 12.2 12.3 signal
201 Exposure During Pregnancy 335 12.2 12.6 signal
202 Complex Regional Pain Syndrome 8 12.2 12.2 signal
203 Sedation 140 12.2 12.4 signal
204 Pulseless Electrical Activity 22 12.0 12.0 signal
205 Vith Nerve Paralysis 6 11.9 11.9 signal
206 Hyporesponsive To Stimuli 6 11.8 11.9 signal
207 Haemodynamic Instability 39 11.8 11.8 signal
208 Deafness Neurosensory 17 11.8 11.8 signal
209 Inadequate Analgesia 44 11.6 11.7 signal
210 Procedural Complication 39 11.5 11.5 signal
211 Monoplegia 22 11.4 11.4 signal
212 Monoparesis 9 11.2 11.2 signal
213 Postoperative Wound Infection 33 11.1 11.1 signal
214 Incorrect Route Of Product Administration 81 10.9 11.0 signal
215 Sacroiliitis 9 10.8 10.8 signal
216 Post Procedural Haematoma 8 10.7 10.7 signal
217 Hyperammonaemic Encephalopathy 8 10.6 10.6 signal
218 Chronic Kidney Disease-mineral And Bone Disorder 5 10.5 10.5 signal
219 Hypopnoea 16 10.5 10.5 signal
220 Hypertrophic Cardiomyopathy 7 10.3 10.3 signal
221 Premature Separation Of Placenta 7 10.2 10.2 signal
222 Stridor 13 10.0 10.0 signal
223 Generalised Tonic-clonic Seizure 72 10.0 10.0 signal
224 Urinary Retention 146 9.9 10.1 signal
225 Quadriplegia 9 9.9 9.9 signal
226 Ventricular Arrhythmia 16 9.9 9.9 signal
227 Cystitis Interstitial 7 9.9 9.9 signal
228 Caesarean Section 51 9.8 9.9 signal
229 Hypertensive Emergency 5 9.7 9.7 signal
230 Unresponsive To Stimuli 110 9.7 9.8 signal
231 Maternal Exposure During Pregnancy 374 9.6 10.0 signal
232 Neonatal Respiratory Distress Syndrome 15 9.6 9.6 signal
233 Electrocardiogram St Segment Elevation 14 9.6 9.6 signal
234 Pulse Absent 20 9.5 9.5 signal
235 Meningitis Bacterial 6 9.5 9.5 signal
236 Anal Incontinence 37 9.4 9.5 signal
237 Motor Dysfunction 42 9.4 9.4 signal
238 Foetal Growth Restriction 25 9.4 9.4 signal
239 Conversion Disorder 8 9.4 9.4 signal
240 Myoclonic Epilepsy 6 9.2 9.2 signal
241 Peripheral Sensorimotor Neuropathy 5 9.1 9.1 signal
242 Drug Clearance Decreased 5 9.0 9.0 signal
243 Hypovolaemia 23 8.9 8.9 signal
244 Mental Status Changes 109 8.9 9.0 signal
245 Methaemoglobinaemia 9 8.9 8.9 signal
246 Bradycardia 207 8.8 9.0 signal
247 Blood Pressure Systolic Decreased 17 8.5 8.5 signal
248 Bundle Branch Block Left 16 8.5 8.5 signal
249 Hypoglycaemia Neonatal 6 8.5 8.5 signal
250 Procedural Pain 103 8.4 8.5 signal
251 Premature Rupture Of Membranes 9 8.4 8.4 signal
252 Emergency Care 11 8.4 8.4 signal
253 Product Packaging Confusion 9 8.4 8.4 signal
254 Necrotising Fasciitis 13 8.4 8.4 signal
255 Substance-induced Psychotic Disorder 8 8.2 8.2 signal
256 Quadriparesis 6 8.2 8.2 signal
257 Ileus Paralytic 16 8.2 8.2 signal
258 Rectal Abscess 6 8.1 8.1 signal
259 Arteriospasm Coronary 14 8.0 8.0 signal
260 Maternal Exposure Timing Unspecified 13 7.9 7.9 signal
261 Facet Joint Syndrome 11 7.9 7.9 signal
262 Medical Device Complication 26 7.8 7.9 signal
263 Ventricular Hypokinesia 11 7.7 7.7 signal
264 Hyperthermia Malignant 5 7.7 7.7 signal
265 Bradypnoea 9 7.6 7.6 signal
266 Vocal Cord Paralysis 6 7.6 7.6 signal
267 Dysaesthesia 10 7.5 7.5 signal
268 Complication Associated With Device 43 7.4 7.4 signal
269 Hypotonia 32 7.2 7.2 signal
270 Drug Withdrawal Syndrome 281 7.2 7.4 signal
271 Electrocardiogram St Segment Depression 7 7.2 7.2 signal
272 Pre-eclampsia 15 7.2 7.2 signal
273 Drug Tolerance 16 7.1 7.1 signal
274 Device Power Source Issue 9 7.1 7.1 signal
275 Compartment Syndrome 8 6.9 6.9 signal
276 Catatonia 16 6.9 7.0 signal
277 Nerve Injury 34 6.9 6.9 signal
278 Injection Site Atrophy 5 6.9 6.9 signal
279 Paradoxical Drug Reaction 11 6.8 6.8 signal
280 Ventricular Fibrillation 33 6.7 6.7 signal
281 Cerebellar Infarction 5 6.7 6.7 signal
282 Atrioventricular Block Second Degree 9 6.7 6.7 signal
283 Circulatory Collapse 50 6.6 6.6 signal
284 Device Connection Issue 6 6.6 6.6 signal
285 Urinary Hesitation 7 6.6 6.6 signal
286 Blood Ph Decreased 5 6.6 6.6 signal
287 Meningitis Aseptic 13 6.6 6.6 signal
288 Anaphylactic Shock 74 6.5 6.6 signal
289 Swollen Joint Count Increased 9 6.5 6.5 signal
290 Grand Mal Convulsion 27 6.5 6.5 signal
291 Staphylococcus Test Positive 6 6.4 6.4 signal
292 Kyphosis 5 6.4 6.4 signal
293 Product Administration Error 56 6.3 6.4 signal
294 Foetal Exposure During Pregnancy 226 6.3 6.4 signal
295 Hypoxia 95 6.1 6.2 signal
296 Hypotension 541 6.1 6.4 signal
297 Dislocation Of Vertebra 6 6.1 6.1 signal
298 Brain Injury 27 6.1 6.1 signal
299 Nuclear Magnetic Resonance Imaging Abnormal 9 6.1 6.1 signal
300 Faecal Incontinence 13 6.0 6.0 signal
301 Crepitations 8 6.0 6.0 signal
302 Intervertebral Discitis 5 6.0 6.0 signal
303 Mechanical Ventilation 5 5.9 5.9 signal
304 Ventricular Tachycardia 43 5.9 5.9 signal
305 Product Preparation Issue 15 5.8 5.8 signal
306 Atrophy 5 5.8 5.8 signal
307 Hypoaesthesia 379 5.7 5.9 signal
308 Vitreous Haemorrhage 7 5.7 5.7 signal
309 Empyema 5 5.7 5.7 signal
310 Acute Pulmonary Oedema 14 5.6 5.6 signal
311 Prescribed Overdose 48 5.6 5.6 signal
312 Adjustment Disorder With Depressed Mood 5 5.6 5.6 signal
313 Stupor 8 5.6 5.6 signal
314 Hearing Impaired 15 5.6 5.6 signal
315 Potentiating Drug Interaction 8 5.5 5.5 signal
316 Hypoventilation 8 5.5 5.5 signal
317 Neuralgia 59 5.5 5.5 signal
318 Wound Infection 26 5.4 5.4 signal
319 Strabismus 7 5.4 5.4 signal
320 Arthritis Infective 11 5.4 5.4 signal
321 Hyperparathyroidism Secondary 6 5.4 5.4 signal
322 Cardiac Arrest 194 5.3 5.4 signal
323 Sinus Tachycardia 33 5.3 5.3 signal
324 Medical Device Pain 5 5.2 5.2 signal
325 Neurotoxicity 40 5.2 5.2 signal
326 Rheumatic Fever 10 5.2 5.2 signal
327 Transfusion 24 5.2 5.2 signal
328 Radiculopathy 6 5.1 5.1 signal
329 Endometrial Cancer 5 5.1 5.1 signal
330 Distributive Shock 5 5.1 5.1 signal
331 Hypertonia 13 5.1 5.1 signal
332 Brain Death 7 5.1 5.1 signal
333 Serotonin Syndrome 43 5.1 5.1 signal
334 Yawning 6 5.1 5.1 signal
335 Device Occlusion 31 5.0 5.1 signal
336 Laryngospasm 6 5.0 5.0 signal
337 Hiccups 18 5.0 5.0 signal
338 Arthritis Bacterial 9 5.0 5.0 signal
339 Neurological Decompensation 5 5.0 5.0 signal
340 Peripheral Ischaemia 9 5.0 5.0 signal
341 Computerised Tomogram Abnormal 5 5.0 5.0 signal
342 Clonus 6 4.9 4.9 signal
343 Muscle Rigidity 26 4.9 4.9 signal
344 Atelectasis 21 4.9 4.9 signal
345 Ischaemia 10 4.9 4.9 signal
346 Respiratory Arrest 60 4.9 4.9 signal
347 Depressed Level Of Consciousness 84 4.8 4.8 signal
348 Status Epilepticus 24 4.8 4.8 signal
349 Premature Labour 12 4.8 4.8 signal
350 Nystagmus 11 4.7 4.7 signal
351 Anaphylactic Reaction 113 4.7 4.7 signal
352 Diplopia 53 4.6 4.6 signal
353 Joint Range Of Motion Decreased 27 4.6 4.6 signal
354 Brain Herniation 6 4.5 4.5 signal
355 Metabolic Encephalopathy 6 4.5 4.5 signal
356 Embolism Venous 6 4.5 4.5 signal
357 Sinus Bradycardia 19 4.4 4.4 signal
358 Atrioventricular Block Complete 13 4.4 4.4 signal
359 Neurological Symptom 11 4.4 4.4 signal
360 Nephrogenic Anaemia 9 4.4 4.4 signal
361 Urinary Incontinence 57 4.4 4.4 signal
362 Skin Necrosis 10 4.3 4.3 signal
363 Miosis 15 4.3 4.3 signal
364 Muscular Weakness 212 4.2 4.3 signal
365 Formication 13 4.2 4.2 signal
366 Electric Shock Sensation 5 4.2 4.2 signal
367 Delirium 64 4.2 4.2 signal
368 Decubitus Ulcer 15 4.2 4.2 signal
369 Drug Exposure During Pregnancy 63 4.1 4.1 signal
370 Respiratory Distress 50 4.1 4.1 signal
371 Subdural Haematoma 26 4.1 4.1 signal
372 Maternal Drugs Affecting Foetus 14 4.1 4.1 signal
373 Hyperammonaemia 9 4.1 4.1 signal
374 Sensory Disturbance 29 4.1 4.1 signal
375 Procedural Haemorrhage 7 4.0 4.0 signal
376 Myositis 16 4.0 4.0 signal
377 Therapeutic Product Effect Delayed 8 4.0 4.0 signal
378 Wound Complication 6 3.9 3.9 signal
379 Hypertonic Bladder 5 3.9 3.9 signal
380 Ventricular Extrasystoles 18 3.9 3.9 signal
381 Type I Hypersensitivity 6 3.9 3.9 signal
382 Hyperreflexia 6 3.9 3.9 signal
383 Pulmonary Toxicity 12 3.9 3.9 signal
384 Sleep Disorder Due To General Medical Condition, Insomnia Type 11 3.9 3.9 signal
385 Ileus 21 3.9 3.9 signal
386 Extra Dose Administered 67 3.8 3.8 signal
387 Bronchospasm 24 3.8 3.8 signal
388 Withdrawal Syndrome 70 3.7 3.8 signal
389 Blood Disorder 13 3.7 3.7 signal
390 Acute Respiratory Failure 31 3.7 3.7 signal
391 Hypoaesthesia Oral 24 3.6 3.6 signal
392 Therapy Non-responder 71 3.6 3.6 signal
393 Drug Toxicity 22 3.6 3.6 signal
394 Hyperthermia 12 3.6 3.6 signal
395 Stress Cardiomyopathy 9 3.5 3.5 signal
396 Acute Generalised Exanthematous Pustulosis 12 3.5 3.5 signal
397 Wound Secretion 6 3.4 3.5 signal
398 Accidental Overdose 55 3.4 3.4 signal
399 Duodenal Ulcer Perforation 11 3.4 3.4 signal
400 Metastases To Spine 5 3.4 3.4 signal
401 Cardiotoxicity 13 3.3 3.3 signal
402 Spinal Column Stenosis 7 3.3 3.3 signal
403 Muscle Injury 12 3.3 3.3 signal
404 Cyanosis 23 3.3 3.3 signal
405 Post Procedural Haemorrhage 17 3.3 3.3 signal
406 Rash Vesicular 7 3.3 3.3 signal
407 Device Dislocation 63 3.3 3.3 signal
408 Blepharospasm 9 3.3 3.3 signal
409 Oliguria 9 3.3 3.3 signal
410 Extravasation 6 3.3 3.3 signal
411 Heart Rate Abnormal 8 3.3 3.3 signal
412 Wrong Drug Administered 13 3.2 3.3 signal
413 Respiratory Failure 104 3.2 3.2 signal
414 Abscess Limb 6 3.2 3.2 signal
415 Facial Paresis 5 3.2 3.2 signal
416 Drug Ineffective For Unapproved Indication 78 3.2 3.2 signal
417 Sciatica 22 3.1 3.1 signal
418 Rheumatoid Factor Positive 8 3.1 3.1 signal
419 Atrioventricular Block First Degree 6 3.1 3.1 signal
420 Tachycardia 122 3.1 3.1 signal
421 Therapeutic Response Shortened 43 3.1 3.1 signal
422 Left Ventricular Dysfunction 9 3.1 3.1 signal
423 Wheelchair User 6 3.0 3.0 signal
424 Loss Of Consciousness 172 3.0 3.1 signal
425 Parosmia 10 3.0 3.0 signal
426 Blood Pressure Decreased 88 3.0 3.0 signal
427 Hepatic Necrosis 5 3.0 3.0 signal
428 Eye Movement Disorder 9 3.0 3.0 signal
429 Body Temperature Decreased 13 3.0 3.0 signal
430 Muscle Tightness 21 2.9 2.9 signal
431 Intervertebral Disc Degeneration 12 2.9 2.9 signal
432 Faecaloma 7 2.9 2.9 signal
433 Dystonia 25 2.9 2.9 signal
434 Pulmonary Congestion 17 2.9 2.9 signal
435 Umbilical Hernia 6 2.9 2.9 signal
436 Exposure Via Breast Milk 5 2.9 2.9 signal
437 Agitation 94 2.9 2.9 signal
438 Brain Oedema 16 2.9 2.9 signal
439 Anti-cyclic Citrullinated Peptide Antibody Positive 9 2.9 2.9 signal
440 Encephalopathy 31 2.9 2.9 signal
441 Pneumothorax 20 2.9 2.9 signal
442 Cardio-respiratory Arrest 53 2.8 2.9 signal
443 Peripheral Venous Disease 5 2.8 2.8 signal
444 Pain 770 2.8 3.0 signal
445 Necrosis 7 2.8 2.8 signal
446 Mydriasis 16 2.8 2.8 signal
447 Intraocular Pressure Increased 16 2.8 2.8 signal
448 Spinal Osteoarthritis 11 2.8 2.8 signal
449 No Adverse Event 218 2.8 2.8 signal
450 Anaphylactoid Reaction 5 2.8 2.8 no signal
451 Heart Rate Decreased 43 2.8 2.8 signal
452 Blood Pressure Diastolic Decreased 9 2.7 2.7 signal
453 Product Label Confusion 7 2.7 2.7 signal
454 Meningitis 8 2.7 2.7 signal
455 Hyperhidrosis 154 2.7 2.7 signal
456 Oxygen Saturation Decreased 66 2.7 2.7 signal
457 Tachypnoea 16 2.7 2.7 signal
458 Therapeutic Response Decreased 71 2.7 2.7 signal
459 Atrioventricular Block 9 2.6 2.6 signal
460 Disorientation 46 2.6 2.6 signal
461 Hypercholesterolaemia 11 2.6 2.6 signal
462 Aplastic Anaemia 6 2.6 2.6 signal
463 Grip Strength Decreased 10 2.6 2.6 signal
464 Metabolic Acidosis 36 2.6 2.6 signal
465 Impaired Healing 37 2.5 2.6 signal
466 Medication Error 62 2.5 2.5 signal
467 Device Malfunction 74 2.5 2.5 signal
468 Impaired Gastric Emptying 14 2.5 2.5 signal
469 Aphasia 33 2.5 2.5 signal
470 Breast Cancer Stage Iii 7 2.5 2.5 signal
471 Adrenal Insufficiency 13 2.5 2.5 signal
472 Overdose 235 2.5 2.5 signal
473 Paraesthesia 171 2.4 2.5 signal
474 Helicobacter Infection 11 2.4 2.4 signal
475 Bursitis 13 2.4 2.4 signal
476 Subarachnoid Haemorrhage 11 2.4 2.4 signal
477 Incorrect Route Of Drug Administration 39 2.4 2.4 signal
478 Seizure 123 2.4 2.4 signal
479 Spinal Compression Fracture 9 2.4 2.4 signal
480 Facial Paralysis 9 2.4 2.4 signal
481 Somnolence 212 2.4 2.4 signal
482 Coma 50 2.4 2.4 signal
483 Pulmonary Oedema 47 2.4 2.4 signal
484 Myocardial Ischaemia 12 2.4 2.4 signal
485 Autoimmune Disorder 10 2.4 2.4 signal
486 Joint Dislocation 11 2.4 2.4 signal
487 Haematoma 27 2.3 2.3 signal
488 Rales 6 2.3 2.3 no signal
489 Off Label Use 895 2.3 2.5 signal
490 Feeling Of Body Temperature Change 6 2.3 2.3 no signal
491 Nervous System Disorder 32 2.3 2.3 signal
492 Groin Pain 9 2.3 2.3 signal
493 Aspiration 11 2.3 2.3 signal
494 Lip Dry 9 2.3 2.3 signal
495 Aphonia 14 2.3 2.3 signal
496 Extrasystoles 7 2.3 2.3 no signal
497 Lethargy 57 2.2 2.2 signal
498 Retinal Haemorrhage 7 2.2 2.2 no signal
499 Eyelid Ptosis 10 2.2 2.2 signal
500 Small Intestinal Obstruction 12 2.2 2.2 signal
501 Panic Reaction 7 2.2 2.2 no signal
502 Partial Seizures 5 2.2 2.2 no signal
503 Musculoskeletal Pain 51 2.2 2.2 signal
504 Benign Prostatic Hyperplasia 5 2.2 2.2 no signal
505 Drug Interaction 153 2.2 2.2 signal
506 Foetal Death 5 2.2 2.2 no signal
507 Periorbital Oedema 5 2.2 2.2 no signal
508 Personality Change 9 2.2 2.2 signal
509 Muscle Twitching 22 2.1 2.2 signal
510 Posterior Reversible Encephalopathy Syndrome 9 2.1 2.1 signal
511 Incontinence 10 2.1 2.1 signal
512 Staphylococcal Infection 31 2.1 2.1 signal
513 C-reactive Protein Abnormal 6 2.1 2.1 no signal
514 Hospitalisation 142 2.1 2.1 signal
515 Mass 13 2.1 2.1 signal
516 Ataxia 11 2.1 2.1 signal
517 Drug Effect Less Than Expected 13 2.1 2.1 signal
518 Hydrocephalus 5 2.1 2.1 no signal
519 Adverse Drug Reaction 82 2.1 2.1 signal
520 Acidosis 7 2.1 2.1 no signal
521 Bladder Disorder 9 2.0 2.0 no signal
522 Movement Disorder 29 2.0 2.0 signal
523 Osteoarthritis 38 2.0 2.0 signal
524 Tinnitus 41 2.0 2.0 signal
525 Toxicity To Various Agents 148 2.0 2.0 no signal
526 Obesity 14 2.0 2.0 no signal
527 Scar 15 2.0 2.0 no signal
528 Folliculitis 9 2.0 2.0 no signal
529 Joint Effusion 6 2.0 2.0 no signal
530 Hyperventilation 5 1.9 1.9 no signal
531 Shock Haemorrhagic 7 1.9 1.9 no signal
532 Erythema Multiforme 8 1.9 1.9 no signal
533 Hallucination, Visual 18 1.9 1.9 no signal
534 Discomfort 52 1.9 1.9 no signal
535 Eyelid Oedema 10 1.9 1.9 no signal
536 Disseminated Intravascular Coagulation 12 1.9 1.9 no signal
537 Oedema 46 1.9 1.9 no signal
538 Restlessness 31 1.9 1.9 no signal
539 Thermal Burn 6 1.9 1.9 no signal
540 Spinal Disorder 8 1.9 1.9 no signal
541 Cardiogenic Shock 12 1.9 1.9 no signal
542 Hand Deformity 11 1.9 1.9 no signal
543 Therapeutic Product Effect Decreased 37 1.9 1.9 no signal
544 Hepatitis Cholestatic 5 1.9 1.9 no signal
545 Accidental Underdose 12 1.9 1.9 no signal
546 Burning Sensation 57 1.8 1.8 no signal
547 Laryngeal Oedema 5 1.8 1.8 no signal
548 Troponin Increased 6 1.8 1.8 no signal
549 Acute Respiratory Distress Syndrome 14 1.8 1.8 no signal
550 Road Traffic Accident 33 1.8 1.8 no signal
551 Respiratory Rate Increased 7 1.8 1.8 no signal
552 Inappropriate Antidiuretic Hormone Secretion 8 1.8 1.8 no signal
553 Coordination Abnormal 11 1.8 1.8 no signal
554 Leukocytosis 14 1.7 1.7 no signal
555 Confusional State 124 1.7 1.7 no signal
556 Dyskinesia 31 1.7 1.7 no signal
557 Torsade De Pointes 6 1.7 1.7 no signal
558 Bradyphrenia 5 1.7 1.7 no signal
559 Abasia 19 1.7 1.7 no signal
560 Neuroleptic Malignant Syndrome 9 1.7 1.7 no signal
561 Device Leakage 32 1.7 1.7 no signal
562 Clostridium Difficile Colitis 8 1.7 1.7 no signal
563 Flank Pain 7 1.7 1.7 no signal
564 Back Pain 172 1.7 1.7 no signal
565 Muscle Spasms 135 1.7 1.7 no signal
566 Drug Effect Decreased 40 1.7 1.7 no signal
567 Pemphigus 9 1.6 1.6 no signal
568 Red Blood Cell Sedimentation Rate Increased 8 1.6 1.6 no signal
569 Pericarditis 12 1.6 1.6 no signal
570 Dysarthria 27 1.6 1.6 no signal
571 Breast Cancer Stage Ii 6 1.6 1.6 no signal
572 Drug-induced Liver Injury 22 1.6 1.6 no signal
573 Acute Myocardial Infarction 21 1.6 1.6 no signal
574 End Stage Renal Disease 13 1.6 1.6 no signal
575 Dysuria 26 1.6 1.6 no signal
576 Paraesthesia Oral 10 1.6 1.6 no signal
577 Hypokinesia 10 1.6 1.6 no signal
578 Brain Fog 10 1.5 1.5 no signal
579 Urine Output Decreased 6 1.5 1.5 no signal
580 Hypophosphataemia 5 1.5 1.5 no signal
581 Euphoric Mood 7 1.5 1.5 no signal
582 Heart Rate Increased 67 1.5 1.5 no signal
583 Device Issue 59 1.5 1.5 no signal
584 Convulsion 39 1.5 1.5 no signal
585 Tenderness 7 1.5 1.5 no signal
586 Respiratory Disorder 20 1.5 1.5 no signal
587 Hypertension 141 1.5 1.5 no signal
588 Spinal Operation 8 1.5 1.5 no signal
589 Hip Arthroplasty 10 1.5 1.5 no signal
590 Shock 15 1.5 1.5 no signal
591 Exostosis 6 1.5 1.5 no signal
592 Irritable Bowel Syndrome 14 1.5 1.5 no signal
593 Nerve Compression 6 1.5 1.5 no signal
594 Urosepsis 6 1.5 1.5 no signal
595 Device Related Infection 10 1.5 1.5 no signal
596 Unevaluable Event 49 1.5 1.5 no signal
597 Wound 18 1.5 1.5 no signal
598 Cognitive Disorder 30 1.5 1.5 no signal
599 Drug Administration Error 20 1.5 1.5 no signal
600 Intervertebral Disc Protrusion 14 1.4 1.4 no signal
601 Electrocardiogram Abnormal 5 1.4 1.4 no signal
602 Malnutrition 7 1.4 1.4 no signal
603 Lower Limb Fracture 12 1.4 1.4 no signal
604 Hallucination, Auditory 10 1.4 1.4 no signal
605 Sleep Apnoea Syndrome 12 1.4 1.4 no signal
606 Supraventricular Tachycardia 6 1.4 1.4 no signal
607 Visual Acuity Reduced 21 1.4 1.4 no signal
608 Blood Pressure Fluctuation 15 1.4 1.4 no signal
609 Pallor 17 1.4 1.4 no signal
610 Feeling Hot 38 1.4 1.4 no signal
611 Haemorrhage 64 1.4 1.4 no signal
612 Synovitis 11 1.4 1.4 no signal
613 Electrolyte Imbalance 7 1.4 1.4 no signal
614 Dysgeusia 45 1.4 1.4 no signal
615 Underdose 44 1.4 1.4 no signal
616 Pneumonia Aspiration 15 1.4 1.4 no signal
617 Blood Pressure Increased 92 1.4 1.4 no signal
618 Acute Coronary Syndrome 5 1.4 1.4 no signal
619 Spinal Pain 7 1.3 1.3 no signal
620 Musculoskeletal Stiffness 52 1.3 1.3 no signal
621 Neck Pain 33 1.3 1.3 no signal
622 Vomiting 276 1.3 1.3 no signal
623 Chills 69 1.3 1.3 no signal
624 Hemiparesis 10 1.3 1.3 no signal
625 Mobility Decreased 42 1.3 1.3 no signal
626 Neutrophil Count Increased 6 1.3 1.3 no signal
627 Delusion 9 1.3 1.3 no signal
628 Hysterectomy 5 1.3 1.3 no signal
629 Anuria 5 1.3 1.3 no signal
630 Respiratory Tract Infection 15 1.3 1.3 no signal
631 Mental Impairment 14 1.3 1.3 no signal
632 Cardiac Murmur 5 1.3 1.3 no signal
633 Gait Inability 19 1.3 1.3 no signal
634 Arrhythmia 27 1.3 1.3 no signal
635 Cold Sweat 10 1.3 1.3 no signal
636 Cardiomegaly 7 1.3 1.3 no signal
637 Contraindicated Product Administered 17 1.3 1.3 no signal
638 Lung Infiltration 5 1.3 1.3 no signal
639 Hallucination 42 1.3 1.3 no signal
640 Altered State Of Consciousness 12 1.3 1.3 no signal
641 Muscle Atrophy 7 1.3 1.3 no signal
642 Haemolytic Anaemia 5 1.3 1.3 no signal
643 Back Injury 6 1.3 1.3 no signal
644 Speech Disorder 29 1.2 1.3 no signal
645 Osteomyelitis 10 1.2 1.2 no signal
646 Abnormal Behaviour 22 1.2 1.2 no signal
647 Infusion Site Pain 7 1.2 1.2 no signal
648 Blood Creatine Phosphokinase Increased 16 1.2 1.2 no signal
649 Swelling 51 1.2 1.2 no signal
650 Hypokalaemia 25 1.2 1.2 no signal
651 Drug Ineffective 717 1.2 1.2 no signal
652 Pregnancy 11 1.2 1.2 no signal
653 Pleural Effusion 33 1.2 1.2 no signal
654 Obstructive Airways Disorder 6 1.2 1.2 no signal
655 Tremor 89 1.2 1.2 no signal
656 Bedridden 7 1.2 1.2 no signal
657 Pharmaceutical Product Complaint 14 1.2 1.2 no signal
658 Condition Aggravated 158 1.2 1.2 no signal
659 Musculoskeletal Disorder 10 1.2 1.2 no signal
660 Nausea 410 1.2 1.2 no signal
661 Product Use Issue 97 1.2 1.2 no signal
662 Anxiety 148 1.2 1.2 no signal
663 Surgery 30 1.2 1.2 no signal
664 Atrial Fibrillation 50 1.2 1.2 no signal
665 Swollen Tongue 16 1.2 1.2 no signal
666 Bacteraemia 6 1.2 1.2 no signal
667 Peripheral Coldness 7 1.1 1.1 no signal
668 Hepatitis 13 1.1 1.1 no signal
669 Wheezing 30 1.1 1.1 no signal
670 Type 2 Diabetes Mellitus 17 1.1 1.1 no signal
671 Asthenia 189 1.1 1.1 no signal
672 Treatment Failure 41 1.1 1.1 no signal
673 Oedema Peripheral 61 1.1 1.1 no signal
674 Liver Injury 12 1.1 1.1 no signal
675 Joint Stiffness 13 1.1 1.1 no signal
676 Fibromyalgia 12 1.1 1.1 no signal
677 Glossodynia 11 1.1 1.1 no signal
678 Body Temperature Increased 10 1.1 1.1 no signal
679 Infection 70 1.1 1.1 no signal
680 Balance Disorder 42 1.1 1.1 no signal
681 Photophobia 9 1.1 1.1 no signal
682 Blister 27 1.1 1.1 no signal
683 Dysstasia 14 1.1 1.1 no signal
684 Constipation 103 1.1 1.1 no signal
685 Cellulitis 24 1.1 1.1 no signal
686 Deep Vein Thrombosis 31 1.1 1.1 no signal
687 Amnesia 31 1.1 1.1 no signal
688 Syncope 47 1.1 1.1 no signal
689 Injury 33 1.1 1.1 no signal
690 Rotator Cuff Syndrome 6 1.1 1.1 no signal
691 Paranoia 8 1.0 1.0 no signal
692 Economic Problem 7 1.0 1.0 no signal
693 Intestinal Obstruction 17 1.0 1.0 no signal
694 Limb Discomfort 14 1.0 1.0 no signal
695 Local Swelling 8 1.0 1.0 no signal
696 Drug Dispensing Error 7 1.0 1.0 no signal
697 Ejection Fraction Decreased 7 1.0 1.0 no signal
698 Fall 149 1.0 1.0 no signal
699 Quality Of Life Decreased 6 1.0 1.0 no signal
700 Chronic Kidney Disease 34 1.0 1.0 no signal
701 White Blood Cell Count Increased 17 1.0 1.0 no signal
702 Rebound Effect 5 1.0 1.0 no signal
703 C-reactive Protein Increased 16 1.0 1.0 no signal
704 Akathisia 6 1.0 1.0 no signal
705 Impaired Driving Ability 5 1.0 1.0 no signal
706 Panic Attack 16 1.0 1.0 no signal
707 Extrapyramidal Disorder 11 1.0 1.0 no signal
708 Increased Tendency To Bruise 4 1.0 1.0 no signal
709 Swelling Face 28 1.0 1.0 no signal
710 Pulmonary Hypertension 9 1.0 1.0 no signal
711 Abdominal Pain 100 1.0 1.0 no signal
712 Multiple Organ Dysfunction Syndrome 12 1.0 1.0 no signal
713 Sexual Dysfunction 5 1.0 1.0 no signal
714 Hepatic Cirrhosis 8 1.0 1.0 no signal
715 Dysphonia 25 1.0 1.0 no signal
716 Carpal Tunnel Syndrome 6 1.0 1.0 no signal
717 Deformity 4 1.0 1.0 no signal
718 Skin Ulcer 11 1.0 1.0 no signal
719 Epilepsy 13 1.0 1.0 no signal
720 Eye Inflammation 4 1.0 1.0 no signal
721 Drug Level Increased 7 1.0 1.0 no signal
722 Psychomotor Hyperactivity 7 0.9 0.9 no signal
723 Dizziness 209 0.9 0.9 no signal
724 Laceration 4 0.9 0.9 no signal
725 Pulmonary Embolism 40 0.9 0.9 no signal
726 Pain In Extremity 123 0.9 0.9 no signal
727 Therapy Change 4 0.9 0.9 no signal
728 Affect Lability 4 0.9 0.9 no signal
729 Presyncope 10 0.9 0.9 no signal
730 Hypersensitivity 76 0.9 0.9 no signal
731 Urticaria 68 0.9 0.9 no signal
732 Rhabdomyolysis 17 0.9 0.9 no signal
733 Pollakiuria 17 0.9 0.9 no signal
734 Musculoskeletal Discomfort 7 0.9 0.9 no signal
735 Disability 8 0.9 0.9 no signal
736 Skin Lesion 11 0.9 0.9 no signal
737 Night Sweats 13 0.9 0.9 no signal
738 Libido Decreased 5 0.9 0.9 no signal
739 Sepsis 45 0.9 0.9 no signal
740 Gait Disturbance 77 0.9 0.9 no signal
741 Haematocrit Decreased 8 0.9 0.9 no signal
742 Acute Kidney Injury 61 0.9 0.9 no signal
743 Sleep Disorder 28 0.9 0.9 no signal
744 Activities Of Daily Living Impaired 8 0.9 0.9 no signal
745 Lymphocyte Count Decreased 7 0.9 0.9 no signal
746 Incorrect Dose Administered By Device 10 0.9 0.9 no signal
747 Septic Shock 17 0.9 0.9 no signal
748 Initial Insomnia 4 0.9 0.9 no signal
749 Haemoglobin Decreased 40 0.9 0.9 no signal
750 Osteoporosis 16 0.9 0.9 no signal
751 Disturbance In Attention 21 0.9 0.9 no signal
752 Ankle Fracture 6 0.9 0.9 no signal
753 Pruritus 145 0.9 0.9 no signal
754 Platelet Count Increased 5 0.9 0.9 no signal
755 Immune System Disorder 5 0.9 0.9 no signal
756 Dyspnoea 213 0.9 0.8 no signal
757 Alanine Aminotransferase Increased 23 0.8 0.8 no signal
758 Chest Pain 69 0.8 0.8 no signal
759 Fear 10 0.8 0.8 no signal
760 Pulmonary Fibrosis 7 0.8 0.8 no signal
761 Vision Blurred 50 0.8 0.8 no signal
762 Cardiac Disorder 34 0.8 0.8 no signal
763 Coagulopathy 6 0.8 0.8 no signal
764 Hypomagnesaemia 5 0.8 0.8 no signal
765 Neuropathy Peripheral 34 0.8 0.8 no signal
766 Feeling Cold 10 0.8 0.8 no signal
767 Hypertensive Crisis 4 0.8 0.8 no signal
768 Blood Pressure Systolic Increased 7 0.8 0.8 no signal
769 Insomnia 95 0.8 0.8 no signal
770 Intestinal Perforation 4 0.8 0.8 no signal
771 Blindness Unilateral 5 0.8 0.8 no signal
772 Chest Discomfort 36 0.8 0.8 no signal
773 Hepatocellular Injury 5 0.8 0.8 no signal
774 Spinal Fracture 7 0.8 0.8 no signal
775 Prescribed Underdose 7 0.8 0.8 no signal
776 Inflammation 18 0.8 0.8 no signal
777 Hypoacusis 15 0.8 0.8 no signal
778 Memory Impairment 48 0.8 0.8 no signal
779 Impaired Quality Of Life 5 0.8 0.8 no signal
780 Lung Disorder 17 0.8 0.8 no signal
781 Hyperthyroidism 5 0.8 0.8 no signal
782 Apathy 5 0.8 0.8 no signal
783 Deafness 9 0.8 0.8 no signal
784 Rib Fracture 7 0.8 0.8 no signal
785 Angioedema 15 0.8 0.8 no signal
786 Psychotic Disorder 10 0.8 0.8 no signal
787 Hepatic Enzyme Increased 23 0.8 0.8 no signal
788 Product Preparation Error 7 0.8 0.8 no signal
789 Cardiomyopathy 5 0.8 0.8 no signal
790 Knee Arthroplasty 7 0.8 0.8 no signal
791 Contusion 32 0.8 0.8 no signal
792 Product Use In Unapproved Indication 81 0.7 0.7 no signal
793 Device Breakage 13 0.7 0.7 no signal
794 Product Administered At Inappropriate Site 6 0.7 0.7 no signal
795 Retching 7 0.7 0.7 no signal
796 Crying 12 0.7 0.7 no signal
797 Inappropriate Schedule Of Product Administration 58 0.7 0.7 no signal
798 Erythema 67 0.7 0.7 no signal
799 Brain Neoplasm 3 0.7 0.7 no signal
800 Blood Thyroid Stimulating Hormone Increased 3 0.7 0.7 no signal
801 Complication Of Device Insertion 6 0.7 0.7 no signal
802 Bacterial Infection 6 0.7 0.7 no signal
803 Injection Site Discolouration 4 0.7 0.7 no signal
804 Hepatic Steatosis 6 0.7 0.7 no signal
805 Dry Mouth 26 0.7 0.7 no signal
806 Tubulointerstitial Nephritis 6 0.7 0.7 no signal
807 Thinking Abnormal 6 0.7 0.7 no signal
808 Aspartate Aminotransferase Increased 17 0.7 0.7 no signal
809 Incorrect Dose Administered 72 0.7 0.7 no signal
810 Nightmare 11 0.7 0.7 no signal
811 Irritability 19 0.7 0.7 no signal
812 Hypophagia 8 0.7 0.7 no signal
813 Feeling Jittery 6 0.7 0.7 no signal
814 Renal Failure 42 0.7 0.7 no signal
815 Oral Pain 7 0.7 0.7 no signal
816 Accidental Exposure To Product 31 0.7 0.7 no signal
817 Hypoglycaemia 15 0.7 0.7 no signal
818 Chronic Obstructive Pulmonary Disease 16 0.7 0.7 no signal
819 Dysphagia 29 0.7 0.7 no signal
820 Anorexia 4 0.7 0.7 no signal
821 Urinary Tract Infection 52 0.7 0.7 no signal
822 Skin Discolouration 14 0.7 0.7 no signal
823 Anhedonia 8 0.7 0.7 no signal
824 Depression 69 0.7 0.7 no signal
825 Blood Cholesterol Increased 14 0.7 0.7 no signal
826 Rash Erythematous 14 0.7 0.7 no signal
827 Psoriatic Arthropathy 12 0.7 0.7 no signal
828 Mental Disorder 13 0.7 0.7 no signal
829 Throat Tightness 8 0.7 0.7 no signal
830 Flushing 30 0.7 0.7 no signal
831 Drug Hypersensitivity 57 0.7 0.7 no signal
832 Pyrexia 101 0.7 0.7 no signal
833 Malaise 128 0.7 0.7 no signal
834 Drug Intolerance 28 0.7 0.7 no signal
835 Headache 182 0.7 0.6 no signal
836 Injection Site Discomfort 3 0.7 0.7 no signal
837 Product Quality Issue 39 0.7 0.7 no signal
838 Central Nervous System Lesion 4 0.7 0.7 no signal
839 Therapeutic Response Unexpected 13 0.7 0.7 no signal
840 Tooth Loss 6 0.6 0.6 no signal
841 Feeling Abnormal 69 0.6 0.6 no signal
842 Orthostatic Hypotension 5 0.6 0.6 no signal
843 Adverse Event 26 0.6 0.6 no signal
844 Liver Function Test Increased 6 0.6 0.6 no signal
845 Poor Quality Sleep 6 0.6 0.6 no signal
846 Hypersomnia 8 0.6 0.6 no signal
847 Influenza Like Illness 23 0.6 0.6 no signal
848 Angina Pectoris 8 0.6 0.6 no signal
849 Joint Swelling 33 0.6 0.6 no signal
850 Cardiovascular Disorder 7 0.6 0.6 no signal
851 Pruritus Generalised 6 0.6 0.6 no signal
852 Intentional Product Use Issue 24 0.6 0.6 no signal
853 Drug Resistance 7 0.6 0.6 no signal
854 Infusion Related Reaction 18 0.6 0.6 no signal
855 Bone Disorder 5 0.6 0.6 no signal
856 Gastrointestinal Disorder 24 0.6 0.6 no signal
857 Liver Disorder 12 0.6 0.6 no signal
858 Stevens-johnson Syndrome 6 0.6 0.6 no signal
859 Haemorrhage Intracranial 4 0.6 0.6 no signal
860 Blood Sodium Decreased 5 0.6 0.6 no signal
861 Transient Ischaemic Attack 9 0.6 0.6 no signal
862 Palpitations 31 0.6 0.6 no signal
863 Fracture 5 0.6 0.6 no signal
864 Ill-defined Disorder 16 0.6 0.6 no signal
865 Frequent Bowel Movements 7 0.6 0.6 no signal
866 Pneumonia 84 0.6 0.6 no signal
867 Metastases To Lung 3 0.6 0.6 no signal
868 Limb Injury 7 0.6 0.6 no signal
869 Weight Decreased 72 0.6 0.6 no signal
870 Choking 5 0.6 0.6 no signal
871 Oral Herpes 5 0.6 0.6 no signal
872 Fluid Retention 13 0.6 0.6 no signal
873 Dyspepsia 25 0.6 0.6 no signal
874 Visual Impairment 31 0.6 0.6 no signal
875 Mood Swings 8 0.6 0.6 no signal
876 Electrocardiogram Qt Prolonged 9 0.6 0.6 no signal
877 Gastrooesophageal Reflux Disease 20 0.6 0.6 no signal
878 Nervousness 13 0.6 0.6 no signal
879 Dehydration 33 0.6 0.6 no signal
880 Cerebral Infarction 6 0.6 0.6 no signal
881 Red Blood Cell Count Decreased 7 0.6 0.6 no signal
882 Cholelithiasis 8 0.6 0.6 no signal
883 Lower Respiratory Tract Infection 11 0.5 0.5 no signal
884 Dermatitis 5 0.5 0.5 no signal
885 Therapeutic Product Effect Incomplete 17 0.5 0.5 no signal
886 Suicidal Ideation 22 0.5 0.5 no signal
887 Liver Function Test Abnormal 7 0.5 0.5 no signal
888 Poisoning 3 0.5 0.5 no signal
889 Injection Site Irritation 3 0.5 0.5 no signal
890 Arthralgia 98 0.5 0.5 no signal
891 Joint Injury 5 0.5 0.5 no signal
892 Renal Injury 7 0.5 0.5 no signal
893 Arthropathy 13 0.5 0.5 no signal
894 Loss Of Personal Independence In Daily Activities 11 0.5 0.5 no signal
895 Hyponatraemia 13 0.5 0.5 no signal
896 Abdominal Distension 24 0.5 0.5 no signal
897 Dysmenorrhoea 3 0.5 0.5 no signal
898 Gastritis 6 0.5 0.5 no signal
899 General Physical Health Deterioration 26 0.5 0.5 no signal
900 Systemic Lupus Erythematosus 8 0.5 0.5 no signal
901 Hepatotoxicity 5 0.5 0.5 no signal
902 Platelet Count Decreased 24 0.5 0.5 no signal
903 Decreased Appetite 52 0.5 0.5 no signal
904 Jaundice 6 0.5 0.5 no signal
905 Peripheral Swelling 34 0.5 0.5 no signal
906 Blindness 9 0.5 0.5 no signal
907 Treatment Noncompliance 12 0.5 0.5 no signal
908 Hyperglycaemia 8 0.5 0.5 no signal
909 Pelvic Pain 4 0.5 0.5 no signal
910 Intentional Overdose 14 0.5 0.5 no signal
911 Intentional Product Misuse 19 0.5 0.5 no signal
912 Eye Pain 12 0.5 0.5 no signal
913 Diverticulitis 6 0.5 0.5 no signal
914 Stomatitis 13 0.5 0.5 no signal
915 Renal Disorder 10 0.5 0.5 no signal
916 Vertigo 13 0.5 0.5 no signal
917 Renal Failure Acute 9 0.5 0.5 no signal
918 Diabetic Ketoacidosis 5 0.5 0.5 no signal
919 Injection Site Urticaria 5 0.5 0.5 no signal
920 Myalgia 35 0.5 0.5 no signal
921 Sinusitis 21 0.5 0.5 no signal
922 Laboratory Test Abnormal 6 0.5 0.5 no signal
923 Osteonecrosis Of Jaw 5 0.5 0.5 no signal
924 Hyperkalaemia 7 0.5 0.5 no signal
925 Migraine 19 0.5 0.5 no signal
926 Injury Associated With Device 4 0.4 0.4 no signal
927 Intentional Self-injury 4 0.4 0.4 no signal
928 Drug Reaction With Eosinophilia And Systemic Symptoms 5 0.4 0.4 no signal
929 Upper Respiratory Tract Infection 9 0.4 0.4 no signal
930 Erectile Dysfunction 5 0.4 0.4 no signal
931 Mucosal Inflammation 5 0.4 0.4 no signal
932 Injection Site Mass 7 0.4 0.4 no signal
933 Ear Infection 5 0.4 0.4 no signal
934 Myocardial Infarction 33 0.4 0.4 no signal
935 Blood Glucose Decreased 9 0.4 0.4 no signal
936 Disease Progression 22 0.4 0.4 no signal
937 Malignant Neoplasm Progression 19 0.4 0.4 no signal
938 Dyspnoea Exertional 7 0.4 0.4 no signal
939 Mood Altered 5 0.4 0.4 no signal
940 Osteonecrosis 6 0.4 0.4 no signal
941 Circumstance Or Information Capable Of Leading To Medication Error 6 0.4 0.4 no signal
942 Flatulence 10 0.4 0.4 no signal
943 Fatigue 137 0.4 0.4 no signal
944 Weight Increased 39 0.4 0.4 no signal
945 Cardiac Failure 14 0.4 0.4 no signal
946 Emotional Distress 21 0.4 0.4 no signal
947 Abdominal Discomfort 28 0.4 0.4 no signal
948 Drug Abuse 14 0.4 0.4 no signal
949 Lacrimation Increased 5 0.4 0.4 no signal
950 Drug Dependence 27 0.4 0.4 no signal
951 Hepatic Failure 5 0.4 0.4 no signal
952 Cerebrovascular Accident 28 0.4 0.4 no signal
953 Vaginal Haemorrhage 7 0.4 0.4 no signal
954 Drug Effect Incomplete 6 0.4 0.4 no signal
955 Eye Swelling 6 0.4 0.4 no signal
956 Emotional Disorder 5 0.4 0.4 no signal
957 Femur Fracture 5 0.4 0.4 no signal
958 Asthma 18 0.4 0.4 no signal
959 Rash 67 0.3 0.3 no signal
960 Application Site Erythema 4 0.3 0.3 no signal
961 Cataract 9 0.3 0.3 no signal
962 Abdominal Pain Upper 31 0.3 0.3 no signal
963 Lip Swelling 5 0.3 0.3 no signal
964 Anaemia 28 0.3 0.3 no signal
965 Diarrhoea 94 0.3 0.3 no signal
966 Hot Flush 11 0.3 0.3 no signal
967 Haematuria 5 0.3 0.3 no signal
968 Injection Site Reaction 10 0.3 0.3 no signal
969 Multiple Sclerosis Relapse 10 0.3 0.3 no signal
970 Arthritis 11 0.3 0.3 no signal
971 Aggression 7 0.3 0.3 no signal
972 Stress 10 0.3 0.3 no signal
973 Pancreatic Carcinoma 4 0.3 0.3 no signal
974 Drug Effective For Unapproved Indication 4 0.3 0.3 no signal
975 Wrong Technique In Drug Usage Process 5 0.3 0.3 no signal
976 Nasopharyngitis 25 0.3 0.3 no signal
977 Thrombocytopenia 15 0.3 0.3 no signal
978 Colitis 5 0.3 0.3 no signal
979 Pancreatitis 7 0.3 0.3 no signal
980 Completed Suicide 11 0.3 0.3 no signal
981 Rash Pruritic 7 0.3 0.3 no signal
982 Alopecia 25 0.3 0.3 no signal
983 Drug Dose Omission 21 0.3 0.3 no signal
984 Multiple Sclerosis 6 0.3 0.3 no signal
985 Thrombosis 10 0.3 0.3 no signal
986 Neutrophil Count Decreased 5 0.3 0.3 no signal
987 Cardiac Failure Congestive 10 0.3 0.3 no signal
988 Death 106 0.3 0.3 no signal
989 Herpes Zoster 7 0.3 0.3 no signal
990 Lung Neoplasm Malignant 5 0.3 0.3 no signal
991 Diabetes Mellitus 9 0.3 0.3 no signal
992 Rheumatoid Arthritis 13 0.3 0.3 no signal
993 Depressed Mood 6 0.3 0.3 no signal
994 Nephrolithiasis 5 0.2 0.2 no signal
995 Haematochezia 6 0.2 0.2 no signal
996 Gastrointestinal Haemorrhage 9 0.2 0.2 no signal
997 Ocular Hyperaemia 5 0.2 0.2 no signal
998 Blood Creatinine Increased 7 0.2 0.2 no signal
999 Neoplasm Malignant 7 0.2 0.2 no signal
1000 Wrong Technique In Product Usage Process 21 0.2 0.2 no signal
1001 Nasal Congestion 6 0.2 0.2 no signal
1002 Bone Pain 6 0.2 0.2 no signal
1003 Injection Site Bruising 8 0.2 0.2 no signal
1004 Leukopenia 5 0.2 0.2 no signal
1005 Cough 28 0.2 0.2 no signal
1006 Suicide Attempt 6 0.2 0.2 no signal
1007 Influenza 11 0.2 0.2 no signal
1008 Bronchitis 7 0.2 0.2 no signal
1009 Eye Irritation 5 0.2 0.2 no signal
1010 Oropharyngeal Pain 8 0.2 0.2 no signal
1011 Blood Glucose Increased 16 0.2 0.2 no signal
1012 Renal Impairment 7 0.2 0.2 no signal
1013 Product Storage Error 7 0.2 0.2 no signal
1014 Illness 8 0.2 0.2 no signal
1015 Febrile Neutropenia 5 0.2 0.2 no signal
1016 White Blood Cell Count Decreased 8 0.2 0.2 no signal
1017 Injection Site Erythema 8 0.1 0.1 no signal
1018 Breast Cancer 6 0.1 0.1 no signal
1019 Psoriasis 8 0.1 0.1 no signal
1020 Injection Site Pain 17 0.1 0.1 no signal
1021 Dry Skin 7 0.1 0.1 no signal
1022 Product Dose Omission Issue 15 0.1 0.1 no signal
1023 Covid-19 5 0.1 0.1 no signal