OpenPV Signal Explorer
FAERS disproportionality dashboard
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Drug

Methyldopa

181 flagged reaction(s) · 8,019 total co-reports · max PRR 162.0
Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.
Reaction Co-reports (a) PRR ROR Signal
1 Premature Delivery 577 162.0 183.8 signal
2 Premature Baby 914 135.2 166.4 signal
3 Foetal Exposure During Pregnancy 1,326 71.8 98.5 signal
4 Caesarean Section 167 62.4 64.5 signal
5 Exposure During Pregnancy 678 47.7 55.3 signal
6 Maternal Exposure During Pregnancy 823 40.8 48.9 signal
7 Drug Exposure During Pregnancy 148 18.7 19.2 signal
8 Ovarian Cyst 42 18.2 18.3 signal
9 Foot Deformity 35 13.7 13.8 signal
10 Proteinuria 53 12.2 12.3 signal
11 Posterior Reversible Encephalopathy Syndrome 26 11.9 11.9 signal
12 Hypertensive Crisis 29 11.3 11.3 signal
13 Abortion Induced 24 11.0 11.1 signal
14 Drug-induced Liver Injury 75 10.6 10.7 signal
15 Pregnancy 47 10.1 10.2 signal
16 Cardiomegaly 25 8.7 8.8 signal
17 Deformity 18 8.3 8.4 signal
18 Blood Pressure Systolic Increased 37 8.2 8.2 signal
19 Abortion Spontaneous 66 7.1 7.2 signal
20 Contraindicated Product Administered 49 7.0 7.1 signal
21 Hepatocellular Injury 22 6.7 6.7 signal
22 Tachypnoea 20 6.4 6.4 signal
23 Drug Withdrawal Syndrome Neonatal 22 6.4 6.4 signal
24 Hyperbilirubinaemia 14 5.9 5.9 signal
25 Mitral Valve Incompetence 15 5.7 5.8 signal
26 Nephropathy 12 5.5 5.6 signal
27 Hypertension 258 5.3 5.5 signal
28 Drug Reaction With Eosinophilia And Systemic Symptoms 31 5.3 5.3 signal
29 Nerve Injury 13 5.1 5.1 signal
30 Blood Pressure Fluctuation 28 5.0 5.1 signal
31 Bursitis 14 5.0 5.0 signal
32 Cyst 14 4.9 4.9 signal
33 Ascites 32 4.7 4.7 signal
34 Hypomagnesaemia 15 4.7 4.7 signal
35 Photosensitivity Reaction 17 4.5 4.5 signal
36 Peritonitis 21 4.4 4.4 signal
37 Nodule 13 4.3 4.3 signal
38 Hypercalcaemia 12 4.2 4.2 signal
39 Heart Rate Decreased 34 4.2 4.2 signal
40 Blood Creatinine Increased 63 4.2 4.2 signal
41 Diabetes Mellitus Inadequate Control 17 4.2 4.2 signal
42 Haematocrit Decreased 19 4.1 4.1 signal
43 Blood Iron Decreased 11 4.0 4.0 signal
44 Thrombotic Microangiopathy 9 4.0 4.0 signal
45 Hypoglycaemia 45 4.0 4.0 signal
46 End Stage Renal Disease 17 4.0 4.0 signal
47 Sinus Tachycardia 13 4.0 4.0 signal
48 Renal Tubular Necrosis 9 4.0 4.0 signal
49 Intervertebral Disc Protrusion 20 4.0 4.0 signal
50 Body Temperature Decreased 9 3.9 3.9 signal
51 Joint Range Of Motion Decreased 12 3.9 3.9 signal
52 Blood Urea Increased 15 3.9 3.9 signal
53 Diabetic Ketoacidosis 21 3.8 3.8 signal
54 Myocardial Ischaemia 10 3.8 3.8 signal
55 Blood Thyroid Stimulating Hormone Increased 8 3.8 3.8 signal
56 Coordination Abnormal 12 3.7 3.7 signal
57 Respiratory Failure 62 3.7 3.7 signal
58 Myoclonus 10 3.6 3.6 signal
59 Amenorrhoea 14 3.6 3.6 signal
60 Renal Failure Acute 36 3.6 3.6 signal
61 Sinus Bradycardia 8 3.6 3.6 signal
62 Eye Haemorrhage 11 3.6 3.6 signal
63 Blood Pressure Increased 125 3.5 3.6 signal
64 Acute Hepatic Failure 11 3.5 3.5 signal
65 Pleural Effusion 48 3.4 3.4 signal
66 Hypokalaemia 36 3.4 3.4 signal
67 Cardiogenic Shock 11 3.3 3.3 signal
68 Hepatotoxicity 17 3.3 3.3 signal
69 Pulmonary Hypertension 16 3.3 3.3 signal
70 Apathy 11 3.3 3.3 signal
71 Hypothyroidism 24 3.3 3.3 signal
72 Blood Lactate Dehydrogenase Increased 12 3.3 3.3 signal
73 Sensory Disturbance 12 3.2 3.2 signal
74 Hypocalcaemia 14 3.2 3.2 signal
75 Systemic Lupus Erythematosus 26 3.2 3.2 signal
76 Haemorrhage Intracranial 11 3.2 3.2 signal
77 Renal Impairment 59 3.1 3.1 signal
78 Oxygen Saturation Decreased 39 3.0 3.0 signal
79 Hypotonia 7 3.0 3.0 signal
80 Renal Failure 93 3.0 3.1 signal
81 Neutrophil Count Increased 7 2.9 3.0 signal
82 Oedema Peripheral 82 2.9 2.9 signal
83 Frequent Bowel Movements 18 2.9 2.9 signal
84 Jaundice 18 2.9 2.9 signal
85 Vaginal Haemorrhage 28 2.8 2.9 signal
86 Generalised Oedema 8 2.8 2.8 signal
87 Laryngitis 7 2.8 2.8 signal
88 Blood Glucose Fluctuation 7 2.8 2.8 signal
89 Metastases To Liver 11 2.7 2.7 signal
90 Presyncope 15 2.7 2.7 signal
91 Respiratory Distress 17 2.7 2.7 signal
92 Pericardial Effusion 14 2.6 2.6 signal
93 Cardiomyopathy 9 2.6 2.6 signal
94 Blood Pressure Abnormal 12 2.6 2.6 signal
95 Coagulopathy 10 2.6 2.6 signal
96 Spinal Pain 7 2.6 2.6 signal
97 Cystitis 19 2.6 2.6 signal
98 Blood Bilirubin Increased 16 2.6 2.6 signal
99 Neck Pain 33 2.6 2.6 signal
100 Economic Problem 9 2.5 2.5 signal
101 Bradycardia 31 2.5 2.5 signal
102 Diplopia 15 2.5 2.5 signal
103 Hyperkalaemia 20 2.5 2.5 signal
104 Multi-organ Failure 10 2.5 2.5 signal
105 Oral Herpes 11 2.4 2.5 signal
106 Abdominal Pain Lower 14 2.4 2.4 signal
107 Retinal Detachment 5 2.4 2.4 no signal
108 Skin Ulcer 14 2.3 2.4 signal
109 Transaminases Increased 12 2.3 2.3 signal
110 Ventricular Fibrillation 6 2.3 2.3 no signal
111 Metabolic Acidosis 17 2.3 2.3 signal
112 Incorrect Route Of Product Administration 9 2.3 2.3 signal
113 Dysarthria 20 2.3 2.3 signal
114 Cerebral Infarction 13 2.3 2.3 signal
115 Speech Disorder 27 2.2 2.2 signal
116 Dysstasia 15 2.2 2.2 signal
117 Liver Injury 12 2.1 2.2 signal
118 Dialysis 7 2.1 2.1 no signal
119 Bronchospasm 7 2.1 2.1 no signal
120 Hypoacusis 21 2.1 2.1 signal
121 Angina Pectoris 14 2.1 2.1 signal
122 Petechiae 5 2.1 2.1 no signal
123 Pulmonary Arterial Hypertension 7 2.1 2.1 no signal
124 Renal Disorder 22 2.0 2.0 signal
125 Drug Resistance 12 2.0 2.0 signal
126 Arrhythmia 22 2.0 2.0 signal
127 Hepatic Function Abnormal 17 2.0 2.0 no signal
128 Joint Stiffness 12 2.0 2.0 no signal
129 Herpes Zoster 26 2.0 2.0 no signal
130 Cognitive Disorder 21 2.0 2.0 no signal
131 Pancreatitis Acute 10 1.9 1.9 no signal
132 Blood Creatine Phosphokinase Increased 13 1.9 1.9 no signal
133 Diverticulitis 12 1.9 1.9 no signal
134 Rheumatoid Arthritis 49 1.9 1.9 no signal
135 Fluid Retention 22 1.9 1.9 no signal
136 Therapeutic Product Effect Decreased 19 1.9 1.9 no signal
137 Squamous Cell Carcinoma 4 1.8 1.8 no signal
138 Panic Attack 15 1.8 1.8 no signal
139 Drug Prescribing Error 8 1.8 1.8 no signal
140 Nasal Congestion 24 1.8 1.8 no signal
141 Colitis Ulcerative 18 1.7 1.8 no signal
142 Brain Injury 4 1.7 1.7 no signal
143 Glycosylated Haemoglobin Increased 10 1.7 1.7 no signal
144 Suicide Attempt 24 1.7 1.7 no signal
145 Hypothermia 4 1.7 1.7 no signal
146 Deafness 10 1.7 1.7 no signal
147 Hereditary Angioedema 4 1.6 1.6 no signal
148 Hunger 5 1.6 1.6 no signal
149 Cholestasis 7 1.6 1.6 no signal
150 Drug Level Increased 6 1.6 1.6 no signal
151 Drug Toxicity 5 1.6 1.6 no signal
152 Extrapyramidal Disorder 9 1.6 1.6 no signal
153 Coma 17 1.5 1.5 no signal
154 Intestinal Perforation 4 1.5 1.5 no signal
155 Tardive Dyskinesia 10 1.5 1.5 no signal
156 Gastric Haemorrhage 4 1.5 1.5 no signal
157 Injection Site Haematoma 5 1.5 1.5 no signal
158 Fluid Overload 5 1.5 1.5 no signal
159 Muscle Rigidity 4 1.4 1.4 no signal
160 Mood Altered 9 1.4 1.4 no signal
161 No Therapeutic Response 4 1.4 1.4 no signal
162 Grand Mal Convulsion 3 1.4 1.4 no signal
163 Parkinsonism 3 1.3 1.3 no signal
164 Prescribed Underdose 6 1.3 1.3 no signal
165 Coronary Artery Occlusion 4 1.3 1.3 no signal
166 Prostatic Specific Antigen Increased 4 1.3 1.3 no signal
167 Breast Pain 3 1.2 1.2 no signal
168 Blood Glucose Abnormal 5 1.2 1.2 no signal
169 Drug Dispensing Error 4 1.1 1.1 no signal
170 Menorrhagia 5 1.1 1.1 no signal
171 Blood Glucose Decreased 12 1.1 1.1 no signal
172 Activities Of Daily Living Impaired 5 1.1 1.1 no signal
173 Hepatic Cytolysis 3 1.1 1.1 no signal
174 Injection Site Discolouration 3 1.0 1.0 no signal
175 Abnormal Weight Gain 3 1.0 1.0 no signal
176 Metrorrhagia 3 0.8 0.8 no signal
177 Intentional Overdose 8 0.5 0.5 no signal
178 Accidental Exposure To Product 11 0.5 0.5 no signal
179 Renal Cancer 4 0.4 0.4 no signal
180 Device Expulsion 3 0.2 0.2 no signal
181 Device Difficult To Use 3 0.2 0.2 no signal