Reaction

Labelled Drug-Drug Interaction Medication Error reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 8,808 reports · 371 co-occurring drugs

As of the last recalculation, Labelled Drug-Drug Interaction Medication Error appears in 8,808 FAERS reports alongside 371 co-occurring drug terms. The strongest observed disproportionality signal is BUPIVACAINE (PRR 64.8).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Bupivacaine	249	64.8	66.5
Clopidogrel Bisulfate	1,199	31.9	32.3
Umeclidinium Bromide And Vilanterol Trifenatate	198	28.6	29.0
Clarithromycin	373	26.8	27.0
Umeclidinium	73	19.4	19.6
Torsemide	256	18.8	18.9
Clopidogrel	1,322	18.4	18.5
Warfarin	878	18.0	18.1
Eplerenone	87	16.2	16.3
Itraconazole	69	14.1	14.1
Ritonavir 100 Mg	87	13.9	14.0
Rifampicin	55	12.9	13.0
Nebivolol	85	12.7	12.8
Apixaban	342	12.5	12.6
Candesartan	182	12.3	12.3
Naltrexone Hydrochloride And Bupropion Hydrochloride	44	12.3	12.3
Warfarin Sodium	226	11.8	11.8
Fluticasone Furoate And Vilanterol Trifenatate	174	11.6	11.7
Ticagrelor	154	11.6	11.6
Cabotegravir	36	10.6	10.6
Bisoprolol Fumarate	540	9.9	10.0
Rifampin	59	9.6	9.6
Ramipril	460	9.2	9.2
Telmisartan	69	9.2	9.2
Febuxostat Tablets 40 Mg	39	9.1	9.1
Febuxostat Tablets 80 Mg	39	9.1	9.1
Fluticasone Furoate, Umeclidinium Bromide And Vilanterol Trifenatate	145	8.4	8.4
Phenytoin	72	8.2	8.2
Posaconazole Delayed-Release	37	8.0	8.0
Rivaroxaban	621	7.5	7.5
Ritonavir	91	7.4	7.4
Doxazosin	86	7.3	7.3
Aspirin	1,431	7.3	7.3
Cefuroxime	35	7.3	7.3
Nebivolol Hydrochloride	100	7.1	7.1
Metoprolol Tartrate Injection	532	7.0	7.0
Aspirin 325 Mg	1,294	6.8	6.8
Aspirin 81 Mg	1,294	6.8	6.8
Trimethoprim	33	6.6	6.7
Heparin Sodium	37	6.4	6.4
Theophylline Anhydrous	33	6.3	6.3
Darunavir	40	6.3	6.3
Atazanavir	38	6.3	6.3
Indapamide	47	6.2	6.2
Theophylline	30	6.2	6.2
Allopurinol	392	6.2	6.2
Terbinafine Hydrochloride	23	6.1	6.1
Valproic Acid	80	6.0	6.1
Pantoprazole	605	6.0	6.0
Doxazosin Mesylate	90	5.9	6.0
Isoniazid	40	5.9	5.9
Pyrazinamide	23	5.8	5.8
Posaconazole	39	5.7	5.7
Ketoprofen	31	5.6	5.6
Dalteparin Sodium	25	5.6	5.6
Sotalol Hydrochloride	39	5.6	5.6
Metoprolol	567	5.6	5.6
Nirmatrelvir And Ritonavir	125	5.5	5.5
Febuxostat	39	5.5	5.5
Valsartan Oral	124	5.5	5.5
Pantoprazole Sodium In 0.9% Sodium Chloride	139	5.4	5.4
Pantoprazole Sodium Injection	139	5.4	5.4
Carbamazepine	149	5.3	5.3
Colchicine	59	5.3	5.3
Simvastatin	531	5.3	5.3
Ranolazine	23	5.2	5.2
Metoprolol Tartrate	569	5.2	5.2
Bumetanide	57	5.1	5.1
Rasagiline Mesylate	24	5.1	5.1
Efavirenz	24	5.1	5.1
Phenobarbital	31	5.1	5.1
Tacrolimus Ointment 0.1%	259	5.0	5.0
Tacrolimus Extended-Release Capsules	259	5.0	5.0
Fondaparinux Sodium	17	5.0	5.0
Fluticasone Propionate And Salmeterol	87	5.0	5.0
Diclofenac	178	5.0	5.0
Captopril	20	4.9	4.9
Spironolactone	280	4.8	4.8
Voriconazole Injection	44	4.8	4.8
Dextrose Monohydrate	27	4.8	4.8
Mirtazapine	181	4.7	4.8
Lidocaine Hydrochloride And Epinephrine Bitartrate	106	4.7	4.7
Lidicaine	97	4.7	4.7
Burn Relief	97	4.7	4.7
Lidocaine Hydrochloride And Epinephrine	97	4.7	4.7
Ciprofolxacin	141	4.7	4.7
Ciprofloxacin Tablets	141	4.7	4.7
Tacrolimus	302	4.7	4.7
Dextrose	26	4.7	4.7
Duloxetine	136	4.7	4.7
Lidocaine, Menthol	97	4.7	4.7
Insulin Glargine-Yfgn	42	4.6	4.6
Escitslopram	106	4.3	4.4
Lidocaine 4%	99	4.3	4.3
Digoxin	130	4.3	4.3
Fluconazole	124	4.2	4.2
Lidocaine Hydrochloride	106	4.2	4.2
Voriconazole	53	4.1	4.1
Lidocaine	99	4.0	4.1
Ciprofloxacin	155	4.0	4.0
Moxifloxacin	24	4.0	4.0
Escitalopram Oxalate	120	3.9	3.9
Ciprofloxacin Hydrochloride	159	3.9	3.9
Diclofenac Sodium	243	3.9	3.9
Extended Phenytoin Sodium	27	3.8	3.8
Senna Leaf	37	3.8	3.8
Amiodarone Hydrochloride	18	3.8	3.8
Levothyroxine Sodium Anhydrous	158	3.8	3.8
Nitroglycerin	85	3.8	3.8
Acetylcysteine	15	3.8	3.8
Rivastigmine	29	3.6	3.7
Lithium Carbonate	26	3.6	3.6
Sennosides 8.6 Mg Tablets	32	3.6	3.6
Senna	32	3.6	3.6
Citalopram Hydrobromide	158	3.5	3.5
Paroxetine Hydrochloride Hemihydrate	49	3.5	3.5
Paroxetine	50	3.5	3.5
Dabigatran Etexilate	113	3.5	3.5
Mycophenilic Acid	30	3.4	3.4
Brivaracetam	13	3.4	3.4
Cefazolin	13	3.4	3.4
Prednisolone	251	3.4	3.4
Prednisolone Oral	251	3.4	3.4
Prednisolone Oral Solution	251	3.4	3.4
Phytonadione	12	3.3	3.3
Fluticasone Furoate	17	3.3	3.3
Isosorbide Mononitrate	29	3.3	3.3
Moxifloxacin Hydrochloride	28	3.3	3.3
Meropenem	44	3.3	3.3
Primidone	14	3.3	3.3
Candesartan Cilexetil	36	3.2	3.2
Oxazepam	29	3.2	3.2
Venlafaxine	95	3.2	3.2
Ezetimibe	99	3.1	3.1
Ipratropium Bromide	47	3.1	3.1
Gemfibrozil	20	3.1	3.1
Valsartan	137	3.1	3.1
Cyanocobalamin	43	3.1	3.1
Valproate Sodium	27	3.1	3.1
Ropinirole	20	3.1	3.1
Omeprazole	431	3.1	3.1
Ketoconazole Foam	19	3.0	3.0
Ketoconazole Cream, 2%	19	3.0	3.0
Carvedilol	171	3.0	3.0
Amlodipine	336	3.0	3.0
Amphotericin B	16	3.0	3.0
Ketoconazole	22	3.0	3.0
Sitagliptin	91	3.0	3.0
Enalapril	69	2.9	2.9
Cefazolin Sodium	15	2.9	2.9
Citalopram	168	2.9	2.9
Pramipexole	19	2.9	2.9
Furosemide	479	2.9	2.9
Lithium	31	2.9	2.9
Lithium Bromatum	31	2.9	2.9
Dutasteride	10	2.9	2.9
Amantadine	19	2.9	2.9
Sertraline	142	2.9	2.9
Fluoxetine	81	2.9	2.9
Omeprazole Magnesium	517	2.8	2.8
Ibuprofen Capsule	234	2.8	2.8
Ibuprofen Tablet, Film Coated	234	2.8	2.8
Ibupfrofen	234	2.8	2.8
Ibuprofen Tablets Usp, 200Mg	234	2.8	2.8
Ibuprofen Oral	234	2.8	2.8
Ibuprofen Capsules 200 Mg	234	2.8	2.8
Ibuprofen 200 Mg	234	2.8	2.8
Ibuprofen 200Mg	234	2.8	2.8
Mycophenolic Acid	38	2.8	2.8
Tamsulosin Hydrochloride	24	2.8	2.8
Dronedarone	12	2.8	2.8
Piperacillin And Tazobactam	15	2.8	2.8
Salmeterol Xinafoate	10	2.7	2.7
Miconazole Nitrate	10	2.7	2.7
Acetaminophen, Aspirin (Nsaid) And Caffeine	19	2.6	2.6
Esomeprazole	69	2.6	2.6
Clobazam	27	2.6	2.6
Sennosides	33	2.6	2.6
Basiliximab	13	2.6	2.6
Piperacillin Sodium,Tazobactam Sodium	29	2.6	2.6
Lamotirigine	78	2.6	2.6
Lamotrigine Extended-Release	78	2.6	2.6
Lamotrigine Chewable Dispersible	78	2.6	2.6
Metformin Er 500 Mg	319	2.6	2.6
Metformin Er 750 Mg	319	2.6	2.6
Pantoprazole Sodium	159	2.6	2.6
Finasteride	65	2.6	2.6
Midazolam Hydrochloride	29	2.6	2.6
Riociguat	35	2.5	2.5
Pitavastatin Calcium	11	2.5	2.5
Fluticasone Propionate And Salmeterol Xinafoate	64	2.5	2.5
Hydrochlorothiazide	153	2.5	2.5
Escitalopram	147	2.5	2.5
Bicalutamide	16	2.5	2.5
Loratadine Oral	51	2.5	2.5
Brinzolamide	9	2.5	2.5
Midazolam	26	2.4	2.4
Levofloxacin	62	2.4	2.4
Levofloxacin In 5% Dextrose	62	2.4	2.4
Norepinephrine	11	2.4	2.4
Isosorbide Dinitrate	20	2.4	2.4
Metformin	357	2.4	2.4
Adrenalinum	42	2.4	2.4
Levetiracetam In Sodium Chloride	78	2.4	2.4
Levetiracetam Oral	78	2.4	2.4
Levetiracetam Injection	78	2.4	2.4
Fentanyl	98	2.4	2.4
Vortioxetine	17	2.4	2.4
Ferrous Sulfate	50	2.4	2.4
Bupropion	44	2.3	2.3
Risperidone	130	2.3	2.3
Doxycycline Hyclate	66	2.3	2.3
Tiotropium Bromide	133	2.3	2.3
Budesonide And Formoterol Fumarate Dihydrate	94	2.3	2.3
Doxycycline	66	2.3	2.3
Aripiprazole Oral	40	2.3	2.3
Aripiprazole Orally Disintegrating	40	2.3	2.3
Diltiazem Hydrochloride Extended-Release Tablets	11	2.3	2.3
Trazodone Hydrochloride	15	2.3	2.3
Carboxymethylcellulose Sodium	9	2.3	2.3
Oxcarbazepine	31	2.3	2.3
Everolimus Tablets	16	2.3	2.3
Ibuprofen	253	2.2	2.2
Rocuronium Bromide	11	2.2	2.2
Linagliptin	17	2.2	2.2
Propofol	34	2.2	2.2
Antacid	44	2.2	2.2
Bisacodyl Suppositories	12	2.2	2.2
Tenofovir Disoproxil Fumarate Tablets	8	2.2	2.2
Divalproex Sodium	43	2.2	2.2
Hydroxyzine	44	2.2	2.2
Rosuvastatin	187	2.2	2.2
Tizanidine	22	2.2	2.2
Amoxicillin	70	2.2	2.2
Mycophenolate Mofetil	124	2.2	2.2
Biscodyl	12	2.2	2.2
Progesterone	21	2.2	2.2
Mycophenolate Mofetil Hydrochloride	124	2.2	2.2
Alendronate Sodium Tablet	17	2.2	2.2
Quetiapine Fumarate	27	2.2	2.2
Lamivudine Oral	23	2.2	2.2
Naproxen Sodium Tablet	48	2.1	2.1
Norepinephrine Bitartrate	13	2.1	2.1
Acetaminophen, Aspirin, And Caffeine	19	2.1	2.1
Tranexamic Acid	8	2.1	2.1
Mometasone Furoate And Formoterol Fumarate Dihydrate	14	2.1	2.1
0Xygen	44	2.1	2.1
Oxygen	44	2.1	2.1
Ceftriaxone	29	2.1	2.1
Glimepiride	34	2.1	2.1
Lansoprazole	154	2.1	2.1
Quetiapine	166	2.1	2.1
Fluoxetine Hydrochloride	110	2.1	2.1
Bisacodyl	12	2.0	2.0
Pregabalin	229	2.0	2.0
Montelukast	71	2.0	2.0
Sevoflurane	7	2.0	2.0
Clozapine	104	2.0	2.0
Acalabrutinib	10	2.0	2.0
Sirolimus	11	1.9	1.9
Quinine	7	1.9	1.9
Diclofenac Sodium 1%	29	1.9	1.9
Diclofenac Sodium Topical	29	1.9	1.9
Naproxen Sodium Tablet, Coated	11	1.9	1.9
Naproxen Sodium, Coated Tablets	11	1.9	1.9
Naproxen Sodium 220Mg	11	1.9	1.9
Diclofenac Sodium Topical Gel, 1%	29	1.9	1.9
Lamivudine	25	1.9	1.9
Lactulose	31	1.9	1.9
Magnesium	66	1.9	1.9
Duloxetine Hydrochloride	149	1.9	1.9
Calcitriol Capsules 0.25 Mcg	16	1.9	1.9
Calcitriol Capsules 0.5 Mcg	16	1.9	1.9
Calcitriol	16	1.9	1.9
Crizotinib	10	1.9	1.9
Metoclopramide	43	1.9	1.9
Ceftriaxone Sodium	30	1.9	1.9
Venlafaxine Hydrochloride	103	1.8	1.8
Insulin	43	1.8	1.8
Suvorexant	10	1.8	1.8
Lamotrigine	101	1.8	1.8
Piperacillin Sodium And Tazobactam Sodium	15	1.8	1.8
Irbesartan	34	1.8	1.8
Sildenafil Powder,	27	1.8	1.8
Lacosamide	28	1.8	1.8
Levothyroxine Sodium	234	1.8	1.8
Enoxaparin Sodium	43	1.8	1.8
Tapentadol Hydrochloride	25	1.8	1.8
Levetiracetam	99	1.8	1.8
Zonisamide	11	1.8	1.8
Haloperidol	18	1.8	1.8
Latanoprost	37	1.7	1.7
Sodium Chloride	58	1.7	1.7
Brimonidine Tartrate	13	1.7	1.7
Haloperidol Lactate	18	1.7	1.7
Raltegravir	12	1.7	1.7
Amlodipine Besylate And Valsartan	8	1.7	1.7
Vancomycin	41	1.7	1.7
Baclofen	61	1.7	1.7
Micafungin Sodium	6	1.7	1.7
Dabigatran Etexilate Mesylate	51	1.7	1.7
Methadone	30	1.7	1.7
Dasatinib	26	1.7	1.7
Vancomycin Hydrochloride	46	1.7	1.7
Oxybutynin	20	1.6	1.6
Rucaparib	6	1.6	1.6
Fenofibrate	24	1.6	1.6
Amlodipine Besylate	98	1.6	1.6
Metformin Hydrochloride Tablets	38	1.6	1.6
Metformin Hydrochloride Extended-Release Tablets	38	1.6	1.6
Metformin Hydrochloride Tablet	38	1.6	1.6
Timolol	8	1.6	1.6
Abiraterone	9	1.6	1.6
Epinephrine	43	1.6	1.6
Valganciclovir Hydrochloride Powder,	8	1.6	1.6
Estradiol	56	1.5	1.5
Metoclopramide Hydrochloride	50	1.5	1.5
Mirabegron	25	1.5	1.5
Amikacin	11	1.5	1.5
Metformin Hydrochloride	38	1.5	1.5
Oseltamivir	5	1.5	1.5
Tiotropium Bromide Inhalation Spray	7	1.5	1.5
Imatinib	11	1.5	1.5
Lovastatin	16	1.5	1.5
Atovaquone	5	1.5	1.5
Atorvastatin Calcium, Film Coated	43	1.5	1.5
Prasugrel Hydrochloride	6	1.4	1.4
Sildenafil	34	1.4	1.4
Loratadine	62	1.4	1.4
Dofetilide	6	1.3	1.3
Tramadol Hydrochloride	21	1.3	1.3
Bosutinib	5	1.3	1.3
Losartan	97	1.3	1.3
Tolvaptan	8	1.3	1.3
Methoxy Polyethylene Glycol-Epoetin Beta	6	1.3	1.3
Lurasidone Hydrochloride	11	1.2	1.2
Empagliflozin	35	1.2	1.2
Donepezil Hydrochloride	19	1.2	1.2
Regorafenib	6	1.2	1.2
Minoxidil Foam 5% (Womens)	17	1.2	1.2
Dapagliflozin	16	1.2	1.2
Insulin Glargine	125	1.2	1.2
Bictegravir Sodium, Emtricitabine, And Tenofovir Alafenamide Fumarate	9	1.2	1.2
Rotigotine	7	1.1	1.1
Sodium Oxybate	31	1.1	1.1
Methadone Hydrochloride	5	1.1	1.1
Fexofenadine Hydrochloride	10	1.1	1.1
Ibrutinib	37	1.1	1.1
Sofosbuvir	9	1.1	1.1
Eltrombopag Olamine	10	1.0	1.0
Etonogestrel	20	1.0	1.0
Velpatasvir And Sofosbuvir	5	0.9	0.9
Naltrexone	12	0.9	0.9
Insulin Lispro	53	0.9	0.9
Minoxidil	17	0.9	0.9
Buprenorphine	35	0.9	0.9
Trametinib	9	0.9	0.9
Sacubitril And Valsartan	43	0.9	0.9
Emtricitabine And Tenofovir Alafenamide	4	0.8	0.8
Emtricitabine And Tenofovir Disoproxil Fumarate	16	0.8	0.8
Alteplase	5	0.8	0.8
Tenofovir Disoproxil Fumarate	10	0.7	0.7
Pseudoephedrine Hydrochloride	3	0.7	0.7
Pseudoephedrine Hcl	3	0.6	0.6
Dulaglutide	24	0.6	0.6
Ledipasvir And Sofosbuvir	5	0.6	0.6
Cinacalcet Hydrochloride	12	0.6	0.6
Enzalutamide	15	0.6	0.6
Abiraterone Acetate	10	0.6	0.6
Aflibercept	7	0.5	0.5
Orlistat	5	0.5	0.5

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.