OpenPV Signal Explorer
FAERS disproportionality dashboard
Reaction

Drug Clearance Decreased reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 1,243 reports · 57 co-occurring drugs

As of the last recalculation, Drug Clearance Decreased appears in 1,243 FAERS reports alongside 57 co-occurring drug terms. The strongest observed disproportionality signal is SODIUM BICARBONATE (PRR 44.6).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.
DrugCo-reportsPRRROR
Sodium Bicarbonate5944.644.7
Sodium Bicarbonate Injection,5944.644.7
Mercaptopurine4444.044.1
Imatinib3938.238.3
Methotrexate Sodium57035.435.5
Pegaspargase2230.630.7
Leucovorin Calcium3127.827.9
Methotrexate43526.126.1
Ifosfamide3124.824.8
Cytarabine7823.123.2
Thiotepa1323.023.1
Piperacillin And Tazobactam1621.221.2
Granisetron Hydrochloride1321.121.1
Granisetron1117.717.7
Piperacillin Sodium And Tazobactam Sodium2017.317.4
Aprepitant1816.616.6
Ranolazine1016.216.2
Insulin Glargine-Yfgn2015.515.6
Piperacillin Sodium,Tazobactam Sodium2415.415.4
Methocarbamol Tablets1515.215.2
Voriconazole Injection1914.914.9
Busulfan1212.912.9
Torsemide2512.912.9
Midazolam1912.812.8
Cisplatin5512.312.3
Temozolomide1512.112.1
Midazolam Hydrochloride1912.012.0
Eplerenone911.811.9
Doxorubicin5811.411.4
Ritonavir 100 Mg1011.311.3
Haloperidol1611.211.2
Haloperidol Lactate1611.011.0
Voriconazole1910.610.6
Etoposide4510.610.6
Dasatinib2310.510.5
Vancomycin Hydrochloride4010.510.5
Vincristine Sulfate1810.410.4
Vancomycin3510.410.4
Dapagliflozin1910.310.3
Dextrose810.210.2
Mesna Injection510.210.2
Iohexol510.110.1
Dextrose Monohydrate810.110.1
Metoclopramide3210.010.0
Mesna510.010.0
Linezolid179.79.7
Norepinephrine69.49.4
Cefepime Hydrochloride99.49.4
Cefepime89.49.4
Propofol209.39.3
Bupivacaine59.09.0
Oseltamivir48.48.4
Tobramycin Solution68.48.4
Remdesivir67.67.6
Daptomycin35.55.5
Salicylic Acid72.22.2
Nirmatrelvir And Ritonavir72.22.2

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Data source: openFDA FAERS. See the OpenPV methodology and limitations.