Reaction
Local Anaesthetic Systemic Toxicity reporting signals
As of the last recalculation, Local Anaesthetic Systemic Toxicity appears in 1,023 FAERS reports alongside 25 co-occurring drug terms. The strongest observed disproportionality signal is LIDOCAINE HYDROCHLORIDE (PRR 913.6).
Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.
| Drug | Co-reports | PRR | ROR |
|---|---|---|---|
| Lidocaine Hydrochloride | 743 | 913.6 | 925.1 |
| Lidocaine Hydrochloride And Epinephrine | 608 | 620.8 | 628.6 |
| Lidicaine | 607 | 619.2 | 627.0 |
| Burn Relief | 607 | 619.2 | 627.0 |
| Lidocaine, Menthol | 607 | 610.9 | 618.5 |
| Lidocaine Hydrochloride And Epinephrine Bitartrate | 622 | 603.4 | 610.6 |
| Lidocaine 4% | 607 | 556.0 | 562.2 |
| Lidocaine | 607 | 519.3 | 524.8 |
| Bupivacaine | 160 | 412.8 | 420.0 |
| Adrenalinum | 142 | 80.7 | 81.0 |
| Midazolam | 63 | 54.1 | 54.3 |
| Midazolam Hydrochloride | 65 | 52.4 | 52.5 |
| Epinephrine | 142 | 51.1 | 51.2 |
| Rocuronium Bromide | 23 | 40.6 | 40.7 |
| Iohexol | 15 | 37.3 | 37.4 |
| Rizatriptan Benzoate | 17 | 34.6 | 34.6 |
| Propofol | 55 | 32.3 | 32.4 |
| Norepinephrine | 14 | 27.0 | 27.0 |
| Fentanyl | 105 | 24.1 | 24.1 |
| Tranexamic Acid | 10 | 23.1 | 23.1 |
| Norepinephrine Bitartrate | 14 | 20.0 | 20.1 |
| Atropine | 8 | 19.8 | 19.8 |
| Epoprostenol | 12 | 18.9 | 18.9 |
| Sodium Bicarbonate | 21 | 18.7 | 18.8 |
| Sodium Bicarbonate Injection, | 21 | 18.7 | 18.8 |