Losartan vs Ramipril: side effects in FDA adverse event reports
At a glance
| Losartan | Ramipril | |
|---|---|---|
| Drug class | – | Angiotensin Converting Enzyme Inhibitor |
| Brand names | Losartan Potassium | – |
| FAERS reports | 173,627 | 123,136 |
| Serious | 63% | 93% |
| Death outcome | 12,522 | 13,282 |
| Boxed warning | Yes FETAL TOXICITY When pregnancy is detected, discontinue losartan potassium tablets as soon as possible. Drugs that act directly on the renin-angiotensin system c | Yes FETAL TOXICITY WARNING: FETAL TOXICITY See full prescribing information for complete boxed warning When pregnancy is detected, discontinue ramipril as soon as p |
Signals both drugs share
No strong shared signal after removing coding and lab terms.
Labeled signals distinctive to Losartan
- Acute kidney injury — n=4,669, PRR 3.8 Labeled — boxed warning
- Chronic kidney disease — n=4,187, PRR 6.9 Labeled — boxed warning
- Renal injury — n=930, PRR 3.8 Labeled (related wording)
- Vasculitis — n=456, PRR 4.9 Labeled adverse reaction
- Tension headache — n=408, PRR 12.6 Labeled (related wording)
- Oligohydramnios — n=100, PRR 3.7 Labeled — boxed warning
- Essential hypertension — n=96, PRR 4.6 Labeled adverse reaction
Labeled signals distinctive to Ramipril
- Pemphigus — n=2,700, PRR 47.1 Labeled adverse reaction
- Sleep disorder due to general medical condition, insomnia type — n=846, PRR 25.7 Labeled (related wording)
- Subcutaneous drug absorption impaired — n=216, PRR 112.1 Labeled (related wording)
Common questions
Which has more reported side effects, Losartan or Ramipril?
Losartan has 173,627 FAERS reports and Ramipril 123,136. More reports does not mean more dangerous: volume follows how widely and how long a drug has been used, prescription vs over-the-counter status, and publicity. The seriousness share (63% vs 93%) is a better like-for-like signal of the kind of problems reported.
Which side effects do Losartan and Ramipril share?
They share no strong flagged signal after artifacts and lab terms are removed.
Is Losartan or Ramipril safer?
FAERS cannot answer that: it has no denominator and no comparator. Use this page to see which risks are already on each label and which signals are unlabeled, then check the prescribing information and your clinician for your situation.
Sources: openFDA FAERS pair statistics (OpenPV build 2026-09-14), FDA labels via openFDA, openFDA count queries for seriousness and deaths. Pair chosen because it is a commonly searched comparison. Generated 2026-10-08.