OpenPV Signal Explorer
FAERS disproportionality dashboard
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Drug

Fulvestrant

1,194 flagged reaction(s) · 156,174 total co-reports · max PRR 677.8
Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.
Reaction Co-reports (a) PRR ROR Signal
1 Pik3ca-activated Mutation 167 677.8 681.2 signal
2 Hormone Receptor Positive Her2 Negative Breast Cancer 126 430.8 432.4 signal
3 Carbohydrate Antigen 15-3 Increased 251 315.2 317.6 signal
4 Elliptocytosis 26 259.6 259.8 signal
5 Carbohydrate Antigen 27.29 Increased 38 215.4 215.6 signal
6 Pseudocirrhosis 79 202.8 203.3 signal
7 Infusion Site Coldness 24 201.3 201.5 signal
8 Metastases To Thorax 47 144.9 145.1 signal
9 Metastases To Eye 39 137.1 137.2 signal
10 Pleural Neoplasm 29 136.1 136.3 signal
11 Metastases To Spinal Cord 33 130.6 130.7 signal
12 Metastases To Pleura 166 121.1 121.8 signal
13 Tumour Marker Abnormal 53 119.9 120.1 signal
14 Metastases To Skin 160 118.3 118.9 signal
15 Breast Cancer Metastatic 1,645 115.7 121.8 signal
16 Tumour Marker Increased 666 102.6 104.7 signal
17 Metastases To Breast 43 96.6 96.7 signal
18 Metastases To Bone 2,131 95.7 102.2 signal
19 Metastases To Chest Wall 45 95.3 95.4 signal
20 Gamma-glutamyltransferase Decreased 24 90.4 90.5 signal
21 Nail Bed Inflammation 39 89.2 89.3 signal
22 Tumour Marker Decreased 22 88.2 88.2 signal
23 Musculoskeletal Toxicity 21 82.1 82.1 signal
24 Hormone Receptor Positive Breast Cancer 27 72.9 73.0 signal
25 Chest Wall Mass 26 71.1 71.2 signal
26 Adnexa Uteri Mass 28 71.0 71.1 signal
27 Metastases To Liver 1,737 70.2 74.1 signal
28 Breast Cancer Recurrent 305 68.4 69.0 signal
29 Intestinal Metastasis 34 68.3 68.4 signal
30 Metastases To The Mediastinum 39 66.1 66.2 signal
31 Metastases To Pelvis 59 65.8 65.9 signal
32 Metastases To Spine 310 65.0 65.7 signal
33 Metastases To Ovary 28 61.8 61.9 signal
34 Oestradiol Increased 25 58.2 58.3 signal
35 Bone Marrow Infiltration 32 57.7 57.7 signal
36 Nasal Mucosal Disorder 47 55.8 55.9 signal
37 Invasive Lobular Breast Carcinoma 41 55.5 55.5 signal
38 Poikilocytosis 21 52.4 52.5 signal
39 Invasive Breast Carcinoma 30 49.9 50.0 signal
40 Bone Lesion 254 48.3 48.7 signal
41 Metastases To Bone Marrow 35 47.7 47.7 signal
42 Carcinoembryonic Antigen Increased 134 47.6 47.8 signal
43 Metastases To Lung 783 46.4 47.5 signal
44 Metastases To Lymph Nodes 454 46.3 47.0 signal
45 Neoplasm Progression 2,129 41.2 44.0 signal
46 Bone Cancer Metastatic 32 41.2 41.2 signal
47 Scan Abnormal 22 40.5 40.5 signal
48 Anisocytosis 38 39.6 39.7 signal
49 Metastases To Peritoneum 146 39.5 39.7 signal
50 Metastases To Stomach 22 38.7 38.7 signal
51 Blood Albumin Abnormal 29 38.2 38.3 signal
52 Osteosclerosis 88 37.7 37.8 signal
53 Osteolysis 107 35.1 35.2 signal
54 Positron Emission Tomogram Abnormal 36 35.1 35.1 signal
55 Primary Sequestrum 47 34.4 34.5 signal
56 Meningoencephalitis Herpetic 23 34.0 34.1 signal
57 Malignant Pleural Effusion 85 33.9 34.0 signal
58 Pleural Thickening 34 33.5 33.5 signal
59 Hypermetabolism 26 33.2 33.2 signal
60 Metastasis 349 32.6 32.9 signal
61 Streptococcal Sepsis 58 32.6 32.6 signal
62 Invasive Ductal Breast Carcinoma 124 30.4 30.5 signal
63 Eastern Cooperative Oncology Group Performance Status Worsened 55 29.5 29.6 signal
64 Decreased Immune Responsiveness 415 28.3 28.6 signal
65 Metastases To Adrenals 39 28.3 28.3 signal
66 Vertebral Foraminal Stenosis 35 28.2 28.2 signal
67 Mean Cell Haemoglobin Increased 70 28.1 28.1 signal
68 Malignant Neoplasm Progression 4,229 27.6 31.6 signal
69 Hepatic Lesion 175 26.9 27.1 signal
70 Hilar Lymphadenopathy 35 26.7 26.7 signal
71 Pleural Disorder 25 26.5 26.5 signal
72 Abdominal Lymphadenopathy 33 25.5 25.5 signal
73 Cancer Pain 96 24.8 24.8 signal
74 Lymphangiosis Carcinomatosa 37 23.5 23.5 signal
75 Blood Bilirubin Abnormal 45 23.5 23.5 signal
76 Malignant Ascites 27 23.3 23.3 signal
77 Intervertebral Disc Space Narrowing 27 22.1 22.2 signal
78 Excessive Granulation Tissue 27 22.0 22.0 signal
79 Basophil Count Increased 25 21.9 21.9 signal
80 Lymphadenopathy Mediastinal 63 21.9 21.9 signal
81 Mean Cell Volume Increased 82 21.0 21.1 signal
82 Pleural Fibrosis 31 19.8 19.8 signal
83 Pseudomonal Sepsis 53 19.8 19.8 signal
84 Post-traumatic Neck Syndrome 24 19.4 19.4 signal
85 Exposed Bone In Jaw 64 19.2 19.2 signal
86 Metastases To Central Nervous System 373 19.1 19.3 signal
87 Osteonecrosis Of Jaw 687 18.1 18.4 signal
88 Blood Alkaline Phosphatase Abnormal 24 17.5 17.5 signal
89 Injection Site Necrosis 54 17.3 17.3 signal
90 Second Primary Malignancy 219 17.3 17.4 signal
91 Metastases To Meninges 57 16.6 16.7 signal
92 Lymphoedema 174 16.5 16.6 signal
93 Hepatic Mass 48 16.3 16.4 signal
94 Macrocytosis 29 16.2 16.3 signal
95 Monocyte Count Decreased 30 16.2 16.2 signal
96 Ovarian Disorder 23 15.9 15.9 signal
97 Fractured Sacrum 30 15.8 15.9 signal
98 Acquired Gene Mutation 31 15.3 15.3 signal
99 Neutrophil Count Abnormal 65 15.0 15.1 signal
100 Hepatic Cyst 76 14.6 14.6 signal
101 Red Cell Distribution Width Increased 93 14.6 14.6 signal
102 Bile Duct Stenosis 26 14.1 14.1 signal
103 Blood Creatinine Abnormal 74 14.0 14.1 signal
104 Vascular Calcification 23 14.0 14.0 signal
105 Tumour Pain 28 13.8 13.8 signal
106 Blood Calcium Abnormal 35 13.8 13.8 signal
107 Gene Mutation 42 13.8 13.8 signal
108 Pathological Fracture 107 13.7 13.8 signal
109 Actinomycosis 20 13.5 13.5 signal
110 Neutrophil Count Decreased 827 13.3 13.6 signal
111 White Blood Cell Count Decreased 2,199 13.2 14.1 signal
112 Body Mass Index Increased 27 13.1 13.1 signal
113 Abscess Jaw 21 13.0 13.0 signal
114 Bone Neoplasm 21 12.6 12.6 signal
115 Metastatic Neoplasm 82 12.4 12.4 signal
116 Vulvovaginal Dryness 61 12.3 12.3 signal
117 Red Blood Cell Count Decreased 533 12.1 12.3 signal
118 Alanine Aminotransferase Abnormal 39 12.1 12.1 signal
119 Neoplasm Recurrence 63 12.0 12.1 signal
120 Hyperglycaemia 671 12.0 12.2 signal
121 White Blood Cell Count Abnormal 117 11.9 12.0 signal
122 Neutropenia 2,485 11.9 12.8 signal
123 Skin Toxicity 101 11.8 11.8 signal
124 Hyperglycaemic Hyperosmolar Nonketotic Syndrome 20 11.7 11.7 signal
125 Superinfection 27 11.7 11.7 signal
126 Periodontal Disease 25 11.5 11.5 signal
127 Aortic Arteriosclerosis 45 11.3 11.3 signal
128 Breast Cancer Stage Iv 50 11.3 11.3 signal
129 Full Blood Count Abnormal 178 10.9 11.0 signal
130 Mean Cell Haemoglobin Decreased 31 10.9 11.0 signal
131 Periodontitis 36 10.9 10.9 signal
132 Aspartate Aminotransferase Abnormal 25 10.7 10.7 signal
133 Full Blood Count Decreased 333 10.7 10.8 signal
134 Mucosal Dryness 33 10.7 10.7 signal
135 Adenocarcinoma 37 10.7 10.7 signal
136 Portal Hypertension 50 10.5 10.5 signal
137 Infusion Site Induration 23 10.5 10.5 signal
138 White Blood Cell Disorder 43 10.4 10.4 signal
139 Onychoclasis 110 10.4 10.4 signal
140 Bone Cancer 69 10.2 10.2 signal
141 Red Blood Cell Count Abnormal 23 10.2 10.2 signal
142 Blood Creatinine Decreased 49 10.1 10.2 signal
143 Vocal Cord Paralysis 28 10.1 10.1 signal
144 Radiculopathy 41 10.1 10.1 signal
145 Pulmonary Mass 229 10.0 10.0 signal
146 Discouragement 35 9.8 9.8 signal
147 Polyneuropathy 179 9.7 9.8 signal
148 Leukopenia 738 9.6 9.8 signal
149 Paronychia 64 9.6 9.6 signal
150 Spinal Pain 170 9.4 9.4 signal
151 Bone Disorder 262 9.2 9.3 signal
152 Ascites 408 9.0 9.1 signal
153 Spondylolisthesis 24 8.9 8.9 signal
154 Haematotoxicity 125 8.7 8.7 signal
155 Vitiligo 31 8.7 8.7 signal
156 Nail Disorder 115 8.5 8.6 signal
157 Hepatic Neoplasm 42 8.3 8.3 signal
158 Recurrent Cancer 52 8.3 8.3 signal
159 Protein Total Increased 34 8.3 8.3 signal
160 Bone Marrow Disorder 38 8.1 8.2 signal
161 Pleural Effusion 766 8.1 8.3 signal
162 Jaw Disorder 69 8.1 8.1 signal
163 Kyphosis 22 8.0 8.0 signal
164 Loose Tooth 40 8.0 8.0 signal
165 Urine Odour Abnormal 73 8.0 8.0 signal
166 Breast Disorder 25 7.9 7.9 signal
167 Neoplasm 138 7.7 7.8 signal
168 Varicose Vein 62 7.7 7.7 signal
169 Haemoglobin Abnormal 76 7.7 7.7 signal
170 Osteitis 30 7.6 7.6 signal
171 Bone Pain 689 7.6 7.7 signal
172 Musculoskeletal Chest Pain 182 7.6 7.6 signal
173 Vascular Device Infection 53 7.6 7.6 signal
174 Portal Vein Thrombosis 37 7.4 7.4 signal
175 Breast Mass 77 7.4 7.4 signal
176 Gingival Swelling 50 7.3 7.3 signal
177 Spinal Cord Compression 44 7.3 7.3 signal
178 Myelosuppression 380 7.2 7.3 signal
179 Disease Progression 1,316 7.2 7.5 signal
180 Vein Disorder 56 7.2 7.2 signal
181 Blood Count Abnormal 170 7.1 7.2 signal
182 Mucosal Inflammation 287 7.1 7.2 signal
183 Hydronephrosis 82 7.1 7.1 signal
184 Stomatitis 654 6.9 7.1 signal
185 Haemangioma 25 6.9 7.0 signal
186 Spinal Osteoarthritis 95 6.9 6.9 signal
187 Gingivitis 58 6.9 6.9 signal
188 Platelet Count Abnormal 63 6.7 6.7 signal
189 Concomitant Disease Aggravated 64 6.7 6.7 signal
190 Cachexia 53 6.7 6.7 signal
191 Vasodilatation 26 6.7 6.7 signal
192 Oral Pain 231 6.6 6.7 signal
193 Aphthous Ulcer 78 6.5 6.6 signal
194 Jaw Fracture 22 6.5 6.5 signal
195 Palmar-plantar Erythrodysaesthesia Syndrome 236 6.5 6.5 signal
196 Breast Cancer 947 6.5 6.6 signal
197 Erysipelas 50 6.4 6.4 signal
198 Erythema Multiforme 91 6.3 6.3 signal
199 Diverticulum Intestinal 42 6.2 6.2 signal
200 Haematocrit Decreased 190 6.1 6.2 signal
201 Lymphadenitis 23 6.1 6.1 signal
202 Tongue Blistering 21 6.0 6.0 signal
203 Gingival Pain 74 6.0 6.0 signal
204 Body Height Decreased 99 5.9 5.9 signal
205 Lymphadenopathy 324 5.9 5.9 signal
206 Hypertransaminasaemia 62 5.9 5.9 signal
207 Bone Marrow Failure 186 5.8 5.9 signal
208 Atelectasis 88 5.8 5.9 signal
209 Hepatotoxicity 200 5.8 5.8 signal
210 Breast Pain 96 5.8 5.8 signal
211 Volvulus 21 5.8 5.8 signal
212 Pneumonitis 243 5.8 5.8 signal
213 Purulent Discharge 38 5.7 5.7 signal
214 Cytopenia 106 5.7 5.7 signal
215 Breast Swelling 24 5.7 5.7 signal
216 Mastication Disorder 27 5.7 5.7 signal
217 Hepatic Failure 264 5.6 5.7 signal
218 Oral Disorder 64 5.6 5.6 signal
219 Toothache 155 5.5 5.5 signal
220 Monocyte Count Increased 31 5.5 5.5 signal
221 Goitre 35 5.5 5.5 signal
222 Glomerular Filtration Rate Decreased 103 5.5 5.5 signal
223 Gastrointestinal Toxicity 40 5.5 5.5 signal
224 Nasal Dryness 53 5.4 5.4 signal
225 Pigmentation Disorder 52 5.4 5.4 signal
226 Oesophageal Stenosis 24 5.4 5.4 signal
227 Osteomyelitis 151 5.4 5.4 signal
228 Platelet Disorder 21 5.3 5.3 signal
229 Dental Caries 91 5.3 5.3 signal
230 Hepatomegaly 81 5.3 5.3 signal
231 Transaminases Increased 181 5.2 5.3 signal
232 Cerebral Thrombosis 23 5.2 5.2 signal
233 Skin Mass 54 5.2 5.2 signal
234 Diastolic Dysfunction 25 5.2 5.2 signal
235 Pain In Jaw 228 5.2 5.2 signal
236 Platelet Count Decreased 850 5.1 5.2 signal
237 Tricuspid Valve Incompetence 63 5.1 5.1 signal
238 Parosmia 60 5.1 5.1 signal
239 Blood Alkaline Phosphatase Increased 198 5.1 5.1 signal
240 Thyroid Neoplasm 22 5.1 5.1 signal
241 Granulocytopenia 45 5.0 5.0 signal
242 Thoracic Vertebral Fracture 23 5.0 5.0 signal
243 Neck Mass 22 5.0 5.0 signal
244 Lung Opacity 20 5.0 5.0 signal
245 Liver Function Test Increased 165 5.0 5.0 signal
246 Blood Test Abnormal 108 4.9 5.0 signal
247 Taste Disorder 154 4.9 5.0 signal
248 Facet Joint Syndrome 24 4.9 4.9 signal
249 Thrombocytopenia 842 4.9 5.0 signal
250 Mouth Swelling 43 4.8 4.8 signal
251 Gamma-glutamyltransferase Increased 165 4.8 4.8 signal
252 Protein Total Decreased 28 4.8 4.8 signal
253 Renal Cyst 59 4.8 4.8 signal
254 Acute Lymphocytic Leukaemia 21 4.8 4.8 signal
255 Ejection Fraction Decreased 114 4.7 4.7 signal
256 Tooth Extraction 91 4.7 4.7 signal
257 Tooth Fracture 80 4.7 4.7 signal
258 Haemoglobin Decreased 746 4.7 4.7 signal
259 Oral Infection 28 4.6 4.6 signal
260 Rectal Cancer 22 4.6 4.6 signal
261 Eating Disorder 152 4.6 4.6 signal
262 Compression Fracture 37 4.6 4.6 signal
263 Injection Site Scar 20 4.6 4.6 signal
264 Infusion Site Haemorrhage 23 4.6 4.6 signal
265 Hot Flush 534 4.5 4.6 signal
266 Thrombophlebitis 25 4.5 4.5 signal
267 Sciatica 112 4.5 4.5 signal
268 Brain Oedema 89 4.5 4.5 signal
269 Alopecia 1,379 4.5 4.7 signal
270 Blood Calcium Decreased 79 4.5 4.5 signal
271 Gingival Disorder 27 4.5 4.5 signal
272 Rhinitis Allergic 31 4.5 4.5 signal
273 Carbohydrate Antigen 125 Increased 24 4.5 4.5 signal
274 Therapy Partial Responder 105 4.5 4.5 signal
275 Lung Infiltration 62 4.5 4.5 signal
276 Aspartate Aminotransferase Increased 368 4.4 4.5 signal
277 Scoliosis 43 4.4 4.4 signal
278 Spinal Compression Fracture 58 4.4 4.4 signal
279 Dyspnoea At Rest 20 4.4 4.4 signal
280 Nodule 90 4.4 4.4 signal
281 Hepatic Steatosis 128 4.4 4.4 signal
282 Anaemia 1,304 4.4 4.5 signal
283 Blood Bilirubin Increased 185 4.4 4.4 signal
284 Hepatic Enzyme Abnormal 34 4.4 4.4 signal
285 Clavicle Fracture 26 4.3 4.4 signal
286 Odynophagia 40 4.3 4.3 signal
287 Glossitis 24 4.3 4.3 signal
288 Mass 94 4.3 4.3 signal
289 Feeding Disorder 133 4.3 4.3 signal
290 Dyspnoea Exertional 250 4.3 4.3 signal
291 Neuropathy Peripheral 621 4.2 4.3 signal
292 Immunodeficiency 96 4.2 4.2 signal
293 Osteonecrosis 216 4.2 4.2 signal
294 Hypercalcaemia 80 4.2 4.2 signal
295 Ovarian Cancer 60 4.2 4.2 signal
296 Spinal Column Stenosis 31 4.2 4.2 signal
297 Skin Atrophy 37 4.1 4.1 signal
298 Lymphocyte Count Increased 21 4.1 4.1 signal
299 Thyroid Mass 24 4.1 4.1 signal
300 Flank Pain 59 4.0 4.1 signal
301 Food Intolerance 23 4.0 4.0 signal
302 Decreased Appetite 1,456 4.0 4.2 signal
303 Interstitial Lung Disease 303 4.0 4.1 signal
304 Tooth Abscess 64 4.0 4.0 signal
305 Synovial Cyst 29 4.0 4.0 signal
306 Phlebitis 32 4.0 4.0 signal
307 Osteopenia 95 4.0 4.0 signal
308 General Physical Health Deterioration 712 4.0 4.0 signal
309 Candida Infection 103 4.0 4.0 signal
310 Lacrimation Increased 184 4.0 4.0 signal
311 Nail Discolouration 24 3.9 3.9 signal
312 Intervertebral Disc Degeneration 57 3.9 3.9 signal
313 Immunosuppression 53 3.9 3.9 signal
314 Decreased Interest 36 3.9 3.9 signal
315 Hiatus Hernia 79 3.9 3.9 signal
316 Hepatic Pain 26 3.9 3.9 signal
317 Blood Creatinine Increased 396 3.9 3.9 signal
318 Femoral Neck Fracture 31 3.9 3.9 signal
319 Oesophagitis 66 3.9 3.9 signal
320 Hyperpyrexia 25 3.9 3.9 signal
321 Trigger Finger 24 3.8 3.8 signal
322 Tooth Disorder 131 3.8 3.8 signal
323 Blood Calcium Increased 51 3.7 3.7 signal
324 Gastritis 152 3.7 3.7 signal
325 Granuloma 20 3.7 3.7 signal
326 Onychomadesis 24 3.7 3.7 signal
327 Hypoalbuminaemia 44 3.7 3.7 signal
328 Rhinitis 46 3.7 3.7 signal
329 Appetite Disorder 37 3.6 3.6 signal
330 Mitral Valve Incompetence 64 3.6 3.6 signal
331 Madarosis 66 3.6 3.6 signal
332 Jaundice 152 3.6 3.6 signal
333 Bundle Branch Block Left 24 3.6 3.6 signal
334 Hepatic Cirrhosis 105 3.6 3.6 signal
335 Haemorrhagic Diathesis 20 3.6 3.6 signal
336 Cardiomegaly 69 3.6 3.6 signal
337 Blood Uric Acid Increased 32 3.6 3.6 signal
338 Liver Disorder 244 3.5 3.5 signal
339 Oropharyngeal Discomfort 49 3.5 3.5 signal
340 Oral Mucosal Blistering 35 3.5 3.5 signal
341 Trigeminal Neuralgia 22 3.5 3.5 signal
342 Skin Fissures 103 3.5 3.5 signal
343 Alanine Aminotransferase Increased 335 3.5 3.5 signal
344 Impaired Healing 178 3.5 3.5 signal
345 Fatigue 4,182 3.5 3.8 signal
346 Skin Odour Abnormal 21 3.4 3.4 signal
347 Yellow Skin 25 3.4 3.4 signal
348 Ocular Icterus 23 3.4 3.4 signal
349 Peripheral Sensory Neuropathy 31 3.4 3.4 signal
350 Spinal Disorder 50 3.4 3.4 signal
351 Lymphocyte Count Decreased 93 3.4 3.4 signal
352 Cerebral Atrophy 21 3.4 3.4 signal
353 Vitamin D Deficiency 51 3.4 3.4 signal
354 Cerebral Ischaemia 27 3.3 3.3 signal
355 Hormone Level Abnormal 25 3.3 3.3 signal
356 Stress Cardiomyopathy 30 3.3 3.3 signal
357 Tooth Infection 68 3.3 3.3 signal
358 Mouth Ulceration 108 3.3 3.3 signal
359 Performance Status Decreased 24 3.3 3.3 signal
360 Laboratory Test Abnormal 151 3.3 3.3 signal
361 Intervertebral Disc Disorder 22 3.3 3.3 signal
362 Pancytopenia 285 3.3 3.3 signal
363 Electrocardiogram Qt Prolonged 184 3.3 3.3 signal
364 Feeling Cold 142 3.3 3.3 signal
365 Rib Fracture 104 3.2 3.3 signal
366 Joint Effusion 35 3.2 3.2 signal
367 Musculoskeletal Discomfort 87 3.2 3.2 signal
368 Drug Intolerance 486 3.2 3.3 signal
369 Hepatic Function Abnormal 187 3.2 3.2 signal
370 Drug Resistance 129 3.2 3.2 signal
371 Pulmonary Toxicity 35 3.2 3.2 signal
372 Haemorrhoids 97 3.2 3.2 signal
373 Cardiotoxicity 44 3.2 3.2 signal
374 Neutrophil Count Increased 51 3.2 3.2 signal
375 Iron Deficiency 22 3.2 3.2 signal
376 Physical Disability 22 3.2 3.2 signal
377 Exostosis 45 3.2 3.2 signal
378 Blood Lactate Dehydrogenase Increased 78 3.1 3.1 signal
379 Overweight 26 3.1 3.1 signal
380 Embolism 40 3.1 3.1 signal
381 Vitamin D Decreased 41 3.1 3.1 signal
382 Groin Pain 42 3.1 3.1 signal
383 Hair Texture Abnormal 64 3.0 3.0 signal
384 Back Pain 1,102 3.0 3.1 signal
385 Asthenia 1,771 3.0 3.1 signal
386 Pericardial Effusion 108 3.0 3.0 signal
387 Blood Urea Increased 79 3.0 3.0 signal
388 Endocarditis 24 3.0 3.0 signal
389 Blood Albumin Decreased 37 3.0 3.0 signal
390 Hyperlipidaemia 56 3.0 3.0 signal
391 Necrosis 26 3.0 3.0 signal
392 Skin Lesion 124 2.9 2.9 signal
393 Product Supply Issue 32 2.9 2.9 signal
394 Tenderness 47 2.9 2.9 signal
395 Ageusia 112 2.9 2.9 signal
396 Epistaxis 332 2.8 2.9 signal
397 Nerve Injury 49 2.8 2.8 signal
398 Hypertensive Crisis 49 2.8 2.8 signal
399 Abdominal Hernia 20 2.8 2.8 signal
400 Musculoskeletal Pain 230 2.8 2.8 signal
401 Incontinence 46 2.8 2.8 signal
402 Hair Growth Abnormal 30 2.8 2.8 signal
403 Blood Glucose Abnormal 80 2.8 2.8 signal
404 Feeling Of Despair 20 2.8 2.8 signal
405 Decubitus Ulcer 35 2.7 2.8 signal
406 Platelet Count Increased 56 2.7 2.7 signal
407 Constipation 924 2.7 2.8 signal
408 Haemorrhoidal Haemorrhage 21 2.7 2.7 signal
409 Pelvic Fracture 33 2.7 2.7 signal
410 Ecchymosis 29 2.7 2.7 signal
411 Sensory Disturbance 68 2.7 2.7 signal
412 C-reactive Protein Increased 153 2.7 2.7 signal
413 Central Nervous System Lesion 58 2.7 2.7 signal
414 Liver Injury 101 2.7 2.7 signal
415 Limb Discomfort 129 2.7 2.7 signal
416 Sensitive Skin 30 2.7 2.7 signal
417 Arteriosclerosis 39 2.6 2.7 signal
418 Muscle Atrophy 52 2.6 2.6 signal
419 Metabolic Disorder 24 2.6 2.6 signal
420 Diabetic Ketoacidosis 99 2.6 2.6 signal
421 Pulmonary Oedema 185 2.6 2.7 signal
422 General Physical Condition Abnormal 28 2.6 2.6 signal
423 Skin Disorder 136 2.6 2.6 signal
424 Arteriosclerosis Coronary Artery 27 2.6 2.6 signal
425 Fistula 46 2.6 2.6 signal
426 Diarrhoea 2,623 2.6 2.8 signal
427 Cough 1,140 2.6 2.7 signal
428 Movement Disorder 131 2.6 2.6 signal
429 Bronchiectasis 27 2.6 2.6 signal
430 Injection Site Inflammation 20 2.6 2.6 signal
431 Wound 112 2.6 2.6 signal
432 Enterocolitis 23 2.6 2.6 signal
433 Retinal Detachment 37 2.6 2.6 signal
434 Gingival Bleeding 55 2.6 2.6 signal
435 Hepatitis 102 2.6 2.6 signal
436 Hypocalcaemia 75 2.5 2.5 signal
437 Intervertebral Disc Protrusion 87 2.5 2.5 signal
438 Fracture 75 2.5 2.5 signal
439 Malnutrition 44 2.5 2.5 signal
440 Pulmonary Embolism 378 2.5 2.6 signal
441 Hair Disorder 33 2.5 2.5 signal
442 Neuralgia 96 2.5 2.5 signal
443 Food Poisoning 21 2.5 2.5 signal
444 Hypokalaemia 178 2.5 2.5 signal
445 Poor Venous Access 40 2.5 2.5 signal
446 Hypercholesterolaemia 37 2.5 2.5 signal
447 Faecaloma 21 2.5 2.5 signal
448 Haematoma 100 2.5 2.5 signal
449 Tongue Disorder 28 2.5 2.5 signal
450 Dry Throat 39 2.5 2.5 signal
451 Nausea 3,029 2.5 2.6 signal
452 Sensory Loss 31 2.5 2.5 signal
453 Body Temperature Decreased 38 2.4 2.5 signal
454 Dermatitis 79 2.4 2.4 signal
455 Product Dose Omission In Error 102 2.4 2.4 signal
456 Weight Decreased 1,057 2.4 2.5 signal
457 Hospice Care 37 2.4 2.4 signal
458 Dry Skin 494 2.4 2.4 signal
459 Coronavirus Infection 25 2.4 2.4 signal
460 Scar 64 2.4 2.4 signal
461 Injection Site Mass 137 2.4 2.4 signal
462 Cellulitis 187 2.4 2.4 signal
463 Blood Potassium Increased 60 2.4 2.4 signal
464 Osteoarthritis 154 2.3 2.3 signal
465 Lung Disorder 177 2.3 2.3 signal
466 Renal Impairment 302 2.3 2.3 signal
467 Diverticulum 26 2.3 2.3 signal
468 Dehydration 480 2.3 2.3 signal
469 Pneumothorax 57 2.3 2.3 signal
470 Faeces Soft 26 2.3 2.3 signal
471 Oral Discomfort 50 2.3 2.3 signal
472 Facial Pain 32 2.3 2.3 signal
473 Lip Dry 32 2.3 2.3 signal
474 Osteoporosis 147 2.3 2.3 signal
475 Spinal Fracture 71 2.3 2.3 signal
476 Injection Site Nodule 39 2.3 2.3 signal
477 Uterine Leiomyoma 26 2.3 2.3 signal
478 Upper-airway Cough Syndrome 29 2.3 2.3 signal
479 Cystitis 113 2.3 2.3 signal
480 Dysgeusia 264 2.3 2.3 signal
481 Pharyngitis 44 2.3 2.3 signal
482 Ear Pain 68 2.2 2.2 signal
483 Immune System Disorder 46 2.2 2.2 signal
484 Blood Disorder 28 2.2 2.2 signal
485 Bronchospasm 50 2.2 2.2 signal
486 Inflammation 179 2.2 2.2 signal
487 Pyelonephritis 30 2.2 2.2 signal
488 Brain Neoplasm 32 2.2 2.2 signal
489 Blood Magnesium Decreased 30 2.2 2.2 signal
490 Dyspepsia 339 2.2 2.2 signal
491 Dermatitis Allergic 43 2.2 2.2 signal
492 Skeletal Injury 36 2.2 2.2 signal
493 Arthralgia 1,425 2.2 2.3 signal
494 Depressed Mood 181 2.2 2.2 signal
495 Hepatic Encephalopathy 32 2.2 2.2 signal
496 Ileus 42 2.2 2.2 signal
497 Pelvic Pain 62 2.2 2.2 signal
498 Renal Pain 36 2.2 2.2 signal
499 Head Discomfort 60 2.2 2.2 signal
500 Discomfort 206 2.2 2.2 signal
501 Hyperbilirubinaemia 35 2.2 2.2 signal
502 Ulcer 54 2.2 2.2 signal
503 Pulmonary Thrombosis 37 2.2 2.2 signal
504 Vomiting 1,577 2.2 2.2 signal
505 Neoplasm Malignant 224 2.1 2.2 signal
506 Small Intestinal Obstruction 41 2.1 2.1 signal
507 Diabetes Mellitus 255 2.1 2.1 signal
508 Acute Hepatic Failure 45 2.1 2.1 signal
509 Aphonia 46 2.1 2.1 signal
510 Scratch 34 2.1 2.1 signal
511 Bowel Movement Irregularity 25 2.1 2.1 signal
512 Dysphagia 310 2.1 2.1 signal
513 Dysphonia 191 2.1 2.1 signal
514 Skin Reaction 46 2.1 2.1 signal
515 Pain In Extremity 962 2.1 2.1 signal
516 Blood Thyroid Stimulating Hormone Increased 30 2.1 2.1 signal
517 Retching 69 2.1 2.1 signal
518 Thermal Burn 23 2.1 2.1 signal
519 Tendon Disorder 21 2.1 2.1 signal
520 Dry Mouth 259 2.0 2.1 signal
521 Cholecystitis 38 2.0 2.0 signal
522 Injection Site Discomfort 33 2.0 2.0 signal
523 Illness 320 2.0 2.0 signal
524 Death 2,742 2.0 2.1 signal
525 Dysuria 117 2.0 2.0 signal
526 Petechiae 33 2.0 2.0 signal
527 Oedema Peripheral 388 2.0 2.0 signal
528 Abnormal Faeces 26 2.0 2.0 signal
529 Tooth Loss 66 2.0 2.0 signal
530 Dry Eye 153 2.0 2.0 signal
531 Hyperaesthesia 26 2.0 2.0 signal
532 Nasal Discomfort 25 2.0 2.0 signal
533 Chills 367 2.0 2.0 no signal
534 Gait Disturbance 597 2.0 2.0 no signal
535 Liver Function Test Abnormal 91 2.0 2.0 no signal
536 Pyrexia 1,076 2.0 2.0 no signal
537 Conjunctivitis 57 2.0 2.0 no signal
538 Blood Pressure Diastolic Decreased 23 2.0 2.0 no signal
539 Skin Ulcer 80 2.0 2.0 no signal
540 Deformity 29 2.0 2.0 no signal
541 Cholelithiasis 101 2.0 2.0 no signal
542 Bursitis 37 2.0 2.0 no signal
543 Abdominal Discomfort 512 2.0 2.0 no signal
544 Hypoaesthesia Oral 46 2.0 2.0 no signal
545 Polyuria 25 2.0 2.0 no signal
546 Hepatic Enzyme Increased 207 1.9 2.0 no signal
547 Oropharyngeal Pain 282 1.9 2.0 no signal
548 Electrolyte Imbalance 35 1.9 1.9 no signal
549 Productive Cough 144 1.9 1.9 no signal
550 Blood Sodium Decreased 57 1.9 1.9 no signal
551 Hypoaesthesia 454 1.9 2.0 no signal
552 Blood Pressure Abnormal 60 1.9 1.9 no signal
553 Thirst 54 1.9 1.9 no signal
554 Skin Discolouration 139 1.9 1.9 no signal
555 Pulmonary Congestion 40 1.9 1.9 no signal
556 Gait Inability 100 1.9 1.9 no signal
557 Breast Cancer Female 81 1.9 1.9 no signal
558 Gastrooesophageal Reflux Disease 241 1.9 1.9 no signal
559 Sleep Disorder 210 1.9 1.9 no signal
560 Pneumocystis Jirovecii Pneumonia 30 1.9 1.9 no signal
561 Blood Potassium Decreased 90 1.9 1.9 no signal
562 Hypokinesia 43 1.9 1.9 no signal
563 Urinary Tract Infection 503 1.9 1.9 no signal
564 Abscess 47 1.9 1.9 no signal
565 Hair Colour Changes 37 1.9 1.9 no signal
566 Iron Deficiency Anaemia 27 1.9 1.9 no signal
567 Asphyxia 24 1.9 1.9 no signal
568 Dysstasia 86 1.9 1.9 no signal
569 White Blood Cell Count Increased 113 1.9 1.9 no signal
570 Blood Pressure Systolic Increased 57 1.9 1.9 no signal
571 Bone Loss 44 1.9 1.9 no signal
572 Rash 1,256 1.9 1.9 no signal
573 Dyspnoea 1,633 1.8 1.9 no signal
574 Red Blood Cell Sedimentation Rate Increased 32 1.8 1.8 no signal
575 Hepatic Cytolysis 35 1.8 1.8 no signal
576 Pain 1,758 1.8 1.9 no signal
577 Peripheral Swelling 438 1.8 1.8 no signal
578 Drug-induced Liver Injury 88 1.8 1.8 no signal
579 Cardiomyopathy 42 1.8 1.8 no signal
580 Femur Fracture 88 1.8 1.8 no signal
581 Choking 55 1.8 1.8 no signal
582 Gastrointestinal Pain 31 1.8 1.8 no signal
583 Muscle Disorder 23 1.8 1.8 no signal
584 Covid-19 494 1.8 1.8 no signal
585 Electrocardiogram Abnormal 22 1.8 1.8 no signal
586 Thrombotic Microangiopathy 27 1.8 1.8 no signal
587 Muscle Strain 24 1.8 1.8 no signal
588 Carpal Tunnel Syndrome 39 1.8 1.8 no signal
589 Malaise 1,219 1.8 1.8 no signal
590 Lymphopenia 39 1.8 1.8 no signal
591 Hepatocellular Injury 39 1.8 1.8 no signal
592 Ischaemic Stroke 49 1.8 1.8 no signal
593 Hypothyroidism 87 1.7 1.7 no signal
594 Rash Pruritic 147 1.7 1.7 no signal
595 Hypophagia 69 1.7 1.7 no signal
596 Urosepsis 25 1.7 1.7 no signal
597 Oedema 146 1.7 1.7 no signal
598 Vaginal Discharge 27 1.7 1.7 no signal
599 Localised Infection 65 1.7 1.7 no signal
600 Peripheral Coldness 37 1.7 1.7 no signal
601 Ovarian Cyst 27 1.7 1.7 no signal
602 Glossodynia 60 1.7 1.7 no signal
603 Treatment Failure 220 1.7 1.7 no signal
604 Incorrect Route Of Product Administration 45 1.7 1.7 no signal
605 Emphysema 27 1.7 1.7 no signal
606 Increased Appetite 50 1.7 1.7 no signal
607 Chromaturia 60 1.7 1.7 no signal
608 Paralysis 38 1.7 1.7 no signal
609 Ligament Sprain 26 1.7 1.7 no signal
610 Contusion 253 1.7 1.7 no signal
611 Posterior Reversible Encephalopathy Syndrome 25 1.7 1.7 no signal
612 Abdominal Distension 273 1.7 1.7 no signal
613 Oral Herpes 51 1.7 1.7 no signal
614 Decreased Activity 28 1.7 1.7 no signal
615 Abdominal Pain 607 1.7 1.7 no signal
616 Abdominal Pain Upper 535 1.7 1.7 no signal
617 Joint Stiffness 68 1.7 1.7 no signal
618 Arrhythmia 123 1.7 1.7 no signal
619 Hip Fracture 83 1.7 1.7 no signal
620 Anal Incontinence 23 1.7 1.7 no signal
621 Laryngitis 28 1.6 1.6 no signal
622 Thrombosis 207 1.6 1.6 no signal
623 Haemolytic Anaemia 23 1.6 1.6 no signal
624 Hypertension 537 1.6 1.6 no signal
625 Neck Pain 141 1.6 1.6 no signal
626 Skin Exfoliation 209 1.6 1.6 no signal
627 Upper Respiratory Tract Infection 116 1.6 1.6 no signal
628 Supraventricular Tachycardia 24 1.6 1.6 no signal
629 Skin Laceration 27 1.6 1.6 no signal
630 Pollakiuria 104 1.6 1.6 no signal
631 Burning Sensation 175 1.6 1.6 no signal
632 Nervousness 131 1.6 1.6 no signal
633 Urinary Retention 83 1.6 1.6 no signal
634 Aspiration 27 1.6 1.6 no signal
635 Infection 359 1.6 1.6 no signal
636 Restlessness 91 1.6 1.6 no signal
637 Cataract 147 1.6 1.6 no signal
638 Memory Impairment 339 1.6 1.6 no signal
639 Pulmonary Fibrosis 47 1.6 1.6 no signal
640 Myalgia 415 1.6 1.6 no signal
641 Multiple Organ Dysfunction Syndrome 68 1.6 1.6 no signal
642 Cardiac Murmur 21 1.5 1.5 no signal
643 Pneumonia Bacterial 22 1.5 1.5 no signal
644 Acute Respiratory Failure 46 1.5 1.5 no signal
645 Dizziness Postural 23 1.5 1.5 no signal
646 Nocturia 29 1.5 1.5 no signal
647 Swelling 223 1.5 1.5 no signal
648 Hypomagnesaemia 33 1.5 1.5 no signal
649 Throat Irritation 106 1.5 1.5 no signal
650 Product Distribution Issue 21 1.5 1.5 no signal
651 Paraesthesia Oral 34 1.5 1.5 no signal
652 Paraesthesia 372 1.5 1.5 no signal
653 Secretion Discharge 29 1.5 1.5 no signal
654 Hypersomnia 67 1.5 1.5 no signal
655 Colitis 88 1.5 1.5 no signal
656 Eye Inflammation 22 1.5 1.5 no signal
657 Brain Fog 34 1.5 1.5 no signal
658 Night Sweats 75 1.5 1.5 no signal
659 Blood Glucose Increased 439 1.5 1.5 no signal
660 Head Injury 73 1.5 1.5 no signal
661 Cardiac Failure 185 1.5 1.5 no signal
662 Glycosylated Haemoglobin Increased 58 1.5 1.5 no signal
663 Rash Maculo-papular 51 1.5 1.5 no signal
664 Scab 26 1.5 1.5 no signal
665 Respiratory Failure 167 1.5 1.5 no signal
666 Nerve Compression 21 1.5 1.5 no signal
667 Thyroid Disorder 35 1.5 1.5 no signal
668 Muscular Weakness 258 1.5 1.5 no signal
669 Drug Eruption 40 1.4 1.5 no signal
670 Blister 127 1.4 1.5 no signal
671 Sinus Tachycardia 32 1.4 1.4 no signal
672 Hypoxia 79 1.4 1.4 no signal
673 Cholestasis 43 1.4 1.4 no signal
674 Deep Vein Thrombosis 147 1.4 1.4 no signal
675 Flatulence 127 1.4 1.4 no signal
676 Renal Tubular Necrosis 22 1.4 1.4 no signal
677 Febrile Neutropenia 146 1.4 1.4 no signal
678 Poor Quality Sleep 47 1.4 1.4 no signal
679 Neurotoxicity 38 1.4 1.4 no signal
680 Chest Pain 405 1.4 1.4 no signal
681 Dizziness 1,086 1.4 1.4 no signal
682 Limb Injury 59 1.4 1.4 no signal
683 Pruritus 823 1.4 1.4 no signal
684 Cyst 27 1.4 1.4 no signal
685 Sinus Bradycardia 21 1.4 1.4 no signal
686 Sluggishness 22 1.4 1.4 no signal
687 Influenza 241 1.4 1.4 no signal
688 Visual Impairment 265 1.4 1.4 no signal
689 Skin Haemorrhage 31 1.4 1.4 no signal
690 Hypoacusis 92 1.4 1.4 no signal
691 Gastroenteritis 31 1.4 1.4 no signal
692 Swelling Face 138 1.4 1.4 no signal
693 Tendonitis 33 1.4 1.4 no signal
694 Hypersensitivity 393 1.4 1.4 no signal
695 Blood Iron Decreased 25 1.4 1.4 no signal
696 Micturition Urgency 24 1.4 1.4 no signal
697 Muscle Spasms 388 1.4 1.4 no signal
698 Pain Of Skin 57 1.3 1.3 no signal
699 Bacterial Infection 39 1.3 1.3 no signal
700 Rotator Cuff Syndrome 27 1.3 1.3 no signal
701 Joint Dislocation 22 1.3 1.3 no signal
702 Feeling Hot 128 1.3 1.3 no signal
703 Sinus Disorder 41 1.3 1.3 no signal
704 Joint Injury 44 1.3 1.3 no signal
705 Temperature Intolerance 21 1.3 1.3 no signal
706 Eye Discharge 21 1.3 1.3 no signal
707 Mobility Decreased 147 1.3 1.3 no signal
708 Coagulopathy 34 1.3 1.3 no signal
709 Arthritis 161 1.3 1.3 no signal
710 Atrial Fibrillation 199 1.3 1.3 no signal
711 Feeling Abnormal 490 1.3 1.3 no signal
712 Erythema 418 1.3 1.3 no signal
713 Throat Tightness 55 1.3 1.3 no signal
714 Renal Disorder 95 1.3 1.3 no signal
715 Herpes Zoster 117 1.3 1.3 no signal
716 Nasopharyngitis 375 1.3 1.3 no signal
717 Diverticulitis 56 1.3 1.3 no signal
718 Renal Failure 271 1.3 1.3 no signal
719 Ventricular Extrasystoles 21 1.3 1.3 no signal
720 Covid-19 Pneumonia 24 1.3 1.3 no signal
721 Device Related Infection 31 1.3 1.3 no signal
722 Oral Candidiasis 26 1.3 1.3 no signal
723 Sepsis 223 1.3 1.3 no signal
724 Eructation 38 1.3 1.3 no signal
725 Coordination Abnormal 28 1.3 1.3 no signal
726 Urinary Incontinence 59 1.3 1.3 no signal
727 Viral Infection 66 1.3 1.3 no signal
728 Acute Kidney Injury 301 1.3 1.3 no signal
729 Bronchitis 147 1.3 1.3 no signal
730 Pancreatitis Acute 44 1.3 1.3 no signal
731 Obstructive Airways Disorder 22 1.3 1.3 no signal
732 Disease Recurrence 94 1.3 1.3 no signal
733 Insomnia 525 1.3 1.3 no signal
734 Pulmonary Hypertension 41 1.3 1.3 no signal
735 Hypoglycaemia 95 1.3 1.3 no signal
736 Product Use Issue 364 1.2 1.2 no signal
737 Deafness 51 1.2 1.2 no signal
738 Gastric Ulcer 37 1.2 1.2 no signal
739 Product Prescribing Error 46 1.2 1.2 no signal
740 Obesity 31 1.2 1.2 no signal
741 Presyncope 47 1.2 1.2 no signal
742 Stress 139 1.2 1.2 no signal
743 Speech Disorder 101 1.2 1.2 no signal
744 Gastric Disorder 67 1.2 1.2 no signal
745 Weight Increased 428 1.2 1.2 no signal
746 Therapy Cessation 98 1.2 1.2 no signal
747 Chest Discomfort 195 1.2 1.2 no signal
748 Emotional Disorder 59 1.2 1.2 no signal
749 Respiratory Disorder 57 1.2 1.2 no signal
750 Anxiety 541 1.2 1.2 no signal
751 Rhinorrhoea 122 1.2 1.2 no signal
752 Abdominal Pain Lower 48 1.2 1.2 no signal
753 Blood Cholesterol Increased 88 1.2 1.2 no signal
754 Diplopia 49 1.2 1.2 no signal
755 Hyponatraemia 106 1.2 1.2 no signal
756 Glaucoma 36 1.2 1.2 no signal
757 Generalised Oedema 23 1.2 1.2 no signal
758 Rash Macular 65 1.2 1.2 no signal
759 Influenza Like Illness 154 1.2 1.2 no signal
760 Blood Triglycerides Increased 33 1.2 1.2 no signal
761 Ear Discomfort 19 1.2 1.2 no signal
762 Haematemesis 47 1.2 1.2 no signal
763 Upper Limb Fracture 37 1.2 1.2 no signal
764 Increased Tendency To Bruise 17 1.2 1.2 no signal
765 Injection Site Extravasation 23 1.2 1.2 no signal
766 Disseminated Intravascular Coagulation 26 1.2 1.2 no signal
767 Wound Infection 20 1.2 1.2 no signal
768 Vertigo 112 1.2 1.2 no signal
769 Syncope 182 1.2 1.2 no signal
770 Tachycardia 161 1.2 1.2 no signal
771 Body Temperature Increased 37 1.2 1.2 no signal
772 Rhabdomyolysis 75 1.2 1.2 no signal
773 Headache 1,128 1.2 1.2 no signal
774 Cerebral Infarction 44 1.1 1.1 no signal
775 Dementia 50 1.1 1.1 no signal
776 Ill-defined Disorder 109 1.1 1.1 no signal
777 Muscle Tightness 29 1.1 1.1 no signal
778 Pneumonia 579 1.1 1.1 no signal
779 Eczema 90 1.1 1.1 no signal
780 Intestinal Obstruction 67 1.1 1.1 no signal
781 Quality Of Life Decreased 24 1.1 1.1 no signal
782 Kidney Infection 35 1.1 1.1 no signal
783 Product Availability Issue 40 1.1 1.1 no signal
784 Blood Pressure Decreased 118 1.1 1.1 no signal
785 Depression 406 1.1 1.1 no signal
786 Hemiparesis 30 1.1 1.1 no signal
787 Sinusitis 180 1.1 1.1 no signal
788 Type 2 Diabetes Mellitus 59 1.1 1.1 no signal
789 Poisoning 22 1.1 1.1 no signal
790 Nasal Congestion 102 1.1 1.1 no signal
791 Fungal Infection 58 1.1 1.1 no signal
792 Delirium 60 1.1 1.1 no signal
793 Lactic Acidosis 55 1.1 1.1 no signal
794 Gastroenteritis Viral 31 1.1 1.1 no signal
795 Fluid Retention 87 1.1 1.1 no signal
796 Hunger 23 1.1 1.1 no signal
797 Frequent Bowel Movements 46 1.1 1.1 no signal
798 Local Swelling 30 1.1 1.1 no signal
799 Hypotonia 17 1.1 1.1 no signal
800 Foot Fracture 32 1.1 1.1 no signal
801 Agranulocytosis 31 1.1 1.1 no signal
802 Balance Disorder 144 1.1 1.1 no signal
803 Back Injury 18 1.1 1.1 no signal
804 Ocular Discomfort 18 1.1 1.1 no signal
805 Face Oedema 28 1.1 1.1 no signal
806 Lung Infection 26 1.1 1.1 no signal
807 Pallor 45 1.1 1.1 no signal
808 Rectal Haemorrhage 71 1.1 1.1 no signal
809 Crying 60 1.1 1.1 no signal
810 Circulatory Collapse 28 1.0 1.0 no signal
811 Weight Fluctuation 17 1.0 1.0 no signal
812 Injection Site Pain 493 1.0 1.0 no signal
813 Injection Site Induration 21 1.0 1.0 no signal
814 Mental Status Changes 45 1.0 1.0 no signal
815 Blood Pressure Increased 248 1.0 1.0 no signal
816 Respiratory Tract Infection 42 1.0 1.0 no signal
817 Nephropathy Toxic 18 1.0 1.0 no signal
818 Faeces Discoloured 35 1.0 1.0 no signal
819 Bacteraemia 19 1.0 1.0 no signal
820 Chronic Obstructive Pulmonary Disease 84 1.0 1.0 no signal
821 Product Dispensing Error 35 1.0 1.0 no signal
822 Colon Cancer 24 1.0 1.0 no signal
823 Hepatic Cancer 39 1.0 1.0 no signal
824 Acute Myeloid Leukaemia 25 1.0 1.0 no signal
825 Diarrhoea Haemorrhagic 15 1.0 1.0 no signal
826 Injury 113 1.0 1.0 no signal
827 Somnolence 321 1.0 1.0 no signal
828 Vision Blurred 218 1.0 1.0 no signal
829 Lip Swelling 53 1.0 1.0 no signal
830 Myocarditis 18 1.0 1.0 no signal
831 Fall 526 1.0 1.0 no signal
832 Laceration 15 1.0 1.0 no signal
833 Lower Limb Fracture 30 1.0 1.0 no signal
834 Therapy Non-responder 70 1.0 1.0 no signal
835 Helicobacter Infection 16 1.0 1.0 no signal
836 Mood Swings 50 1.0 1.0 no signal
837 Rash Erythematous 73 1.0 1.0 no signal
838 Gastrointestinal Disorder 137 1.0 1.0 no signal
839 Haemorrhage 159 1.0 1.0 no signal
840 Myelodysplastic Syndrome 22 1.0 1.0 no signal
841 Off Label Use 1,317 1.0 1.0 no signal
842 Anosmia 22 1.0 1.0 no signal
843 Eye Pruritus 50 1.0 1.0 no signal
844 Accident 18 1.0 1.0 no signal
845 Mood Altered 41 1.0 1.0 no signal
846 Gallbladder Disorder 27 1.0 1.0 no signal
847 Arthropathy 84 1.0 1.0 no signal
848 Septic Shock 65 1.0 1.0 no signal
849 Wrist Fracture 18 1.0 1.0 no signal
850 Injection Site Haematoma 22 1.0 1.0 no signal
851 Photophobia 28 1.0 1.0 no signal
852 Sars-cov-2 Test Positive 20 1.0 1.0 no signal
853 Mental Disorder 65 1.0 1.0 no signal
854 Restless Legs Syndrome 27 0.9 0.9 no signal
855 Confusional State 239 0.9 0.9 no signal
856 Basal Cell Carcinoma 23 0.9 0.9 no signal
857 Hyperhidrosis 189 0.9 0.9 no signal
858 Blood Glucose Fluctuation 16 0.9 0.9 no signal
859 Heart Rate Increased 144 0.9 0.9 no signal
860 Hyperthyroidism 21 0.9 0.9 no signal
861 Gout 26 0.9 0.9 no signal
862 Fear 39 0.9 0.9 no signal
863 Anhedonia 38 0.9 0.9 no signal
864 Product Dose Omission 95 0.9 0.9 no signal
865 Oxygen Saturation Decreased 80 0.9 0.9 no signal
866 Skin Infection 16 0.9 0.9 no signal
867 Toxicity To Various Agents 240 0.9 0.9 no signal
868 Rash Papular 32 0.9 0.9 no signal
869 Clostridium Difficile Colitis 15 0.9 0.9 no signal
870 Migraine 134 0.9 0.9 no signal
871 Sleep Apnoea Syndrome 27 0.9 0.9 no signal
872 Road Traffic Accident 59 0.9 0.9 no signal
873 Eye Disorder 46 0.9 0.9 no signal
874 Amnesia 91 0.9 0.9 no signal
875 Sneezing 31 0.9 0.9 no signal
876 Toxic Skin Eruption 14 0.9 0.9 no signal
877 Clostridium Difficile Infection 30 0.9 0.9 no signal
878 Anaphylactic Reaction 76 0.9 0.9 no signal
879 Eye Swelling 51 0.9 0.9 no signal
880 Eyelid Ptosis 14 0.9 0.9 no signal
881 Hyperkalaemia 48 0.9 0.9 no signal
882 Vasculitis 16 0.9 0.9 no signal
883 Bedridden 18 0.9 0.9 no signal
884 Syringe Issue 24 0.9 0.9 no signal
885 Splenomegaly 16 0.9 0.9 no signal
886 Adverse Reaction 18 0.9 0.9 no signal
887 Angina Pectoris 39 0.9 0.9 no signal
888 Lung Neoplasm Malignant 55 0.8 0.8 no signal
889 Leukocytosis 24 0.8 0.8 no signal
890 Proteinuria 25 0.8 0.8 no signal
891 Lower Respiratory Tract Infection 60 0.8 0.8 no signal
892 Blood Urine Present 25 0.8 0.8 no signal
893 Condition Aggravated 396 0.8 0.8 no signal
894 Stevens-johnson Syndrome 29 0.8 0.8 no signal
895 Pharyngitis Streptococcal 14 0.8 0.8 no signal
896 Lymphoma 20 0.8 0.8 no signal
897 Motor Dysfunction 13 0.8 0.8 no signal
898 Swollen Tongue 40 0.8 0.8 no signal
899 Initial Insomnia 13 0.8 0.8 no signal
900 Joint Range Of Motion Decreased 17 0.8 0.8 no signal
901 Poor Quality Product Administered 13 0.8 0.8 no signal
902 Respiratory Distress 35 0.8 0.8 no signal
903 Musculoskeletal Stiffness 111 0.8 0.8 no signal
904 Loss Of Personal Independence In Daily Activities 60 0.8 0.8 no signal
905 Ataxia 15 0.8 0.8 no signal
906 Respiratory Tract Congestion 20 0.8 0.8 no signal
907 Sinus Congestion 17 0.8 0.8 no signal
908 Altered State Of Consciousness 27 0.8 0.8 no signal
909 Intestinal Perforation 14 0.8 0.8 no signal
910 Acute Respiratory Distress Syndrome 22 0.8 0.8 no signal
911 Palpitations 145 0.8 0.8 no signal
912 Apathy 18 0.8 0.8 no signal
913 Vitreous Floaters 12 0.8 0.8 no signal
914 Back Disorder 20 0.8 0.8 no signal
915 Nephrolithiasis 56 0.8 0.8 no signal
916 Vaginal Haemorrhage 52 0.8 0.8 no signal
917 Coma 58 0.8 0.8 no signal
918 Amenorrhoea 20 0.8 0.8 no signal
919 Urticaria 199 0.8 0.8 no signal
920 Inappropriate Schedule Of Product Administration 211 0.8 0.8 no signal
921 Wheezing 70 0.8 0.8 no signal
922 Disorientation 47 0.8 0.8 no signal
923 Impaired Quality Of Life 17 0.8 0.8 no signal
924 Transient Ischaemic Attack 40 0.8 0.8 no signal
925 Haematochezia 65 0.8 0.8 no signal
926 Tubulointerstitial Nephritis 22 0.7 0.7 no signal
927 Foot Deformity 13 0.7 0.7 no signal
928 Anaphylactic Shock 30 0.7 0.7 no signal
929 Heart Rate Decreased 41 0.7 0.7 no signal
930 Ankle Fracture 18 0.7 0.7 no signal
931 Cognitive Disorder 54 0.7 0.7 no signal
932 Skin Cancer 25 0.7 0.7 no signal
933 Procedural Pain 32 0.7 0.7 no signal
934 Thyroid Cancer 14 0.7 0.7 no signal
935 Musculoskeletal Disorder 22 0.7 0.7 no signal
936 Staphylococcal Infection 38 0.7 0.7 no signal
937 Lethargy 66 0.7 0.7 no signal
938 Heart Rate Irregular 26 0.7 0.7 no signal
939 Hypotension 229 0.7 0.7 no signal
940 Drug Interaction 181 0.7 0.7 no signal
941 Therapy Change 11 0.7 0.7 no signal
942 Seasonal Allergy 16 0.7 0.7 no signal
943 Cold Sweat 20 0.7 0.7 no signal
944 Myocardial Ischaemia 13 0.7 0.7 no signal
945 Diabetes Mellitus Inadequate Control 20 0.7 0.7 no signal
946 Blood Pressure Fluctuation 27 0.7 0.7 no signal
947 Epilepsy 34 0.7 0.7 no signal
948 Haemoptysis 31 0.7 0.7 no signal
949 Bladder Disorder 11 0.7 0.7 no signal
950 Rash Generalised 29 0.7 0.7 no signal
951 Joint Swelling 133 0.7 0.7 no signal
952 Salivary Hypersecretion 11 0.7 0.7 no signal
953 Post Procedural Complication 21 0.7 0.7 no signal
954 Macular Degeneration 13 0.7 0.7 no signal
955 Meningioma 16 0.7 0.7 no signal
956 Product Use In Unapproved Indication 265 0.7 0.7 no signal
957 Injection Site Swelling 82 0.7 0.7 no signal
958 Cerebrovascular Accident 183 0.7 0.7 no signal
959 Personality Change 10 0.7 0.7 no signal
960 Thinking Abnormal 20 0.7 0.7 no signal
961 Nephropathy 10 0.7 0.7 no signal
962 Dysarthria 40 0.7 0.7 no signal
963 Intentional Product Misuse 92 0.7 0.7 no signal
964 Tremor 176 0.7 0.7 no signal
965 Cardiac Disorder 99 0.7 0.7 no signal
966 Coronary Artery Disease 32 0.7 0.7 no signal
967 Eye Haemorrhage 14 0.7 0.7 no signal
968 Acute Myocardial Infarction 31 0.7 0.7 no signal
969 Pharyngeal Swelling 10 0.7 0.7 no signal
970 Affect Lability 10 0.7 0.7 no signal
971 Mental Impairment 25 0.7 0.7 no signal
972 Sudden Death 11 0.7 0.7 no signal
973 Pharyngeal Oedema 16 0.7 0.7 no signal
974 Aphasia 31 0.7 0.7 no signal
975 Cardiac Failure Congestive 83 0.7 0.7 no signal
976 Product Dose Omission Issue 291 0.7 0.6 no signal
977 Visual Acuity Reduced 34 0.6 0.6 no signal
978 Cyanosis 16 0.6 0.6 no signal
979 Panic Attack 37 0.6 0.6 no signal
980 Peritonitis 21 0.6 0.6 no signal
981 Disability 20 0.6 0.6 no signal
982 Shock 23 0.6 0.6 no signal
983 Upper Gastrointestinal Haemorrhage 17 0.6 0.6 no signal
984 Tinnitus 46 0.6 0.6 no signal
985 Brain Injury 10 0.6 0.6 no signal
986 Hernia 19 0.6 0.6 no signal
987 Ocular Hyperaemia 46 0.6 0.6 no signal
988 Encephalopathy 24 0.6 0.6 no signal
989 Generalised Tonic-clonic Seizure 16 0.6 0.6 no signal
990 Orthostatic Hypotension 17 0.6 0.6 no signal
991 Appendicitis 9 0.6 0.6 no signal
992 Disturbance In Attention 52 0.6 0.6 no signal
993 Skin Irritation 44 0.6 0.6 no signal
994 Blindness 39 0.6 0.6 no signal
995 Squamous Cell Carcinoma 9 0.6 0.6 no signal
996 Drug Hypersensitivity 185 0.6 0.6 no signal
997 Melaena 21 0.6 0.6 no signal
998 Injection Site Bruising 75 0.6 0.6 no signal
999 Loss Of Consciousness 121 0.6 0.6 no signal
1000 Infusion Site Pain 12 0.6 0.6 no signal
1001 Therapeutic Response Unexpected 42 0.6 0.6 no signal
1002 Pneumonia Aspiration 23 0.6 0.6 no signal
1003 Drug Ineffective 1,213 0.6 0.6 no signal
1004 Anorexia 12 0.6 0.6 no signal
1005 Metabolic Acidosis 29 0.6 0.6 no signal
1006 Mania 15 0.6 0.6 no signal
1007 Photosensitivity Reaction 15 0.6 0.6 no signal
1008 Spinal Operation 11 0.6 0.6 no signal
1009 Injection Site Pruritus 60 0.6 0.6 no signal
1010 Flushing 92 0.6 0.6 no signal
1011 Activities Of Daily Living Impaired 18 0.6 0.6 no signal
1012 Pulmonary Arterial Hypertension 13 0.6 0.6 no signal
1013 Eye Infection 10 0.6 0.6 no signal
1014 Irritable Bowel Syndrome 19 0.6 0.6 no signal
1015 Eye Pain 49 0.6 0.6 no signal
1016 Tachypnoea 12 0.6 0.6 no signal
1017 Cardiac Arrest 73 0.6 0.6 no signal
1018 Acne 67 0.6 0.6 no signal
1019 Haematuria 30 0.6 0.6 no signal
1020 Needle Issue 25 0.6 0.6 no signal
1021 Seizure 100 0.6 0.6 no signal
1022 Muscle Twitching 20 0.6 0.6 no signal
1023 Impaired Gastric Emptying 11 0.6 0.6 no signal
1024 Therapeutic Response Decreased 52 0.6 0.5 no signal
1025 Middle Insomnia 16 0.5 0.5 no signal
1026 Tuberculosis 11 0.5 0.5 no signal
1027 Blindness Unilateral 12 0.5 0.5 no signal
1028 Product Administration Error 17 0.5 0.5 no signal
1029 Intentional Dose Omission 23 0.5 0.5 no signal
1030 Cerebral Haemorrhage 30 0.5 0.5 no signal
1031 Product Use Complaint 13 0.5 0.5 no signal
1032 Product Prescribing Issue 17 0.5 0.5 no signal
1033 Injection Site Reaction 57 0.5 0.5 no signal
1034 Blood Glucose Decreased 40 0.5 0.5 no signal
1035 Fibromyalgia 20 0.5 0.5 no signal
1036 Injection Site Discolouration 10 0.5 0.5 no signal
1037 Agitation 59 0.5 0.5 no signal
1038 Therapy Interrupted 55 0.5 0.5 no signal
1039 Eye Irritation 44 0.5 0.5 no signal
1040 Subarachnoid Haemorrhage 8 0.5 0.5 no signal
1041 Therapeutic Product Effect Incomplete 54 0.5 0.5 no signal
1042 Skin Burning Sensation 54 0.5 0.5 no signal
1043 Gastrointestinal Haemorrhage 63 0.5 0.5 no signal
1044 Adverse Drug Reaction 67 0.5 0.5 no signal
1045 Fluid Overload 11 0.5 0.5 no signal
1046 Leukaemia 7 0.5 0.5 no signal
1047 Depressed Level Of Consciousness 28 0.5 0.5 no signal
1048 Dermatitis Contact 8 0.4 0.4 no signal
1049 Cardiogenic Shock 10 0.4 0.4 no signal
1050 Irritability 42 0.4 0.4 no signal
1051 Subdural Haematoma 10 0.4 0.4 no signal
1052 Peritonitis Bacterial 7 0.4 0.4 no signal
1053 Inappropriate Antidiuretic Hormone Secretion 7 0.4 0.4 no signal
1054 Pruritus Generalised 15 0.4 0.4 no signal
1055 Ear Infection 18 0.4 0.4 no signal
1056 Product Odour Abnormal 7 0.4 0.4 no signal
1057 Knee Arthroplasty 14 0.4 0.4 no signal
1058 Product Taste Abnormal 9 0.4 0.4 no signal
1059 Toxic Epidermal Necrolysis 10 0.4 0.4 no signal
1060 Drug Dose Omission 111 0.4 0.4 no signal
1061 Unresponsive To Stimuli 17 0.4 0.4 no signal
1062 Asthma 74 0.4 0.4 no signal
1063 Myocardial Infarction 116 0.4 0.4 no signal
1064 Hip Arthroplasty 10 0.4 0.4 no signal
1065 Hepatitis C 8 0.4 0.4 no signal
1066 Product Packaging Issue 6 0.4 0.4 no signal
1067 Nervous System Disorder 20 0.4 0.4 no signal
1068 Sputum Discoloured 6 0.4 0.4 no signal
1069 Injection Site Irritation 8 0.4 0.4 no signal
1070 Accidental Overdose 23 0.4 0.4 no signal
1071 Hallucination 47 0.4 0.4 no signal
1072 Chronic Kidney Disease 48 0.4 0.4 no signal
1073 Injection Site Erythema 77 0.4 0.4 no signal
1074 Cholecystectomy 7 0.4 0.4 no signal
1075 Internal Haemorrhage 7 0.4 0.4 no signal
1076 Inability To Afford Medication 6 0.4 0.4 no signal
1077 Renal Failure Acute 26 0.4 0.4 no signal
1078 Underdose 44 0.4 0.4 no signal
1079 Uveitis 8 0.4 0.4 no signal
1080 Colitis Ulcerative 26 0.4 0.4 no signal
1081 Euphoric Mood 6 0.4 0.4 no signal
1082 Folliculitis 6 0.4 0.4 no signal
1083 Incorrect Route Of Drug Administration 21 0.4 0.4 no signal
1084 Sedation 15 0.4 0.4 no signal
1085 Bradycardia 30 0.4 0.4 no signal
1086 Injection Site Rash 17 0.4 0.4 no signal
1087 Abasia 14 0.4 0.4 no signal
1088 Sleep Disorder Due To A General Medical Condition 9 0.4 0.4 no signal
1089 Bipolar Disorder 6 0.3 0.3 no signal
1090 Blood Creatine Phosphokinase Increased 16 0.3 0.3 no signal
1091 Gastric Cancer 14 0.3 0.3 no signal
1092 Intentional Product Use Issue 48 0.3 0.3 no signal
1093 Multiple Fractures 9 0.3 0.3 no signal
1094 Medication Error 30 0.3 0.3 no signal
1095 Adverse Event 49 0.3 0.3 no signal
1096 Anger 18 0.3 0.3 no signal
1097 Complication Associated With Device 7 0.3 0.3 no signal
1098 Device Failure 8 0.3 0.3 no signal
1099 Hallucination, Visual 11 0.3 0.3 no signal
1100 Feeling Jittery 10 0.3 0.3 no signal
1101 Emotional Distress 63 0.3 0.3 no signal
1102 Therapeutic Product Effect Decreased 23 0.3 0.3 no signal
1103 Delusion 8 0.3 0.3 no signal
1104 Parkinsonism 5 0.3 0.3 no signal
1105 Expired Product Administered 17 0.3 0.3 no signal
1106 Drug Reaction With Eosinophilia And Systemic Symptoms 13 0.3 0.3 no signal
1107 Cardiovascular Disorder 13 0.3 0.3 no signal
1108 Application Site Pain 11 0.3 0.3 no signal
1109 Angioedema 22 0.3 0.3 no signal
1110 No Therapeutic Response 6 0.3 0.3 no signal
1111 Drug Administration Error 15 0.3 0.3 no signal
1112 No Adverse Event 85 0.3 0.3 no signal
1113 Transfusion 5 0.3 0.3 no signal
1114 Plasma Cell Myeloma 18 0.3 0.3 no signal
1115 Injection Site Haemorrhage 36 0.3 0.3 no signal
1116 International Normalised Ratio Increased 13 0.3 0.3 no signal
1117 Malignant Melanoma 6 0.3 0.3 no signal
1118 Circumstance Or Information Capable Of Leading To Medication Error 15 0.3 0.3 no signal
1119 Status Epilepticus 5 0.3 0.3 no signal
1120 Gastric Haemorrhage 5 0.3 0.3 no signal
1121 Surgery 25 0.3 0.3 no signal
1122 Wrong Technique In Product Usage Process 86 0.3 0.3 no signal
1123 Drug Effect Less Than Expected 6 0.3 0.3 no signal
1124 Drug Level Increased 7 0.3 0.3 no signal
1125 Incorrect Dose Administered 95 0.3 0.3 no signal
1126 Pericarditis 7 0.3 0.3 no signal
1127 Myoclonus 5 0.3 0.3 no signal
1128 Pancreatitis 22 0.3 0.3 no signal
1129 Coeliac Disease 4 0.3 0.3 no signal
1130 Libido Decreased 5 0.3 0.3 no signal
1131 Muscle Spasticity 5 0.3 0.3 no signal
1132 Nightmare 14 0.3 0.3 no signal
1133 Product Physical Issue 8 0.3 0.3 no signal
1134 Renal Injury 12 0.3 0.3 no signal
1135 Aggression 20 0.3 0.3 no signal
1136 Injury Associated With Device 8 0.3 0.3 no signal
1137 Unevaluable Event 30 0.3 0.3 no signal
1138 Drug Administered At Inappropriate Site 4 0.2 0.2 no signal
1139 Impaired Work Ability 8 0.2 0.2 no signal
1140 Device Defective 6 0.2 0.2 no signal
1141 Dyskinesia 15 0.2 0.2 no signal
1142 Bladder Cancer 22 0.2 0.2 no signal
1143 Coronary Artery Occlusion 5 0.2 0.2 no signal
1144 Hospitalisation 54 0.2 0.2 no signal
1145 Rebound Effect 4 0.2 0.2 no signal
1146 Impaired Driving Ability 4 0.2 0.2 no signal
1147 Paranoia 6 0.2 0.2 no signal
1148 Pancreatic Carcinoma 10 0.2 0.2 no signal
1149 Eosinophilia 6 0.2 0.2 no signal
1150 Device Leakage 14 0.2 0.2 no signal
1151 Schizophrenia 4 0.2 0.2 no signal
1152 Respiratory Arrest 9 0.2 0.2 no signal
1153 Tendon Rupture 4 0.2 0.2 no signal
1154 Bone Density Decreased 10 0.2 0.2 no signal
1155 Intraocular Pressure Increased 4 0.2 0.2 no signal
1156 Knee Operation 3 0.2 0.2 no signal
1157 Menstruation Irregular 8 0.2 0.2 no signal
1158 Psychomotor Hyperactivity 5 0.2 0.2 no signal
1159 Wrong Technique In Drug Usage Process 11 0.2 0.2 no signal
1160 Incorrect Product Administration Duration 6 0.2 0.2 no signal
1161 Drug Level Decreased 3 0.2 0.2 no signal
1162 Convulsion 17 0.2 0.2 no signal
1163 Rheumatoid Arthritis 33 0.2 0.2 no signal
1164 Product Storage Error 25 0.2 0.2 no signal
1165 Injection Site Urticaria 7 0.2 0.2 no signal
1166 Suicidal Ideation 26 0.2 0.2 no signal
1167 Intentional Drug Misuse 6 0.2 0.2 no signal
1168 Device Breakage 11 0.2 0.2 no signal
1169 Synovitis 5 0.2 0.2 no signal
1170 Product Packaging Quantity Issue 3 0.2 0.2 no signal
1171 Drug Effect Incomplete 10 0.2 0.2 no signal
1172 Multiple Sclerosis 13 0.2 0.2 no signal
1173 Product Substitution Issue 15 0.2 0.2 no signal
1174 Sexual Dysfunction 3 0.2 0.2 no signal
1175 Systemic Lupus Erythematosus 9 0.2 0.2 no signal
1176 Abnormal Dreams 7 0.2 0.2 no signal
1177 Metrorrhagia 4 0.1 0.1 no signal
1178 Device Use Issue 4 0.1 0.1 no signal
1179 Inappropriate Schedule Of Drug Administration 16 0.1 0.1 no signal
1180 Product Administered At Inappropriate Site 4 0.1 0.1 no signal
1181 Psoriasis 27 0.1 0.1 no signal
1182 Drug Prescribing Error 4 0.1 0.1 no signal
1183 Menorrhagia 4 0.1 0.1 no signal
1184 Extra Dose Administered 8 0.1 0.1 no signal
1185 Wrong Technique In Device Usage Process 9 0.1 0.1 no signal
1186 Withdrawal Syndrome 8 0.1 0.1 no signal
1187 Overdose 38 0.1 0.1 no signal
1188 Suicide Attempt 10 0.1 0.1 no signal
1189 Device Malfunction 11 0.1 0.1 no signal
1190 Product Quality Issue 22 0.1 0.1 no signal
1191 Incorrect Dose Administered By Device 4 0.1 0.1 no signal
1192 Injection Site Warmth 3 0.1 0.1 no signal
1193 Oesophageal Carcinoma 3 0.1 0.1 no signal
1194 Device Use Error 3 0.1 0.1 no signal