Drug

Promethazine Hydrochloride And Codeine Phosphate

42 flagged reaction(s) · 5,734 total co-reports · max PRR 395.8

Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.

	Reaction	Co-reports (a)	PRR	ROR	Signal
1	Dependence	3,495	395.8	21,956.3	signal
2	Back Injury	238	132.4	141.8	signal
3	Spinal Operation	77	37.7	38.5	signal
4	Knee Operation	34	20.7	20.9	signal
5	Overdose	680	18.6	22.7	signal
6	Intervertebral Disc Degeneration	27	17.1	17.3	signal
7	Joint Injury	48	13.3	13.4	signal
8	Intervertebral Disc Protrusion	48	12.9	13.1	signal
9	Road Traffic Accident	84	11.8	12.1	signal
10	Back Pain	420	10.7	12.0	signal
11	Drug Withdrawal Syndrome Neonatal	24	9.5	9.5	signal
12	Ill-defined Disorder	78	7.6	7.7	signal
13	Limb Injury	34	7.4	7.5	signal
14	Neck Pain	65	6.9	7.0	signal
15	Withdrawal Syndrome	46	6.4	6.5	signal
16	Fibromyalgia	26	6.3	6.4	signal
17	Spinal Fracture	21	6.2	6.2	signal
18	Rotator Cuff Syndrome	13	5.9	6.0	signal
19	Toothache	17	5.5	5.6	signal
20	Caesarean Section	11	5.5	5.5	signal
21	Brain Injury	9	5.3	5.3	signal
22	Knee Arthroplasty	15	4.2	4.3	signal
23	Ankle Fracture	11	4.2	4.2	signal
24	Hip Arthroplasty	10	3.9	3.9	signal
25	Nerve Injury	7	3.7	3.7	signal
26	Carpal Tunnel Syndrome	8	3.4	3.4	signal
27	Product Prescribing Issue	11	3.2	3.2	signal
28	Tooth Disorder	12	3.2	3.2	signal
29	Fracture	10	3.1	3.1	signal
30	Lower Limb Fracture	10	3.1	3.1	signal
31	Arthritis	37	2.8	2.8	signal
32	Disability	9	2.7	2.7	signal
33	Injury	29	2.4	2.4	signal
34	Hepatitis C	4	1.9	1.9	no signal
35	Brain Neoplasm	3	1.9	1.9	no signal
36	Surgery	18	1.8	1.8	no signal
37	Foetal Exposure During Pregnancy	25	1.8	1.8	no signal
38	Euphoric Mood	3	1.7	1.7	no signal
39	Sexual Dysfunction	3	1.5	1.5	no signal
40	Respiratory Depression	3	1.4	1.4	no signal
41	Dysmenorrhoea	3	1.4	1.4	no signal
42	Drug Abuse	8	0.6	0.6	no signal