Reaction

Secondary Immunodeficiency reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 1,179 reports · 78 co-occurring drugs

As of the last recalculation, Secondary Immunodeficiency appears in 1,179 FAERS reports alongside 78 co-occurring drug terms. The strongest observed disproportionality signal is PEGASPARGASE (PRR 409.6).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Pegaspargase	229	409.6	417.4
Mercaptopurine	244	312.9	317.4
Mesna Injection	91	210.6	212.9
Mesna	91	206.7	209.0
Vincristine Sulfate	211	154.6	155.7
Filgrastim	233	136.0	136.9
Cytarabine	256	95.8	96.2
Etoposide	255	77.9	78.1
Anti-Itch	222	71.8	72.0
Anti-Pruritic	222	71.8	72.0
Antipruritic (Anti-Itch)	222	71.8	72.0
Cool Relief Gel With Aloe	222	71.8	72.0
Drs. Hydrocortisone	222	71.8	72.0
Hydrocortisone Continuous Spray	222	71.8	72.0
Hydrocortisone Spray	222	71.8	72.0
Anti-Itch Cream	222	71.8	72.0
Hydrocortisone Lotion	222	71.8	72.0
Hydrocortisone Cream 1%	222	71.7	72.0
Hydrocortisone Cream 1/2%	222	71.7	72.0
Hydrocortisone 1%	222	71.7	71.9
Hydrocortisone Cream	222	71.4	71.7
Hydrocortisone Acetate	222	66.2	66.4
Ciclesonide	46	62.0	62.2
Hydrocortisone	223	54.2	54.3
Hydrocortisone Sodium Succinate	28	53.8	54.0
Leucovorin Calcium	50	48.2	48.3
Moxifloxacin Hydrochloride	50	45.4	45.5
Methylprednisolone	274	45.3	45.4
Methylprednisolone Acetate	17	38.0	38.1
Cyclophosphamide Injection, Solution	283	36.8	36.9
Cyclophosphamide	283	36.8	36.9
Cyclophosphamide For Injection	283	36.8	36.9
Rabeprazole	44	36.4	36.4
Moxifloxacin	27	34.6	34.7
Human Immunoglobulin G	35	30.8	30.9
Methylprednisolone Sodium Succinate	73	29.5	29.6
Bendamustine Hcl	25	29.1	29.1
Nicotine Polacrilex Mini	24	28.8	28.8
Nicotine Polarilex	24	28.8	28.8
Tacrolimus Ointment 0.1%	170	28.0	28.0
Tacrolimus Extended-Release Capsules	170	27.9	28.0
Fludarabine Phosphate	59	27.8	27.9
Valganciclovir Hydrochloride Powder,	18	26.4	26.5
Tacrolimus	187	24.9	24.9
Dexamethasone Sodium Phosphate	14	24.6	24.6
Rituximab	223	22.7	22.8
Prednisone	420	22.4	22.4
Fluticasone Furoate And Vilanterol Trifenatate	43	21.9	21.9
Micafungin Sodium	10	21.0	21.0
Rabeprazole Sodium	31	20.6	20.6
Dexamethasone 1.5 Mg	260	19.8	19.8
Antacid	51	19.8	19.8
Dexamethasone	260	19.6	19.6
Valganciclovir	20	19.0	19.1
Valganciclovir Hydrochloride	20	19.0	19.1
Mycophenilic Acid	21	18.2	18.2
Doxorubicin	83	17.6	17.6
Mycophenolic Acid	29	16.4	16.4
Prednisolone	144	15.9	15.9
Prednisolone Oral	144	15.9	15.9
Prednisolone Oral Solution	144	15.9	15.9
Amphotericin B	11	15.6	15.6
Methotrexate Sodium	314	15.2	15.2
Sirolimus	11	14.5	14.6
Ceftriaxone	25	13.7	13.7
Bendamustine Hydrochloride	9	13.4	13.4
Cyclosporine	78	13.2	13.2
Obinutuzumab	11	11.9	11.9
Ceftriaxone Sodium	25	11.7	11.7
Nicotine Polacrilex	24	11.3	11.3
Carfilzomib	17	10.8	10.8
Nicotine	24	10.7	10.7
Bleomycin Sulfate	6	10.3	10.3
Doxorubicin Hydrochloride	16	8.8	8.8
Blinatumomab	5	8.5	8.5
Daratumumab	18	8.1	8.1
Ixazomib	8	4.9	4.9
Tapentadol Hydrochloride	6	3.2	3.2

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.