Reaction

Rebound Acid Hypersecretion reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 3,027 reports · 366 co-occurring drugs

As of the last recalculation, Rebound Acid Hypersecretion appears in 3,027 FAERS reports alongside 366 co-occurring drug terms. The strongest observed disproportionality signal is ESOMEPRAZOLE MAGNESIUM (PRR 422.0).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Esomeprazole Magnesium	2,505	422.0	426.6
Dexlansoprazole	1,167	312.5	321.5
Omeprazole Magnesium	2,370	164.4	165.2
Lansoprazole	1,718	152.1	153.6
Pantoprazole Sodium	1,321	107.9	108.9
Cephalexin	234	80.5	81.4
Cimetidine	106	78.4	79.3
Benzonatate	125	54.2	54.6
Calcium Carbonate	439	52.4	52.7
Cefuroxime	77	47.5	47.8
Meclizine Hcl 12.5Mg	91	47.3	47.6
Meclizine Hcl 25Mg	91	47.3	47.6
Meclizine Hcl 12.5 Mg	91	47.3	47.6
Meclizine Hcl 25 Mg	91	47.3	47.6
Amoxicillin	440	46.2	46.4
Sevelamer Carbonate	70	42.9	43.1
Ciprofolxacin	384	42.1	42.3
Ciprofloxacin Tablets	384	42.1	42.3
Magnesium Hydroxide	80	41.9	42.1
Meclizine	93	40.4	40.6
Famotidine	552	39.3	39.5
Ciprofloxacin	431	37.5	37.7
Cyclobenzaprine	241	36.0	36.2
Tizanidine	120	36.0	36.1
Ciprofloxacin Hydrochloride	437	35.9	36.1
Meclizine Hydrochloride	97	35.1	35.3
Calcitriol Capsules 0.25 Mcg	98	34.7	34.9
Calcitriol Capsules 0.5 Mcg	98	34.7	34.9
Meloxicam	267	34.6	34.7
Indomethacin	65	34.4	34.6
Calcitriol	98	34.3	34.5
Sucralfate Oral	68	33.6	33.8
Sucralfate Oral Suspension	68	33.5	33.7
Dicyclomine Hydrochloride	67	33.0	33.2
Sucralfate	107	31.8	31.9
Polyethylene Glycol	49	31.6	31.8
Levofloxacin	244	30.2	30.3
Levofloxacin In 5% Dextrose	244	30.2	30.3
Metolazone	48	29.8	29.9
Mupirocin	57	29.6	29.7
Doxycycline Hyclate	263	29.2	29.4
Mupirocin Calcium	57	29.0	29.2
Doxycycline	263	28.9	29.0
Doxepin	42	28.9	29.0
Methocarbamol Tablets	64	26.8	26.9
Lubiprostone	36	26.5	26.6
Clindamycin	104	26.1	26.1
Ampicillin	31	26.0	26.1
Ampicillin Sodium	31	26.0	26.1
Doxepin Hydrochloride	45	24.9	24.9
Clonidine	174	24.7	24.8
Erythromycin	64	23.9	24.0
Methocarbamol	76	23.6	23.7
Clindamycin Phosphate	110	23.5	23.5
Ropinirole	51	23.2	23.3
Labetalol	44	23.0	23.1
Nitrofurantoin	54	22.9	23.0
Nitrofurantoin (Monohydrate/Macrocrystals)	54	22.6	22.7
Isosorbide Dinitrate	61	21.9	22.0
Nitroglycerin	161	21.7	21.8
Azithromycin	122	21.7	21.7
Chlorthalidone	36	21.6	21.6
Azithromycin Monohydrate	124	21.3	21.4
Lisinopril	729	21.3	21.3
Trimethoprim	36	21.2	21.3
Doxyclycline Hyclate	51	20.9	21.0
Naproxen	222	20.9	20.9
Rabeprazole Sodium	79	20.4	20.5
Hyoscyamine Sulfate	27	20.4	20.4
Carisoprodol	55	20.2	20.2
Bumetanide	71	18.9	19.0
Tobramycin Solution	32	18.5	18.6
Azithromycin Dihydrate	148	18.2	18.2
Loratadine Oral	124	18.1	18.1
Tobramycin Sulfate	32	17.9	18.0
Terazosin Hydrochloride	23	17.9	18.0
Bisacodyl Suppositories	33	17.7	17.8
Biscodyl	33	17.6	17.6
Clotrimazole	31	17.5	17.6
Ciprofloxacin Hydrochloride And Hydrocortisone	52	17.5	17.5
Carvedilol	307	17.3	17.3
Drs. Clotrimazole	28	16.8	16.8
Family Wellness Clotrimazole	28	16.8	16.8
Clotrimazole Topical	28	16.8	16.8
Quinapril Hydrochloride	19	16.7	16.7
Lovastatin	61	16.7	16.7
Nystatin Ointment	62	16.6	16.6
Nystatin Cream	62	16.5	16.6
Amlodipine Besylate And Benazepril Hydrochloride	22	16.5	16.5
Terbinafine Hydrochloride	21	16.4	16.4
Bisacodyl	33	16.3	16.3
Nystatin	63	16.2	16.2
Isosorbide Mononitrate	46	15.5	15.5
Furosemide	701	15.4	15.4
Bupropion	96	15.3	15.3
Fexofenadine	36	15.2	15.2
Losartan	339	14.9	14.9
Metronidazole Topical	100	14.9	14.9
Torsemide	70	14.9	14.9
Ferrous Sulfate	104	14.7	14.7
Gentamicin	27	14.3	14.3
Niacin	24	14.3	14.3
Ondansetron	212	14.3	14.3
Ondansetron Tablets	212	14.3	14.3
Omeprazole	586	14.2	14.3
Ketoconazole Foam	30	14.1	14.1
Ketoconazole Cream, 2%	30	14.0	14.1
Hydroxyzine	94	14.0	14.0
Glimepiride	77	13.9	13.9
Fenofibrate	70	13.9	13.9
Glipizide	117	13.7	13.7
Nifedipine	91	13.6	13.7
Hydrochlorothiazide	263	13.5	13.6
Naproxen Sodium	256	13.4	13.4
Gemfibrozil	29	13.3	13.3
Sodium Bicarbonate	44	13.2	13.2
Sodium Bicarbonate Injection,	44	13.2	13.2
Minocycline	22	13.1	13.1
Temazepam	70	13.0	13.1
Ondansetron Hydrochloride	215	12.9	12.9
Ketoconazole	32	12.8	12.9
Pantoprazole	412	12.8	12.8
Fluconazole	125	12.7	12.8
Moxifloxacin Hydrochloride	37	12.7	12.7
Glyburide	44	12.7	12.7
Hydrocodone Bitartrate And Acetaminophen	100	12.6	12.6
Oxycodone And Acetaminophen	42	12.6	12.6
Naproxen Sodium, Dextromethorphan Hydrobromide, Guaifenesin	37	12.5	12.5
Insulin Aspart	116	12.5	12.5
Naproxen Sodium, Pseudoephedrine Hydrochloride	37	12.5	12.5
Simvastatin	399	12.5	12.5
Allopurinol	261	12.5	12.5
Metronidazole	111	12.4	12.4
Gentamicin Sulfate	28	12.3	12.3
Paricalcitol	25	12.3	12.3
Paroxetine Hydrochloride Hemihydrate	58	12.2	12.2
Metoprolol	393	12.1	12.1
Metoprolol Tartrate Injection	301	12.0	12.0
Clopidogrel Bisulfate	169	12.0	12.0
Metoroprolol Tartrate	111	12.0	12.0
Paroxetine	58	11.9	12.0
Metoprolol Tartrate	415	11.9	12.0
Guaifenesin	52	11.9	11.9
Zolpidem Tartrate	217	11.8	11.8
Diazepam Oral Solution (Concentrate)	146	11.8	11.8
Diazepam Oral	146	11.8	11.8
Esomeprazole	103	11.8	11.8
Amlodipine Besylate	230	11.6	11.6
Febuxostat	28	11.6	11.6
Fluticasone Propionate	204	11.5	11.5
Doxazosin	46	11.5	11.5
Docusate Sodium 100Mg	39	11.3	11.4
Olmesartan Medoxomil	58	11.3	11.3
Linaclotide	43	11.2	11.2
Acetaminophen, Guaifenesin, And Phenylephrine Hydrochloride	242	11.2	11.2
Ranitidine	295	11.2	11.2
Epoetin Alfa	19	11.1	11.1
Human Insulin	20	11.1	11.1
Metoclopramide	86	11.1	11.1
Ezetimibe And Simvastatin	24	10.9	11.0
Pioglitazone	67	10.9	10.9
Alendronate Sodium Tablet	29	10.9	10.9
Colchicine	41	10.8	10.9
Gabapentin	490	10.8	10.8
Docusate Sodium - Sennosides	50	10.8	10.8
Lidicaine	75	10.8	10.8
Burn Relief	75	10.8	10.8
Lidocaine Hydrochloride And Epinephrine	75	10.8	10.8
Docusate Sodium	87	10.6	10.7
Lidocaine, Menthol	75	10.6	10.7
Meperidine Hydrochloride	14	10.5	10.5
Clopidogrel	277	10.5	10.5
Tobramycin	36	10.4	10.4
Potassium Chloride	163	10.3	10.4
Lidocaine Hydrochloride And Epinephrine Bitartrate	78	10.3	10.3
Loratadine	152	10.2	10.2
Lidocaine 4%	78	10.1	10.1
Promethazine Hydrochloride	27	10.1	10.1
Diclofenac	121	10.0	10.0
Esomeprazole Magnesium Capsule, Delayed Release	21	10.0	10.0
Esomeprazole Magnesium Delayed Release Capsules	21	10.0	10.0
Esomeprazole Magnesium Dihydrate	21	10.0	10.0
Metoclopramide Hydrochloride	108	9.9	10.0
Amlodipine	347	9.9	9.9
Fluoxetine	93	9.9	9.9
Doxazosin Mesylate	51	9.9	9.9
Albuterol	162	9.7	9.8
Diazepam	164	9.7	9.8
Nicotine Polacrilex Mini	21	9.7	9.7
Nicotine Polarilex	21	9.7	9.7
Rosuvastatin	264	9.6	9.6
Ibuprofen Capsule	257	9.6	9.6
Ibuprofen Tablet, Film Coated	257	9.6	9.6
Ibupfrofen	257	9.6	9.6
Ibuprofen Tablets Usp, 200Mg	257	9.6	9.6
Ibuprofen Oral	257	9.6	9.6
Ibuprofen Capsules 200 Mg	257	9.6	9.6
Ibuprofen 200 Mg	257	9.6	9.6
Ibuprofen 200Mg	257	9.6	9.6
Oxybutynin	40	9.5	9.5
Montelukast	110	9.3	9.3
Cyanocobalamin	44	9.3	9.3
Metoprolol Succinate	113	9.3	9.3
Lidocaine Hydrochloride	79	9.2	9.2
Mometasone Furoate	55	9.2	9.2
Aspirin 325 Mg	570	9.2	9.2
Aspirin 81 Mg	570	9.2	9.2
Valsartan	135	9.2	9.2
Lidocaine	76	9.2	9.2
Cholestyramine	16	9.1	9.2
Fluticasone Propionate And Salmeterol Xinafoate	78	9.1	9.2
Alprazolam	252	9.1	9.1
Diclofenac Sodium	187	9.0	9.1
Aspirin	581	9.0	9.0
Lactulose	49	8.9	8.9
Escitslopram	72	8.7	8.7
Oxycodone And Acetaminophen Tablets	15	8.7	8.7
Magnesium Oxide	52	8.7	8.7
Oseltamivir Phosphate	30	8.5	8.5
Citalopram Hydrobromide	126	8.4	8.4
Ergocalciferol	413	8.4	8.4
Valsartan Oral	65	8.4	8.4
Psyllium Husk	12	8.4	8.4
Linagliptin	22	8.3	8.4
Estradiol Gel 0.1%	54	8.3	8.4
Estradiol Transdermal	54	8.3	8.4
Duloxetine	82	8.3	8.3
Eszopiclone	30	8.2	8.2
Potassium Chloride, Dextrose Monohydrate	104	8.0	8.0
Potassium Chloride Oral	104	8.0	8.0
Potassium Chloride Extended-Release	104	8.0	8.0
Sitagliptin	81	7.9	7.9
Clarithromycin	39	7.9	7.9
Dextrose	15	7.9	7.9
Acetaminophen, Chlorpheniramine Maleate, Phenylephrine Hcl	56	7.8	7.8
Oseltamivir	9	7.8	7.8
Losartan Potassium	87	7.8	7.8
Dextrose Monohydrate	15	7.8	7.8
Cetiirizine	47	7.7	7.7
Citalopram	146	7.7	7.7
Ibuprofen	277	7.6	7.6
Mometasone Furoate And Formoterol Fumarate Dihydrate	17	7.5	7.5
Primidone	11	7.4	7.5
Celecoxib	137	7.4	7.5
Nebivolol Hydrochloride	36	7.4	7.4
Atenolol	137	7.4	7.4
Moxifloxacin	15	7.4	7.4
Spironolactone	144	7.3	7.4
Pravastatin Sodium	21	7.3	7.3
Escitalopram Oxalate	75	7.2	7.2
Atorvastatin Calcium	242	7.2	7.2
Budesonide And Formoterol Fumarate Dihydrate	99	7.2	7.2
Morphine	76	7.2	7.2
Losartan Potassium And Hydrochlorothiazide	12	7.1	7.1
Topiramate	94	7.1	7.1
Acetaminophen	405	7.0	7.0
Oxycodone	180	7.0	7.0
Sertraline	115	7.0	7.0
Metoprolol Succinate Er Tablets	62	6.9	7.0
Fish Oil	89	6.9	6.9
Duloxetine Hydrochloride	180	6.9	6.9
Azelastine	18	6.9	6.9
Enalapril	55	6.9	6.9
Diphenhydramine Hydrochloride	158	6.9	6.9
Sumatriptan Succinate	25	6.8	6.9
Ezetimibe	73	6.8	6.8
Lisinopril And Hydrochlorothiazide	10	6.7	6.8
Pitavastatin Calcium	10	6.7	6.7
Fluoxetine Hydrochloride	120	6.7	6.7
Warfarin	118	6.6	6.6
Diltiazem Hydrochloride	32	6.4	6.4
Escitalopram	126	6.4	6.4
Vitamin E	29	6.4	6.4
Metformin Er 500 Mg	259	6.4	6.4
Metformin Er 750 Mg	259	6.4	6.4
Clonazepam	142	6.3	6.4
Baclofen	77	6.3	6.3
Vitamin C	82	6.3	6.3
Melatonin	49	6.3	6.3
Buspirone Hydrochloride	10	6.2	6.3
Amlodipine Besylate And Valsartan	10	6.2	6.2
Albuterol Sulfate	249	6.2	6.2
Lisinopril And Hydrochlorothiazide Tablets	7	6.1	6.1
Prasugrel Hydrochloride	9	6.1	6.1
Paroxetine Hydrochloride	79	6.1	6.1
Acetaminophen, Aspirin (Nsaid) And Caffeine	15	6.1	6.1
Vancomycin	50	6.0	6.0
Cinacalcet Hydrochloride	40	6.0	6.0
Venlafaxine	61	6.0	6.0
Irbesartan	38	5.9	5.9
Montelukast Sodium	99	5.7	5.7
Lorazepam	144	5.7	5.7
Timolol	10	5.7	5.7
Multivitamin	41	5.7	5.7
Metformin	271	5.6	5.6
Vancomycin Hydrochloride	53	5.6	5.6
Sennosides 8.6 Mg Tablets	17	5.6	5.6
Senna	17	5.6	5.6
Biotin	25	5.5	5.6
Diphenoxylate Hydrochloride And Atropine Sulfate	11	5.5	5.5
Ziprasidone	14	5.5	5.5
Sumatriptan	30	5.5	5.5
Cetirizine Hydrochloride	124	5.3	5.4
Estradiol	66	5.3	5.4
Fexofenadine Hcl	7	5.2	5.2
Finasteride	45	5.2	5.2
Senna Leaf	17	5.1	5.1
Fesoterodine Fumarate	8	5.1	5.1
Valsartan And Hydrochlorothiazide	10	5.1	5.1
Cetirizine	56	5.0	5.0
Nicotine	29	5.0	5.0
Oxycodone Hydrochloride And Acetaminophen	70	5.0	5.0
Acetaminophen, Aspirin, And Caffeine	15	4.9	4.9
Insulin Glargine	166	4.8	4.8
Ziprasidone Mesylate	10	4.8	4.8
Rizatriptan Benzoate	7	4.7	4.7
Prochlorperazine	19	4.7	4.7
Hydroxyzine Hydrochloride	9	4.7	4.7
Hydroxyzine Hydrochloride Oral	9	4.7	4.7
Oxybutynin Chloride	6	4.7	4.7
Brimonidine Tartrate	12	4.6	4.6
Umeclidinium	6	4.6	4.6
Naproxen Sodium Tablet, Coated	9	4.6	4.6
Naproxen Sodium, Coated Tablets	9	4.6	4.6
Naproxen Sodium 220Mg	9	4.6	4.6
Haloperidol	16	4.5	4.5
Acetaminophen And Codeine	8	4.5	4.5
Insulin Lispro	88	4.5	4.5
Vilazodone Hydrochloride	6	4.5	4.5
Haloperidol Lactate	16	4.5	4.5
Diclofenac Sodium 1%	23	4.5	4.5
Diclofenac Sodium Topical	23	4.5	4.5
Naproxen Sodium Tablet	34	4.4	4.4
Diclofenac Sodium Topical Gel, 1%	23	4.4	4.4
Guanfacine	5	4.4	4.4
Fluticasone Propionate And Salmeterol	26	4.3	4.3
Lurasidone Hydrochloride	13	4.3	4.3
Conjugated Estrogens	36	4.3	4.3
Estrogens, Conjugated	36	4.2	4.2
Minoxidil Foam 5% (Womens)	20	4.2	4.2
Nicotine Polacrilex	22	4.0	4.0
Sildenafil Citrate	72	4.0	4.0
Miconazole Nitrate	5	3.9	3.9
Acyclovir	62	3.8	3.8
Loratadine Tablet	28	3.6	3.6
Donepezil Hydrochloride	19	3.6	3.6
Tiotropium Bromide	70	3.6	3.6
Ticagrelor	16	3.5	3.5
Methadone	21	3.4	3.4
Amphetamine	4	3.3	3.3
Desvenlafaxine Succinate	13	3.3	3.3
Ranitidine Hydrochloride	26	3.3	3.3
Latanoprost	24	3.3	3.3
Brinzolamide	4	3.2	3.2
Liraglutide	22	3.1	3.1
Minoxidil	20	3.1	3.1
Umeclidinium Bromide And Vilanterol Trifenatate	7	2.9	2.9
Ranolazine	4	2.6	2.6
Suvorexant	4	2.1	2.1
Paliperidone	7	2.1	2.1
Patiromer	4	2.0	2.0
Methoxy Polyethylene Glycol-Epoetin Beta	3	1.9	1.9
Varenicline Tartrate	20	1.7	1.7
Exenatide	13	1.7	1.7
Tapentadol Hydrochloride	7	1.4	1.4
Salicylic Acid	4	0.5	0.5

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.