Lisinopril vs Hydrochlorothiazide: side effects in FDA adverse event reports
At a glance
| Lisinopril | Hydrochlorothiazide | |
|---|---|---|
| Drug class | – | Thiazide Diuretic |
| Brand names | – | – |
| FAERS reports | 304,208 | 144,362 |
| Serious | 61% | 67% |
| Death outcome | 25,263 | 10,118 |
| Boxed warning | Yes FETAL TOXICITY See full prescribing information for complete boxed warning. When pregnancy is detected, discontinue lisinopril as soon as possible. ( 5.1 ) Drug | No |
Signals both drugs share
| Reaction | Lisinopril | Hydrochlorothiazide | Label screen (A / B) |
|---|---|---|---|
| Nephrogenic anaemia | 1,334 · PRR 27.2 | 531 · PRR 18.5 | Not in label — unassessed / Likely indication confounding |
| Rebound acid hypersecretion | 729 · PRR 21.3 | 263 · PRR 13.5 | Not in label — unassessed / Not in label — unassessed |
| Hyperparathyroidism secondary | 682 · PRR 25.1 | 270 · PRR 17.2 | Not in label — unassessed / Not in label — unassessed |
| Chronic kidney disease-mineral and bone disorder | 386 · PRR 38.3 | 124 · PRR 18.8 | Not in label — unassessed / Not in label — unassessed |
| Adjustment disorder | 200 · PRR 12.3 | 183 · PRR 23.6 | Not in label — unassessed / Not in label — unassessed |
| Carotid artery thrombosis | 198 · PRR 20.6 | 183 · PRR 39.5 | Not in label — unassessed / Not in label — unassessed |
| Neurologic neglect syndrome | 179 · PRR 32.1 | 180 · PRR 68.7 | Not in label — unassessed / Not in label — unassessed |
Labeled signals distinctive to Lisinopril
- Chronic kidney disease — n=9,125, PRR 9.2 Labeled adverse reaction
- Angioedema — n=6,693, PRR 12.2 Labeled — boxed warning
- Intestinal angioedema — n=265, PRR 86.6 Labeled — boxed warning
- Subcutaneous drug absorption impaired — n=203, PRR 40.6 Labeled (related wording)
Labeled signals distinctive to Hydrochlorothiazide
- Vasculitis — n=630, PRR 8.2 Labeled adverse reaction
- Tension headache — n=434, PRR 16.2 Labeled (related wording)
- Respiratory symptom — n=149, PRR 8.1 Labeled (related wording)
- Pulmonary vasculitis — n=131, PRR 47.7 Labeled (related wording)
Common questions
Which has more reported side effects, Lisinopril or Hydrochlorothiazide?
Lisinopril has 304,208 FAERS reports and Hydrochlorothiazide 144,362. More reports does not mean more dangerous: volume follows how widely and how long a drug has been used, prescription vs over-the-counter status, and publicity. The seriousness share (61% vs 67%) is a better like-for-like signal of the kind of problems reported.
Which side effects do Lisinopril and Hydrochlorothiazide share?
Both drugs carry disproportionality signals for nephrogenic anaemia, rebound acid hypersecretion, hyperparathyroidism secondary, chronic kidney disease-mineral and bone disorder, adjustment disorder. Shared signals often reflect a shared drug class or the condition both are used for.
Is Lisinopril or Hydrochlorothiazide safer?
FAERS cannot answer that: it has no denominator and no comparator. Use this page to see which risks are already on each label and which signals are unlabeled, then check the prescribing information and your clinician for your situation.
Sources: openFDA FAERS pair statistics (OpenPV build 2026-09-14), FDA labels via openFDA, openFDA count queries for seriousness and deaths. Pair chosen because it is a commonly searched comparison. Generated 2026-10-08.