OpenPV Signal Explorer
FAERS disproportionality dashboard
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Drug

Lapatinib

1,024 flagged reaction(s) · 51,086 total co-reports · max PRR 435.1
Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.
Reaction Co-reports (a) PRR ROR Signal
1 Skin Chapped 99 435.1 437.9 signal
2 Botryomycosis 7 293.2 293.4 signal
3 Transaminases 10 273.6 273.7 signal
4 Leukonychia 8 214.5 214.6 signal
5 Nail Bed Inflammation 38 184.6 185.0 signal
6 Her-2 Positive Breast Cancer 13 136.1 136.3 signal
7 Limbal Stem Cell Deficiency 6 114.9 114.9 signal
8 Nasal Mucosal Disorder 38 94.5 94.7 signal
9 Metastases To Skin 59 83.1 83.4 signal
10 Streptococcal Sepsis 57 68.2 68.4 signal
11 Her2 Positive Breast Cancer 16 61.6 61.7 signal
12 Hormone Receptor Positive Breast Cancer 11 59.2 59.3 signal
13 Anal Erythema 5 58.8 58.8 signal
14 Perianal Erythema 5 57.8 57.8 signal
15 Paronychia 174 56.9 57.6 signal
16 Palmar-plantar Erythrodysaesthesia Syndrome 928 56.1 59.7 signal
17 Metastases To Central Nervous System 483 53.2 54.9 signal
18 Metastases To The Mediastinum 15 50.9 51.0 signal
19 Onychalgia 34 47.8 47.9 signal
20 Breast Cancer Metastatic 359 47.0 48.1 signal
21 Lymphangiosis Carcinomatosa 34 45.8 45.9 signal
22 Pseudomonal Sepsis 56 44.6 44.8 signal
23 Osteoradionecrosis 7 43.4 43.5 signal
24 Neutrophil Count 6 40.2 40.2 signal
25 Nail Bed Bleeding 16 39.5 39.5 signal
26 Superior Vena Cava Syndrome 16 36.9 36.9 signal
27 Nail Infection 37 36.0 36.1 signal
28 Milia 9 35.2 35.2 signal
29 Breast Neoplasm 26 35.2 35.2 signal
30 Radiation Necrosis 14 34.2 34.3 signal
31 Metastases To Breast 8 34.0 34.1 signal
32 Metastases To Chest Wall 8 32.1 32.1 signal
33 Metastases To Lymph Nodes 151 31.3 31.6 signal
34 Pik3ca-activated Mutation 7 29.8 29.8 signal
35 Stent Occlusion 11 28.3 28.3 signal
36 Onycholysis 31 27.7 27.7 signal
37 Joint Ankylosis 11 26.6 26.6 signal
38 Metastases To Lung 202 24.2 24.5 signal
39 Subclavian Vein Thrombosis 19 23.0 23.0 signal
40 Vascular Device Infection 74 22.6 22.7 signal
41 Skin Toxicity 90 22.3 22.4 signal
42 Bone Marrow Infiltration 6 21.4 21.5 signal
43 Dermatitis Acneiform 94 21.4 21.6 signal
44 Metastases To Spine 52 21.4 21.5 signal
45 Gastrointestinal Toxicity 72 21.1 21.2 signal
46 Brain Cancer Metastatic 10 19.9 19.9 signal
47 Hypocapnia 6 19.8 19.8 signal
48 Metastases To Liver 247 19.4 19.7 signal
49 Biliary Dilatation 20 18.7 18.7 signal
50 Nail Disorder 116 18.4 18.5 signal
51 Invasive Ductal Breast Carcinoma 36 18.2 18.2 signal
52 Ejection Fraction Abnormal 16 17.9 17.9 signal
53 Breast Cancer Recurrent 40 17.5 17.5 signal
54 Gastric Neoplasm 8 17.4 17.4 signal
55 Metastases To Bone 206 17.3 17.5 signal
56 Ingrowing Nail 29 16.9 16.9 signal
57 Onychomadesis 51 16.9 16.9 signal
58 Gastrointestinal Bacterial Infection 14 16.8 16.9 signal
59 Nail Bed Disorder 5 16.1 16.1 signal
60 Ejection Fraction Decreased 181 16.0 16.2 signal
61 Retroperitoneal Lymphadenopathy 6 15.6 15.7 signal
62 Bone Cancer Metastatic 6 15.6 15.6 signal
63 Palmar Erythema 13 15.6 15.6 signal
64 Metastases To Meninges 25 15.3 15.3 signal
65 Lip Ulceration 13 15.2 15.3 signal
66 Oropharyngeal Candidiasis 10 15.2 15.2 signal
67 Brain Operation 25 15.2 15.2 signal
68 Pyogenic Granuloma 5 14.8 14.8 signal
69 Soft Tissue Disorder 12 14.7 14.7 signal
70 Malignant Pleural Effusion 18 14.7 14.7 signal
71 Bronchitis Viral 7 14.2 14.2 signal
72 Computerised Tomogram Thorax Abnormal 7 13.8 13.8 signal
73 Bile Duct Obstruction 19 13.5 13.6 signal
74 Metastasis 69 13.2 13.2 signal
75 Metastases To Pleura 10 13.2 13.2 signal
76 Intracranial Mass 9 13.1 13.1 signal
77 Nasal Ulcer 15 12.8 12.9 signal
78 Hepatic Cancer Metastatic 8 12.7 12.7 signal
79 Carbohydrate Antigen 15-3 Increased 7 12.6 12.6 signal
80 Malignant Ascites 7 12.5 12.5 signal
81 Metastatic Neoplasm 39 12.4 12.4 signal
82 Lymphangitis 7 12.0 12.0 signal
83 Recurrent Cancer 35 11.8 11.9 signal
84 Cardiotoxicity 76 11.7 11.8 signal
85 Disease Progression 1,005 11.7 12.4 signal
86 Vasogenic Cerebral Oedema 6 11.6 11.6 signal
87 Onychoclasis 58 11.6 11.6 signal
88 Skin Fissures 158 11.5 11.6 signal
89 Tumour Marker Increased 40 11.4 11.4 signal
90 Varicose Vein 43 11.3 11.4 signal
91 Brain Neoplasm 74 11.0 11.1 signal
92 Radiation Skin Injury 9 10.6 10.6 signal
93 Mucosal Inflammation 198 10.4 10.5 signal
94 Hyperbilirubinaemia 77 10.2 10.3 signal
95 Intervertebral Disc Space Narrowing 6 10.2 10.2 signal
96 Axillary Pain 11 10.2 10.2 signal
97 Cerebral Cyst 5 9.9 9.9 signal
98 Brain Oedema 89 9.6 9.7 signal
99 Orthostatic Intolerance 5 9.6 9.6 signal
100 Osteosclerosis 11 9.5 9.5 signal
101 Breast Disorder 14 9.4 9.4 signal
102 Pleural Fibrosis 7 9.3 9.3 signal
103 Cerebral Vasoconstriction 5 9.2 9.2 signal
104 Paraparesis 12 9.2 9.2 signal
105 Dyschezia 20 9.1 9.1 signal
106 Blood Bilirubin Increased 179 9.0 9.1 signal
107 Metastases To Adrenals 6 8.9 8.9 signal
108 Diarrhoea 4,173 8.9 11.8 signal
109 Cheilitis 35 8.9 8.9 signal
110 Anorexia 84 8.8 8.8 signal
111 Abdominal Symptom 5 8.6 8.6 signal
112 Carcinoembryonic Antigen Increased 12 8.5 8.5 signal
113 Jaundice Cholestatic 22 8.5 8.5 signal
114 Neoplasm Recurrence 21 8.4 8.5 signal
115 Stomatitis 373 8.4 8.6 signal
116 Haematotoxicity 57 8.4 8.4 signal
117 Pyuria 6 8.3 8.3 signal
118 Radiation Pneumonitis 13 8.3 8.3 signal
119 Left Ventricular Dysfunction 40 8.2 8.2 signal
120 Brain Neoplasm Malignant 27 8.2 8.2 signal
121 Bile Duct Stenosis 7 8.0 8.0 signal
122 Erysipelas 29 7.8 7.9 signal
123 Peripheral Motor Neuropathy 8 7.8 7.8 signal
124 Mastectomy 10 7.8 7.8 signal
125 Drug Tolerance Decreased 16 7.8 7.8 signal
126 Hospice Care 56 7.8 7.8 signal
127 Malignant Neoplasm Progression 565 7.6 7.8 signal
128 Hepatic Neoplasm 18 7.5 7.5 signal
129 Second Primary Malignancy 45 7.4 7.4 signal
130 Lymphoedema 37 7.3 7.3 signal
131 Chapped Lips 23 7.2 7.2 signal
132 Bone Lesion 19 7.2 7.2 signal
133 Lip Pain 15 7.1 7.2 signal
134 Palliative Care 8 7.1 7.1 signal
135 Biliary Colic 15 7.1 7.1 signal
136 Intracranial Pressure Increased 29 7.1 7.1 signal
137 Rash Pustular 38 7.1 7.1 signal
138 Oncologic Complication 5 7.0 7.0 signal
139 Performance Status Decreased 24 7.0 7.0 signal
140 Thrombocytopenic Purpura 7 6.9 6.9 signal
141 Enteritis 32 6.9 6.9 signal
142 Jaundice 135 6.8 6.9 signal
143 Hepatotoxicity 110 6.8 6.8 signal
144 Alveolitis 7 6.7 6.7 signal
145 Osteolysis 10 6.7 6.7 signal
146 Catheter Related Infection 5 6.7 6.7 signal
147 Mouth Ulceration 101 6.6 6.6 signal
148 Nasal Inflammation 5 6.5 6.5 signal
149 Blood Bilirubin Abnormal 6 6.5 6.5 signal
150 Hepatic Infection 6 6.4 6.4 signal
151 Radiotherapy 9 6.4 6.4 signal
152 Bone Neoplasm 5 6.3 6.3 signal
153 Nail Discolouration 18 6.3 6.3 signal
154 Thrombosis In Device 15 6.2 6.2 signal
155 Polymyositis 8 6.2 6.2 signal
156 Nail Growth Abnormal 5 6.2 6.2 signal
157 Neoplasm 52 6.2 6.2 signal
158 Hypokalaemia 207 6.2 6.2 signal
159 Lung Infiltration 40 6.1 6.1 signal
160 Granulocyte Count Decreased 8 6.1 6.1 signal
161 Oral Intake Reduced 11 6.1 6.1 signal
162 Device Related Sepsis 9 6.0 6.0 signal
163 Effusion 6 6.0 6.0 signal
164 Ureteric Obstruction 6 6.0 6.0 signal
165 Cushingoid 14 5.9 5.9 signal
166 Mucous Membrane Disorder 6 5.9 5.9 signal
167 Peripheral Sensory Neuropathy 25 5.8 5.8 signal
168 Cholangitis 26 5.8 5.8 signal
169 Hepatic Cyst 14 5.6 5.6 signal
170 Enteritis Infectious 7 5.6 5.6 signal
171 Exposed Bone In Jaw 9 5.6 5.6 signal
172 Investigation 13 5.6 5.6 signal
173 Lip Discolouration 5 5.4 5.4 signal
174 Aspartate Aminotransferase Abnormal 6 5.4 5.4 signal
175 Dehydration 524 5.4 5.5 signal
176 Metastatic Malignant Melanoma 9 5.3 5.4 signal
177 Muscle Contracture 8 5.3 5.3 signal
178 Pigmentation Disorder 24 5.3 5.3 signal
179 Hypertrophic Cardiomyopathy 6 5.3 5.3 signal
180 Candida Infection 64 5.2 5.2 signal
181 Alanine Aminotransferase Abnormal 8 5.2 5.2 signal
182 Arteriospasm Coronary 15 5.2 5.2 signal
183 Skin Mass 25 5.1 5.1 signal
184 Neoplasm Progression 132 5.1 5.2 signal
185 Lobar Pneumonia 7 5.1 5.1 signal
186 Ventricular Hypokinesia 12 5.1 5.1 signal
187 Hepatic Lesion 16 5.0 5.1 signal
188 Laceration 35 5.0 5.0 signal
189 Crepitations 11 5.0 5.0 signal
190 Oropharyngeal Blistering 6 5.0 5.0 signal
191 Faeces Pale 8 4.9 4.9 signal
192 Metastases To Peritoneum 9 4.9 4.9 signal
193 Glioblastoma 6 4.9 4.9 signal
194 Purulent Discharge 15 4.8 4.8 signal
195 Lung Neoplasm 15 4.8 4.8 signal
196 Neutropenia 471 4.7 4.9 signal
197 Pleural Effusion 210 4.7 4.8 signal
198 Sensitivity Of Teeth 6 4.7 4.7 signal
199 Change Of Bowel Habit 7 4.7 4.7 signal
200 Febrile Neutropenia 224 4.6 4.7 signal
201 Impetigo 5 4.6 4.6 signal
202 Dysaesthesia 10 4.5 4.5 signal
203 Compression Fracture 17 4.5 4.5 signal
204 Pericardial Effusion 75 4.4 4.5 signal
205 Ocular Icterus 14 4.4 4.4 signal
206 Hypertransaminasaemia 22 4.4 4.4 signal
207 Skin Hypertrophy 9 4.4 4.4 signal
208 Breast Cancer 301 4.4 4.4 signal
209 Atypical Femur Fracture 9 4.3 4.3 signal
210 Ileus Paralytic 14 4.3 4.3 signal
211 Orthopnoea 10 4.3 4.3 signal
212 Pseudomembranous Colitis 7 4.2 4.3 signal
213 Cancer Pain 8 4.2 4.2 signal
214 Oral Pain 69 4.2 4.2 signal
215 Colorectal Cancer Metastatic 7 4.2 4.2 signal
216 Exfoliative Rash 8 4.2 4.2 signal
217 Hepatic Function Abnormal 113 4.2 4.2 signal
218 Skin Discolouration 139 4.1 4.2 signal
219 Hyperaesthesia 25 4.1 4.1 signal
220 Dry Skin 397 4.1 4.2 signal
221 Bilirubin Conjugated Increased 7 4.1 4.1 signal
222 Skin Ulcer 77 4.1 4.1 signal
223 Tongue Ulceration 10 4.0 4.0 signal
224 Temporomandibular Joint Syndrome 8 4.0 4.0 signal
225 Cardiac Tamponade 14 4.0 4.0 signal
226 Lip Blister 8 4.0 4.0 signal
227 Left Ventricular Failure 10 4.0 4.0 signal
228 Skin Hyperpigmentation 25 4.0 4.0 signal
229 Rash Vesicular 14 4.0 4.0 signal
230 Ascites 85 3.9 4.0 signal
231 Neurotoxicity 50 3.9 3.9 signal
232 Aphagia 14 3.9 3.9 signal
233 Alanine Aminotransferase Increased 176 3.9 3.9 signal
234 Polyneuropathy 34 3.9 3.9 signal
235 Neutrophil Count Abnormal 8 3.9 3.9 signal
236 Iron Deficiency Anaemia 26 3.9 3.9 signal
237 Uterine Haemorrhage 12 3.8 3.8 signal
238 Hepatic Enzyme Abnormal 14 3.8 3.8 signal
239 Hepatic Pain 12 3.8 3.8 signal
240 Pneumomediastinum 5 3.8 3.8 signal
241 Dyspnoea At Rest 8 3.8 3.8 signal
242 Pathological Fracture 14 3.8 3.8 signal
243 Hypertriglyceridaemia 16 3.7 3.7 signal
244 Conduction Disorder 5 3.7 3.7 signal
245 Aortic Arteriosclerosis 7 3.7 3.7 signal
246 Electrolyte Imbalance 31 3.7 3.7 signal
247 Hyperuricaemia 11 3.7 3.7 signal
248 Adenocarcinoma Of Colon 5 3.6 3.6 signal
249 Adenocarcinoma 6 3.6 3.6 signal
250 Mitral Valve Incompetence 30 3.6 3.6 signal
251 Osteonecrosis Of Jaw 66 3.6 3.6 signal
252 Neurological Decompensation 6 3.6 3.6 signal
253 Clostridial Infection 9 3.6 3.6 signal
254 Lymphadenopathy Mediastinal 5 3.6 3.6 signal
255 Hypoalbuminaemia 20 3.6 3.6 signal
256 Central Nervous System Lesion 36 3.5 3.6 signal
257 Granuloma 9 3.5 3.5 signal
258 Haemangioma 6 3.5 3.5 signal
259 Leukopenia 129 3.5 3.5 signal
260 Skin Wrinkling 7 3.5 3.5 signal
261 Vomiting 1,209 3.5 3.7 signal
262 Gamma-glutamyltransferase Increased 57 3.5 3.5 signal
263 Pulmonary Mass 38 3.5 3.5 signal
264 Thrombophlebitis 9 3.5 3.5 signal
265 Aspartate Aminotransferase Increased 135 3.5 3.5 signal
266 Pneumonitis 68 3.4 3.4 signal
267 Rash Generalised 66 3.4 3.4 signal
268 Mucosal Dryness 5 3.4 3.4 signal
269 Tongue Discolouration 11 3.4 3.4 signal
270 Rash 1,062 3.3 3.5 signal
271 Breast Cancer Stage Iv 7 3.3 3.3 signal
272 Neuropathy Peripheral 228 3.3 3.3 signal
273 Embolism 20 3.3 3.3 signal
274 Dermatitis 49 3.2 3.2 signal
275 Aphthous Ulcer 18 3.2 3.2 signal
276 Oral Mucosal Blistering 15 3.2 3.2 signal
277 Blister 131 3.2 3.2 signal
278 Epistaxis 175 3.2 3.2 signal
279 Excoriation 6 3.2 3.2 signal
280 Local Swelling 41 3.2 3.2 signal
281 Mouth Haemorrhage 17 3.2 3.2 signal
282 Spinal Cord Compression 9 3.1 3.1 signal
283 Epigastric Discomfort 9 3.1 3.1 signal
284 Venous Thrombosis 9 3.1 3.1 signal
285 Atelectasis 22 3.1 3.1 signal
286 Cerebellar Syndrome 5 3.1 3.1 signal
287 Diastolic Dysfunction 7 3.1 3.1 signal
288 Decreased Appetite 519 3.1 3.1 signal
289 Nasal Dryness 14 3.0 3.0 signal
290 Hypocalcaemia 42 3.0 3.0 signal
291 Candidiasis 9 3.0 3.0 signal
292 Hydrocephalus 12 3.0 3.0 signal
293 Menopausal Symptoms 5 3.0 3.0 signal
294 Oral Fungal Infection 6 3.0 3.0 signal
295 Skin Lesion 59 3.0 3.0 signal
296 Cellulitis 109 2.9 3.0 signal
297 Tricuspid Valve Incompetence 17 2.9 2.9 signal
298 C-reactive Protein Increased 78 2.9 2.9 signal
299 Device Related Infection 33 2.9 2.9 signal
300 Blood Potassium Decreased 64 2.9 2.9 signal
301 Acute Myeloid Leukaemia 33 2.9 2.9 signal
302 Tenderness 22 2.9 2.9 signal
303 Stomach Discomfort 11 2.9 2.9 signal
304 Neutropenic Sepsis 15 2.9 2.9 signal
305 Blood Alkaline Phosphatase Increased 52 2.8 2.9 signal
306 Cytolytic Hepatitis 7 2.8 2.8 signal
307 Monoplegia 9 2.8 2.8 signal
308 Bone Cancer 9 2.8 2.8 signal
309 Hepatic Failure 62 2.8 2.8 signal
310 Liver Function Test Abnormal 60 2.8 2.8 signal
311 Nausea 1,615 2.8 3.0 signal
312 Cardiopulmonary Failure 8 2.8 2.8 signal
313 Wound Secretion 8 2.8 2.8 signal
314 Electrocardiogram Qt Prolonged 73 2.8 2.8 signal
315 Transaminases Increased 45 2.8 2.8 signal
316 Eating Disorder 43 2.7 2.7 signal
317 Hypercapnia 6 2.7 2.7 signal
318 Bone Marrow Failure 41 2.7 2.7 signal
319 Urinary Tract Disorder 9 2.7 2.7 signal
320 Gastroenteritis 29 2.7 2.7 signal
321 Skin Exfoliation 165 2.7 2.7 signal
322 Localised Infection 48 2.7 2.7 signal
323 Skin Disorder 66 2.7 2.7 signal
324 Sudden Death 21 2.7 2.7 signal
325 Phlebitis 10 2.7 2.7 signal
326 Thrombocytopenia 217 2.6 2.7 signal
327 Skin Haemorrhage 28 2.6 2.6 signal
328 Neoplasm Malignant 129 2.6 2.6 signal
329 Failure To Thrive 10 2.6 2.6 signal
330 Drug Toxicity 26 2.6 2.6 signal
331 Skin Erosion 6 2.6 2.6 signal
332 Dyspepsia 184 2.6 2.6 signal
333 Ileus 23 2.5 2.5 signal
334 Vulvovaginal Dryness 6 2.5 2.5 signal
335 Loose Tooth 6 2.5 2.5 signal
336 Skin Laceration 20 2.5 2.5 signal
337 Lymphadenopathy 65 2.5 2.5 signal
338 Onychomycosis 8 2.5 2.5 signal
339 Faeces Soft 13 2.4 2.4 signal
340 Lip Dry 16 2.4 2.4 signal
341 Blood Test Abnormal 25 2.4 2.4 signal
342 Lung Consolidation 5 2.4 2.4 no signal
343 Duodenal Ulcer Perforation 13 2.4 2.4 signal
344 Scab 20 2.4 2.4 signal
345 Ataxia 21 2.4 2.4 signal
346 Convulsion 102 2.4 2.4 signal
347 Cachexia 9 2.4 2.4 signal
348 Abdominal Hernia 8 2.4 2.4 signal
349 Oesophageal Stenosis 5 2.4 2.4 no signal
350 Blood Creatinine Abnormal 6 2.4 2.4 no signal
351 Dysphagia 165 2.4 2.4 signal
352 Skin Atrophy 10 2.4 2.4 signal
353 Lung Cancer Metastatic 5 2.4 2.4 no signal
354 Gastrointestinal Necrosis 5 2.3 2.3 no signal
355 Breast Cancer Stage Iii 11 2.3 2.3 signal
356 Skin Tightness 8 2.3 2.3 signal
357 Yellow Skin 8 2.3 2.3 signal
358 Duodenal Ulcer 12 2.3 2.3 signal
359 Death 1,462 2.3 2.4 signal
360 General Physical Health Deterioration 195 2.3 2.3 signal
361 Ill-defined Disorder 103 2.3 2.3 signal
362 Cardiomyopathy 25 2.3 2.3 signal
363 Rash Pruritic 91 2.3 2.3 signal
364 Anorectal Discomfort 9 2.3 2.3 signal
365 Fatigue 1,306 2.3 2.4 signal
366 Acne 128 2.3 2.3 signal
367 Gingivitis 9 2.3 2.3 signal
368 Aortic Valve Incompetence 7 2.2 2.2 no signal
369 Erythema 336 2.2 2.3 signal
370 Cholestasis 31 2.2 2.2 signal
371 Multiple-drug Resistance 5 2.2 2.2 no signal
372 Interstitial Lung Disease 78 2.2 2.2 signal
373 Asthenia 607 2.2 2.2 signal
374 Necrosis 9 2.2 2.2 signal
375 Drug Administration Error 50 2.2 2.2 signal
376 Diarrhoea Haemorrhagic 15 2.2 2.2 signal
377 Eczema 80 2.2 2.2 signal
378 Hyperthermia 12 2.2 2.2 signal
379 Liver Disorder 70 2.1 2.2 signal
380 Pneumothorax 25 2.1 2.1 signal
381 Mass 22 2.1 2.1 signal
382 Ammonia Increased 8 2.1 2.1 no signal
383 Proctalgia 10 2.1 2.1 signal
384 Portal Vein Thrombosis 5 2.1 2.1 no signal
385 Metabolic Disorder 9 2.1 2.1 signal
386 Rales 9 2.1 2.1 signal
387 Hepatic Enzyme Increased 105 2.1 2.1 signal
388 Cerebral Ischaemia 8 2.1 2.1 no signal
389 Hypovolaemia 9 2.1 2.1 signal
390 Sensation Of Heaviness 6 2.1 2.1 no signal
391 Pyrexia 527 2.1 2.1 signal
392 Gastritis 40 2.1 2.1 signal
393 Oesophageal Pain 6 2.1 2.1 no signal
394 Nerve Compression 14 2.1 2.1 signal
395 Hepatomegaly 15 2.1 2.1 signal
396 Oedema Mouth 5 2.1 2.1 no signal
397 Ischaemia 7 2.1 2.1 no signal
398 Otitis Media 5 2.1 2.1 no signal
399 Gingival Pain 12 2.0 2.1 signal
400 Retching 32 2.0 2.0 signal
401 Restlessness 55 2.0 2.0 signal
402 Anaemia 286 2.0 2.1 signal
403 Fungal Skin Infection 6 2.0 2.0 no signal
404 Oedema Peripheral 182 2.0 2.0 signal
405 Breast Mass 10 2.0 2.0 signal
406 Abasia 37 2.0 2.0 signal
407 Decubitus Ulcer 12 2.0 2.0 signal
408 Spinal Stenosis 6 2.0 2.0 no signal
409 Bone Pain 86 2.0 2.0 no signal
410 Pulmonary Thrombosis 16 2.0 2.0 no signal
411 Regurgitation 5 2.0 2.0 no signal
412 Rash Papular 32 1.9 1.9 no signal
413 Gastrointestinal Sounds Abnormal 7 1.9 1.9 no signal
414 Skin Reaction 20 1.9 1.9 no signal
415 Pulmonary Embolism 135 1.9 1.9 no signal
416 Food Craving 7 1.9 1.9 no signal
417 Escherichia Urinary Tract Infection 6 1.9 1.9 no signal
418 Abdominal Pain 328 1.9 1.9 no signal
419 Nervous System Disorder 44 1.9 1.9 no signal
420 Bundle Branch Block Left 6 1.9 1.9 no signal
421 Myocardial Ischaemia 16 1.9 1.9 no signal
422 Neutrophil Count Decreased 56 1.9 1.9 no signal
423 Hyperventilation 8 1.9 1.9 no signal
424 Pain Of Skin 37 1.9 1.9 no signal
425 Adverse Drug Reaction 122 1.9 1.9 no signal
426 Rash Maculo-papular 30 1.8 1.8 no signal
427 Sepsis 151 1.8 1.8 no signal
428 Lymphopenia 19 1.8 1.8 no signal
429 Skin Infection 15 1.8 1.8 no signal
430 Hydronephrosis 10 1.8 1.8 no signal
431 Leukoencephalopathy 5 1.8 1.8 no signal
432 Oedema 72 1.8 1.8 no signal
433 Weight Decreased 369 1.8 1.8 no signal
434 Fracture 25 1.8 1.8 no signal
435 Anal Fissure 7 1.8 1.8 no signal
436 Drooling 9 1.8 1.8 no signal
437 Conjunctival Haemorrhage 5 1.8 1.8 no signal
438 Oral Candidiasis 17 1.8 1.8 no signal
439 Clavicle Fracture 5 1.8 1.8 no signal
440 Sensory Disturbance 21 1.8 1.8 no signal
441 Pharyngolaryngeal Pain 7 1.8 1.8 no signal
442 Hypomagnesaemia 18 1.8 1.8 no signal
443 Localised Oedema 6 1.8 1.8 no signal
444 Pelvic Fracture 10 1.8 1.8 no signal
445 Muscle Atrophy 16 1.7 1.7 no signal
446 Myopathy 11 1.7 1.7 no signal
447 Electrocardiogram Abnormal 10 1.7 1.7 no signal
448 Hyperkeratosis 7 1.7 1.7 no signal
449 Hypophagia 32 1.7 1.7 no signal
450 Nasal Discomfort 10 1.7 1.7 no signal
451 Hepatic Steatosis 23 1.7 1.7 no signal
452 Renal Failure Acute 53 1.7 1.7 no signal
453 Enterocolitis 7 1.7 1.7 no signal
454 Organising Pneumonia 6 1.7 1.7 no signal
455 Dysgeusia 91 1.7 1.7 no signal
456 Lacrimation Increased 36 1.6 1.6 no signal
457 Gastrointestinal Perforation 5 1.6 1.6 no signal
458 Liver Injury 29 1.6 1.6 no signal
459 Constipation 258 1.6 1.6 no signal
460 Odynophagia 7 1.6 1.6 no signal
461 Lipase Increased 9 1.6 1.6 no signal
462 Lip Oedema 5 1.6 1.6 no signal
463 Rash Erythematous 55 1.6 1.6 no signal
464 Femoral Neck Fracture 6 1.6 1.6 no signal
465 Partial Seizures 6 1.6 1.6 no signal
466 Glossodynia 26 1.6 1.6 no signal
467 Adverse Event 107 1.6 1.6 no signal
468 Encephalitis 8 1.6 1.6 no signal
469 Foetal Growth Restriction 7 1.6 1.6 no signal
470 Cardiac Failure 93 1.6 1.6 no signal
471 Hepatitis B 7 1.6 1.6 no signal
472 Hypoaesthesia 171 1.6 1.6 no signal
473 Spinal Osteoarthritis 10 1.5 1.5 no signal
474 No Therapeutic Response 14 1.5 1.5 no signal
475 Clostridium Difficile Colitis 12 1.5 1.5 no signal
476 Cardiomegaly 14 1.5 1.5 no signal
477 Oliguria 7 1.5 1.5 no signal
478 Breast Pain 12 1.5 1.5 no signal
479 Retinal Haemorrhage 8 1.5 1.5 no signal
480 Lung Disorder 55 1.5 1.5 no signal
481 White Blood Cell Count Decreased 121 1.5 1.5 no signal
482 Nonspecific Reaction 6 1.5 1.5 no signal
483 Hypoxia 39 1.5 1.5 no signal
484 Disease Recurrence 53 1.5 1.5 no signal
485 Leukocytosis 20 1.5 1.5 no signal
486 Myelodysplastic Syndrome 16 1.5 1.5 no signal
487 Wound Infection 12 1.5 1.5 no signal
488 Hiccups 9 1.5 1.5 no signal
489 Pain In Extremity 324 1.5 1.5 no signal
490 Oesophagitis 12 1.5 1.5 no signal
491 Gingival Bleeding 15 1.5 1.5 no signal
492 Impaired Healing 36 1.5 1.5 no signal
493 Renal Function Test Abnormal 5 1.5 1.5 no signal
494 Peripheral Coldness 15 1.5 1.5 no signal
495 Pancytopenia 60 1.5 1.5 no signal
496 Erythema Multiforme 10 1.5 1.5 no signal
497 Deep Vein Thrombosis 70 1.5 1.5 no signal
498 Blood Lactate Dehydrogenase Increased 17 1.4 1.5 no signal
499 Dyspnoea Exertional 40 1.4 1.5 no signal
500 Therapy Partial Responder 16 1.4 1.4 no signal
501 Neutrophilia 6 1.4 1.4 no signal
502 Hemiparesis 18 1.4 1.4 no signal
503 Exercise Tolerance Decreased 6 1.4 1.4 no signal
504 Epilepsy 32 1.4 1.4 no signal
505 Pyelonephritis 9 1.4 1.4 no signal
506 Pharyngitis 13 1.4 1.4 no signal
507 Blood Magnesium Decreased 9 1.4 1.4 no signal
508 Dizziness Postural 10 1.4 1.4 no signal
509 Breast Cancer Female 28 1.4 1.4 no signal
510 Blood Uric Acid Increased 6 1.4 1.4 no signal
511 Musculoskeletal Chest Pain 16 1.4 1.4 no signal
512 Tumour Lysis Syndrome 9 1.4 1.4 no signal
513 Multi-organ Failure 18 1.4 1.4 no signal
514 Faecal Incontinence 5 1.4 1.4 no signal
515 Cardiac Failure Congestive 83 1.4 1.4 no signal
516 Pain In Jaw 29 1.4 1.4 no signal
517 Paraesthesia 161 1.4 1.4 no signal
518 Decreased Interest 6 1.4 1.4 no signal
519 Hyponatraemia 57 1.4 1.4 no signal
520 Fluid Intake Reduced 5 1.4 1.4 no signal
521 Drug Resistance 26 1.4 1.4 no signal
522 Colitis 38 1.4 1.4 no signal
523 Facial Pain 9 1.4 1.4 no signal
524 Blood Disorder 8 1.4 1.4 no signal
525 Nodule 13 1.4 1.4 no signal
526 Bursitis 12 1.4 1.4 no signal
527 Rhinitis 8 1.3 1.3 no signal
528 Dyspnoea 560 1.3 1.4 no signal
529 Malnutrition 11 1.3 1.3 no signal
530 Dermatitis Exfoliative 5 1.3 1.3 no signal
531 Abdominal Pain Upper 203 1.3 1.3 no signal
532 Cough 275 1.3 1.3 no signal
533 Pulmonary Congestion 13 1.3 1.3 no signal
534 Conjunctivitis 18 1.3 1.3 no signal
535 Hypercalcaemia 12 1.3 1.3 no signal
536 Haemorrhoids 19 1.3 1.3 no signal
537 Pruritus 367 1.3 1.3 no signal
538 Pericarditis 16 1.3 1.3 no signal
539 Hair Disorder 8 1.3 1.3 no signal
540 Lung Infection 15 1.3 1.3 no signal
541 Red Blood Cell Count Decreased 27 1.3 1.3 no signal
542 Treatment Noncompliance 51 1.3 1.3 no signal
543 Herpes Zoster 54 1.3 1.3 no signal
544 Pulmonary Oedema 42 1.3 1.3 no signal
545 Flatulence 53 1.3 1.3 no signal
546 Bacteraemia 11 1.3 1.3 no signal
547 Chromaturia 21 1.3 1.3 no signal
548 Drug Intolerance 89 1.3 1.3 no signal
549 Infection 133 1.3 1.3 no signal
550 Disseminated Intravascular Coagulation 13 1.3 1.3 no signal
551 Chills 108 1.3 1.3 no signal
552 Blood Creatinine Increased 60 1.2 1.2 no signal
553 Dry Mouth 74 1.2 1.2 no signal
554 Intestinal Ischaemia 5 1.2 1.2 no signal
555 Pruritus Generalised 20 1.2 1.2 no signal
556 Photosensitivity Reaction 15 1.2 1.2 no signal
557 Blood Sodium Decreased 17 1.2 1.2 no signal
558 Small Intestinal Obstruction 11 1.2 1.2 no signal
559 Inflammation 46 1.2 1.2 no signal
560 Dysuria 33 1.2 1.2 no signal
561 Terminal State 6 1.2 1.2 no signal
562 Frequent Bowel Movements 24 1.2 1.2 no signal
563 Ulcer Haemorrhage 6 1.2 1.2 no signal
564 Blood Albumin Decreased 7 1.2 1.2 no signal
565 Osteomyelitis 16 1.2 1.2 no signal
566 Hyperglycaemia 32 1.2 1.2 no signal
567 Pelvic Pain 16 1.2 1.2 no signal
568 Circulatory Collapse 15 1.2 1.2 no signal
569 Atrial Flutter 7 1.2 1.2 no signal
570 Bone Disorder 16 1.2 1.2 no signal
571 Granulocytopenia 5 1.2 1.2 no signal
572 Presyncope 21 1.2 1.2 no signal
573 Hair Growth Abnormal 6 1.2 1.2 no signal
574 Haematemesis 22 1.2 1.2 no signal
575 Platelet Count Decreased 92 1.2 1.2 no signal
576 Defaecation Urgency 6 1.2 1.2 no signal
577 Hepatic Encephalopathy 8 1.2 1.2 no signal
578 Pulmonary Toxicity 6 1.2 1.2 no signal
579 Abnormal Faeces 7 1.2 1.2 no signal
580 Thermal Burn 6 1.1 1.1 no signal
581 Cholecystitis 10 1.1 1.1 no signal
582 Hemiplegia 7 1.1 1.1 no signal
583 Supraventricular Tachycardia 8 1.1 1.1 no signal
584 Spinal Compression Fracture 7 1.1 1.1 no signal
585 Back Pain 193 1.1 1.1 no signal
586 Toothache 15 1.1 1.1 no signal
587 Hypokinesia 12 1.1 1.1 no signal
588 Upper Respiratory Tract Infection 38 1.1 1.1 no signal
589 Tongue Disorder 6 1.1 1.1 no signal
590 Gastrointestinal Pain 9 1.1 1.1 no signal
591 Quality Of Life Decreased 11 1.1 1.1 no signal
592 Uterine Leiomyoma 6 1.1 1.1 no signal
593 Oral Disorder 6 1.1 1.1 no signal
594 Hair Texture Abnormal 11 1.1 1.1 no signal
595 Dental Caries 9 1.1 1.1 no signal
596 Pulmonary Hypertension 17 1.1 1.1 no signal
597 Generalised Oedema 10 1.1 1.1 no signal
598 Tachypnoea 11 1.1 1.1 no signal
599 Concomitant Disease Aggravated 5 1.1 1.1 no signal
600 Alopecia 159 1.1 1.1 no signal
601 Rash Macular 28 1.1 1.1 no signal
602 Hypersomnia 23 1.1 1.1 no signal
603 Intestinal Perforation 9 1.1 1.1 no signal
604 Blood Calcium Decreased 9 1.1 1.1 no signal
605 Thrombosis 64 1.1 1.1 no signal
606 Cholelithiasis 26 1.1 1.1 no signal
607 Muscular Weakness 90 1.1 1.1 no signal
608 Toxic Skin Eruption 8 1.1 1.1 no signal
609 Wound 22 1.1 1.1 no signal
610 Osteopenia 12 1.1 1.1 no signal
611 Cystitis 25 1.1 1.1 no signal
612 Body Temperature Increased 16 1.1 1.1 no signal
613 Haemoglobin Abnormal 5 1.1 1.1 no signal
614 Folliculitis 8 1.1 1.1 no signal
615 Malaise 339 1.0 1.0 no signal
616 Dysphonia 45 1.0 1.0 no signal
617 Paraesthesia Oral 11 1.0 1.0 no signal
618 Refusal Of Treatment By Patient 5 1.0 1.0 no signal
619 Bedridden 10 1.0 1.0 no signal
620 Transfusion 8 1.0 1.0 no signal
621 Tooth Disorder 17 1.0 1.0 no signal
622 Dysgraphia 5 1.0 1.0 no signal
623 Renal Cyst 6 1.0 1.0 no signal
624 Intervertebral Disc Degeneration 7 1.0 1.0 no signal
625 Haematocrit Decreased 15 1.0 1.0 no signal
626 Bronchiectasis 5 1.0 1.0 no signal
627 Gastrooesophageal Reflux Disease 60 1.0 1.0 no signal
628 Meningitis 5 1.0 1.0 no signal
629 Therapeutic Response Decreased 45 1.0 1.0 no signal
630 Chest Pain 138 1.0 1.0 no signal
631 Abdominal Distension 77 1.0 1.0 no signal
632 Productive Cough 35 1.0 1.0 no signal
633 Limb Injury 20 1.0 1.0 no signal
634 Vertigo 45 1.0 1.0 no signal
635 Muscle Disorder 6 1.0 1.0 no signal
636 Laryngitis 8 1.0 1.0 no signal
637 General Physical Condition Abnormal 5 1.0 1.0 no signal
638 Eructation 14 1.0 1.0 no signal
639 Abdominal Discomfort 123 1.0 1.0 no signal
640 Dizziness 366 1.0 1.0 no signal
641 Asphyxia 6 1.0 1.0 no signal
642 Aphasia 22 1.0 1.0 no signal
643 Thrombotic Microangiopathy 7 1.0 1.0 no signal
644 Dry Eye 35 1.0 1.0 no signal
645 Oral Herpes 14 1.0 1.0 no signal
646 Gait Disturbance 138 1.0 1.0 no signal
647 Vitamin D Deficiency 7 1.0 1.0 no signal
648 Cardiac Disorder 67 1.0 1.0 no signal
649 Extrasystoles 5 1.0 1.0 no signal
650 Blood Urea Increased 12 1.0 1.0 no signal
651 Coordination Abnormal 10 1.0 1.0 no signal
652 Pneumonia 228 1.0 1.0 no signal
653 Cholecystectomy 8 1.0 1.0 no signal
654 Musculoskeletal Discomfort 12 0.9 0.9 no signal
655 Skin Irritation 32 0.9 0.9 no signal
656 Sciatica 11 0.9 0.9 no signal
657 Respiratory Tract Infection 18 0.9 0.9 no signal
658 Diplopia 18 0.9 0.9 no signal
659 Ulcer 11 0.9 0.9 no signal
660 Splenomegaly 8 0.9 0.9 no signal
661 Rhinorrhoea 44 0.9 0.9 no signal
662 Neutrophil Count Increased 7 0.9 0.9 no signal
663 Hypophosphataemia 5 0.9 0.9 no signal
664 Rectal Haemorrhage 29 0.9 0.9 no signal
665 Gastrointestinal Infection 6 0.9 0.9 no signal
666 Haematochezia 37 0.9 0.9 no signal
667 Burning Sensation 47 0.9 0.9 no signal
668 Muscle Spasms 122 0.9 0.9 no signal
669 Staphylococcal Infection 22 0.9 0.9 no signal
670 Incontinence 7 0.9 0.9 no signal
671 Palpitations 77 0.9 0.9 no signal
672 Exostosis 6 0.9 0.9 no signal
673 Face Oedema 11 0.9 0.9 no signal
674 Aspiration 7 0.9 0.9 no signal
675 Proteinuria 12 0.9 0.9 no signal
676 Confusional State 103 0.9 0.9 no signal
677 Urinary Tract Infection 108 0.9 0.9 no signal
678 Sinus Tachycardia 9 0.9 0.9 no signal
679 Cyanosis 10 0.9 0.9 no signal
680 Gait Inability 21 0.9 0.9 no signal
681 Gastric Disorder 22 0.9 0.9 no signal
682 Swelling Face 41 0.9 0.9 no signal
683 Visual Acuity Reduced 21 0.9 0.9 no signal
684 Pancreatitis 33 0.8 0.8 no signal
685 Muscle Tightness 10 0.8 0.8 no signal
686 Heart Rate Irregular 14 0.8 0.8 no signal
687 Intentional Product Use Issue 54 0.8 0.8 no signal
688 Decreased Immune Responsiveness 6 0.8 0.8 no signal
689 Haemorrhage 64 0.8 0.8 no signal
690 Femur Fracture 19 0.8 0.8 no signal
691 Mental Status Changes 17 0.8 0.8 no signal
692 Treatment Failure 50 0.8 0.8 no signal
693 Coma 29 0.8 0.8 no signal
694 Chest Discomfort 62 0.8 0.8 no signal
695 Swollen Tongue 19 0.8 0.8 no signal
696 Pharmaceutical Product Complaint 16 0.8 0.8 no signal
697 Hospitalisation 92 0.8 0.8 no signal
698 Cardiac Arrest 50 0.8 0.8 no signal
699 Altered State Of Consciousness 13 0.8 0.8 no signal
700 Amnesia 39 0.8 0.8 no signal
701 Ovarian Cyst 6 0.8 0.8 no signal
702 International Normalised Ratio Increased 17 0.8 0.8 no signal
703 Melaena 13 0.8 0.8 no signal
704 Movement Disorder 19 0.8 0.8 no signal
705 Arrhythmia 28 0.8 0.8 no signal
706 Eye Discharge 6 0.8 0.8 no signal
707 Musculoskeletal Pain 31 0.8 0.8 no signal
708 Peripheral Swelling 90 0.8 0.8 no signal
709 Hypotension 117 0.8 0.8 no signal
710 Stevens-johnson Syndrome 13 0.8 0.8 no signal
711 Dysstasia 17 0.8 0.8 no signal
712 Syncope 58 0.8 0.8 no signal
713 Gastric Ulcer 11 0.8 0.8 no signal
714 Pharyngeal Oedema 9 0.8 0.8 no signal
715 Ventricular Extrasystoles 6 0.8 0.8 no signal
716 Musculoskeletal Disorder 11 0.8 0.8 no signal
717 Lethargy 33 0.8 0.8 no signal
718 Oropharyngeal Pain 53 0.8 0.8 no signal
719 Viral Infection 19 0.8 0.8 no signal
720 Surgery 33 0.8 0.8 no signal
721 Balance Disorder 49 0.8 0.8 no signal
722 Acute Respiratory Distress Syndrome 10 0.8 0.8 no signal
723 Haemoglobin Decreased 58 0.8 0.8 no signal
724 Tachycardia 50 0.8 0.8 no signal
725 Tooth Extraction 7 0.8 0.8 no signal
726 Respiratory Failure 41 0.8 0.8 no signal
727 Intestinal Obstruction 21 0.8 0.8 no signal
728 Depressed Level Of Consciousness 22 0.8 0.8 no signal
729 Skin Cancer 12 0.8 0.8 no signal
730 Haemolytic Anaemia 5 0.8 0.8 no signal
731 Insomnia 148 0.8 0.8 no signal
732 Angina Pectoris 16 0.8 0.8 no signal
733 Pharyngitis Streptococcal 6 0.8 0.8 no signal
734 Feeling Hot 34 0.8 0.8 no signal
735 Pulmonary Arterial Hypertension 8 0.7 0.7 no signal
736 Activities Of Daily Living Impaired 11 0.7 0.7 no signal
737 Hepatitis 14 0.7 0.7 no signal
738 Retinal Detachment 5 0.7 0.7 no signal
739 Increased Tendency To Bruise 5 0.7 0.7 no signal
740 Urosepsis 5 0.7 0.7 no signal
741 Hiatus Hernia 7 0.7 0.7 no signal
742 Amenorrhoea 9 0.7 0.7 no signal
743 Bacterial Infection 10 0.7 0.7 no signal
744 Neck Pain 30 0.7 0.7 no signal
745 Rib Fracture 11 0.7 0.7 no signal
746 Colon Cancer 8 0.7 0.7 no signal
747 Speech Disorder 28 0.7 0.7 no signal
748 Hypersensitivity 99 0.7 0.7 no signal
749 Deformity 5 0.7 0.7 no signal
750 Headache 330 0.7 0.7 no signal
751 Scar 9 0.7 0.7 no signal
752 Cataract 31 0.7 0.7 no signal
753 Pain 321 0.7 0.7 no signal
754 Gastrointestinal Disorder 46 0.7 0.7 no signal
755 Thyroid Disorder 8 0.7 0.7 no signal
756 Product Use Complaint 8 0.7 0.7 no signal
757 Swelling 48 0.7 0.7 no signal
758 Abdominal Pain Lower 13 0.7 0.7 no signal
759 Fungal Infection 17 0.7 0.7 no signal
760 Lymphocyte Count Decreased 9 0.7 0.7 no signal
761 Hot Flush 38 0.7 0.7 no signal
762 Disorientation 20 0.7 0.7 no signal
763 Oral Discomfort 7 0.7 0.7 no signal
764 Feeling Cold 14 0.7 0.7 no signal
765 Intervertebral Disc Protrusion 11 0.7 0.7 no signal
766 Abscess 8 0.7 0.7 no signal
767 Spinal Fracture 10 0.7 0.7 no signal
768 Deafness 13 0.7 0.7 no signal
769 Haematuria 17 0.7 0.7 no signal
770 Pancreatitis Acute 11 0.7 0.7 no signal
771 Dry Throat 5 0.7 0.7 no signal
772 Hepatocellular Injury 7 0.7 0.7 no signal
773 Blindness 20 0.7 0.7 no signal
774 Initial Insomnia 5 0.7 0.7 no signal
775 Therapy Cessation 25 0.7 0.7 no signal
776 Tooth Abscess 5 0.7 0.7 no signal
777 Toxicity To Various Agents 82 0.7 0.7 no signal
778 Ear Discomfort 5 0.7 0.7 no signal
779 Paralysis 7 0.7 0.7 no signal
780 Renal Failure 65 0.7 0.7 no signal
781 Septic Shock 21 0.7 0.7 no signal
782 Peritonitis 10 0.7 0.7 no signal
783 Somnolence 97 0.7 0.7 no signal
784 Nasopharyngitis 89 0.7 0.7 no signal
785 Hepatic Cirrhosis 9 0.7 0.7 no signal
786 Lip Swelling 16 0.7 0.7 no signal
787 Coagulopathy 8 0.7 0.7 no signal
788 Petechiae 5 0.7 0.7 no signal
789 Pollakiuria 20 0.7 0.7 no signal
790 Dysarthria 18 0.7 0.6 no signal
791 Immunodeficiency 7 0.6 0.6 no signal
792 Head Injury 15 0.6 0.6 no signal
793 Acute Myocardial Infarction 14 0.6 0.6 no signal
794 Blood Urine Present 9 0.6 0.6 no signal
795 Hypothyroidism 15 0.6 0.6 no signal
796 Respiratory Distress 13 0.6 0.6 no signal
797 Therapeutic Response Unexpected 21 0.6 0.6 no signal
798 Haemoptysis 13 0.6 0.6 no signal
799 Hypoaesthesia Oral 7 0.6 0.6 no signal
800 Faeces Discoloured 10 0.6 0.6 no signal
801 Platelet Count Increased 6 0.6 0.6 no signal
802 Tooth Infection 6 0.6 0.6 no signal
803 Product Use In Unapproved Indication 111 0.6 0.6 no signal
804 Drug-induced Liver Injury 14 0.6 0.6 no signal
805 Neuralgia 11 0.6 0.6 no signal
806 Seizure 52 0.6 0.6 no signal
807 Hepatic Cancer 11 0.6 0.6 no signal
808 Upper Limb Fracture 9 0.6 0.6 no signal
809 Nephropathy Toxic 5 0.6 0.6 no signal
810 Sinusitis 46 0.6 0.6 no signal
811 Myalgia 76 0.6 0.6 no signal
812 Gallbladder Disorder 8 0.6 0.6 no signal
813 Hunger 6 0.6 0.6 no signal
814 Fistula 5 0.6 0.6 no signal
815 Sinus Congestion 6 0.6 0.6 no signal
816 Gastroenteritis Viral 8 0.6 0.6 no signal
817 Myocarditis 5 0.6 0.6 no signal
818 White Blood Cell Count Increased 17 0.6 0.6 no signal
819 Ageusia 11 0.6 0.6 no signal
820 Obesity 7 0.6 0.6 no signal
821 Hip Fracture 14 0.6 0.6 no signal
822 Eye Swelling 16 0.6 0.6 no signal
823 Middle Insomnia 8 0.6 0.6 no signal
824 Vasculitis 5 0.6 0.6 no signal
825 Sleep Disorder 30 0.6 0.6 no signal
826 Ocular Hyperaemia 20 0.6 0.6 no signal
827 Eyelid Oedema 5 0.6 0.6 no signal
828 Spinal Pain 5 0.6 0.6 no signal
829 Drug Ineffective 561 0.6 0.6 no signal
830 Infusion Related Reaction 28 0.6 0.6 no signal
831 Drug Interaction 67 0.6 0.6 no signal
832 Blood Pressure Decreased 28 0.6 0.6 no signal
833 Liver Function Test Increased 9 0.6 0.6 no signal
834 Loss Of Consciousness 54 0.6 0.6 no signal
835 Foot Fracture 8 0.6 0.6 no signal
836 Poor Quality Sleep 9 0.6 0.6 no signal
837 Macular Degeneration 5 0.6 0.6 no signal
838 Bronchospasm 6 0.6 0.6 no signal
839 Cytopenia 5 0.6 0.6 no signal
840 Renal Impairment 35 0.6 0.6 no signal
841 Acute Respiratory Failure 8 0.6 0.6 no signal
842 Hyperlipidaemia 5 0.6 0.6 no signal
843 Post Procedural Complication 8 0.6 0.6 no signal
844 Mental Impairment 10 0.6 0.6 no signal
845 Feeding Disorder 8 0.5 0.5 no signal
846 Pneumonia Aspiration 10 0.5 0.5 no signal
847 Depressed Mood 21 0.5 0.5 no signal
848 Brain Injury 4 0.5 0.5 no signal
849 Drug Eruption 7 0.5 0.5 no signal
850 Cold Sweat 7 0.5 0.5 no signal
851 Shock 9 0.5 0.5 no signal
852 Hypothermia 4 0.5 0.5 no signal
853 Sluggishness 4 0.5 0.5 no signal
854 Inappropriate Antidiuretic Hormone Secretion 4 0.5 0.5 no signal
855 Subarachnoid Haemorrhage 4 0.5 0.5 no signal
856 Tinnitus 18 0.5 0.5 no signal
857 Lung Neoplasm Malignant 16 0.5 0.5 no signal
858 Cognitive Disorder 18 0.5 0.5 no signal
859 Injury 27 0.5 0.5 no signal
860 Visual Impairment 47 0.5 0.5 no signal
861 Gastrointestinal Haemorrhage 32 0.5 0.5 no signal
862 Immune System Disorder 5 0.5 0.5 no signal
863 Discomfort 23 0.5 0.5 no signal
864 Arthralgia 155 0.5 0.5 no signal
865 Increased Appetite 7 0.5 0.5 no signal
866 Urinary Incontinence 11 0.5 0.5 no signal
867 Hypoglycaemia 18 0.5 0.5 no signal
868 Blood Potassium Increased 6 0.5 0.5 no signal
869 Atrial Fibrillation 36 0.5 0.5 no signal
870 Respiratory Disorder 11 0.5 0.5 no signal
871 Pulmonary Fibrosis 7 0.5 0.5 no signal
872 Joint Swelling 44 0.5 0.5 no signal
873 Heart Rate Increased 36 0.5 0.5 no signal
874 Influenza Like Illness 30 0.5 0.5 no signal
875 Bronchitis 27 0.5 0.5 no signal
876 Angioedema 16 0.5 0.5 no signal
877 Osteonecrosis 12 0.5 0.5 no signal
878 Urinary Retention 12 0.5 0.5 no signal
879 Kidney Infection 7 0.5 0.5 no signal
880 Crying 13 0.5 0.5 no signal
881 Limb Discomfort 11 0.5 0.5 no signal
882 Hypertension 75 0.5 0.5 no signal
883 Status Epilepticus 4 0.5 0.5 no signal
884 Myelosuppression 12 0.5 0.5 no signal
885 Cardiovascular Disorder 9 0.5 0.5 no signal
886 Gastric Cancer 9 0.5 0.5 no signal
887 Gastric Haemorrhage 4 0.5 0.5 no signal
888 Orthostatic Hypotension 6 0.5 0.5 no signal
889 Madarosis 4 0.5 0.5 no signal
890 Anhedonia 9 0.5 0.5 no signal
891 Thirst 6 0.5 0.5 no signal
892 Urticaria 56 0.5 0.5 no signal
893 Off Label Use 291 0.5 0.4 no signal
894 Tooth Loss 7 0.5 0.5 no signal
895 Depression 76 0.5 0.4 no signal
896 Mood Altered 9 0.4 0.4 no signal
897 Vaginal Haemorrhage 14 0.4 0.4 no signal
898 Hepatitis C 4 0.4 0.4 no signal
899 Hepatic Cytolysis 4 0.4 0.4 no signal
900 Hypoacusis 14 0.4 0.4 no signal
901 Therapeutic Product Effect Incomplete 23 0.4 0.4 no signal
902 Clostridium Difficile Infection 7 0.4 0.4 no signal
903 Fall 107 0.4 0.4 no signal
904 Renal Disorder 15 0.4 0.4 no signal
905 Vision Blurred 43 0.4 0.4 no signal
906 Lower Respiratory Tract Infection 14 0.4 0.4 no signal
907 Ear Pain 6 0.4 0.4 no signal
908 Chronic Obstructive Pulmonary Disease 16 0.4 0.4 no signal
909 Eye Disorder 10 0.4 0.4 no signal
910 Eye Pruritus 10 0.4 0.4 no signal
911 Disability 6 0.4 0.4 no signal
912 Sinus Disorder 6 0.4 0.4 no signal
913 Accidental Overdose 11 0.4 0.4 no signal
914 Vaginal Discharge 3 0.4 0.4 no signal
915 Malignant Melanoma 4 0.4 0.4 no signal
916 Full Blood Count Decreased 6 0.4 0.4 no signal
917 Incorrect Route Of Product Administration 5 0.4 0.4 no signal
918 Fluid Retention 15 0.4 0.4 no signal
919 Pallor 8 0.4 0.4 no signal
920 Therapy Non-responder 13 0.4 0.4 no signal
921 Memory Impairment 40 0.4 0.4 no signal
922 Hyperkalaemia 10 0.4 0.4 no signal
923 Cerebral Infarction 7 0.4 0.4 no signal
924 Encephalopathy 7 0.4 0.4 no signal
925 Cardio-respiratory Arrest 12 0.4 0.4 no signal
926 Ischaemic Stroke 5 0.4 0.4 no signal
927 Drug Dose Omission 46 0.4 0.4 no signal
928 Unresponsive To Stimuli 7 0.4 0.4 no signal
929 Laboratory Test Abnormal 8 0.4 0.4 no signal
930 Tremor 45 0.4 0.4 no signal
931 Agranulocytosis 5 0.4 0.4 no signal
932 Contusion 26 0.4 0.4 no signal
933 Medication Error 15 0.4 0.4 no signal
934 Throat Irritation 12 0.4 0.4 no signal
935 Photophobia 5 0.4 0.4 no signal
936 Joint Stiffness 7 0.4 0.4 no signal
937 Transient Ischaemic Attack 9 0.4 0.4 no signal
938 Bone Loss 4 0.4 0.4 no signal
939 Throat Tightness 7 0.4 0.4 no signal
940 Drug Dispensing Error 4 0.4 0.4 no signal
941 Emotional Disorder 8 0.4 0.4 no signal
942 Respiratory Arrest 7 0.3 0.3 no signal
943 Dementia 7 0.3 0.3 no signal
944 Anxiety 71 0.3 0.3 no signal
945 Product Use Issue 45 0.3 0.3 no signal
946 Nephrolithiasis 11 0.3 0.3 no signal
947 Poisoning 3 0.3 0.3 no signal
948 Mobility Decreased 17 0.3 0.3 no signal
949 Anaphylactic Reaction 13 0.3 0.3 no signal
950 Inappropriate Schedule Of Drug Administration 17 0.3 0.3 no signal
951 Myocardial Infarction 41 0.3 0.3 no signal
952 Feeling Abnormal 56 0.3 0.3 no signal
953 Influenza 26 0.3 0.3 no signal
954 Haematoma 6 0.3 0.3 no signal
955 Ear Infection 6 0.3 0.3 no signal
956 Nasal Congestion 13 0.3 0.3 no signal
957 Blood Pressure Increased 34 0.3 0.3 no signal
958 Covid-19 39 0.3 0.3 no signal
959 Akathisia 3 0.3 0.3 no signal
960 Mood Swings 7 0.3 0.3 no signal
961 Panic Attack 8 0.3 0.3 no signal
962 Diverticulitis 6 0.3 0.3 no signal
963 Road Traffic Accident 9 0.3 0.3 no signal
964 Condition Aggravated 64 0.3 0.3 no signal
965 Osteoarthritis 9 0.3 0.3 no signal
966 Cerebrovascular Accident 36 0.3 0.3 no signal
967 Acute Kidney Injury 32 0.3 0.3 no signal
968 Nervousness 11 0.3 0.3 no signal
969 Exposure During Pregnancy 13 0.3 0.3 no signal
970 Therapy Interrupted 14 0.3 0.3 no signal
971 Weight Increased 45 0.3 0.3 no signal
972 Drug Effect Decreased 11 0.3 0.3 no signal
973 Device Failure 3 0.3 0.3 no signal
974 Oxygen Saturation Decreased 11 0.3 0.3 no signal
975 Skin Burning Sensation 14 0.3 0.3 no signal
976 Coronary Artery Disease 6 0.3 0.3 no signal
977 Premature Delivery 3 0.3 0.3 no signal
978 Wheezing 11 0.3 0.3 no signal
979 Musculoskeletal Stiffness 16 0.2 0.2 no signal
980 Aggression 9 0.2 0.2 no signal
981 Multiple Organ Dysfunction Syndrome 5 0.2 0.2 no signal
982 Underdose 13 0.2 0.2 no signal
983 Product Quality Issue 23 0.2 0.2 no signal
984 Heart Rate Decreased 6 0.2 0.2 no signal
985 Bradycardia 9 0.2 0.2 no signal
986 Stress 12 0.2 0.2 no signal
987 Disturbance In Attention 9 0.2 0.2 no signal
988 Arthritis 13 0.2 0.2 no signal
989 Eye Pain 9 0.2 0.2 no signal
990 Eye Irritation 9 0.2 0.2 no signal
991 Metabolic Acidosis 5 0.2 0.2 no signal
992 Asthma 17 0.2 0.2 no signal
993 Product Dose Omission 10 0.2 0.2 no signal
994 Osteoporosis 6 0.2 0.2 no signal
995 Overdose 31 0.2 0.2 no signal
996 Pancreatic Carcinoma 4 0.2 0.2 no signal
997 Migraine 13 0.2 0.2 no signal
998 Drug Hypersensitivity 26 0.2 0.2 no signal
999 Hallucination 10 0.2 0.2 no signal
1000 Hyperhidrosis 17 0.2 0.2 no signal
1001 Arthropathy 7 0.2 0.2 no signal
1002 Incorrect Dose Administered 28 0.2 0.2 no signal
1003 Abortion Spontaneous 5 0.2 0.2 no signal
1004 No Adverse Event 22 0.2 0.2 no signal
1005 Dyskinesia 5 0.2 0.2 no signal
1006 Flushing 12 0.2 0.2 no signal
1007 Emotional Distress 14 0.2 0.2 no signal
1008 Maternal Exposure During Pregnancy 10 0.2 0.2 no signal
1009 Menstruation Irregular 3 0.2 0.2 no signal
1010 Blood Glucose Increased 21 0.2 0.1 no signal
1011 Unevaluable Event 8 0.1 0.1 no signal
1012 Blood Glucose Decreased 5 0.1 0.1 no signal
1013 Suicidal Ideation 9 0.1 0.1 no signal
1014 Agitation 7 0.1 0.1 no signal
1015 Inappropriate Schedule Of Product Administration 16 0.1 0.1 no signal
1016 Drug Exposure During Pregnancy 3 0.1 0.1 no signal
1017 Diabetes Mellitus 6 0.1 0.1 no signal
1018 Foetal Exposure During Pregnancy 5 0.1 0.1 no signal
1019 Completed Suicide 5 0.1 0.1 no signal
1020 Illness 5 0.1 0.1 no signal
1021 Injection Site Pain 12 0.1 0.1 no signal
1022 Psoriasis 5 0.1 0.1 no signal
1023 Wrong Technique In Product Usage Process 7 0.0 0.0 no signal
1024 Product Dose Omission Issue 8 0.0 0.0 no signal