Reaction

Gastrointestinal Toxicity reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 4,647 reports · 184 co-occurring drugs

As of the last recalculation, Gastrointestinal Toxicity appears in 4,647 FAERS reports alongside 184 co-occurring drug terms. The strongest observed disproportionality signal is TOFACITINIB CITRATE (PRR 39.9).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Tofacitinib Citrate	114	39.9	40.2
Thiotepa	81	38.6	39.0
Oxaliplatin	440	29.2	29.4
Capecitabine	516	28.3	28.4
Fluorouracil Cream, 0.5%	420	27.0	27.2
Fluorouracil	420	26.6	26.8
Imatinib	98	25.4	25.5
Erlotinib	52	24.3	24.4
Cisplatin	370	23.0	23.1
Busulfan	74	21.4	21.5
Lapatinib	72	21.1	21.2
Erlotinib Hydrochloride	57	20.6	20.7
Melphalan Hydrochloride	102	18.6	18.7
Gemcitabine Hydrochloride	203	17.9	17.9
Irinotecan Hydrochloride	50	17.6	17.7
Panitumumab	59	17.1	17.1
Gemcitabine	139	16.3	16.3
Leucovorin Calcium	68	16.2	16.2
Diphenhydramine Hydrochloride Capsule, Liquid Filled	74	15.7	15.8
Pemetrexed	74	15.7	15.7
Abemaciclib	64	14.5	14.6
Cetuximab	99	14.4	14.5
Etoposide	222	14.2	14.2
Doxorubicin	266	14.1	14.2
Methylprednisolone Acetate	25	14.1	14.1
Carboplatin	369	14.0	14.1
Bortezomib	259	13.7	13.7
Pemetrexed Disodium	113	13.6	13.6
Ifosfamide	64	13.5	13.6
Fam-Trastuzumab Deruxtecan-Nxki	30	13.4	13.4
Paclitaxel (Aibumin-Bound)	228	13.0	13.0
Melphalan	65	13.0	13.0
Durvalumab	58	12.9	13.0
Carfilzomib	78	12.5	12.6
Docetaxel Anhydrous	180	12.4	12.4
Docetaxel	180	12.4	12.4
Cytarabine	159	12.2	12.3
Paclitaxel	246	11.7	11.7
Acalabrutinib	31	11.5	11.6
Posaconazole Delayed-Release	28	11.5	11.5
Bevacizumab	283	10.8	10.9
Doxorubicin Hydrochloride	75	10.4	10.5
Fludarabine Phosphate	90	10.4	10.5
Sulfasalazine	176	10.4	10.5
Cladribine	22	10.3	10.3
Pertuzumab	61	10.2	10.2
Filgrastim	84	10.2	10.2
Ado-Trastuzumab Emtansine	19	10.1	10.2
Ipilimumab	95	10.0	10.1
Cyclophosphamide Injection, Solution	367	10.0	10.0
Cyclophosphamide	367	10.0	10.0
Cyclophosphamide For Injection	367	10.0	10.0
Bendamustine Hcl	34	9.9	9.9
Mesna Injection	18	9.8	9.8
Trastuzumab	142	9.5	9.5
Mesna	17	9.1	9.1
Micafungin Sodium	17	9.0	9.0
Trimethoprim	23	8.8	8.8
Brentuximab Vedotin	20	8.8	8.8
Human Immunoglobulin G	40	8.8	8.8
Hydroxychloroquine	141	8.7	8.7
Sorafenib	40	8.7	8.7
Posaconazole	31	8.6	8.6
Crizotinib	24	8.5	8.5
Selinexor	16	8.3	8.3
Tretinoin	15	8.3	8.3
Rituximab	361	8.2	8.2
Gefitinib	16	8.0	8.0
Bendamustine Hydrochloride	20	7.5	7.5
Bosutinib	15	7.5	7.5
Azacitidine For	29	7.2	7.2
Valganciclovir Hydrochloride Powder,	19	7.0	7.0
Nivolumab	146	7.0	7.0
Atezolizumab	59	6.9	6.9
Tocilizumab	169	6.8	6.9
Dasatinib	55	6.7	6.7
Everolimus Tablets	24	6.4	6.4
Trifluridine And Tipiracil	15	6.3	6.3
Azacitidine	41	6.2	6.2
Esomeprazole Magnesium Capsule, Delayed Release	20	6.2	6.2
Esomeprazole Magnesium Delayed Release Capsules	20	6.2	6.2
Esomeprazole Magnesium Dihydrate	20	6.2	6.2
Amphotericin B	17	6.1	6.1
Leflunomide	138	6.1	6.1
Cabozantinib	64	6.0	6.0
Temozolomide	28	6.0	6.0
Naproxen Sodium Tablet, Coated	18	6.0	6.0
Naproxen Sodium, Coated Tablets	18	6.0	6.0
Naproxen Sodium 220Mg	18	6.0	6.0
Regorafenib	15	5.8	5.8
Celecoxib	165	5.8	5.8
Golimumab	106	5.6	5.6
Polatuzumab Vedotin	12	5.5	5.5
Ganciclovir Sodium	13	5.5	5.5
Fulvestrant	40	5.5	5.5
Osimertinib	38	5.3	5.4
Axitinib	23	5.3	5.3
Tacrolimus Ointment 0.1%	143	5.3	5.3
Ganciclovir	12	5.3	5.3
Tacrolimus Extended-Release Capsules	143	5.3	5.3
Vincristine Sulfate	34	5.2	5.2
Sunitinib Malate	45	5.2	5.2
Dexamethasone 1.5 Mg	318	5.1	5.1
Ritonavir 100 Mg	17	5.1	5.1
Dalteparin Sodium	12	5.1	5.1
Dexamethasone	318	5.1	5.1
Nilotinib	33	5.0	5.0
Hydroxychloroquine Sulfate	98	4.9	4.9
Ixazomib	31	4.9	4.9
Pembrolizumab	111	4.8	4.8
Valganciclovir	20	4.8	4.8
Valganciclovir Hydrochloride	20	4.8	4.8
Blinatumomab	11	4.7	4.7
Sirolimus	14	4.7	4.7
Methotrexate	400	4.6	4.6
Olaparib	21	4.5	4.5
Methotrexate Sodium	450	4.5	4.5
Tacrolimus	152	4.5	4.5
Tofacitinib	176	4.4	4.4
Bleomycin Sulfate	10	4.3	4.3
Itraconazole	11	4.2	4.2
Thalidomide	34	4.2	4.2
Certolizumab Pegol	107	4.2	4.2
Mycophenolate Mofetil	123	4.1	4.1
Mycophenolate Mofetil Hydrochloride	123	4.1	4.1
Encorafenib	9	4.1	4.1
Amikacin	15	3.9	4.0
Mycophenilic Acid	18	3.9	3.9
Aprepitant	16	3.9	3.9
Fondaparinux Sodium	7	3.9	3.9
Basiliximab	10	3.8	3.8
Vemurafenib	10	3.7	3.7
Pazopanib Hydrochloride	22	3.7	3.7
Abatacept	111	3.7	3.7
Daratumumab	32	3.6	3.6
Adalimumab-Fkjp	37	3.6	3.6
Letrozole Tablets	38	3.6	3.6
Adalimumab-Aaty	37	3.5	3.5
Ibuprofen Oral	152	3.5	3.5
Ibuprofen Capsule	151	3.5	3.5
Ibuprofen Tablet, Film Coated	151	3.5	3.5
Ibupfrofen	151	3.5	3.5
Ibuprofen Tablets Usp, 200Mg	151	3.5	3.5
Ibuprofen Capsules 200 Mg	151	3.5	3.5
Ibuprofen 200 Mg	151	3.5	3.5
Ibuprofen 200Mg	151	3.5	3.5
Letrozole	47	3.4	3.4
Imatinib Mesylate	21	3.4	3.4
Abiraterone	10	3.3	3.3
Adalimumab-Adaz	37	3.2	3.2
Ritonavir	20	3.1	3.1
Goserelin	9	3.0	3.0
Hydroxyurea	14	3.0	3.0
Mycophenolic Acid	21	2.9	2.9
Fosaprepitant Dimeglumine	9	2.9	2.9
Atorvastatin Calcium	157	2.9	2.9
Ibrutinib	51	2.8	2.8
Lenvatinib	20	2.7	2.7
Ribociclib	19	2.7	2.7
Meropenem	19	2.7	2.7
Everolimus	30	2.7	2.7
Voriconazole	17	2.5	2.5
Anakinra	9	2.4	2.4
Venetoclax	32	2.3	2.3
Nintedanib	16	2.3	2.3
Deferasirox	13	2.2	2.2
Dexlansoprazole	20	2.2	2.2
Alpelisib	4	2.1	2.1
Niraparib	10	2.0	2.0
Entecavir	5	1.9	1.9
Aflibercept	13	1.9	1.9
Trametinib	10	1.9	1.9
Pegaspargase	5	1.8	1.8
Pseudoephedrine Hydrochloride	4	1.7	1.7
Ranitidine Hydrochloride	20	1.7	1.7
Palbociclib	35	1.6	1.6
Pseudoephedrine Hcl	4	1.6	1.6
Dabrafenib	7	1.5	1.5
Lenalidomide	139	1.5	1.5
Pegfilgrastim	30	1.4	1.4
Etanercept	179	1.4	1.4
Abiraterone Acetate	10	1.1	1.1
Tapentadol Hydrochloride	7	0.9	0.9
Pomalidomide	18	0.8	0.8

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.