Reaction

Essential Hypertension reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 2,556 reports · 268 co-occurring drugs

As of the last recalculation, Essential Hypertension appears in 2,556 FAERS reports alongside 268 co-occurring drug terms. The strongest observed disproportionality signal is ALENDRONATE SODIUM (PRR 24.1).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Alendronate Sodium	269	24.1	24.2
Tafamidis	31	21.7	21.7
Chlorhexidine Gluconate	18	16.1	16.2
Nitroglycerin	96	15.1	15.1
Carisoprodol	32	13.8	13.8
Esomeprazole Magnesium Capsule, Delayed Release	24	13.6	13.6
Esomeprazole Magnesium Delayed Release Capsules	24	13.6	13.6
Esomeprazole Magnesium Dihydrate	24	13.5	13.5
Standardized Senna Concentrate	20	13.0	13.1
Metoprolol Succinate	130	12.8	12.8
Mometasone Furoate And Formoterol Fumarate Dihydrate	24	12.6	12.7
Meclizine Hcl 12.5Mg	21	12.6	12.7
Meclizine Hcl 25Mg	21	12.6	12.7
Meclizine Hcl 12.5 Mg	21	12.6	12.7
Meclizine Hcl 25 Mg	21	12.6	12.7
Meperidine Hydrochloride	14	12.4	12.5
Enalapril Maleate	37	12.3	12.3
Lisinopril And Hydrochlorothiazide	15	12.0	12.0
Methocarbamol	33	12.0	12.0
Prochlorperazine Maleate	13	11.5	11.6
Benzonatate	23	11.4	11.4
Meclizine Hydrochloride	27	11.3	11.3
Niacin	16	11.3	11.3
Doxyclycline Hyclate	23	11.1	11.1
Sitagliptin And Metformin Hydrochloride	29	11.1	11.1
Meclizine	22	11.1	11.1
Ascorbic Acid	31	11.0	11.0
Finasteride	77	10.7	10.7
Losartan Potassium And Hydrochlorothiazide	15	10.6	10.6
Docusate Sodium - Sennosides	41	10.5	10.5
Acetaminophen, Chlorpheniramine Maleate, Phenylephrine Hcl	62	10.3	10.3
Methocarbamol Tablets	21	10.3	10.3
Nystatin	34	10.2	10.3
Vitamin E	39	10.2	10.2
Cimetidine	12	10.2	10.2
Tizanidine Hydrochloride	22	10.0	10.0
Nitrofurantoin	20	9.9	10.0
Metoroprolol Tartrate	78	9.9	9.9
Nitrofurantoin (Monohydrate/Macrocrystals)	20	9.8	9.8
Amlodipine Besylate	166	9.8	9.8
Amlodipine Besylate And Benazepril Hydrochloride	11	9.7	9.7
Ferrous Sulfate	58	9.6	9.6
Glipizide	70	9.6	9.6
Potassium Chloride	128	9.6	9.6
Dexlansoprazole	48	9.5	9.5
Amiodarone Hydrochloride	13	9.5	9.5
Losartan Potassium	89	9.5	9.5
Carvedilol	149	9.5	9.5
Cyanocobalamin	37	9.3	9.3
Docusate Sodium	64	9.2	9.2
Cyclobenzaprine	55	9.2	9.2
Magnesium Hydroxide	15	9.1	9.1
Cephalexin	24	9.1	9.1
Nystatin Ointment	29	9.1	9.1
Nystatin Cream	29	9.1	9.1
Colchicine	29	9.1	9.1
Valsartan And Hydrochlorothiazide	15	9.0	9.1
Diphenoxylate Hydrochloride And Atropine Sulfate	15	9.0	9.0
Metoprolol Succinate Er Tablets	67	8.9	9.0
Sitagliptin	77	8.9	8.9
Potassium Chloride, Dextrose Monohydrate	98	8.9	8.9
Potassium Chloride Oral	98	8.9	8.9
Potassium Chloride Extended-Release	98	8.9	8.9
Hyoscyamine Sulfate	10	8.9	8.9
Pantoprazole Sodium	153	8.9	8.9
Digoxin	76	8.9	8.9
Thiamine Hydrochloride, Riboflavin 5 Phosphate Sodium, Dexpanthenol And Niacinamide	32	8.7	8.7
Fluticasone Propionate Nasal	32	8.7	8.7
Prednisolone Acetate	11	8.7	8.7
Esomeprazole Magnesium	229	8.7	8.7
Ezetimibe And Simvastatin	16	8.6	8.6
Lisinopril	289	8.5	8.5
Human Insulin	13	8.5	8.5
Risedronate Sodium	32	8.5	8.5
Carfilzomib	29	8.4	8.4
Triamcinolone Acetonide Ointment Usp, 0.05%	24	8.4	8.4
Desloratadine	11	8.4	8.4
Promethazine Hydrochloride	19	8.4	8.4
Methimazole	8	8.3	8.3
Lisinopril And Hydrochlorothiazide Tablets	8	8.3	8.3
Pravastatin Sodium	20	8.3	8.3
Quinapril Hydrochloride	8	8.3	8.3
Testosterone Cypionate	9	8.2	8.2
Lansoprazole	168	8.2	8.2
Guaifenesin	30	8.1	8.1
Gemfibrozil	15	8.1	8.1
Metolazone	11	8.0	8.0
Sodium Oxybate	63	8.0	8.0
Aspirin	443	7.9	7.9
Docusate Sodium 100Mg	23	7.9	7.9
Lubiprostone	9	7.8	7.8
Ibuprofen And Diphenhydramine Citrate	22	7.8	7.8
Omeprazole Magnesium	371	7.7	7.7
Magnesium Oxide	39	7.7	7.7
Captopril	9	7.6	7.7
Melatonin	50	7.6	7.6
Aspirin 325 Mg	411	7.6	7.6
Aspirin 81 Mg	411	7.6	7.6
Fluticasone Propionate	116	7.6	7.6
Naproxen Sodium, Dextromethorphan Hydrobromide, Guaifenesin	19	7.6	7.6
Ketoconazole	16	7.6	7.6
Naproxen Sodium, Pseudoephedrine Hydrochloride	19	7.6	7.6
Sucralfate	22	7.5	7.5
Clindamycin	26	7.5	7.5
Liothyronine Sodium	8	7.5	7.5
Bumetanide	24	7.5	7.5
Hydrochlorothiazide	127	7.4	7.4
Ergocalciferol	313	7.4	7.4
Clindamycin Phosphate	30	7.4	7.4
Diltiazem Hydrochloride	31	7.4	7.4
Nifedipine	42	7.4	7.4
Furosemide	320	7.3	7.3
Cyclobenzaprine Hydrochloride	8	7.3	7.3
Budesonide And Formoterol Fumarate Dihydrate	84	7.3	7.3
Temazepam	33	7.2	7.2
Triamcinolone Acetonide	27	7.2	7.2
Clobetasol Propionate Ointment Usp, 0.05%	9	7.1	7.1
Clobetasol Propionate	9	7.1	7.1
Dronabinol	7	7.1	7.1
Azithromycin Dihydrate	50	7.1	7.1
Atenolol	111	7.0	7.0
Chlorthalidone	10	7.0	7.0
Atorvastatin Calcium	199	7.0	7.0
Epoetin Alfa	10	6.9	6.9
Butalbital, Acetaminophen, And Caffeine	9	6.9	6.9
Dicyclomine Hydrochloride	12	6.9	6.9
Doxazosin Mesylate	30	6.8	6.8
Trazodone Hydrochloride	13	6.8	6.8
Insulin Aspart	54	6.8	6.8
Glyburide	20	6.8	6.8
Donepezil Hydrochloride	30	6.7	6.7
Loratadine Oral	40	6.7	6.7
Isosorbide Mononitrate	17	6.7	6.7
Acetaminophen, Guaifenesin, And Phenylephrine Hydrochloride	126	6.7	6.7
Loratadine Tablet	43	6.6	6.6
Loratadine	85	6.6	6.6
Timolol Maleate	8	6.6	6.6
Tiotropium Bromide Inhalation Spray	9	6.6	6.6
Oxybutynin Chloride	7	6.5	6.5
Doxazosin	22	6.4	6.5
Terazosin Hydrochloride	7	6.4	6.4
Rizatriptan Benzoate	8	6.4	6.4
Lovastatin	20	6.4	6.4
Rosuvastatin	152	6.4	6.4
Tolterodine Tartrate	7	6.4	6.4
Spironolactone	106	6.4	6.4
Bosutinib	7	6.4	6.4
Famotidine	89	6.4	6.4
Vitamin C	70	6.4	6.4
Sodium Bicarbonate	18	6.3	6.3
Sodium Bicarbonate Injection,	18	6.3	6.3
Nebivolol Hydrochloride	26	6.3	6.3
Ciprofloxacin Hydrochloride And Hydrocortisone	16	6.3	6.3
Metformin Hcl	42	6.3	6.3
Cefazolin	7	6.3	6.3
Metoprolol Tartrate	196	6.2	6.2
Tizanidine	18	6.2	6.2
Sertraline Hydrochloride	87	6.2	6.2
Nilotinib	22	6.1	6.1
Dapsone	8	6.1	6.1
Omeprazole	238	6.1	6.1
Albuterol Sulfate	207	6.1	6.1
Clopidogrel	141	6.1	6.1
Mupirocin	10	6.1	6.1
Biotin	23	6.0	6.1
Mupirocin Calcium	10	5.9	5.9
Azelastine	13	5.9	5.9
Zolpidem Tartrate	95	5.9	5.9
Oxybutynin	21	5.9	5.9
Isosorbide Dinitrate	14	5.9	5.9
Amoxicillin	54	5.9	5.9
Ropinirole	11	5.9	5.9
Armodafinil	15	5.8	5.8
Mirabegron	27	5.7	5.7
Rabeprazole Sodium	19	5.7	5.7
Pioglitazone	30	5.7	5.7
Fish Oil	62	5.7	5.7
Dexamethasone Sodium Phosphate	7	5.6	5.6
Tamsulosin Hydrochloride	14	5.6	5.6
Modafinil	22	5.6	5.6
Alprazolam	135	5.6	5.6
Latanoprost	34	5.6	5.6
Fenofibrate	24	5.6	5.6
Simvastatin	160	5.5	5.5
Oxycodone And Acetaminophen Tablets	8	5.5	5.5
Cetirizine Hcl	6	5.3	5.3
Metoprolol	157	5.3	5.3
Loratadine And Pseudoephedrine Sulfate	5	5.1	5.1
Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, And Amphetamine Sulfate	22	5.1	5.1
Conjugated Estrogens	36	5.1	5.1
Loperamide Hcl	8	5.1	5.1
Rifaximin	13	5.1	5.1
Ezetimibe	46	5.1	5.1
Olmesartan Medoxomil	22	5.0	5.0
Hydroxyzine Hydrochloride	8	5.0	5.0
Hydroxyzine Hydrochloride Oral	8	5.0	5.0
Fexofenadine	10	4.9	4.9
Polyethylene Glycol 3350	57	4.9	4.9
Insulin Degludec	14	4.9	4.9
Febuxostat	10	4.9	4.9
Insulin Glargine-Yfgn	13	4.9	4.9
Estrogens, Conjugated	35	4.9	4.9
Bicalutamide	9	4.8	4.8
Icosapent Ethyl	5	4.8	4.8
Calcium, Magnesium, Potassium, And Sodium Oxybates	5	4.7	4.7
Budesonide, Glycopyrrolate, And Formoterol Fumarate	6	4.7	4.7
Losartan	96	4.6	4.6
Linaclotide	15	4.6	4.6
Dextroamphetamine Sulfate, Dextroamphetamine Saccharate, Amphetamine Sulfate And Amphetamine Aspartate	23	4.5	4.5
Methadone Hydrochloride	6	4.5	4.5
Hydrocodone Bitartrate And Acetaminophen	31	4.5	4.5
Fesoterodine Fumarate	6	4.5	4.5
Polyethylene Glycol 400	7	4.5	4.5
Etonogestrel And Ethinyl Estradiol	12	4.4	4.4
Ticagrelor	17	4.4	4.4
Carboxymethylcellulose Sodium	5	4.3	4.3
Fluticasone Furoate And Vilanterol Trifenatate	19	4.3	4.3
Sevelamer Carbonate	6	4.3	4.3
Glimepiride	20	4.2	4.2
Oxycodone Hydrochloride And Acetaminophen	50	4.2	4.2
Eszopiclone	13	4.2	4.2
Conjugated Estrogens And Medroxyprogesterone Acetate	12	4.2	4.2
Vibegron	4	4.1	4.1
Iohexol	4	3.9	3.9
Umeclidinium Bromide And Vilanterol Trifenatate	8	3.9	3.9
Ranolazine	5	3.9	3.9
Dapagliflozin	15	3.9	3.9
Dofetilide	5	3.9	3.9
Acetaminophen, Aspirin (Nsaid) And Caffeine	8	3.8	3.8
Fexofenadine Hydrochloride	10	3.8	3.8
Denosumab	86	3.5	3.5
Vilazodone Hydrochloride	4	3.5	3.5
Rocuronium Bromide	5	3.5	3.5
Acalabrutinib	5	3.4	3.4
Fluticasone Propionate And Salmeterol	17	3.3	3.3
Venetoclax	25	3.3	3.3
Insulin Glargine	95	3.2	3.2
Prasugrel Hydrochloride	4	3.2	3.2
Brimonidine Tartrate	7	3.2	3.2
Sacubitril And Valsartan	45	3.2	3.2
Oxycodone Hydrochloride	83	3.2	3.2
Liraglutide	19	3.1	3.1
Acetaminophen, Aspirin, And Caffeine	8	3.1	3.1
Abiraterone	5	3.0	3.0
Axitinib	7	2.9	2.9
Eltrombopag Olamine	8	2.8	2.8
Travoprost	3	2.8	2.8
Voclosporin	3	2.8	2.8
Tolvaptan	5	2.8	2.8
Alpelisib	3	2.8	2.8
Rucaparib	3	2.8	2.8
Varenicline Tartrate	27	2.8	2.8
Daratumumab	13	2.7	2.7
Cortisone Acetate	4	2.6	2.6
Rimegepant Sulfate	4	2.6	2.6
Fluticasone Furoate, Umeclidinium Bromide And Vilanterol Trifenatate	13	2.6	2.6
Encorafenib	3	2.5	2.5
Romosozumab-Aqqg	4	2.4	2.4
Ledipasvir And Sofosbuvir	5	2.1	2.1
Benralizumab	5	2.0	2.0
Abiraterone Acetate	9	1.8	1.8
Patiromer	3	1.8	1.8
Hydrocodone Bitartrate	9	1.7	1.7
Galcanezumab-Gnlm	6	1.6	1.6
Minoxidil Foam 5% (Womens)	6	1.5	1.5
Evolocumab	28	1.4	1.4
Cinacalcet Hydrochloride	7	1.2	1.2
Minoxidil	6	1.1	1.1

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.