OpenPV Signal Explorer
FAERS disproportionality dashboard
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Drug

Leucovorin Calcium

1,159 flagged reaction(s) · 71,262 total co-reports · max PRR 1,292.0
Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.
Reaction Co-reports (a) PRR ROR Signal
1 Monocyte Chemotactic Protein-1 Increased 19 1,292.0 1,293.3 signal
2 Lymphoid Tissue Hypoplasia 32 302.8 303.3 signal
3 Alpha Tumour Necrosis Factor Increased 19 279.4 279.6 signal
4 Thymus Hypoplasia 32 252.3 252.7 signal
5 Nipple Swelling 35 176.3 176.6 signal
6 Teratogenicity 28 112.4 112.6 signal
7 Central Nervous System Lupus 18 99.9 100.0 signal
8 Neutropenia Neonatal 15 78.5 78.5 signal
9 Sleep Disorder Therapy 12 75.9 76.0 signal
10 Laryngeal Dyspnoea 13 68.0 68.0 signal
11 Non-cirrhotic Portal Hypertension 21 67.6 67.7 signal
12 Colorectal Cancer Metastatic 130 66.5 66.9 signal
13 Anastomotic Complication 19 63.2 63.3 signal
14 Congenital Aplasia 15 60.2 60.3 signal
15 Disseminated Aspergillosis 24 59.5 59.6 signal
16 Oesophageal Atresia 28 51.5 51.6 signal
17 Portal Venous Gas 15 49.0 49.0 signal
18 Mycobacterium Chelonae Infection 31 48.5 48.5 signal
19 Secondary Immunodeficiency 50 48.2 48.3 signal
20 Rectal Cancer Metastatic 14 46.4 46.5 signal
21 Analgesic Therapy 12 44.9 44.9 signal
22 Interleukin Level Increased 20 42.9 43.0 signal
23 Subretinal Fluid 37 40.1 40.1 signal
24 Anastomotic Leak 24 39.4 39.4 signal
25 Pseudomonal Sepsis 57 36.9 37.0 signal
26 Minimal Residual Disease 14 33.9 33.9 signal
27 Rectal Perforation 16 33.7 33.7 signal
28 Overlap Syndrome 20 32.9 33.0 signal
29 Klebsiella Test Positive 18 31.3 31.3 signal
30 Catheter Related Infection 28 31.0 31.0 signal
31 Colon Cancer Metastatic 43 30.3 30.4 signal
32 Reversible Posterior Leukoencephalopathy Syndrome 21 30.0 30.1 signal
33 Granulocyte Count Decreased 47 29.9 29.9 signal
34 Malignant Ascites 20 29.5 29.6 signal
35 Drug Clearance Decreased 31 27.8 27.9 signal
36 Foetal Disorder 20 26.7 26.8 signal
37 Dilated Cardiomyopathy 21 25.5 25.5 signal
38 Diffuse Alveolar Damage 25 24.4 24.4 signal
39 Stenotrophomonas Infection 29 24.4 24.4 signal
40 Peritoneal Disorder 14 24.1 24.2 signal
41 Catheter Related Complication 24 23.7 23.7 signal
42 Rectal Adenocarcinoma 12 22.6 22.6 signal
43 Blood Culture Positive 58 21.5 21.6 signal
44 Butterfly Rash 19 21.3 21.3 signal
45 Hypochromic Anaemia 19 21.1 21.1 signal
46 Arteriospasm Coronary 72 20.5 20.6 signal
47 Nipple Pain 37 20.4 20.5 signal
48 Troponin T Increased 23 20.3 20.3 signal
49 Aortic Thrombosis 21 20.3 20.3 signal
50 Rectal Tenesmus 22 20.1 20.1 signal
51 Skin Toxicity 96 19.3 19.4 signal
52 Hyperphosphataemia 36 19.1 19.1 signal
53 Gastrointestinal Perforation 68 18.4 18.4 signal
54 Deep Vein Thrombosis Postoperative 32 18.3 18.3 signal
55 Culture Urine Positive 23 18.2 18.3 signal
56 Vascular Access Complication 13 18.0 18.0 signal
57 Dermatitis Acneiform 96 17.8 17.9 signal
58 Subclavian Vein Thrombosis 18 17.6 17.7 signal
59 Neutropenic Infection 15 17.4 17.4 signal
60 Loss Of Employment 47 17.3 17.3 signal
61 Tumour Necrosis 16 17.1 17.1 signal
62 Troponin I Increased 25 16.8 16.9 signal
63 Mucosal Inflammation 377 16.2 16.5 signal
64 Gastrointestinal Toxicity 68 16.2 16.2 signal
65 Leukoencephalopathy 54 16.1 16.2 signal
66 Metastases To Peritoneum 36 16.1 16.1 signal
67 Obstruction Gastric 18 15.9 15.9 signal
68 Culture Positive 12 15.9 15.9 signal
69 Jugular Vein Thrombosis 25 15.8 15.9 signal
70 Gastrointestinal Stoma Complication 22 15.8 15.8 signal
71 Prinzmetal Angina 14 15.7 15.7 signal
72 Hyperammonaemic Encephalopathy 24 15.7 15.7 signal
73 Enterocolitis Infectious 13 15.6 15.6 signal
74 Cerebral Toxoplasmosis 13 15.5 15.6 signal
75 Thrombocytopenic Purpura 19 15.4 15.4 signal
76 Drug Toxicity 188 15.2 15.4 signal
77 Carcinoembryonic Antigen Increased 26 15.0 15.1 signal
78 C-reactive Protein 12 14.8 14.8 signal
79 Peripheral Sensory Neuropathy 77 14.7 14.8 signal
80 Pneumatosis Intestinalis 37 14.6 14.6 signal
81 Arrhythmia Supraventricular 14 14.2 14.2 signal
82 Perirectal Abscess 14 14.0 14.0 signal
83 Enteritis 78 13.7 13.8 signal
84 Pelvic Abscess 14 13.7 13.7 signal
85 Oral Intake Reduced 30 13.7 13.7 signal
86 Myelosuppression 416 13.7 13.9 signal
87 N-terminal Prohormone Brain Natriuretic Peptide Increased 17 13.5 13.5 signal
88 Large Intestinal Obstruction 24 12.1 12.1 signal
89 Peripheral Motor Neuropathy 15 12.0 12.0 signal
90 Haematotoxicity 99 11.9 12.0 signal
91 Febrile Bone Marrow Aplasia 44 11.7 11.7 signal
92 Peripheral Sensorimotor Neuropathy 13 11.7 11.7 signal
93 Bone Erosion 37 11.6 11.7 signal
94 Neuropathy 18 11.6 11.6 signal
95 Portal Hypertension 32 11.5 11.6 signal
96 Enterocolitis 58 11.3 11.3 signal
97 Adenocarcinoma Of Colon 19 11.3 11.3 signal
98 Aplasia 20 11.2 11.2 signal
99 Neoplasm Recurrence 34 11.1 11.2 signal
100 Escherichia Test Positive 12 11.1 11.1 signal
101 Febrile Neutropenia 652 11.0 11.3 signal
102 Neurotoxicity 171 11.0 11.0 signal
103 Intestinal Dilatation 13 10.9 10.9 signal
104 Lupus Nephritis 18 10.9 10.9 signal
105 Metastases To Liver 170 10.8 10.9 signal
106 Hypoalbuminaemia 74 10.8 10.8 signal
107 Small Intestinal Perforation 18 10.7 10.7 signal
108 Stoma Site Pain 14 10.7 10.7 signal
109 Neutrophil Count Abnormal 27 10.6 10.7 signal
110 Small Intestinal Obstruction 117 10.6 10.7 signal
111 Clostridial Infection 32 10.4 10.4 signal
112 Tumour Lysis Syndrome 81 10.3 10.4 signal
113 Stoma Site Haemorrhage 14 10.2 10.2 signal
114 Cytomegalovirus Viraemia 40 10.2 10.2 signal
115 Large Intestine Polyp 63 10.1 10.1 signal
116 Neutropenic Sepsis 65 10.1 10.1 signal
117 Parainfluenzae Virus Infection 14 10.1 10.1 signal
118 Pleuritic Pain 25 10.0 10.0 signal
119 Paronychia 39 10.0 10.0 signal
120 Metastases To Lung 102 9.8 9.9 signal
121 Cytomegalovirus Chorioretinitis 17 9.8 9.8 signal
122 Pulmonary Infarction 21 9.8 9.8 signal
123 Large Intestine Perforation 61 9.8 9.8 signal
124 Ureteric Obstruction 12 9.7 9.7 signal
125 Gastrointestinal Wall Thickening 13 9.7 9.7 signal
126 Neutropenic Colitis 18 9.7 9.7 signal
127 Tenosynovitis 24 9.7 9.7 signal
128 Red Blood Cell Sedimentation Rate Abnormal 20 9.6 9.6 signal
129 Subileus 18 9.5 9.6 signal
130 Alanine Aminotransferase Abnormal 18 9.5 9.5 signal
131 Laryngospasm 23 9.5 9.5 signal
132 Failure To Thrive 44 9.4 9.4 signal
133 Therapy Partial Responder 126 9.3 9.4 signal
134 Polyneuropathy 99 9.3 9.3 signal
135 Rectal Abscess 14 9.2 9.3 signal
136 Abdominal Abscess 36 9.1 9.1 signal
137 Hypomagnesaemia 113 9.1 9.1 signal
138 Cholangitis 50 9.0 9.0 signal
139 Gastric Perforation 22 9.0 9.0 signal
140 Neutropenia 1,094 9.0 9.5 signal
141 Liver Abscess 26 8.9 8.9 signal
142 Neutrophil Count Decreased 323 8.9 9.0 signal
143 Adhesion 12 8.8 8.8 signal
144 Ileus 97 8.8 8.8 signal
145 Venous Thrombosis 31 8.7 8.8 signal
146 Electrocardiogram St Segment Elevation 26 8.7 8.7 signal
147 Change Of Bowel Habit 16 8.7 8.7 signal
148 Bile Duct Obstruction 15 8.7 8.7 signal
149 Blood Lactic Acid Increased 40 8.5 8.5 signal
150 Gene Mutation 15 8.4 8.4 signal
151 Rectal Cancer 23 8.3 8.3 signal
152 Computerised Tomogram Abnormal 17 8.3 8.3 signal
153 Treatment Delayed 12 8.2 8.2 signal
154 Cytokine Release Syndrome 141 8.2 8.3 signal
155 Osteolysis 15 8.1 8.1 signal
156 Facet Joint Syndrome 23 8.1 8.1 signal
157 Peripheral Venous Disease 29 8.1 8.1 signal
158 Hyperammonaemia 36 8.0 8.0 signal
159 Proctitis 20 7.9 7.9 signal
160 Pneumoperitoneum 13 7.9 7.9 signal
161 Abdominal Infection 18 7.8 7.9 signal
162 Intestinal Perforation 77 7.6 7.6 signal
163 Blood Albumin Decreased 54 7.6 7.6 signal
164 Lymphopenia 95 7.5 7.5 signal
165 Venoocclusive Liver Disease 33 7.4 7.5 signal
166 Embolism 56 7.4 7.5 signal
167 Metastases To Meninges 15 7.4 7.4 signal
168 Optic Neuropathy 14 7.4 7.4 signal
169 Soft Tissue Infection 12 7.3 7.4 signal
170 Disease Progression 770 7.2 7.5 signal
171 Leukopenia 324 7.2 7.3 signal
172 Escherichia Bacteraemia 15 7.2 7.2 signal
173 Anorexia 84 7.1 7.2 signal
174 Lung Consolidation 18 7.1 7.1 signal
175 Haemolytic Uraemic Syndrome 15 7.1 7.1 signal
176 Hyperuricaemia 26 7.0 7.0 signal
177 Cardiotoxicity 56 7.0 7.0 signal
178 Clostridium Difficile Colitis 67 7.0 7.0 signal
179 Bacterial Infection 117 7.0 7.0 signal
180 Electrocardiogram T Wave Inversion 14 7.0 7.0 signal
181 Blood Bicarbonate Decreased 12 7.0 7.0 signal
182 Oesophagitis 68 6.9 6.9 signal
183 Enterococcal Infection 30 6.9 6.9 signal
184 Hypokalaemia 284 6.9 7.0 signal
185 Neuropathy Peripheral 574 6.7 6.9 signal
186 Respiratory Symptom 17 6.7 6.7 signal
187 Hypovolaemia 35 6.6 6.6 signal
188 Klebsiella Infection 30 6.6 6.6 signal
189 Varices Oesophageal 18 6.6 6.6 signal
190 Clostridium Test Positive 13 6.6 6.6 signal
191 Hepatic Cytolysis 72 6.5 6.6 signal
192 Acidosis 45 6.5 6.5 signal
193 Type Iv Hypersensitivity Reaction 16 6.5 6.5 signal
194 Dermatitis Exfoliative Generalised 20 6.5 6.5 signal
195 Adenocarcinoma 13 6.4 6.4 signal
196 Atelectasis 56 6.4 6.4 signal
197 Hydronephrosis 43 6.4 6.4 signal
198 Bronchopulmonary Aspergillosis 44 6.3 6.3 signal
199 Bacteraemia 67 6.3 6.3 signal
200 Polyp 37 6.3 6.3 signal
201 Dengue Fever 13 6.3 6.3 signal
202 Dysaesthesia 17 6.2 6.2 signal
203 Hypocalcaemia 106 6.2 6.3 signal
204 Wound Dehiscence 19 6.2 6.2 signal
205 Portal Vein Thrombosis 18 6.2 6.2 signal
206 Thrombocytopenia 623 6.2 6.4 signal
207 Oesophageal Candidiasis 22 6.2 6.2 signal
208 Palmar-plantar Erythrodysaesthesia Syndrome 130 6.2 6.2 signal
209 Hepatic Lesion 24 6.2 6.2 signal
210 Immune Effector Cell-associated Neurotoxicity Syndrome 31 6.1 6.1 signal
211 Metastases To Lymph Nodes 37 6.1 6.1 signal
212 Gastrointestinal Necrosis 16 6.1 6.1 signal
213 Activated Partial Thromboplastin Time Prolonged 28 6.1 6.1 signal
214 Lung Infiltration 49 6.1 6.1 signal
215 Myopia 13 6.1 6.1 signal
216 Ascites 160 6.0 6.1 signal
217 Troponin Increased 41 6.0 6.0 signal
218 Blood Creatinine Decreased 17 6.0 6.0 signal
219 Hepatic Steatosis 101 6.0 6.0 signal
220 Candidiasis 22 6.0 6.0 signal
221 Stomatitis 324 5.9 6.0 signal
222 Sudden Death 57 5.9 5.9 signal
223 Hypophosphataemia 39 5.9 5.9 signal
224 Proctalgia 34 5.9 5.9 signal
225 Left Ventricular Dysfunction 35 5.8 5.8 signal
226 Protein Urine Present 26 5.8 5.8 signal
227 Interstitial Lung Disease 251 5.8 5.8 signal
228 Necrotising Fasciitis 18 5.7 5.7 signal
229 Metastatic Neoplasm 22 5.7 5.7 signal
230 Mouth Ulceration 107 5.6 5.7 signal
231 Hyperbilirubinaemia 52 5.6 5.6 signal
232 Splenomegaly 59 5.6 5.6 signal
233 Therapeutic Agent Toxicity 17 5.6 5.6 signal
234 Gastrointestinal Obstruction 12 5.6 5.6 signal
235 Neoplasm Progression 176 5.6 5.6 signal
236 Second Primary Malignancy 41 5.5 5.5 signal
237 Intestinal Ischaemia 27 5.5 5.5 signal
238 Organising Pneumonia 24 5.4 5.4 signal
239 Type I Hypersensitivity 17 5.4 5.4 signal
240 Cerebral Ischaemia 25 5.3 5.3 signal
241 Pulmonary Embolism 456 5.3 5.4 signal
242 Hypophagia 121 5.3 5.3 signal
243 Performance Status Decreased 22 5.2 5.2 signal
244 Agranulocytosis 87 5.2 5.2 signal
245 Electrolyte Imbalance 54 5.2 5.2 signal
246 Anal Haemorrhage 13 5.1 5.1 signal
247 Duodenal Ulcer Perforation 34 5.1 5.1 signal
248 Blood Chloride Decreased 12 5.1 5.1 signal
249 Bronchopneumonia 16 5.1 5.1 signal
250 Malnutrition 51 5.1 5.1 signal
251 Lower Gastrointestinal Haemorrhage 34 5.1 5.1 signal
252 Guillain-barre Syndrome 22 5.1 5.1 signal
253 Sepsis 508 5.0 5.2 signal
254 Duodenal Ulcer 32 5.0 5.0 signal
255 Jaundice Cholestatic 16 5.0 5.0 signal
256 Posterior Reversible Encephalopathy Syndrome 43 5.0 5.0 signal
257 Ileus Paralytic 20 5.0 5.0 signal
258 Leukocytosis 81 5.0 5.0 signal
259 Necrosis 25 5.0 5.0 signal
260 Folliculitis 46 4.9 4.9 signal
261 Colitis 166 4.9 4.9 signal
262 Bone Marrow Failure 90 4.9 4.9 signal
263 Blood Phosphorus Decreased 16 4.9 4.9 signal
264 Anaphylactoid Reaction 18 4.9 4.9 signal
265 Disseminated Intravascular Coagulation 62 4.9 4.9 signal
266 Staphylococcal Bacteraemia 19 4.9 4.9 signal
267 Dehydration 584 4.8 5.0 signal
268 Nephrotic Syndrome 30 4.8 4.9 signal
269 Multi-organ Failure 76 4.8 4.8 signal
270 Prothrombin Time Prolonged 26 4.8 4.8 signal
271 Rash Maculo-papular 95 4.7 4.8 signal
272 Bacterial Sepsis 14 4.7 4.7 signal
273 Hypertriglyceridaemia 25 4.7 4.7 signal
274 Blood Bilirubin Increased 116 4.7 4.8 signal
275 Myocardial Ischaemia 49 4.7 4.7 signal
276 Pancytopenia 237 4.7 4.8 signal
277 Proteinuria 80 4.7 4.7 signal
278 Hepatotoxicity 94 4.7 4.7 signal
279 Rash Pustular 31 4.7 4.7 signal
280 Diffuse Large B-cell Lymphoma 32 4.6 4.6 signal
281 Pulse Absent 20 4.6 4.6 signal
282 Septic Shock 180 4.6 4.6 signal
283 Sinus Tachycardia 59 4.6 4.6 signal
284 Escherichia Infection 34 4.6 4.6 signal
285 Cachexia 21 4.5 4.5 signal
286 Pharyngolaryngeal Pain 22 4.5 4.5 signal
287 Hiccups 33 4.5 4.5 signal
288 Metastasis 29 4.5 4.5 signal
289 Normochromic Normocytic Anaemia 12 4.4 4.4 signal
290 Stress Cardiomyopathy 23 4.4 4.4 signal
291 Thrombotic Thrombocytopenic Purpura 14 4.4 4.4 signal
292 Rales 23 4.4 4.4 signal
293 Fibrin D Dimer Increased 14 4.4 4.4 signal
294 Acute Pulmonary Oedema 22 4.3 4.3 signal
295 Blood Lactate Dehydrogenase Increased 62 4.3 4.3 signal
296 Blood Sodium Decreased 73 4.3 4.3 signal
297 Oesophageal Ulcer 15 4.3 4.3 signal
298 Ischaemic Cardiomyopathy 12 4.3 4.3 signal
299 Intestinal Obstruction 145 4.3 4.3 signal
300 Colitis Ischaemic 26 4.3 4.3 signal
301 Swollen Joint Count Increased 12 4.3 4.3 signal
302 Purpura 34 4.3 4.3 signal
303 Hyperthermia 29 4.2 4.2 signal
304 Deep Vein Thrombosis 250 4.2 4.3 signal
305 C-reactive Protein Increased 139 4.2 4.3 signal
306 Refusal Of Treatment By Patient 25 4.2 4.2 signal
307 Hyponatraemia 214 4.2 4.3 signal
308 Haematocrit Decreased 75 4.2 4.2 signal
309 Circulatory Collapse 64 4.1 4.2 signal
310 Left Ventricular Hypertrophy 16 4.1 4.1 signal
311 Odynophagia 22 4.1 4.1 signal
312 Lung Neoplasm 16 4.1 4.1 signal
313 Nephropathy Toxic 41 4.1 4.1 signal
314 Acute Graft Versus Host Disease 17 4.1 4.1 signal
315 Fluid Intake Reduced 18 4.0 4.0 signal
316 Intercepted Medication Error 17 4.0 4.0 signal
317 C-reactive Protein Abnormal 23 4.0 4.0 signal
318 Blood Creatinine Increased 234 4.0 4.0 signal
319 Hypovolaemic Shock 17 3.9 4.0 signal
320 Anal Fistula 19 3.9 3.9 signal
321 Vascular Device Infection 16 3.9 3.9 signal
322 Hypoxia 124 3.9 3.9 signal
323 Renal Failure Acute 152 3.9 3.9 signal
324 Low Birth Weight Baby 28 3.9 3.9 signal
325 Red Blood Cell Sedimentation Rate Increased 39 3.9 3.9 signal
326 Hepatic Fibrosis 12 3.9 3.9 signal
327 Pulmonary Fibrosis 67 3.9 3.9 signal
328 Bursitis 42 3.9 3.9 signal
329 Ischaemic Stroke 62 3.8 3.8 signal
330 Blood Uric Acid Increased 20 3.8 3.8 signal
331 Cholecystitis 41 3.8 3.8 signal
332 Covid-19 Pneumonia 41 3.8 3.8 signal
333 Haemolytic Anaemia 31 3.8 3.8 signal
334 Drug Reaction With Eosinophilia And Systemic Symptoms 88 3.8 3.8 signal
335 Rheumatic Fever 15 3.8 3.8 signal
336 Vasculitis 40 3.8 3.8 signal
337 Staphylococcal Sepsis 17 3.8 3.8 signal
338 Hypernatraemia 17 3.8 3.8 signal
339 Oliguria 21 3.7 3.7 signal
340 Anal Fissure 18 3.7 3.7 signal
341 Metastases To Central Nervous System 43 3.7 3.7 signal
342 Acute Respiratory Distress Syndrome 59 3.7 3.7 signal
343 Cardiopulmonary Failure 13 3.7 3.7 signal
344 Flank Pain 31 3.7 3.7 signal
345 Encephalopathy 81 3.7 3.7 signal
346 Blood Alkaline Phosphatase Increased 82 3.6 3.7 signal
347 Gastroenteritis 48 3.6 3.7 signal
348 Food Intolerance 12 3.6 3.6 signal
349 Benign Prostatic Hyperplasia 17 3.6 3.6 signal
350 Pulmonary Toxicity 23 3.6 3.6 signal
351 Incorrect Route Of Product Administration 55 3.6 3.6 signal
352 Polyarthritis 17 3.6 3.6 signal
353 Anti-cyclic Citrullinated Peptide Antibody Positive 23 3.6 3.6 signal
354 Blepharospasm 20 3.6 3.6 signal
355 Malignant Neoplasm Progression 328 3.6 3.6 signal
356 Protein Total Decreased 12 3.5 3.5 signal
357 Peritonitis 66 3.5 3.5 signal
358 Anaemia 603 3.5 3.6 signal
359 Systemic Inflammatory Response Syndrome 12 3.5 3.5 signal
360 Blood Creatine Increased 14 3.5 3.5 signal
361 Respiratory Rate Increased 28 3.5 3.5 signal
362 Extravasation 13 3.5 3.5 signal
363 Blood Iron Decreased 37 3.5 3.5 signal
364 Granulocytopenia 18 3.5 3.5 signal
365 Infusion Related Reaction 207 3.5 3.5 signal
366 Hand Deformity 41 3.5 3.5 signal
367 Haemoglobin Decreased 322 3.5 3.5 signal
368 Wound Infection 34 3.5 3.5 signal
369 Haemoglobin Abnormal 20 3.5 3.5 signal
370 White Blood Cell Count Decreased 339 3.5 3.5 signal
371 Phlebitis 16 3.5 3.5 signal
372 Aortic Dissection 13 3.4 3.4 signal
373 Neutrophil Count Increased 32 3.4 3.4 signal
374 Haemoglobin Increased 14 3.4 3.4 signal
375 Finger Deformity 15 3.4 3.4 signal
376 Liver Disorder 137 3.4 3.4 signal
377 Blood Potassium Decreased 93 3.4 3.4 signal
378 Herpes Simplex 20 3.4 3.4 signal
379 Shock Haemorrhagic 25 3.4 3.4 signal
380 Ventricular Fibrillation 34 3.4 3.4 signal
381 Encephalitis 21 3.4 3.4 signal
382 Breath Sounds Abnormal 15 3.4 3.4 signal
383 Tachypnoea 41 3.3 3.4 signal
384 Tachycardia 267 3.3 3.4 signal
385 Cerebral Atrophy 12 3.3 3.3 signal
386 Alanine Aminotransferase Increased 184 3.3 3.3 signal
387 Pleural Effusion 182 3.3 3.3 signal
388 Diverticulum Intestinal 13 3.3 3.3 signal
389 Device Related Infection 46 3.3 3.3 signal
390 Aspartate Aminotransferase Increased 158 3.3 3.3 signal
391 Blood Urea Increased 50 3.3 3.3 signal
392 Peripheral Ischaemia 12 3.2 3.2 signal
393 Autoimmune Disorder 28 3.2 3.2 signal
394 Pyrexia 1,012 3.2 3.4 signal
395 Partial Seizures 15 3.2 3.2 signal
396 Liver Injury 70 3.2 3.2 signal
397 Hyperpyrexia 12 3.2 3.2 signal
398 Grand Mal Convulsion 27 3.2 3.2 signal
399 Pancreatitis Acute 64 3.2 3.2 signal
400 Abdominal Pain 666 3.2 3.2 signal
401 Cholecystitis Acute 16 3.1 3.1 signal
402 Ejection Fraction Decreased 44 3.1 3.1 signal
403 Ulcer 45 3.1 3.1 signal
404 Diarrhoea 1,799 3.1 3.3 signal
405 Electrocardiogram Abnormal 22 3.1 3.1 signal
406 Lip Dry 25 3.1 3.1 signal
407 Thrombotic Microangiopathy 27 3.1 3.1 signal
408 Contraindicated Product Administered 84 3.1 3.1 signal
409 Staphylococcal Infection 92 3.1 3.1 signal
410 Pneumothorax 44 3.1 3.1 signal
411 Coronary Artery Stenosis 14 3.1 3.1 signal
412 Respiratory Failure 202 3.1 3.1 signal
413 Hydrocephalus 15 3.0 3.1 signal
414 Helicobacter Infection 28 3.0 3.0 signal
415 Dysarthria 103 3.0 3.0 signal
416 Supraventricular Tachycardia 26 3.0 3.0 signal
417 Platelet Count Decreased 289 3.0 3.0 signal
418 Ataxia 32 3.0 3.0 signal
419 Muscle Injury 22 3.0 3.0 signal
420 Aplastic Anaemia 14 3.0 3.0 signal
421 Progressive Multifocal Leukoencephalopathy 22 2.9 2.9 signal
422 Cardiogenic Shock 38 2.9 2.9 signal
423 Mitral Valve Incompetence 30 2.9 2.9 signal
424 Hypertransaminasaemia 18 2.9 2.9 signal
425 Body Temperature Increased 54 2.9 2.9 signal
426 Therapeutic Product Effect Decreased 117 2.9 2.9 signal
427 Myelodysplastic Syndrome 38 2.9 2.9 signal
428 Aspergillus Infection 17 2.9 2.9 signal
429 Blood Pressure Systolic Increased 51 2.9 2.9 signal
430 Bundle Branch Block Right 12 2.9 2.9 signal
431 Jaundice 70 2.9 2.9 signal
432 Aspiration 28 2.9 2.9 signal
433 Acute Kidney Injury 393 2.9 2.9 signal
434 Transaminases Increased 57 2.8 2.8 signal
435 Cholestasis 49 2.8 2.8 signal
436 Diarrhoea Haemorrhagic 24 2.8 2.8 signal
437 Inappropriate Antidiuretic Hormone Secretion 26 2.8 2.8 signal
438 Pneumonitis 69 2.8 2.8 signal
439 Temperature Intolerance 26 2.8 2.8 signal
440 Respiratory Syncytial Virus Infection 22 2.8 2.8 signal
441 Pre-eclampsia 12 2.8 2.8 signal
442 Acute Coronary Syndrome 21 2.8 2.8 signal
443 Streptococcal Infection 14 2.8 2.8 signal
444 Hyperglycaemia 91 2.8 2.8 signal
445 Synovitis 45 2.8 2.8 signal
446 White Blood Cell Count Increased 96 2.8 2.8 signal
447 Graft Versus Host Disease 18 2.7 2.8 signal
448 Lymphocyte Count Decreased 44 2.7 2.8 signal
449 Rectal Haemorrhage 107 2.7 2.8 signal
450 Aphthous Ulcer 19 2.7 2.7 signal
451 Peroneal Nerve Palsy 14 2.7 2.7 signal
452 Concussion 19 2.7 2.7 signal
453 Chills 288 2.7 2.7 signal
454 Nephropathy 23 2.7 2.7 signal
455 Post Procedural Complication 47 2.7 2.7 signal
456 Gamma-glutamyltransferase Increased 54 2.7 2.7 signal
457 Cytopenia 29 2.7 2.7 signal
458 Vomiting 1,136 2.7 2.8 signal
459 Body Temperature Decreased 24 2.7 2.7 signal
460 Coagulopathy 40 2.7 2.7 signal
461 Hemiparesis 41 2.7 2.7 signal
462 Metabolic Acidosis 76 2.7 2.7 signal
463 Immune Reconstitution Inflammatory Syndrome 12 2.6 2.6 signal
464 Postoperative Wound Infection 16 2.6 2.6 signal
465 Dermatitis Exfoliative 12 2.6 2.6 signal
466 Petit Mal Epilepsy 12 2.6 2.6 signal
467 Oral Pain 53 2.6 2.6 signal
468 Haemodialysis 20 2.6 2.6 signal
469 White Blood Cell Count Abnormal 15 2.6 2.6 signal
470 Oxygen Saturation Decreased 130 2.6 2.6 signal
471 General Physical Health Deterioration 267 2.6 2.6 signal
472 Drug Intolerance 223 2.6 2.6 signal
473 Blood Magnesium Decreased 20 2.6 2.6 signal
474 Cardio-respiratory Arrest 97 2.5 2.6 signal
475 Tenderness 24 2.5 2.5 signal
476 Blood Pressure Diastolic Decreased 17 2.5 2.5 signal
477 Conjunctivitis 42 2.5 2.5 signal
478 Disease Recurrence 109 2.5 2.5 signal
479 Blood Calcium Increased 20 2.5 2.5 signal
480 Tricuspid Valve Incompetence 18 2.5 2.5 signal
481 Toxic Skin Eruption 23 2.5 2.5 signal
482 Behaviour Disorder 12 2.5 2.5 signal
483 Viral Infection 75 2.5 2.5 signal
484 Rheumatoid Factor Positive 13 2.5 2.5 signal
485 Pseudomonas Infection 19 2.5 2.5 signal
486 Psoriatic Arthropathy 90 2.5 2.5 signal
487 Rhinitis 18 2.5 2.5 signal
488 Petechiae 23 2.4 2.4 signal
489 Colon Cancer 33 2.4 2.4 signal
490 Gastric Ulcer 42 2.4 2.4 signal
491 Lung Disorder 108 2.4 2.4 signal
492 Haematemesis 56 2.4 2.4 signal
493 Pneumocystis Jirovecii Pneumonia 22 2.4 2.4 signal
494 Hypercholesterolaemia 21 2.4 2.4 signal
495 Urosepsis 20 2.4 2.4 signal
496 Foetal Growth Restriction 13 2.4 2.4 signal
497 Hepatic Failure 65 2.4 2.4 signal
498 Hypotension 429 2.4 2.4 signal
499 Mental Status Changes 59 2.3 2.3 signal
500 Hyperkalaemia 74 2.3 2.3 signal
501 Hypertension 447 2.3 2.4 signal
502 Exercise Tolerance Decreased 12 2.3 2.3 signal
503 Joint Range Of Motion Decreased 28 2.3 2.3 signal
504 Scoliosis 13 2.3 2.3 signal
505 Angina Pectoris 60 2.3 2.3 signal
506 Multiple Organ Dysfunction Syndrome 58 2.3 2.3 signal
507 Hepatic Function Abnormal 77 2.3 2.3 signal
508 Oral Candidiasis 27 2.3 2.3 signal
509 Infection 298 2.3 2.3 signal
510 Sinus Bradycardia 20 2.3 2.3 signal
511 Hypokinesia 30 2.3 2.3 signal
512 Pericarditis 34 2.3 2.3 signal
513 Acute Respiratory Failure 39 2.3 2.3 signal
514 Therapeutic Product Effect Incomplete 144 2.2 2.3 signal
515 Sleep Disorder Due To General Medical Condition, Insomnia Type 13 2.2 2.2 signal
516 Sciatica 32 2.2 2.2 signal
517 Pemphigus 25 2.2 2.2 signal
518 Myositis 18 2.2 2.2 signal
519 Haemodynamic Instability 15 2.2 2.2 signal
520 Acute Myocardial Infarction 59 2.2 2.2 signal
521 Acute Myeloid Leukaemia 31 2.2 2.2 signal
522 Unresponsive To Stimuli 51 2.2 2.2 signal
523 Gastrointestinal Disorder 175 2.2 2.2 signal
524 Gastrointestinal Haemorrhage 166 2.2 2.2 signal
525 Pyelonephritis 17 2.2 2.2 signal
526 Pneumonia Bacterial 18 2.2 2.2 signal
527 Bronchospasm 28 2.2 2.2 signal
528 Respiratory Distress 54 2.2 2.2 signal
529 Coronavirus Infection 13 2.2 2.2 signal
530 Inflammation 100 2.2 2.2 signal
531 Drug-induced Liver Injury 60 2.1 2.2 signal
532 Device Occlusion 27 2.1 2.1 signal
533 Hiatus Hernia 25 2.1 2.1 signal
534 Personality Change 18 2.1 2.1 signal
535 Hepatomegaly 19 2.1 2.1 signal
536 Cytomegalovirus Infection 32 2.1 2.1 signal
537 Apnoea 15 2.1 2.1 signal
538 Prescribed Overdose 37 2.1 2.1 signal
539 Myasthenia Gravis 15 2.1 2.1 signal
540 Melaena 42 2.1 2.1 signal
541 Gastrointestinal Infection 17 2.1 2.1 signal
542 Brain Oedema 24 2.1 2.1 signal
543 Lymphadenopathy 67 2.1 2.1 signal
544 Incontinence 20 2.1 2.1 signal
545 Lower Limb Fracture 36 2.1 2.1 signal
546 Cellulitis 95 2.1 2.1 signal
547 Impaired Gastric Emptying 24 2.1 2.1 signal
548 Cerebral Infarction 46 2.1 2.1 signal
549 Generalised Oedema 23 2.1 2.1 signal
550 Fistula 21 2.1 2.1 signal
551 Blood Calcium Decreased 21 2.1 2.1 signal
552 Neuralgia 45 2.0 2.1 signal
553 Cardiomegaly 23 2.0 2.0 signal
554 Renal Failure 248 2.0 2.1 signal
555 Hyperlipidaemia 22 2.0 2.0 signal
556 Orthostatic Hypotension 32 2.0 2.0 signal
557 Rheumatoid Arthritis 207 2.0 2.0 signal
558 Blood Pressure Fluctuation 44 2.0 2.0 signal
559 Gastric Haemorrhage 21 2.0 2.0 signal
560 Drug Level Increased 30 2.0 2.0 signal
561 Dental Caries 20 2.0 2.0 no signal
562 Haemolysis 14 2.0 2.0 no signal
563 Atrial Fibrillation 176 2.0 2.0 no signal
564 Fungal Infection 60 2.0 2.0 no signal
565 Asthenia 676 2.0 2.0 no signal
566 Haemorrhoids 35 2.0 2.0 no signal
567 Hypercalcaemia 22 2.0 2.0 no signal
568 Motor Dysfunction 18 2.0 2.0 no signal
569 No Therapeutic Response 22 2.0 2.0 no signal
570 Mouth Haemorrhage 13 2.0 2.0 no signal
571 Anaphylactic Reaction 97 2.0 2.0 no signal
572 Osteoarthritis 75 2.0 2.0 no signal
573 Nausea 1,389 1.9 2.0 no signal
574 Cardiomyopathy 26 1.9 1.9 no signal
575 Abscess 28 1.9 1.9 no signal
576 Gastritis 46 1.9 1.9 no signal
577 Pancreatitis 92 1.9 1.9 no signal
578 Systemic Lupus Erythematosus 61 1.9 1.9 no signal
579 Premature Baby 52 1.9 1.9 no signal
580 Eosinophilia 30 1.9 1.9 no signal
581 Hepatic Encephalopathy 16 1.9 1.9 no signal
582 Decreased Appetite 396 1.9 1.9 no signal
583 Clostridium Difficile Infection 37 1.9 1.9 no signal
584 Impaired Healing 56 1.9 1.9 no signal
585 Squamous Cell Carcinoma 16 1.9 1.9 no signal
586 Musculoskeletal Stiffness 148 1.9 1.9 no signal
587 Acute Generalised Exanthematous Pustulosis 13 1.9 1.9 no signal
588 Laceration 16 1.9 1.9 no signal
589 Subdural Haematoma 24 1.8 1.8 no signal
590 Hypersensitivity 308 1.8 1.8 no signal
591 Urinary Retention 55 1.8 1.8 no signal
592 Ventricular Tachycardia 27 1.8 1.8 no signal
593 Dysphagia 154 1.8 1.8 no signal
594 Renal Tubular Necrosis 16 1.8 1.8 no signal
595 Hospice Care 16 1.8 1.8 no signal
596 Atrial Flutter 13 1.8 1.8 no signal
597 Oedema Peripheral 198 1.8 1.8 no signal
598 Hepatic Enzyme Increased 110 1.8 1.8 no signal
599 Abdominal Pain Lower 41 1.8 1.8 no signal
600 Appendicitis 15 1.8 1.8 no signal
601 Sensory Loss 13 1.8 1.8 no signal
602 Gingival Bleeding 22 1.8 1.8 no signal
603 Upper Gastrointestinal Haemorrhage 27 1.8 1.8 no signal
604 Urine Output Decreased 14 1.8 1.8 no signal
605 Decubitus Ulcer 13 1.8 1.8 no signal
606 Arteriosclerosis 15 1.8 1.8 no signal
607 Cyanosis 25 1.8 1.8 no signal
608 Emphysema 16 1.7 1.7 no signal
609 Haematuria 54 1.7 1.7 no signal
610 Depressed Level Of Consciousness 62 1.7 1.7 no signal
611 Subarachnoid Haemorrhage 16 1.7 1.7 no signal
612 Transient Ischaemic Attack 53 1.7 1.7 no signal
613 Live Birth 13 1.7 1.7 no signal
614 Epistaxis 117 1.7 1.7 no signal
615 Dyspnoea Exertional 58 1.7 1.7 no signal
616 Post Procedural Haemorrhage 18 1.7 1.7 no signal
617 Respiratory Tract Infection 40 1.7 1.7 no signal
618 Blood Pressure Decreased 102 1.7 1.7 no signal
619 Blood Urine Present 29 1.7 1.7 no signal
620 Dysuria 56 1.7 1.7 no signal
621 Flushing 154 1.7 1.7 no signal
622 Intervertebral Disc Degeneration 14 1.7 1.7 no signal
623 Obesity 24 1.7 1.7 no signal
624 Haemoptysis 42 1.7 1.7 no signal
625 Cystitis 48 1.7 1.7 no signal
626 Chest Pain 278 1.7 1.7 no signal
627 Nail Disorder 13 1.7 1.7 no signal
628 Pulmonary Oedema 67 1.7 1.7 no signal
629 Fibromyalgia 36 1.6 1.6 no signal
630 Metastases To Bone 24 1.6 1.6 no signal
631 Hypoaesthesia Oral 22 1.6 1.6 no signal
632 International Normalised Ratio Increased 42 1.6 1.6 no signal
633 Syncope 146 1.6 1.6 no signal
634 Photosensitivity Reaction 24 1.6 1.6 no signal
635 Poor Venous Access 15 1.6 1.6 no signal
636 Aphasia 44 1.6 1.6 no signal
637 Abdominal Distension 151 1.6 1.6 no signal
638 Irritable Bowel Syndrome 31 1.6 1.6 no signal
639 Hepatic Cirrhosis 27 1.6 1.6 no signal
640 Pharyngitis 18 1.6 1.6 no signal
641 Gastric Cancer 37 1.6 1.6 no signal
642 Epilepsy 44 1.6 1.6 no signal
643 Therapy Non-responder 64 1.6 1.6 no signal
644 Skin Infection 16 1.6 1.6 no signal
645 Paraesthesia 226 1.6 1.6 no signal
646 Hypertensive Crisis 16 1.6 1.6 no signal
647 Skin Ulcer 37 1.6 1.6 no signal
648 Cholelithiasis 47 1.6 1.6 no signal
649 Spinal Compression Fracture 12 1.6 1.6 no signal
650 Mass 20 1.6 1.6 no signal
651 Coma 68 1.6 1.6 no signal
652 Gait Inability 47 1.6 1.6 no signal
653 Cardiac Failure 114 1.6 1.6 no signal
654 Urinary Incontinence 42 1.6 1.6 no signal
655 Facial Paralysis 12 1.6 1.6 no signal
656 Convulsion 82 1.6 1.6 no signal
657 Joint Swelling 170 1.6 1.6 no signal
658 Pneumonia 456 1.6 1.6 no signal
659 Liver Function Test Increased 30 1.6 1.6 no signal
660 Anaphylactic Shock 36 1.6 1.6 no signal
661 Gout 25 1.5 1.5 no signal
662 Upper Respiratory Tract Infection 64 1.5 1.5 no signal
663 Haematochezia 76 1.5 1.5 no signal
664 Eyelid Ptosis 14 1.5 1.5 no signal
665 Night Sweats 44 1.5 1.5 no signal
666 Blood Test Abnormal 19 1.5 1.5 no signal
667 Anal Incontinence 12 1.5 1.5 no signal
668 Altered State Of Consciousness 29 1.5 1.5 no signal
669 Oropharyngeal Discomfort 12 1.5 1.5 no signal
670 Lactic Acidosis 43 1.5 1.5 no signal
671 Disorientation 53 1.5 1.5 no signal
672 Haemorrhage Intracranial 20 1.5 1.5 no signal
673 Transfusion 14 1.5 1.5 no signal
674 Hyperhidrosis 171 1.5 1.5 no signal
675 Confusional State 214 1.5 1.5 no signal
676 Pallor 36 1.5 1.5 no signal
677 Rotator Cuff Syndrome 17 1.5 1.5 no signal
678 Oedema 71 1.4 1.4 no signal
679 Osteoporosis 54 1.4 1.4 no signal
680 Haematoma 34 1.4 1.4 no signal
681 Nodule 17 1.4 1.4 no signal
682 Joint Stiffness 34 1.4 1.4 no signal
683 Blood Potassium Increased 21 1.4 1.4 no signal
684 Condition Aggravated 389 1.4 1.4 no signal
685 Hallucination, Visual 27 1.4 1.4 no signal
686 Basal Cell Carcinoma 20 1.4 1.4 no signal
687 Delirium 44 1.4 1.4 no signal
688 Pericardial Effusion 29 1.4 1.4 no signal
689 Toxic Epidermal Necrolysis 19 1.4 1.4 no signal
690 Psychomotor Hyperactivity 21 1.4 1.4 no signal
691 Dyspnoea 711 1.4 1.4 no signal
692 Glossodynia 28 1.4 1.4 no signal
693 Premature Delivery 20 1.4 1.4 no signal
694 Drug Eruption 22 1.4 1.4 no signal
695 Weight Fluctuation 13 1.4 1.4 no signal
696 Micturition Urgency 14 1.4 1.4 no signal
697 Diverticulitis 34 1.4 1.4 no signal
698 Thrombosis 99 1.4 1.4 no signal
699 Platelet Count Increased 16 1.4 1.4 no signal
700 Urinary Tract Infection 208 1.4 1.4 no signal
701 Red Blood Cell Count Decreased 35 1.3 1.4 no signal
702 Psychotic Disorder 36 1.3 1.3 no signal
703 Skin Reaction 17 1.3 1.3 no signal
704 Cardiac Arrest 100 1.3 1.3 no signal
705 Treatment Failure 99 1.3 1.3 no signal
706 Product Use In Unapproved Indication 294 1.3 1.3 no signal
707 Speech Disorder 63 1.3 1.3 no signal
708 Back Injury 13 1.3 1.3 no signal
709 Candida Infection 20 1.3 1.3 no signal
710 Pulmonary Hypertension 25 1.3 1.3 no signal
711 Muscle Atrophy 15 1.3 1.3 no signal
712 Musculoskeletal Pain 63 1.3 1.3 no signal
713 Arthropathy 66 1.3 1.3 no signal
714 Drug Resistance 30 1.3 1.3 no signal
715 Abdominal Pain Upper 239 1.3 1.3 no signal
716 Hypoaesthesia 174 1.3 1.3 no signal
717 Tendonitis 18 1.3 1.3 no signal
718 Diplopia 30 1.3 1.3 no signal
719 Ventricular Extrasystoles 12 1.3 1.3 no signal
720 Status Epilepticus 13 1.3 1.3 no signal
721 Rhinorrhoea 74 1.3 1.3 no signal
722 Myocarditis 13 1.3 1.3 no signal
723 Lethargy 66 1.3 1.3 no signal
724 Secretion Discharge 14 1.3 1.3 no signal
725 Hypothyroidism 36 1.2 1.2 no signal
726 Vitamin D Deficiency 11 1.2 1.2 no signal
727 Neoplasm 13 1.2 1.2 no signal
728 Fatigue 874 1.2 1.3 no signal
729 Arthralgia 465 1.2 1.2 no signal
730 Cardiac Failure Congestive 91 1.2 1.2 no signal
731 Paraesthesia Oral 16 1.2 1.2 no signal
732 Skin Fissures 21 1.2 1.2 no signal
733 Dermatitis 23 1.2 1.2 no signal
734 Gastroenteritis Viral 20 1.2 1.2 no signal
735 Acute Hepatic Failure 15 1.2 1.2 no signal
736 Erythema 226 1.2 1.2 no signal
737 Muscular Weakness 125 1.2 1.2 no signal
738 Off Label Use 953 1.2 1.2 no signal
739 Drug Hypersensitivity 213 1.2 1.2 no signal
740 Drug Interaction 174 1.2 1.2 no signal
741 Abdominal Discomfort 183 1.2 1.2 no signal
742 Hepatitis 28 1.2 1.2 no signal
743 Cough 304 1.2 1.2 no signal
744 Retching 23 1.2 1.2 no signal
745 Oral Herpes 21 1.2 1.2 no signal
746 Back Pain 249 1.2 1.2 no signal
747 Maternal Exposure During Pregnancy 94 1.2 1.2 no signal
748 Scratch 11 1.2 1.2 no signal
749 Face Oedema 18 1.2 1.2 no signal
750 Rash 460 1.2 1.2 no signal
751 Lower Respiratory Tract Infection 48 1.2 1.2 no signal
752 Blood Pressure Increased 162 1.2 1.2 no signal
753 Colorectal Cancer 51 1.2 1.2 no signal
754 Shock 24 1.2 1.2 no signal
755 Rash Erythematous 49 1.2 1.2 no signal
756 Joint Dislocation 11 1.2 1.2 no signal
757 Full Blood Count Abnormal 11 1.2 1.2 no signal
758 Haemorrhage 109 1.2 1.2 no signal
759 Weight Decreased 290 1.1 1.1 no signal
760 Dry Mouth 84 1.1 1.1 no signal
761 Throat Tightness 28 1.1 1.1 no signal
762 Neck Pain 58 1.1 1.1 no signal
763 Localised Infection 25 1.1 1.1 no signal
764 Joint Injury 22 1.1 1.1 no signal
765 Skin Lesion 28 1.1 1.1 no signal
766 Road Traffic Accident 43 1.1 1.1 no signal
767 Skin Laceration 11 1.1 1.1 no signal
768 Ear Infection 27 1.1 1.1 no signal
769 Coronary Artery Disease 31 1.1 1.1 no signal
770 Renal Impairment 85 1.1 1.1 no signal
771 Loss Of Consciousness 130 1.1 1.1 no signal
772 Central Nervous System Lesion 14 1.1 1.1 no signal
773 Tuberculosis 13 1.1 1.1 no signal
774 Chest Discomfort 103 1.1 1.1 no signal
775 Constipation 218 1.1 1.1 no signal
776 Toxicity To Various Agents 169 1.1 1.1 no signal
777 Intentional Product Use Issue 88 1.1 1.1 no signal
778 Ovarian Cyst 10 1.1 1.1 no signal
779 Liver Function Test Abnormal 29 1.1 1.1 no signal
780 Tooth Disorder 22 1.1 1.1 no signal
781 Dialysis 14 1.1 1.1 no signal
782 Oropharyngeal Pain 91 1.1 1.1 no signal
783 Iron Deficiency Anaemia 9 1.1 1.1 no signal
784 Cerebral Haemorrhage 35 1.1 1.1 no signal
785 Respiratory Depression 12 1.1 1.1 no signal
786 Tooth Abscess 10 1.1 1.1 no signal
787 Ear Pain 19 1.1 1.1 no signal
788 Increased Tendency To Bruise 9 1.1 1.1 no signal
789 Limb Discomfort 30 1.1 1.1 no signal
790 Lymphoma 15 1.1 1.1 no signal
791 Erythema Multiforme 9 1.1 1.1 no signal
792 Heart Rate Decreased 34 1.1 1.1 no signal
793 Cold Sweat 17 1.1 1.1 no signal
794 Pneumonia Aspiration 24 1.1 1.1 no signal
795 Lung Infection 15 1.1 1.1 no signal
796 Presyncope 23 1.0 1.0 no signal
797 Rash Macular 33 1.0 1.0 no signal
798 Cataract 56 1.0 1.0 no signal
799 Covid-19 167 1.0 1.0 no signal
800 Coronary Artery Occlusion 13 1.0 1.0 no signal
801 Product Use Issue 176 1.0 1.0 no signal
802 Bradycardia 50 1.0 1.0 no signal
803 Knee Operation 9 1.0 1.0 no signal
804 Sinusitis 95 1.0 1.0 no signal
805 Foetal Exposure During Pregnancy 75 1.0 1.0 no signal
806 Faeces Discoloured 20 1.0 1.0 no signal
807 Neoplasm Malignant 61 1.0 1.0 no signal
808 Muscle Twitching 21 1.0 1.0 no signal
809 Emotional Disorder 28 1.0 1.0 no signal
810 Bronchitis 67 1.0 1.0 no signal
811 Taste Disorder 18 1.0 1.0 no signal
812 Hypotonia 9 1.0 1.0 no signal
813 Eructation 17 1.0 1.0 no signal
814 Frequent Bowel Movements 24 1.0 1.0 no signal
815 Immunodeficiency 13 1.0 1.0 no signal
816 Blood Cholesterol Increased 41 1.0 1.0 no signal
817 Osteonecrosis 29 1.0 1.0 no signal
818 Discomfort 53 1.0 1.0 no signal
819 Lip Swelling 29 1.0 1.0 no signal
820 Sensory Disturbance 14 1.0 1.0 no signal
821 Wound 24 1.0 1.0 no signal
822 Heart Rate Increased 85 0.9 0.9 no signal
823 Blister 48 0.9 0.9 no signal
824 Tremor 142 0.9 0.9 no signal
825 Coordination Abnormal 12 0.9 0.9 no signal
826 Feeding Disorder 17 0.9 0.9 no signal
827 Diabetic Ketoacidosis 20 0.9 0.9 no signal
828 Pulmonary Congestion 11 0.9 0.9 no signal
829 Nervous System Disorder 26 0.9 0.9 no signal
830 Laryngitis 9 0.9 0.9 no signal
831 Fall 274 0.9 0.9 no signal
832 Pain 507 0.9 0.9 no signal
833 Malignant Melanoma 11 0.9 0.9 no signal
834 Knee Arthroplasty 17 0.9 0.9 no signal
835 End Stage Renal Disease 15 0.9 0.9 no signal
836 Skin Disorder 27 0.9 0.9 no signal
837 Tendon Rupture 10 0.9 0.9 no signal
838 Pulmonary Mass 12 0.9 0.9 no signal
839 Cyst 10 0.9 0.9 no signal
840 Tooth Extraction 10 0.9 0.9 no signal
841 Seizure 92 0.9 0.9 no signal
842 Respiratory Disorder 24 0.9 0.9 no signal
843 Swollen Tongue 25 0.9 0.9 no signal
844 Vision Blurred 109 0.9 0.9 no signal
845 Scab 9 0.9 0.9 no signal
846 Pregnancy 16 0.9 0.9 no signal
847 Aphonia 11 0.9 0.9 no signal
848 Musculoskeletal Disorder 15 0.9 0.9 no signal
849 Feeling Hot 48 0.9 0.9 no signal
850 Cardiovascular Disorder 20 0.9 0.9 no signal
851 Malaise 343 0.9 0.9 no signal
852 Visual Acuity Reduced 26 0.9 0.9 no signal
853 Eczema 39 0.9 0.9 no signal
854 Dyspepsia 76 0.9 0.9 no signal
855 Diabetes Mellitus 59 0.9 0.8 no signal
856 Retinal Detachment 7 0.8 0.8 no signal
857 Abasia 19 0.8 0.8 no signal
858 Alopecia 149 0.8 0.8 no signal
859 Complication Associated With Device 10 0.8 0.8 no signal
860 Respiratory Arrest 21 0.8 0.8 no signal
861 Swelling Face 49 0.8 0.8 no signal
862 Dysphonia 44 0.8 0.8 no signal
863 Chromaturia 17 0.8 0.8 no signal
864 Adrenal Insufficiency 9 0.8 0.8 no signal
865 Activities Of Daily Living Impaired 15 0.8 0.8 no signal
866 Quality Of Life Decreased 10 0.8 0.8 no signal
867 Dry Eye 36 0.8 0.8 no signal
868 Rash Pruritic 40 0.8 0.8 no signal
869 Pharyngitis Streptococcal 8 0.8 0.8 no signal
870 Contusion 71 0.8 0.8 no signal
871 Arthritis 58 0.8 0.8 no signal
872 Local Swelling 13 0.8 0.8 no signal
873 Myocardial Infarction 129 0.8 0.8 no signal
874 Generalised Tonic-clonic Seizure 12 0.8 0.8 no signal
875 Herpes Zoster 42 0.8 0.8 no signal
876 Head Injury 23 0.8 0.8 no signal
877 Swelling 68 0.8 0.8 no signal
878 Therapy Change 7 0.8 0.8 no signal
879 Affect Lability 7 0.8 0.8 no signal
880 Ill-defined Disorder 44 0.8 0.8 no signal
881 Hypoglycaemia 35 0.8 0.8 no signal
882 Stevens-johnson Syndrome 16 0.8 0.8 no signal
883 Nerve Injury 8 0.8 0.8 no signal
884 Obstructive Airways Disorder 8 0.8 0.8 no signal
885 Loss Of Personal Independence In Daily Activities 34 0.8 0.8 no signal
886 Blindness Unilateral 10 0.8 0.8 no signal
887 Femur Fracture 22 0.8 0.8 no signal
888 Bladder Disorder 7 0.8 0.8 no signal
889 Palpitations 82 0.8 0.8 no signal
890 Salivary Hypersecretion 7 0.8 0.8 no signal
891 Nephrolithiasis 32 0.8 0.8 no signal
892 Gastrooesophageal Reflux Disease 56 0.8 0.8 no signal
893 Brain Injury 7 0.8 0.8 no signal
894 Urticaria 116 0.8 0.8 no signal
895 Photophobia 13 0.8 0.8 no signal
896 Peritonitis Bacterial 7 0.8 0.8 no signal
897 Impaired Quality Of Life 10 0.8 0.8 no signal
898 Arrhythmia 33 0.8 0.8 no signal
899 Headache 433 0.8 0.8 no signal
900 Dyskinesia 28 0.8 0.8 no signal
901 Flatulence 39 0.8 0.8 no signal
902 Gait Disturbance 132 0.8 0.8 no signal
903 Initial Insomnia 7 0.8 0.8 no signal
904 Hip Fracture 22 0.8 0.8 no signal
905 Therapy Cessation 35 0.8 0.8 no signal
906 Dysstasia 20 0.8 0.8 no signal
907 Type 2 Diabetes Mellitus 23 0.8 0.8 no signal
908 Drug Effect Incomplete 25 0.7 0.7 no signal
909 Pain In Extremity 200 0.7 0.7 no signal
910 Productive Cough 32 0.7 0.7 no signal
911 Sars-cov-2 Test Positive 9 0.7 0.7 no signal
912 Rash Papular 15 0.7 0.7 no signal
913 Pruritus 252 0.7 0.7 no signal
914 Therapy Interrupted 46 0.7 0.7 no signal
915 Cognitive Disorder 31 0.7 0.7 no signal
916 Uveitis 9 0.7 0.7 no signal
917 Peripheral Swelling 102 0.7 0.7 no signal
918 Therapeutic Response Decreased 40 0.7 0.7 no signal
919 Renal Pain 7 0.7 0.7 no signal
920 Wheezing 39 0.7 0.7 no signal
921 Hip Arthroplasty 10 0.7 0.7 no signal
922 Balance Disorder 57 0.7 0.7 no signal
923 Vertigo 40 0.7 0.7 no signal
924 Eating Disorder 14 0.7 0.7 no signal
925 Decreased Activity 7 0.7 0.7 no signal
926 Peripheral Coldness 9 0.7 0.7 no signal
927 Bone Disorder 12 0.7 0.7 no signal
928 Spinal Fracture 13 0.7 0.7 no signal
929 Abnormal Behaviour 26 0.7 0.7 no signal
930 Dizziness 324 0.7 0.7 no signal
931 Skin Cancer 14 0.7 0.7 no signal
932 Deafness 17 0.7 0.7 no signal
933 Nasopharyngitis 119 0.7 0.7 no signal
934 Dermatitis Allergic 8 0.7 0.7 no signal
935 Gastrointestinal Pain 7 0.7 0.7 no signal
936 Aggression 32 0.7 0.7 no signal
937 Lacrimation Increased 19 0.7 0.7 no signal
938 Angioedema 28 0.7 0.7 no signal
939 Rib Fracture 13 0.7 0.7 no signal
940 Spinal Disorder 6 0.7 0.7 no signal
941 Nasal Congestion 37 0.7 0.7 no signal
942 Foot Deformity 7 0.7 0.7 no signal
943 Limb Injury 17 0.7 0.7 no signal
944 Paralysis 9 0.7 0.7 no signal
945 Stress 45 0.7 0.7 no signal
946 Blood Triglycerides Increased 11 0.7 0.7 no signal
947 Mental Impairment 15 0.7 0.7 no signal
948 Vitreous Floaters 6 0.7 0.7 no signal
949 Skin Exfoliation 51 0.7 0.7 no signal
950 Ligament Sprain 6 0.7 0.7 no signal
951 Osteomyelitis 11 0.7 0.7 no signal
952 Somnolence 122 0.7 0.7 no signal
953 Asthma 68 0.7 0.7 no signal
954 Tooth Infection 8 0.7 0.7 no signal
955 Muscle Spasms 111 0.7 0.7 no signal
956 Throat Irritation 27 0.7 0.7 no signal
957 Mobility Decreased 43 0.7 0.7 no signal
958 Pain In Jaw 17 0.7 0.7 no signal
959 Vaginal Discharge 6 0.7 0.7 no signal
960 Hypothermia 6 0.7 0.7 no signal
961 Pancreatic Carcinoma 17 0.6 0.6 no signal
962 Electrocardiogram Qt Prolonged 21 0.6 0.6 no signal
963 Musculoskeletal Discomfort 10 0.6 0.6 no signal
964 Musculoskeletal Chest Pain 9 0.6 0.6 no signal
965 Laboratory Test Abnormal 17 0.6 0.6 no signal
966 Feeling Jittery 11 0.6 0.6 no signal
967 Restlessness 21 0.6 0.6 no signal
968 Cerebrovascular Accident 96 0.6 0.6 no signal
969 Hepatocellular Injury 8 0.6 0.6 no signal
970 Thirst 10 0.6 0.6 no signal
971 Hypersomnia 16 0.6 0.6 no signal
972 Gallbladder Disorder 10 0.6 0.6 no signal
973 Cardiac Disorder 52 0.6 0.6 no signal
974 Pulmonary Thrombosis 6 0.6 0.6 no signal
975 Pulmonary Arterial Hypertension 8 0.6 0.6 no signal
976 Blood Creatine Phosphokinase Increased 16 0.6 0.6 no signal
977 Gastric Disorder 19 0.6 0.6 no signal
978 Drug Ineffective 718 0.6 0.6 no signal
979 Influenza Like Illness 45 0.6 0.6 no signal
980 Sleep Disorder 38 0.6 0.6 no signal
981 Vaginal Haemorrhage 23 0.6 0.6 no signal
982 Feeling Cold 15 0.6 0.6 no signal
983 Chronic Obstructive Pulmonary Disease 28 0.6 0.6 no signal
984 Disturbance In Attention 29 0.6 0.6 no signal
985 Tubulointerstitial Nephritis 10 0.6 0.6 no signal
986 Immune System Disorder 7 0.6 0.6 no signal
987 Agitation 39 0.6 0.6 no signal
988 Sputum Discoloured 5 0.6 0.6 no signal
989 Bone Pain 31 0.6 0.6 no signal
990 Pollakiuria 22 0.6 0.6 no signal
991 Foot Fracture 10 0.6 0.6 no signal
992 Pharyngeal Swelling 5 0.6 0.6 no signal
993 Tinnitus 24 0.6 0.6 no signal
994 Anxiety 148 0.6 0.6 no signal
995 Delusion 8 0.6 0.6 no signal
996 Exposure During Pregnancy 32 0.6 0.6 no signal
997 Ocular Hyperaemia 24 0.6 0.6 no signal
998 Pharyngeal Oedema 8 0.6 0.6 no signal
999 Kidney Infection 10 0.6 0.6 no signal
1000 Coeliac Disease 5 0.6 0.6 no signal
1001 Oral Discomfort 7 0.6 0.6 no signal
1002 Influenza 56 0.6 0.6 no signal
1003 Acne 38 0.6 0.5 no signal
1004 Carpal Tunnel Syndrome 7 0.5 0.5 no signal
1005 Toothache 9 0.5 0.5 no signal
1006 Dry Skin 65 0.5 0.5 no signal
1007 Incorrect Product Administration Duration 10 0.5 0.5 no signal
1008 Sneezing 11 0.5 0.5 no signal
1009 Eye Discharge 5 0.5 0.5 no signal
1010 Burning Sensation 34 0.5 0.5 no signal
1011 Injection Site Discomfort 5 0.5 0.5 no signal
1012 Meningioma 7 0.5 0.5 no signal
1013 Fluid Overload 7 0.5 0.5 no signal
1014 Insurance Issue 7 0.5 0.5 no signal
1015 Eye Pain 26 0.5 0.5 no signal
1016 Impaired Work Ability 10 0.5 0.5 no signal
1017 Device Dislocation 20 0.5 0.5 no signal
1018 Ocular Discomfort 5 0.5 0.5 no signal
1019 Eye Swelling 17 0.5 0.5 no signal
1020 Amnesia 30 0.5 0.5 no signal
1021 Intervertebral Disc Protrusion 10 0.5 0.5 no signal
1022 Medication Error 25 0.5 0.5 no signal
1023 Sinus Congestion 6 0.5 0.5 no signal
1024 Death 379 0.5 0.5 no signal
1025 Cholecystectomy 5 0.5 0.5 no signal
1026 Therapeutic Response Shortened 14 0.5 0.5 no signal
1027 Ageusia 11 0.5 0.5 no signal
1028 Restless Legs Syndrome 8 0.5 0.5 no signal
1029 Injection Site Pruritus 29 0.5 0.5 no signal
1030 Plasma Cell Myeloma 17 0.5 0.5 no signal
1031 Procedural Pain 12 0.5 0.5 no signal
1032 Spinal Pain 5 0.5 0.5 no signal
1033 Caesarean Section 5 0.5 0.5 no signal
1034 Product Prescribing Error 10 0.5 0.5 no signal
1035 Blindness 17 0.5 0.5 no signal
1036 Skin Haemorrhage 6 0.5 0.5 no signal
1037 Product Dispensing Error 9 0.5 0.5 no signal
1038 Apathy 6 0.5 0.5 no signal
1039 Drug Ineffective For Unapproved Indication 23 0.5 0.5 no signal
1040 Underdose 30 0.5 0.5 no signal
1041 Inflammatory Bowel Disease 4 0.4 0.4 no signal
1042 Drug Effect Decreased 22 0.4 0.4 no signal
1043 Intentional Dose Omission 11 0.4 0.4 no signal
1044 Osteonecrosis Of Jaw 10 0.4 0.4 no signal
1045 Prescribed Underdose 8 0.4 0.4 no signal
1046 Nervousness 21 0.4 0.4 no signal
1047 Blood Glucose Increased 75 0.4 0.4 no signal
1048 Heart Rate Irregular 9 0.4 0.4 no signal
1049 Hypoacusis 17 0.4 0.4 no signal
1050 Device Failure 6 0.4 0.4 no signal
1051 Diabetes Mellitus Inadequate Control 7 0.4 0.4 no signal
1052 Drug Level Decreased 4 0.4 0.4 no signal
1053 Ear Discomfort 4 0.4 0.4 no signal
1054 Mydriasis 5 0.4 0.4 no signal
1055 Mental Disorder 17 0.4 0.4 no signal
1056 Injection Site Warmth 8 0.4 0.4 no signal
1057 Erectile Dysfunction 10 0.4 0.4 no signal
1058 Dysgeusia 29 0.4 0.4 no signal
1059 Treatment Noncompliance 21 0.4 0.4 no signal
1060 Weight Increased 86 0.4 0.4 no signal
1061 Ankylosing Spondylitis 5 0.4 0.4 no signal
1062 Sedation 10 0.4 0.4 no signal
1063 Tooth Loss 8 0.4 0.4 no signal
1064 Hereditary Angioedema 4 0.4 0.4 no signal
1065 Migraine 36 0.4 0.4 no signal
1066 Illness 38 0.4 0.4 no signal
1067 Myalgia 64 0.4 0.4 no signal
1068 Breast Pain 4 0.4 0.4 no signal
1069 Injury 26 0.4 0.4 no signal
1070 Pruritus Generalised 8 0.4 0.4 no signal
1071 Eye Pruritus 12 0.4 0.4 no signal
1072 Surgery 21 0.4 0.4 no signal
1073 Overdose 78 0.4 0.4 no signal
1074 Amenorrhoea 6 0.4 0.4 no signal
1075 Injection Site Swelling 27 0.4 0.4 no signal
1076 Upper Limb Fracture 7 0.4 0.4 no signal
1077 Depression 79 0.4 0.4 no signal
1078 Hot Flush 26 0.4 0.4 no signal
1079 Rash Generalised 9 0.4 0.4 no signal
1080 Eyelid Oedema 4 0.4 0.4 no signal
1081 Eye Irritation 19 0.4 0.4 no signal
1082 Rhabdomyolysis 14 0.4 0.4 no signal
1083 Injection Site Reaction 23 0.4 0.4 no signal
1084 Muscle Rigidity 4 0.4 0.4 no signal
1085 Injection Site Erythema 41 0.4 0.4 no signal
1086 Spinal Operation 4 0.4 0.4 no signal
1087 Pelvic Pain 6 0.4 0.4 no signal
1088 Gastrointestinal Carcinoma 3 0.4 0.4 no signal
1089 Brain Neoplasm 3 0.4 0.4 no signal
1090 Blood Glucose Abnormal 6 0.4 0.4 no signal
1091 Ovarian Cancer 3 0.4 0.4 no signal
1092 Dementia 9 0.4 0.4 no signal
1093 Depressed Mood 17 0.4 0.4 no signal
1094 Inappropriate Schedule Of Product Administration 57 0.4 0.4 no signal
1095 Insomnia 85 0.4 0.3 no signal
1096 Eye Inflammation 3 0.4 0.4 no signal
1097 Injection Site Bruising 25 0.3 0.3 no signal
1098 Injection Site Irritation 4 0.3 0.3 no signal
1099 Colitis Ulcerative 14 0.3 0.3 no signal
1100 Psoriasis 41 0.3 0.3 no signal
1101 Adverse Drug Reaction 28 0.3 0.3 no signal
1102 Visual Impairment 38 0.3 0.3 no signal
1103 Injection Site Induration 4 0.3 0.3 no signal
1104 Parkinsonism 3 0.3 0.3 no signal
1105 Memory Impairment 42 0.3 0.3 no signal
1106 Crying 11 0.3 0.3 no signal
1107 Adverse Reaction 4 0.3 0.3 no signal
1108 Renal Disorder 14 0.3 0.3 no signal
1109 Intentional Product Misuse 26 0.3 0.3 no signal
1110 Adverse Event 27 0.3 0.3 no signal
1111 Drug Exposure During Pregnancy 10 0.3 0.3 no signal
1112 Therapeutic Response Unexpected 13 0.3 0.3 no signal
1113 Unevaluable Event 21 0.3 0.3 no signal
1114 Injection Site Haemorrhage 22 0.3 0.3 no signal
1115 Fluid Retention 14 0.3 0.3 no signal
1116 Injection Site Pain 81 0.3 0.3 no signal
1117 Hallucination 20 0.3 0.3 no signal
1118 Irritability 16 0.3 0.3 no signal
1119 Bone Loss 4 0.3 0.3 no signal
1120 Feeling Abnormal 63 0.3 0.3 no signal
1121 Dystonia 5 0.3 0.3 no signal
1122 Unintentional Medical Device Removal 3 0.3 0.3 no signal
1123 Hospitalisation 39 0.3 0.3 no signal
1124 Hallucination, Auditory 4 0.3 0.3 no signal
1125 Device Deployment Issue 3 0.3 0.3 no signal
1126 Schizophrenia 3 0.3 0.3 no signal
1127 Mania 4 0.3 0.3 no signal
1128 Product Dose Omission Issue 69 0.3 0.3 no signal
1129 Libido Decreased 3 0.3 0.3 no signal
1130 Device Malfunction 16 0.3 0.3 no signal
1131 Device Mechanical Issue 3 0.3 0.3 no signal
1132 Lung Neoplasm Malignant 9 0.2 0.2 no signal
1133 Blood Glucose Decreased 10 0.2 0.2 no signal
1134 Device Issue 18 0.2 0.2 no signal
1135 Hepatic Cancer 5 0.2 0.2 no signal
1136 Emotional Distress 25 0.2 0.2 no signal
1137 Incorrect Dose Administered 45 0.2 0.2 no signal
1138 Drug Dispensing Error 3 0.2 0.2 no signal
1139 Drug Administration Error 6 0.2 0.2 no signal
1140 Bone Density Decreased 6 0.2 0.2 no signal
1141 Breast Cancer 17 0.2 0.2 no signal
1142 Device Breakage 7 0.2 0.2 no signal
1143 Abortion Spontaneous 7 0.2 0.2 no signal
1144 Injection Site Rash 5 0.2 0.2 no signal
1145 Wrong Technique In Drug Usage Process 6 0.2 0.2 no signal
1146 Suicidal Ideation 14 0.2 0.2 no signal
1147 Pharmaceutical Product Complaint 4 0.2 0.2 no signal
1148 Breast Cancer Female 4 0.2 0.2 no signal
1149 Dermatitis Atopic 7 0.2 0.2 no signal
1150 Oesophageal Carcinoma 4 0.1 0.1 no signal
1151 Intentional Overdose 8 0.1 0.1 no signal
1152 Drug Dose Omission 21 0.1 0.1 no signal
1153 Injection Site Urticaria 3 0.1 0.1 no signal
1154 Incorrect Dose Administered By Device 3 0.1 0.1 no signal
1155 Product Quality Issue 15 0.1 0.1 no signal
1156 Drug Abuse 7 0.1 0.1 no signal
1157 Prostate Cancer 6 0.1 0.1 no signal
1158 No Adverse Event 12 0.1 0.1 no signal
1159 Bladder Cancer 3 0.1 0.1 no signal