Amoxicillin vs Doxycycline Hyclate: side effects in FDA adverse event reports
At a glance
| Amoxicillin | Doxycycline Hyclate | |
|---|---|---|
| Drug class | – | – |
| Brand names | – | – |
| FAERS reports | 75,882 | 67,065 |
| Serious | 80% | 73% |
| Death outcome | 5,023 | 6,708 |
| Boxed warning | No | No |
Signals both drugs share
| Reaction | Amoxicillin | Doxycycline Hyclate | Label screen (A / B) |
|---|---|---|---|
| Nephrogenic anaemia | 661 · PRR 45.4 | 403 · PRR 29.4 | Not in label — unassessed / Not in label — unassessed |
| Rebound acid hypersecretion | 440 · PRR 46.2 | 263 · PRR 29.2 | Not in label — unassessed / Not in label — unassessed |
| Hyperparathyroidism secondary | 343 · PRR 43.2 | 224 · PRR 30.3 | Not in label — unassessed / Not in label — unassessed |
| Chronic kidney disease-mineral and bone disorder | 185 · PRR 57.3 | 119 · PRR 38.8 | Not in label — unassessed / Not in label — unassessed |
| Amyloid arthropathy | 59 · PRR 3,204.4 | 55 · PRR 1,878.3 | Not in label — unassessed / Not in label — unassessed |
Labeled signals distinctive to Amoxicillin
- Acute generalised exanthematous pustulosis — n=421, PRR 15.8 Labeled adverse reaction
- Lip oedema — n=251, PRR 17.3 Labeled (related wording)
- Meningitis aseptic — n=238, PRR 15.5 Labeled (related wording)
- Crystalluria — n=119, PRR 76.8 Labeled adverse reaction
- Enterocolitis haemorrhagic — n=103, PRR 20.5 Labeled (related wording)
- Serum sickness-like reaction — n=81, PRR 42.1 Labeled adverse reaction
Labeled signals distinctive to Doxycycline Hyclate
- Sleep disorder due to general medical condition, insomnia type — n=893, PRR 50.3 Labeled (related wording)
- Jarisch-herxheimer reaction — n=312, PRR 244.0 Labeled adverse reaction
- Subcutaneous drug absorption impaired — n=50, PRR 31.5 Labeled (related wording)
Common questions
Which has more reported side effects, Amoxicillin or Doxycycline Hyclate?
Amoxicillin has 75,882 FAERS reports and Doxycycline Hyclate 67,065. More reports does not mean more dangerous: volume follows how widely and how long a drug has been used, prescription vs over-the-counter status, and publicity. The seriousness share (80% vs 73%) is a better like-for-like signal of the kind of problems reported.
Which side effects do Amoxicillin and Doxycycline Hyclate share?
Both drugs carry disproportionality signals for nephrogenic anaemia, rebound acid hypersecretion, hyperparathyroidism secondary, chronic kidney disease-mineral and bone disorder, amyloid arthropathy. Shared signals often reflect a shared drug class or the condition both are used for.
Is Amoxicillin or Doxycycline Hyclate safer?
FAERS cannot answer that: it has no denominator and no comparator. Use this page to see which risks are already on each label and which signals are unlabeled, then check the prescribing information and your clinician for your situation.
Sources: openFDA FAERS pair statistics (OpenPV build 2026-09-14), FDA labels via openFDA, openFDA count queries for seriousness and deaths. Pair chosen because it is a commonly searched comparison. Generated 2026-10-08.