OpenPV Signal Explorer
FAERS disproportionality dashboard
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Drug

Tapentadol Hydrochloride

1,046 flagged reaction(s) · 70,298 total co-reports · max PRR 1,596.7
Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.
Reaction Co-reports (a) PRR ROR Signal
1 Paroxysmal Extreme Pain Disorder 18 1,596.7 1,597.5 signal
2 Opiates Negative 7 334.3 334.4 signal
3 Corrosive Oropharyngeal Injury 8 216.0 216.0 signal
4 Polyneuropathy In Malignant Disease 18 177.4 177.5 signal
5 Confusional Arousal 19 85.5 85.5 signal
6 Pharyngeal Enanthema 6 69.0 69.0 signal
7 Post Procedural Hypothyroidism 20 67.1 67.2 signal
8 Post Cholecystectomy Syndrome 26 64.1 64.1 signal
9 Ocular Pemphigoid 10 57.5 57.5 signal
10 Tender Joint Count 7 56.4 56.5 signal
11 Aspartate Aminotransferase 18 50.3 50.4 signal
12 Drug Withdrawal Syndrome Neonatal 944 42.4 43.6 signal
13 Granulocyte Count Increased 25 41.4 41.4 signal
14 Toxicity To Various Agents 9,796 39.0 54.9 signal
15 Chronic Respiratory Disease 20 38.2 38.2 signal
16 Blood Immunoglobulin A Increased 25 30.8 30.8 signal
17 Drug Dose Titration Not Performed 78 29.9 29.9 signal
18 Degenerative Bone Disease 19 28.2 28.2 signal
19 Vitamin B12 Increased 27 22.2 22.3 signal
20 Electric Shock 28 21.5 21.5 signal
21 Convulsive Threshold Lowered 13 21.5 21.5 signal
22 Application Site Injury 6 20.8 20.8 signal
23 Glomerular Filtration Rate Increased 26 20.8 20.8 signal
24 Drug Diversion 163 18.4 18.5 signal
25 Dactylitis 27 17.8 17.8 signal
26 Overdose 5,888 17.6 21.2 signal
27 Allodynia 29 16.7 16.7 signal
28 Rheumatoid Factor Increased 26 15.0 15.0 signal
29 Breakthrough Pain 52 14.4 14.4 signal
30 Clubbing 8 12.5 12.5 signal
31 Accidental Overdose 712 12.5 12.8 signal
32 Drug Abuse 1,552 11.9 12.4 signal
33 Parasomnia 13 11.9 11.9 signal
34 Short-bowel Syndrome 12 11.8 11.8 signal
35 Reflexes Abnormal 12 11.8 11.8 signal
36 Amnestic Disorder 8 10.7 10.7 signal
37 Drug Screen Negative 29 10.5 10.5 signal
38 Sepsis Neonatal 13 10.3 10.3 signal
39 Intervertebral Discitis 28 9.4 9.5 signal
40 Post Herpetic Neuralgia 20 8.9 8.9 signal
41 Death 11,643 8.6 12.7 signal
42 Joint Noise 26 8.6 8.6 signal
43 Serotonin Syndrome 245 8.2 8.2 signal
44 Complex Regional Pain Syndrome 19 8.1 8.1 signal
45 Myofascial Pain Syndrome 9 8.0 8.0 signal
46 Bacteriuria 7 8.0 8.0 signal
47 Opiates Positive 6 7.9 7.9 signal
48 Mouth Injury 18 7.5 7.5 signal
49 White Blood Cells Urine Positive 22 7.5 7.5 signal
50 Therapeutic Response Increased 11 7.5 7.5 signal
51 Aspartate Aminotransferase Abnormal 17 7.2 7.2 signal
52 Hepatitis C 128 6.7 6.7 signal
53 Hyperthermia Malignant 15 6.5 6.5 signal
54 Polymyalgia Rheumatica 31 6.3 6.3 signal
55 Application Site Ulcer 7 6.2 6.2 signal
56 False Positive Investigation Result 9 5.7 5.7 signal
57 Drug Screen Positive 70 5.6 5.6 signal
58 Miosis 64 5.1 5.1 signal
59 Small Intestinal Resection 9 4.9 4.9 signal
60 Monocyte Count Increased 28 4.9 4.9 signal
61 Application Site Hypersensitivity 9 4.7 4.7 signal
62 Somatic Symptom Disorder 8 4.7 4.7 signal
63 Hyperaesthesia 59 4.5 4.5 signal
64 Vitamin B12 Deficiency 28 4.4 4.4 signal
65 Sleep Deficit 14 4.3 4.3 signal
66 Throat Clearing 25 4.3 4.3 signal
67 Blood Alkaline Phosphatase Abnormal 6 4.2 4.2 signal
68 Drug Dependence 1,071 4.2 4.3 signal
69 Demyelination 27 4.1 4.2 signal
70 Oral Mucosa Erosion 8 4.1 4.1 signal
71 Drug Tolerance 33 4.1 4.1 signal
72 Suspected Transmission Of An Infectious Agent Via Product 8 4.1 4.1 signal
73 Hiv Infection 19 4.0 4.0 signal
74 Product Monitoring Error 9 4.0 4.0 signal
75 Respiratory Depression 76 3.9 3.9 signal
76 Myoclonic Epilepsy 9 3.9 3.9 signal
77 Drowning 6 3.8 3.8 signal
78 Post-traumatic Stress Disorder 40 3.8 3.8 signal
79 Product Distribution Issue 52 3.7 3.7 signal
80 Product Packaging Quantity Issue 64 3.7 3.7 signal
81 Immunoglobulins Decreased 8 3.7 3.7 signal
82 Peptic Ulcer 19 3.6 3.6 signal
83 Asterixis 6 3.6 3.6 signal
84 Alcohol Interaction 11 3.6 3.6 signal
85 Delirium 193 3.5 3.5 signal
86 Blood Pressure Systolic Decreased 25 3.5 3.5 signal
87 Disturbance In Social Behaviour 13 3.5 3.5 signal
88 Clonus 15 3.5 3.5 signal
89 Spinal Disorder 51 3.4 3.4 signal
90 Drug Screen False Positive 15 3.4 3.4 signal
91 Tongue Discomfort 22 3.3 3.3 signal
92 Respiratory Rate Decreased 16 3.2 3.2 signal
93 Sudden Onset Of Sleep 7 3.2 3.2 signal
94 Secondary Immunodeficiency 6 3.2 3.2 signal
95 Cholecystitis Acute 28 3.1 3.1 signal
96 Medical Procedure 8 3.1 3.1 signal
97 Vitamin D Deficiency 47 3.0 3.1 signal
98 Medication Error 267 3.0 3.1 signal
99 Quality Of Life Decreased 64 3.0 3.0 signal
100 Knee Deformity 7 3.0 3.0 signal
101 Gaze Palsy 8 3.0 3.0 signal
102 Blood Uric Acid Increased 27 3.0 3.0 signal
103 Chronic Kidney Disease-mineral And Bone Disorder 5 2.9 2.9 signal
104 Dysaesthesia 14 2.9 2.9 signal
105 Intentional Product Misuse 400 2.9 2.9 signal
106 Atrophy 9 2.9 2.9 signal
107 Hypoxic-ischaemic Encephalopathy 12 2.9 2.9 signal
108 Accident 54 2.9 2.9 signal
109 Oral Mucosal Erythema 7 2.9 2.9 signal
110 Dyslipidaemia 23 2.9 2.9 signal
111 Rhinitis Allergic 20 2.8 2.8 signal
112 Blood Loss Anaemia 10 2.8 2.8 signal
113 Bundle Branch Block Left 19 2.8 2.8 signal
114 Hyperparathyroidism Secondary 11 2.7 2.7 signal
115 Stenosis 8 2.7 2.7 signal
116 Pre-existing Condition Improved 27 2.7 2.7 signal
117 Loss Of Employment 13 2.7 2.7 signal
118 Drug Titration Error 11 2.7 2.7 signal
119 Withdrawal Syndrome 179 2.7 2.7 signal
120 Systemic Infection 7 2.7 2.7 signal
121 Inadequate Analgesia 36 2.7 2.7 signal
122 Pulmonary Sepsis 6 2.6 2.6 signal
123 Nasal Polyps 20 2.6 2.6 signal
124 Substance Abuse 33 2.6 2.6 signal
125 Euphoric Mood 41 2.5 2.5 signal
126 Accidental Exposure To Product By Child 27 2.5 2.5 signal
127 Drug Prescribing Error 76 2.5 2.5 signal
128 Gingivitis 21 2.5 2.5 signal
129 Pupillary Reflex Impaired 7 2.4 2.4 signal
130 Adjustment Disorder 5 2.4 2.4 no signal
131 Nephrogenic Anaemia 17 2.3 2.3 signal
132 Sedation Complication 9 2.3 2.3 signal
133 Sopor 47 2.2 2.2 signal
134 Blood Pressure Diastolic Decreased 26 2.2 2.2 signal
135 Cataplexy 5 2.2 2.2 no signal
136 Hypophysitis 7 2.2 2.2 no signal
137 Reaction To Excipient 8 2.2 2.2 signal
138 Benign Prostatic Hyperplasia 17 2.1 2.1 signal
139 Breast Cancer Metastatic 35 2.1 2.1 signal
140 Drug Withdrawal Syndrome 289 2.1 2.1 signal
141 Abnormal Loss Of Weight 22 2.1 2.1 signal
142 Hypopnoea 11 2.0 2.0 signal
143 Functional Gastrointestinal Disorder 11 2.0 2.0 signal
144 Progressive Multifocal Leukoencephalopathy 26 2.0 2.0 no signal
145 Chronic Gastritis 7 2.0 2.0 no signal
146 Cachexia 16 2.0 2.0 no signal
147 Cancer Pain 8 2.0 2.0 no signal
148 Sedation 80 1.9 1.9 no signal
149 Red Blood Cell Sedimentation Rate Increased 34 1.9 1.9 no signal
150 Potentiating Drug Interaction 10 1.9 1.9 no signal
151 Psychomotor Skills Impaired 8 1.9 1.9 no signal
152 Drug Use Disorder 25 1.9 1.9 no signal
153 Spinal Fusion Surgery 12 1.9 1.9 no signal
154 Inability To Afford Medication 29 1.9 1.9 no signal
155 Incoherent 19 1.8 1.8 no signal
156 Slow Speech 7 1.8 1.8 no signal
157 Amyloidosis 5 1.8 1.8 no signal
158 Inflammatory Marker Increased 14 1.8 1.8 no signal
159 Ulcer 45 1.8 1.8 no signal
160 Labelled Drug-drug Interaction Medication Error 25 1.8 1.8 no signal
161 Hallucination 207 1.7 1.7 no signal
162 Cerebral Atrophy 11 1.7 1.7 no signal
163 Trigeminal Neuralgia 11 1.7 1.7 no signal
164 Hallucination, Visual 57 1.7 1.7 no signal
165 Substance-induced Psychotic Disorder 6 1.7 1.7 no signal
166 Radiculopathy 7 1.7 1.7 no signal
167 Temperature Intolerance 27 1.7 1.7 no signal
168 Alcohol Poisoning 7 1.7 1.7 no signal
169 Completed Suicide 221 1.7 1.7 no signal
170 Adrenal Disorder 5 1.6 1.6 no signal
171 Social Avoidant Behaviour 15 1.6 1.6 no signal
172 Intervertebral Disc Degeneration 24 1.6 1.6 no signal
173 Brain Death 8 1.6 1.6 no signal
174 Impaired Driving Ability 29 1.6 1.6 no signal
175 Neutrophil Count Increased 26 1.6 1.6 no signal
176 Disability 50 1.6 1.6 no signal
177 Adrenal Insufficiency 30 1.6 1.6 no signal
178 Drug Effect Increased 8 1.6 1.6 no signal
179 Osteopenia 38 1.6 1.6 no signal
180 Thrombocytosis 9 1.6 1.6 no signal
181 Intervertebral Disc Protrusion 54 1.6 1.6 no signal
182 Altered State Of Consciousness 53 1.6 1.6 no signal
183 Unresponsive To Stimuli 63 1.5 1.5 no signal
184 Disorientation 97 1.5 1.5 no signal
185 Self-medication 10 1.5 1.5 no signal
186 Neuralgia 59 1.5 1.5 no signal
187 Speech Disorder Developmental 7 1.5 1.5 no signal
188 Hypertensive Crisis 27 1.5 1.5 no signal
189 Haemothorax 7 1.5 1.5 no signal
190 Dependence 133 1.5 1.5 no signal
191 Neck Injury 7 1.5 1.5 no signal
192 Hallucinations, Mixed 10 1.5 1.5 no signal
193 Exposure Via Ingestion 6 1.5 1.5 no signal
194 Coordination Abnormal 33 1.5 1.5 no signal
195 Urine Analysis Abnormal 7 1.5 1.5 no signal
196 Drug Interaction 365 1.5 1.5 no signal
197 Bradyphrenia 15 1.4 1.4 no signal
198 Rebound Acid Hypersecretion 7 1.4 1.4 no signal
199 Thrombophlebitis 8 1.4 1.4 no signal
200 Spinal Osteoarthritis 20 1.4 1.4 no signal
201 Urinary Retention 75 1.4 1.4 no signal
202 Ileus Paralytic 10 1.4 1.4 no signal
203 Pneumonia Aspiration 55 1.4 1.4 no signal
204 Faecaloma 12 1.4 1.4 no signal
205 Myoclonus 26 1.4 1.4 no signal
206 Apnoea 17 1.4 1.4 no signal
207 Attention Deficit Hyperactivity Disorder 9 1.4 1.4 no signal
208 Poisoning Deliberate 20 1.4 1.4 no signal
209 Performance Status Decreased 10 1.3 1.3 no signal
210 Nystagmus 11 1.3 1.3 no signal
211 Helicobacter Infection 21 1.3 1.3 no signal
212 Ileus 25 1.3 1.3 no signal
213 Iron Deficiency 9 1.3 1.3 no signal
214 Fibromyalgia 49 1.3 1.3 no signal
215 End Stage Renal Disease 37 1.3 1.3 no signal
216 Delusion 31 1.3 1.3 no signal
217 Adverse Event 184 1.3 1.3 no signal
218 Agitation 147 1.3 1.3 no signal
219 Exposure During Pregnancy 124 1.3 1.3 no signal
220 Multiple Drug Overdose 10 1.3 1.3 no signal
221 Somnolence 398 1.2 1.3 no signal
222 Cognitive Disorder 92 1.2 1.2 no signal
223 Suicide Attempt 119 1.2 1.2 no signal
224 Product Physical Issue 39 1.2 1.2 no signal
225 Mydriasis 25 1.2 1.2 no signal
226 Intentional Overdose 124 1.2 1.2 no signal
227 Restlessness 71 1.2 1.2 no signal
228 Mental Impairment 47 1.2 1.2 no signal
229 Feeling Of Despair 9 1.2 1.2 no signal
230 Blood Test Abnormal 27 1.2 1.2 no signal
231 Drug Effect Decreased 105 1.2 1.2 no signal
232 Actinic Keratosis 5 1.2 1.2 no signal
233 Metastases To Lung 22 1.2 1.2 no signal
234 Polyarthritis 10 1.2 1.2 no signal
235 Depressed Level Of Consciousness 75 1.2 1.2 no signal
236 Sleep Apnoea Syndrome 36 1.2 1.2 no signal
237 Screaming 12 1.2 1.2 no signal
238 Hypogammaglobulinaemia 12 1.2 1.2 no signal
239 Bradypnoea 5 1.2 1.2 no signal
240 Autoimmune Thyroiditis 7 1.2 1.2 no signal
241 Loose Tooth 6 1.2 1.2 no signal
242 Dermatitis Allergic 23 1.2 1.2 no signal
243 Asphyxia 15 1.2 1.2 no signal
244 Confusional State 296 1.2 1.2 no signal
245 Dysphemia 8 1.1 1.1 no signal
246 Somnambulism 12 1.1 1.1 no signal
247 Hyperhidrosis 234 1.1 1.1 no signal
248 Panic Reaction 13 1.1 1.1 no signal
249 Rotator Cuff Syndrome 23 1.1 1.1 no signal
250 Blood Urea Increased 30 1.1 1.1 no signal
251 Coma Scale Abnormal 5 1.1 1.1 no signal
252 Formication 12 1.1 1.1 no signal
253 Skin Abrasion 8 1.1 1.1 no signal
254 Logorrhoea 6 1.1 1.1 no signal
255 Drug Specific Antibody Present 11 1.1 1.1 no signal
256 Hangover 6 1.1 1.1 no signal
257 Mental Status Changes 47 1.1 1.1 no signal
258 Muscle Twitching 39 1.1 1.1 no signal
259 Polyneuropathy 20 1.1 1.1 no signal
260 Self-injurious Ideation 7 1.1 1.1 no signal
261 Abnormal Dreams 45 1.0 1.0 no signal
262 Middle Insomnia 30 1.0 1.0 no signal
263 Restless Legs Syndrome 29 1.0 1.0 no signal
264 Joint Effusion 11 1.0 1.0 no signal
265 Metastases To Bone 26 1.0 1.0 no signal
266 Bladder Pain 5 1.0 1.0 no signal
267 Thyroid Mass 6 1.0 1.0 no signal
268 Blood Pressure Fluctuation 38 1.0 1.0 no signal
269 Body Height Decreased 17 1.0 1.0 no signal
270 Hallucination, Auditory 25 1.0 1.0 no signal
271 Application Site Reaction 11 1.0 1.0 no signal
272 Thinking Abnormal 29 1.0 1.0 no signal
273 Skin Warm 9 1.0 1.0 no signal
274 Dry Mouth 125 1.0 1.0 no signal
275 Peripheral Sensory Neuropathy 9 1.0 1.0 no signal
276 Developmental Delay 14 1.0 1.0 no signal
277 Ankylosing Spondylitis 20 1.0 1.0 no signal
278 Bacterial Sepsis 5 1.0 1.0 no signal
279 Constipation 328 1.0 1.0 no signal
280 Energy Increased 9 1.0 1.0 no signal
281 Chronic Kidney Disease 116 1.0 1.0 no signal
282 Obstruction 6 0.9 0.9 no signal
283 Disturbance In Attention 81 0.9 0.9 no signal
284 Intracranial Aneurysm 6 0.9 0.9 no signal
285 Blindness Transient 11 0.9 0.9 no signal
286 Wrong Technique In Drug Usage Process 55 0.9 0.9 no signal
287 Anxiety Disorder 5 0.9 0.9 no signal
288 Gastrointestinal Toxicity 7 0.9 0.9 no signal
289 Motor Dysfunction 15 0.9 0.9 no signal
290 Back Injury 16 0.9 0.9 no signal
291 Prescription Drug Used Without A Prescription 9 0.9 0.9 no signal
292 Application Site Discolouration 6 0.9 0.9 no signal
293 Amnesia 96 0.9 0.9 no signal
294 Suspected Suicide 7 0.9 0.9 no signal
295 Spinal Column Stenosis 7 0.9 0.9 no signal
296 Bipolar Disorder 16 0.9 0.9 no signal
297 Meniscus Injury 9 0.9 0.9 no signal
298 Cholangitis 9 0.9 0.9 no signal
299 Bedridden 19 0.9 0.9 no signal
300 Blood Alkaline Phosphatase Increased 36 0.9 0.9 no signal
301 Photopsia 9 0.9 0.9 no signal
302 Sleep Terror 6 0.9 0.9 no signal
303 Drug Dispensing Error 22 0.9 0.9 no signal
304 Drug Dose Omission 238 0.9 0.9 no signal
305 Impaired Gastric Emptying 18 0.9 0.9 no signal
306 Aspiration 15 0.9 0.9 no signal
307 Osteoporosis 57 0.9 0.9 no signal
308 Hyperventilation 8 0.9 0.9 no signal
309 Petit Mal Epilepsy 7 0.9 0.9 no signal
310 Atrioventricular Block First Degree 6 0.9 0.9 no signal
311 Hypovolaemia 8 0.9 0.9 no signal
312 Therapeutic Response Decreased 82 0.9 0.9 no signal
313 Product Prescribing Error 32 0.9 0.9 no signal
314 Peripheral Vascular Disorder 7 0.9 0.9 no signal
315 Anal Incontinence 12 0.8 0.8 no signal
316 Poisoning 17 0.8 0.8 no signal
317 Tremor 223 0.8 0.8 no signal
318 Sinus Tachycardia 19 0.8 0.8 no signal
319 Feeling Drunk 10 0.8 0.8 no signal
320 Hyperthermia 10 0.8 0.8 no signal
321 Behaviour Disorder 7 0.8 0.8 no signal
322 Product Administration Interrupted 10 0.8 0.8 no signal
323 Concussion 10 0.8 0.8 no signal
324 Blepharospasm 8 0.8 0.8 no signal
325 Depression 293 0.8 0.8 no signal
326 Seizure 147 0.8 0.8 no signal
327 Inappropriate Antidiuretic Hormone Secretion 13 0.8 0.8 no signal
328 Tooth Fracture 14 0.8 0.8 no signal
329 Hand Fracture 9 0.8 0.8 no signal
330 Head Injury 40 0.8 0.8 no signal
331 Endometriosis 6 0.8 0.8 no signal
332 Hypersomnia 36 0.8 0.8 no signal
333 Psychotic Disorder 37 0.8 0.8 no signal
334 Road Traffic Accident 52 0.8 0.8 no signal
335 Spinal Operation 15 0.8 0.8 no signal
336 Humerus Fracture 6 0.8 0.8 no signal
337 Tachycardia 110 0.8 0.8 no signal
338 C-reactive Protein Increased 45 0.8 0.8 no signal
339 Dysphagia 117 0.8 0.8 no signal
340 Suicidal Ideation 113 0.8 0.8 no signal
341 Dyskinesia 50 0.8 0.8 no signal
342 Pain 756 0.8 0.8 no signal
343 Abnormal Behaviour 49 0.8 0.8 no signal
344 Major Depression 9 0.8 0.8 no signal
345 Dysarthria 46 0.8 0.8 no signal
346 Limb Injury 33 0.8 0.8 no signal
347 Cardiac Valve Disease 7 0.8 0.8 no signal
348 Sudden Death 13 0.8 0.8 no signal
349 Pemphigoid 9 0.8 0.8 no signal
350 Impaired Work Ability 26 0.8 0.8 no signal
351 Herpes Virus Infection 7 0.8 0.8 no signal
352 Arteriosclerosis Coronary Artery 8 0.8 0.8 no signal
353 Psychomotor Hyperactivity 20 0.8 0.8 no signal
354 Neuropathy Peripheral 113 0.8 0.8 no signal
355 Hypoglycaemia 58 0.8 0.8 no signal
356 Symptom Recurrence 7 0.8 0.8 no signal
357 Cold Sweat 21 0.7 0.7 no signal
358 Aphasia 36 0.7 0.7 no signal
359 Encephalopathy 29 0.7 0.7 no signal
360 Joint Stiffness 31 0.7 0.7 no signal
361 Loss Of Consciousness 150 0.7 0.7 no signal
362 Rib Fracture 24 0.7 0.7 no signal
363 Respiratory Disorder 35 0.7 0.7 no signal
364 Multiple Sclerosis 56 0.7 0.7 no signal
365 Therapeutic Product Effect Incomplete 82 0.7 0.7 no signal
366 Lymphoedema 8 0.7 0.7 no signal
367 Foot Fracture 22 0.7 0.7 no signal
368 Feeling Jittery 22 0.7 0.7 no signal
369 Activities Of Daily Living Impaired 23 0.7 0.7 no signal
370 Depressed Mood 60 0.7 0.7 no signal
371 Prescribed Overdose 22 0.7 0.7 no signal
372 Product Quality Issue 153 0.7 0.7 no signal
373 Feeling Abnormal 270 0.7 0.7 no signal
374 Hip Arthroplasty 17 0.7 0.7 no signal
375 Red Blood Cell Count Decreased 32 0.7 0.7 no signal
376 Migraine 106 0.7 0.7 no signal
377 Presyncope 27 0.7 0.7 no signal
378 Mucosal Inflammation 29 0.7 0.7 no signal
379 Balance Disorder 96 0.7 0.7 no signal
380 Gastritis 29 0.7 0.7 no signal
381 Back Disorder 18 0.7 0.7 no signal
382 Haematemesis 28 0.7 0.7 no signal
383 Polyuria 9 0.7 0.7 no signal
384 Neurotoxicity 19 0.7 0.7 no signal
385 Emphysema 11 0.7 0.7 no signal
386 Nerve Compression 10 0.7 0.7 no signal
387 Cyanosis 17 0.7 0.7 no signal
388 Bursitis 13 0.7 0.7 no signal
389 Aggression 54 0.7 0.7 no signal
390 Glycosylated Haemoglobin Increased 27 0.7 0.7 no signal
391 Incorrect Route Of Product Administration 18 0.7 0.7 no signal
392 Arteriosclerosis 10 0.7 0.7 no signal
393 Blood Pressure Abnormal 21 0.7 0.7 no signal
394 Troponin Increased 8 0.7 0.7 no signal
395 Drug Effect Incomplete 39 0.7 0.7 no signal
396 Malignant Neoplasm Progression 107 0.7 0.7 no signal
397 Nervousness 55 0.7 0.7 no signal
398 Application Site Pain 23 0.7 0.7 no signal
399 Respiratory Arrest 29 0.7 0.7 no signal
400 Paranoia 18 0.7 0.7 no signal
401 Glaucoma 20 0.7 0.7 no signal
402 Mental Disorder 45 0.7 0.6 no signal
403 Ankle Fracture 16 0.7 0.6 no signal
404 Dysuria 38 0.6 0.6 no signal
405 Eating Disorder 22 0.6 0.6 no signal
406 Oxygen Saturation Decreased 57 0.6 0.6 no signal
407 Affective Disorder 8 0.6 0.6 no signal
408 Epilepsy 31 0.6 0.6 no signal
409 Encephalitis 7 0.6 0.6 no signal
410 Panic Attack 37 0.6 0.6 no signal
411 Ligament Sprain 10 0.6 0.6 no signal
412 Product Dose Omission 67 0.6 0.6 no signal
413 Application Site Burn 5 0.6 0.6 no signal
414 Type 2 Diabetes Mellitus 34 0.6 0.6 no signal
415 Anxiety 287 0.6 0.6 no signal
416 Unevaluable Event 76 0.6 0.6 no signal
417 Anaphylactic Reaction 55 0.6 0.6 no signal
418 Hypoxia 35 0.6 0.6 no signal
419 Insomnia 265 0.6 0.6 no signal
420 Intentional Self-injury 20 0.6 0.6 no signal
421 Arthritis 78 0.6 0.6 no signal
422 Muscle Tightness 16 0.6 0.6 no signal
423 Application Site Erythema 26 0.6 0.6 no signal
424 Fall 327 0.6 0.6 no signal
425 Neck Pain 55 0.6 0.6 no signal
426 Decubitus Ulcer 8 0.6 0.6 no signal
427 Tinnitus 45 0.6 0.6 no signal
428 Hypercalcaemia 12 0.6 0.6 no signal
429 Cardiomegaly 12 0.6 0.6 no signal
430 Oliguria 6 0.6 0.6 no signal
431 Surgery 56 0.6 0.6 no signal
432 Drug Eruption 17 0.6 0.6 no signal
433 Intestinal Obstruction 36 0.6 0.6 no signal
434 Crying 35 0.6 0.6 no signal
435 Back Pain 223 0.6 0.6 no signal
436 Nephropathy 9 0.6 0.6 no signal
437 Burning Sensation 67 0.6 0.6 no signal
438 Therapeutic Response Unexpected 43 0.6 0.6 no signal
439 Drug Hypersensitivity 184 0.6 0.6 no signal
440 Renal Pain 10 0.6 0.6 no signal
441 Peripheral Coldness 13 0.6 0.6 no signal
442 Retching 20 0.6 0.6 no signal
443 White Blood Cell Count Increased 36 0.6 0.6 no signal
444 Drug Ineffective For Unapproved Indication 52 0.6 0.6 no signal
445 Therapy Partial Responder 14 0.6 0.6 no signal
446 Bronchitis 69 0.6 0.6 no signal
447 Hysterectomy 8 0.6 0.6 no signal
448 Knee Operation 9 0.6 0.6 no signal
449 Carpal Tunnel Syndrome 13 0.6 0.6 no signal
450 Breast Tenderness 7 0.6 0.6 no signal
451 Hiatus Hernia 12 0.6 0.6 no signal
452 Muscular Weakness 105 0.6 0.6 no signal
453 Seasonal Allergy 13 0.6 0.6 no signal
454 Asthenopia 5 0.6 0.6 no signal
455 Nausea 724 0.6 0.6 no signal
456 Abasia 23 0.6 0.6 no signal
457 Pruritus Generalised 20 0.6 0.6 no signal
458 Economic Problem 14 0.6 0.6 no signal
459 Hypophagia 23 0.6 0.6 no signal
460 Dysgraphia 6 0.6 0.6 no signal
461 Paralysis 13 0.6 0.6 no signal
462 Cardio-respiratory Arrest 38 0.6 0.6 no signal
463 Blood Creatinine Increased 59 0.6 0.6 no signal
464 Acute Kidney Injury 137 0.6 0.6 no signal
465 Pharyngeal Oedema 14 0.6 0.6 no signal
466 Speech Disorder 47 0.6 0.6 no signal
467 Nerve Injury 10 0.6 0.6 no signal
468 Skin Infection 10 0.6 0.6 no signal
469 Intentional Drug Misuse 19 0.6 0.6 no signal
470 Throat Irritation 40 0.6 0.6 no signal
471 Pulmonary Oedema 40 0.6 0.6 no signal
472 Breast Mass 6 0.6 0.6 no signal
473 Liver Function Test Increased 19 0.6 0.6 no signal
474 Postoperative Wound Infection 6 0.6 0.6 no signal
475 Joint Injury 19 0.6 0.6 no signal
476 Ill-defined Disorder 54 0.6 0.6 no signal
477 Inappropriate Schedule Of Drug Administration 64 0.6 0.6 no signal
478 Lethargy 51 0.6 0.6 no signal
479 Sleep Disorder 62 0.6 0.6 no signal
480 Respiratory Tract Infection 23 0.6 0.6 no signal
481 Angiopathy 5 0.6 0.6 no signal
482 Drug Intolerance 85 0.6 0.6 no signal
483 Scab 10 0.6 0.6 no signal
484 Palpitations 103 0.6 0.6 no signal
485 Syncope 88 0.6 0.6 no signal
486 Heart Rate Increased 87 0.6 0.6 no signal
487 Exostosis 8 0.6 0.6 no signal
488 Rheumatoid Arthritis 99 0.6 0.6 no signal
489 Dystonia 17 0.6 0.5 no signal
490 Osteoarthritis 37 0.5 0.5 no signal
491 Electrolyte Imbalance 10 0.5 0.5 no signal
492 Autoimmune Hepatitis 6 0.5 0.5 no signal
493 Treatment Noncompliance 47 0.5 0.5 no signal
494 Nightmare 30 0.5 0.5 no signal
495 Feeling Cold 24 0.5 0.5 no signal
496 Orthostatic Hypotension 15 0.5 0.5 no signal
497 Bradykinesia 5 0.5 0.5 no signal
498 Hepatic Encephalopathy 8 0.5 0.5 no signal
499 Tubulointerstitial Nephritis 16 0.5 0.5 no signal
500 Spinal Pain 10 0.5 0.5 no signal
501 Stevens-johnson Syndrome 19 0.5 0.5 no signal
502 Vertigo 52 0.5 0.5 no signal
503 Spinal Fracture 17 0.5 0.5 no signal
504 Renal Failure 114 0.5 0.5 no signal
505 Chills 100 0.5 0.5 no signal
506 Product Supply Issue 6 0.5 0.5 no signal
507 Intentional Product Use Issue 74 0.5 0.5 no signal
508 Nasal Congestion 49 0.5 0.5 no signal
509 Hyponatraemia 47 0.5 0.5 no signal
510 Autoimmune Disorder 8 0.5 0.5 no signal
511 Drug Administration Error 26 0.5 0.5 no signal
512 Gastric Disorder 29 0.5 0.5 no signal
513 Nephrolithiasis 38 0.5 0.5 no signal
514 Adverse Reaction 11 0.5 0.5 no signal
515 Vomiting 388 0.5 0.5 no signal
516 Dizziness 411 0.5 0.5 no signal
517 Chronic Obstructive Pulmonary Disease 43 0.5 0.5 no signal
518 Intentional Underdose 6 0.5 0.5 no signal
519 Dysstasia 24 0.5 0.5 no signal
520 Product Use In Unapproved Indication 200 0.5 0.5 no signal
521 Hypertension 173 0.5 0.5 no signal
522 Knee Arthroplasty 17 0.5 0.5 no signal
523 Irritability 49 0.5 0.5 no signal
524 Urinary Incontinence 24 0.5 0.5 no signal
525 Blood Glucose Decreased 39 0.5 0.5 no signal
526 Tooth Disorder 18 0.5 0.5 no signal
527 Pharyngitis 10 0.5 0.5 no signal
528 Swollen Tongue 25 0.5 0.5 no signal
529 Brain Injury 8 0.5 0.5 no signal
530 Parosmia 6 0.5 0.5 no signal
531 Contraindicated Product Administered 24 0.5 0.5 no signal
532 Status Epilepticus 9 0.5 0.5 no signal
533 Generalised Tonic-clonic Seizure 13 0.5 0.5 no signal
534 Application Site Pruritus 18 0.5 0.5 no signal
535 Dermatitis Contact 9 0.5 0.5 no signal
536 Muscle Spasms 145 0.5 0.5 no signal
537 Blood Pressure Increased 121 0.5 0.5 no signal
538 Hypotension 158 0.5 0.5 no signal
539 Hypothermia 8 0.5 0.5 no signal
540 Thirst 14 0.5 0.5 no signal
541 Initial Insomnia 8 0.5 0.5 no signal
542 Dry Eye 38 0.5 0.5 no signal
543 Acidosis 6 0.5 0.5 no signal
544 Acute Respiratory Failure 15 0.5 0.5 no signal
545 Subarachnoid Haemorrhage 8 0.5 0.5 no signal
546 Drug Ineffective 1,024 0.5 0.5 no signal
547 Wrong Drug Administered 7 0.5 0.5 no signal
548 Gastrooesophageal Reflux Disease 62 0.5 0.5 no signal
549 Mood Altered 21 0.5 0.5 no signal
550 Pallor 21 0.5 0.5 no signal
551 Hypoaesthesia 115 0.5 0.5 no signal
552 Alanine Aminotransferase Increased 47 0.5 0.5 no signal
553 Brain Neoplasm 7 0.5 0.5 no signal
554 Asthma 85 0.5 0.5 no signal
555 Metabolic Acidosis 24 0.5 0.5 no signal
556 Cholecystitis 9 0.5 0.5 no signal
557 Hypokinesia 11 0.5 0.5 no signal
558 Musculoskeletal Discomfort 13 0.5 0.5 no signal
559 Gastroenteritis 11 0.5 0.5 no signal
560 Gingival Pain 6 0.5 0.5 no signal
561 Feeding Disorder 15 0.5 0.5 no signal
562 Decreased Appetite 174 0.5 0.5 no signal
563 Infection 108 0.5 0.5 no signal
564 Cardiac Arrest 62 0.5 0.5 no signal
565 Poor Quality Sleep 16 0.5 0.5 no signal
566 Decreased Activity 8 0.5 0.5 no signal
567 Weight Decreased 208 0.5 0.5 no signal
568 Sensory Disturbance 12 0.5 0.5 no signal
569 Colitis Ischaemic 5 0.5 0.5 no signal
570 Product Taste Abnormal 10 0.5 0.5 no signal
571 Obsessive-compulsive Disorder 6 0.5 0.5 no signal
572 Nocturia 9 0.5 0.5 no signal
573 Sensory Loss 6 0.5 0.5 no signal
574 Metastases To Liver 13 0.5 0.5 no signal
575 Throat Tightness 20 0.5 0.5 no signal
576 Post Procedural Infection 6 0.5 0.5 no signal
577 Chest Pain 137 0.5 0.5 no signal
578 Head Discomfort 13 0.5 0.5 no signal
579 Fear 20 0.5 0.5 no signal
580 Loss Of Personal Independence In Daily Activities 35 0.5 0.5 no signal
581 Small Intestinal Obstruction 9 0.5 0.5 no signal
582 Product Adhesion Issue 26 0.5 0.5 no signal
583 Haemorrhage Intracranial 11 0.5 0.5 no signal
584 Musculoskeletal Stiffness 64 0.5 0.5 no signal
585 Tendon Rupture 9 0.5 0.5 no signal
586 Memory Impairment 100 0.5 0.5 no signal
587 Asthenia 273 0.5 0.5 no signal
588 Muscle Spasticity 9 0.5 0.5 no signal
589 Dental Caries 8 0.5 0.5 no signal
590 Blood Testosterone Decreased 5 0.5 0.5 no signal
591 Application Site Irritation 9 0.5 0.5 no signal
592 Injury 51 0.5 0.5 no signal
593 Ear Infection 19 0.5 0.5 no signal
594 Blood Pressure Systolic Increased 14 0.4 0.4 no signal
595 Coma 34 0.4 0.4 no signal
596 Discomfort 43 0.4 0.4 no signal
597 Myocarditis 8 0.4 0.4 no signal
598 Sinus Disorder 14 0.4 0.4 no signal
599 Micturition Urgency 8 0.4 0.4 no signal
600 Bladder Disorder 7 0.4 0.4 no signal
601 Skin Ulcer 18 0.4 0.4 no signal
602 Hepatic Cirrhosis 13 0.4 0.4 no signal
603 Arrhythmia 33 0.4 0.4 no signal
604 Hypothyroidism 22 0.4 0.4 no signal
605 Cardiac Murmur 6 0.4 0.4 no signal
606 Obesity 11 0.4 0.4 no signal
607 Apathy 10 0.4 0.4 no signal
608 Gait Disturbance 132 0.4 0.4 no signal
609 Grip Strength Decreased 6 0.4 0.4 no signal
610 Malaise 301 0.4 0.4 no signal
611 Body Temperature Increased 14 0.4 0.4 no signal
612 Cytokine Release Syndrome 13 0.4 0.4 no signal
613 Sinusitis 70 0.4 0.4 no signal
614 Blood Iron Decreased 8 0.4 0.4 no signal
615 Sars-cov-2 Test Positive 9 0.4 0.4 no signal
616 Joint Range Of Motion Decreased 9 0.4 0.4 no signal
617 Insurance Issue 10 0.4 0.4 no signal
618 Gastrointestinal Infection 6 0.4 0.4 no signal
619 Ataxia 8 0.4 0.4 no signal
620 Loss Of Libido 6 0.4 0.4 no signal
621 Joint Dislocation 7 0.4 0.4 no signal
622 Blood Potassium Decreased 20 0.4 0.4 no signal
623 Tachypnoea 9 0.4 0.4 no signal
624 Leukocytosis 12 0.4 0.4 no signal
625 Arthropathy 37 0.4 0.4 no signal
626 Kidney Infection 13 0.4 0.4 no signal
627 Musculoskeletal Pain 35 0.4 0.4 no signal
628 Headache 412 0.4 0.4 no signal
629 Abdominal Pain Upper 135 0.4 0.4 no signal
630 Cystitis 21 0.4 0.4 no signal
631 Irritable Bowel Syndrome 14 0.4 0.4 no signal
632 Drug Administered At Inappropriate Site 7 0.4 0.4 no signal
633 Cerebral Infarction 16 0.4 0.4 no signal
634 Application Site Rash 9 0.4 0.4 no signal
635 Prescribed Underdose 13 0.4 0.4 no signal
636 Urosepsis 6 0.4 0.4 no signal
637 Generalised Oedema 8 0.4 0.4 no signal
638 Face Oedema 11 0.4 0.4 no signal
639 Thyroid Disorder 10 0.4 0.4 no signal
640 Skin Laceration 7 0.4 0.4 no signal
641 Anger 22 0.4 0.4 no signal
642 Pharyngitis Streptococcal 7 0.4 0.4 no signal
643 Erythema Multiforme 6 0.4 0.4 no signal
644 Tooth Extraction 8 0.4 0.4 no signal
645 Leukopenia 32 0.4 0.4 no signal
646 Scar 11 0.4 0.4 no signal
647 Pneumonia 207 0.4 0.4 no signal
648 Gastrointestinal Pain 7 0.4 0.4 no signal
649 Nervous System Disorder 20 0.4 0.4 no signal
650 Dyspnoea 361 0.4 0.4 no signal
651 Convulsion 37 0.4 0.4 no signal
652 Weight Increased 142 0.4 0.4 no signal
653 Squamous Cell Carcinoma 6 0.4 0.4 no signal
654 Infusion Related Reaction 42 0.4 0.4 no signal
655 General Physical Health Deterioration 73 0.4 0.4 no signal
656 Feeling Hot 39 0.4 0.4 no signal
657 Staphylococcal Infection 21 0.4 0.4 no signal
658 Gastric Ulcer 12 0.4 0.4 no signal
659 Hyperkalaemia 22 0.4 0.4 no signal
660 Vision Blurred 86 0.4 0.4 no signal
661 Bronchospasm 9 0.4 0.4 no signal
662 Supraventricular Tachycardia 6 0.4 0.4 no signal
663 Mood Swings 20 0.4 0.4 no signal
664 Subdural Haematoma 9 0.4 0.4 no signal
665 Product Availability Issue 14 0.4 0.4 no signal
666 Hernia 12 0.4 0.4 no signal
667 Therapy Change 6 0.4 0.4 no signal
668 Diabetes Mellitus Inadequate Control 11 0.4 0.4 no signal
669 Localised Infection 15 0.4 0.4 no signal
670 Oral Herpes 12 0.4 0.4 no signal
671 Cholecystectomy 7 0.4 0.4 no signal
672 Gallbladder Disorder 11 0.4 0.4 no signal
673 Emotional Disorder 19 0.4 0.4 no signal
674 Urinary Tract Infection 104 0.4 0.4 no signal
675 Coeliac Disease 6 0.4 0.4 no signal
676 Hot Flush 46 0.4 0.4 no signal
677 Pain In Extremity 180 0.4 0.4 no signal
678 Immune System Disorder 8 0.4 0.4 no signal
679 Therapy Non-responder 27 0.4 0.4 no signal
680 Pulmonary Mass 9 0.4 0.4 no signal
681 Pneumocystis Jirovecii Pneumonia 6 0.4 0.4 no signal
682 Hunger 8 0.4 0.4 no signal
683 Anaemia 113 0.4 0.4 no signal
684 Productive Cough 28 0.4 0.4 no signal
685 Sinus Congestion 8 0.4 0.4 no signal
686 Ear Discomfort 6 0.4 0.4 no signal
687 Blood Sodium Decreased 11 0.4 0.4 no signal
688 Nasopharyngitis 108 0.4 0.4 no signal
689 Fracture 11 0.4 0.4 no signal
690 Blood Magnesium Decreased 5 0.4 0.4 no signal
691 Dermatitis 12 0.4 0.4 no signal
692 Fatigue 448 0.4 0.4 no signal
693 Weight Fluctuation 6 0.4 0.4 no signal
694 Blood Pressure Decreased 38 0.4 0.4 no signal
695 Condition Aggravated 173 0.4 0.4 no signal
696 Contusion 55 0.4 0.4 no signal
697 Stress 41 0.4 0.4 no signal
698 Therapy Cessation 29 0.4 0.4 no signal
699 Local Swelling 10 0.4 0.4 no signal
700 Inflammation 29 0.4 0.4 no signal
701 Cyst 7 0.4 0.4 no signal
702 Hepatic Failure 17 0.4 0.4 no signal
703 Peripheral Swelling 86 0.4 0.4 no signal
704 Colitis 21 0.4 0.4 no signal
705 Impaired Quality Of Life 8 0.3 0.3 no signal
706 Arthralgia 230 0.3 0.3 no signal
707 Gastrointestinal Disorder 49 0.3 0.3 no signal
708 Toothache 10 0.3 0.3 no signal
709 Pollakiuria 23 0.3 0.3 no signal
710 Deep Vein Thrombosis 36 0.3 0.3 no signal
711 Pelvic Pain 10 0.3 0.3 no signal
712 Upper Limb Fracture 11 0.3 0.3 no signal
713 Limb Discomfort 17 0.3 0.3 no signal
714 Hepatitis 14 0.3 0.3 no signal
715 Abdominal Pain 127 0.3 0.3 no signal
716 Stomatitis 33 0.3 0.3 no signal
717 Gait Inability 18 0.3 0.3 no signal
718 Diabetic Ketoacidosis 13 0.3 0.3 no signal
719 Increased Tendency To Bruise 5 0.3 0.3 no signal
720 Lip Swelling 18 0.3 0.3 no signal
721 Gamma-glutamyltransferase Increased 12 0.3 0.3 no signal
722 Chest Discomfort 55 0.3 0.3 no signal
723 Product Packaging Issue 5 0.3 0.3 no signal
724 Oral Candidiasis 7 0.3 0.3 no signal
725 Pancreatitis Acute 12 0.3 0.3 no signal
726 Sneezing 12 0.3 0.3 no signal
727 Personality Change 5 0.3 0.3 no signal
728 Respiratory Failure 39 0.3 0.3 no signal
729 Grand Mal Convulsion 5 0.3 0.3 no signal
730 Renal Injury 16 0.3 0.3 no signal
731 Septic Shock 23 0.3 0.3 no signal
732 Circulatory Collapse 9 0.3 0.3 no signal
733 Adverse Drug Reaction 47 0.3 0.3 no signal
734 Dehydration 70 0.3 0.3 no signal
735 Swelling 49 0.3 0.3 no signal
736 Myocardial Ischaemia 6 0.3 0.3 no signal
737 Urticaria 87 0.3 0.3 no signal
738 Diabetes Mellitus 40 0.3 0.3 no signal
739 Skin Discolouration 24 0.3 0.3 no signal
740 Dizziness Postural 5 0.3 0.3 no signal
741 Dyspepsia 51 0.3 0.3 no signal
742 Pruritus 196 0.3 0.3 no signal
743 Therapeutic Product Effect Decreased 23 0.3 0.3 no signal
744 Affect Lability 5 0.3 0.3 no signal
745 Mobility Decreased 37 0.3 0.3 no signal
746 Sinus Bradycardia 5 0.3 0.3 no signal
747 Oedema Peripheral 63 0.3 0.3 no signal
748 Skin Lesion 14 0.3 0.3 no signal
749 Eye Swelling 19 0.3 0.3 no signal
750 Sexual Dysfunction 6 0.3 0.3 no signal
751 Blood Creatine Phosphokinase Increased 15 0.3 0.3 no signal
752 Abdominal Pain Lower 13 0.3 0.3 no signal
753 Influenza 57 0.3 0.3 no signal
754 Respiratory Distress 14 0.3 0.3 no signal
755 Acute Myocardial Infarction 15 0.3 0.3 no signal
756 Wrong Technique In Product Usage Process 102 0.3 0.3 no signal
757 Foetal Exposure During Pregnancy 41 0.3 0.3 no signal
758 Sciatica 8 0.3 0.3 no signal
759 Atrial Fibrillation 49 0.3 0.3 no signal
760 Emotional Distress 61 0.3 0.3 no signal
761 Muscle Rigidity 6 0.3 0.3 no signal
762 Renal Impairment 42 0.3 0.3 no signal
763 Hypersensitivity 93 0.3 0.3 no signal
764 Hypokalaemia 23 0.3 0.3 no signal
765 Gout 9 0.3 0.3 no signal
766 Cardiac Disorder 47 0.3 0.3 no signal
767 Pyrexia 173 0.3 0.3 no signal
768 Diarrhoea 321 0.3 0.3 no signal
769 Hypotonia 5 0.3 0.3 no signal
770 Hip Fracture 16 0.3 0.3 no signal
771 Skin Reaction 7 0.3 0.3 no signal
772 Movement Disorder 16 0.3 0.3 no signal
773 Flatulence 28 0.3 0.3 no signal
774 Schizophrenia 6 0.3 0.3 no signal
775 Blood Potassium Increased 8 0.3 0.3 no signal
776 Anhedonia 13 0.3 0.3 no signal
777 Abdominal Distension 51 0.3 0.3 no signal
778 Eye Discharge 5 0.3 0.3 no signal
779 Hepatic Function Abnormal 18 0.3 0.3 no signal
780 No Therapeutic Response 6 0.3 0.3 no signal
781 Bacterial Infection 9 0.3 0.3 no signal
782 Poor Venous Access 5 0.3 0.3 no signal
783 Hepatic Steatosis 9 0.3 0.3 no signal
784 Heart Rate Decreased 17 0.3 0.3 no signal
785 Skin Disorder 16 0.3 0.3 no signal
786 Fungal Infection 16 0.3 0.3 no signal
787 Visual Impairment 59 0.3 0.3 no signal
788 Paraesthesia 75 0.3 0.3 no signal
789 Pancreatitis 25 0.3 0.3 no signal
790 Pulmonary Embolism 45 0.3 0.3 no signal
791 Aspartate Aminotransferase Increased 25 0.3 0.3 no signal
792 Myalgia 80 0.3 0.3 no signal
793 Procedural Pain 13 0.3 0.3 no signal
794 Neutrophil Count Decreased 19 0.3 0.3 no signal
795 Incorrect Route Of Drug Administration 17 0.3 0.3 no signal
796 Febrile Neutropenia 31 0.3 0.3 no signal
797 Hyperglycaemia 17 0.3 0.3 no signal
798 Drug Resistance 12 0.3 0.3 no signal
799 Product Use Issue 87 0.3 0.3 no signal
800 Neoplasm Malignant 31 0.3 0.3 no signal
801 Rectal Haemorrhage 20 0.3 0.3 no signal
802 Rash Pruritic 25 0.3 0.3 no signal
803 Clostridium Difficile Infection 10 0.3 0.3 no signal
804 Flushing 47 0.3 0.3 no signal
805 Influenza Like Illness 38 0.3 0.3 no signal
806 Dysgeusia 34 0.3 0.3 no signal
807 Liver Injury 11 0.3 0.3 no signal
808 Oropharyngeal Pain 42 0.3 0.3 no signal
809 Pulmonary Congestion 6 0.3 0.3 no signal
810 Musculoskeletal Chest Pain 7 0.3 0.3 no signal
811 Rash Maculo-papular 10 0.3 0.3 no signal
812 Viral Infection 15 0.3 0.3 no signal
813 Rhinorrhoea 29 0.3 0.3 no signal
814 Eye Haemorrhage 6 0.3 0.3 no signal
815 Basal Cell Carcinoma 7 0.3 0.3 no signal
816 Ischaemic Stroke 8 0.3 0.3 no signal
817 Blister 25 0.3 0.3 no signal
818 Electrocardiogram Qt Prolonged 16 0.3 0.3 no signal
819 Blood Calcium Decreased 5 0.3 0.3 no signal
820 Transient Ischaemic Attack 15 0.3 0.3 no signal
821 Blindness 18 0.3 0.3 no signal
822 Therapeutic Response Shortened 14 0.3 0.3 no signal
823 Blood Lactate Dehydrogenase Increased 7 0.3 0.3 no signal
824 Cough 122 0.3 0.3 no signal
825 Coronary Artery Occlusion 6 0.3 0.3 no signal
826 Night Sweats 14 0.3 0.3 no signal
827 Diverticulitis 12 0.3 0.3 no signal
828 Multiple Sclerosis Relapse 30 0.3 0.3 no signal
829 Central Nervous System Lesion 6 0.3 0.3 no signal
830 Hospitalisation 66 0.3 0.3 no signal
831 Gastric Haemorrhage 5 0.3 0.3 no signal
832 Device Occlusion 6 0.3 0.3 no signal
833 Oral Discomfort 6 0.3 0.3 no signal
834 Tooth Loss 9 0.3 0.3 no signal
835 Angioedema 19 0.3 0.3 no signal
836 Photophobia 8 0.3 0.3 no signal
837 Illness 43 0.3 0.3 no signal
838 Dysphonia 25 0.3 0.3 no signal
839 Mouth Ulceration 9 0.3 0.3 no signal
840 Erectile Dysfunction 11 0.3 0.3 no signal
841 Lymphopenia 6 0.3 0.3 no signal
842 Drug Effect Less Than Expected 6 0.3 0.3 no signal
843 Oedema 23 0.3 0.3 no signal
844 Proteinuria 8 0.3 0.3 no signal
845 Diplopia 11 0.3 0.3 no signal
846 Sepsis 47 0.3 0.3 no signal
847 Laceration 4 0.3 0.3 no signal
848 Cholestasis 8 0.3 0.3 no signal
849 Paraesthesia Oral 6 0.3 0.3 no signal
850 Wrist Fracture 5 0.3 0.3 no signal
851 Herpes Zoster 24 0.3 0.3 no signal
852 Swelling Face 27 0.3 0.3 no signal
853 Joint Swelling 50 0.3 0.3 no signal
854 Ear Pain 8 0.3 0.3 no signal
855 Bone Density Decreased 13 0.3 0.3 no signal
856 Liver Function Test Abnormal 12 0.3 0.3 no signal
857 Decreased Immune Responsiveness 4 0.3 0.3 no signal
858 Bone Pain 24 0.3 0.3 no signal
859 Melaena 9 0.3 0.3 no signal
860 Transaminases Increased 9 0.3 0.3 no signal
861 Glossodynia 9 0.3 0.3 no signal
862 Alopecia 79 0.3 0.3 no signal
863 Product Administration Error 8 0.3 0.3 no signal
864 Rash Papular 9 0.3 0.3 no signal
865 Oral Pain 9 0.3 0.3 no signal
866 Cerebrovascular Accident 68 0.3 0.3 no signal
867 Ageusia 10 0.3 0.3 no signal
868 Hypoaesthesia Oral 6 0.3 0.3 no signal
869 Cardiac Failure 32 0.3 0.2 no signal
870 Ovarian Cyst 4 0.3 0.3 no signal
871 Premature Baby 12 0.3 0.2 no signal
872 Brain Oedema 5 0.2 0.2 no signal
873 Dementia 11 0.2 0.2 no signal
874 Cardiac Failure Congestive 32 0.2 0.2 no signal
875 Multiple Organ Dysfunction Syndrome 11 0.2 0.2 no signal
876 Metastases To Central Nervous System 5 0.2 0.2 no signal
877 Osteomyelitis 7 0.2 0.2 no signal
878 Gastroenteritis Viral 7 0.2 0.2 no signal
879 Product Odour Abnormal 4 0.2 0.2 no signal
880 Liver Disorder 17 0.2 0.2 no signal
881 Angina Pectoris 11 0.2 0.2 no signal
882 Colitis Ulcerative 17 0.2 0.2 no signal
883 Bone Disorder 7 0.2 0.2 no signal
884 Hereditary Angioedema 4 0.2 0.2 no signal
885 Off Label Use 327 0.2 0.2 no signal
886 Cellulitis 19 0.2 0.2 no signal
887 Bradycardia 20 0.2 0.2 no signal
888 Abscess 6 0.2 0.2 no signal
889 Ascites 11 0.2 0.2 no signal
890 Rash Macular 13 0.2 0.2 no signal
891 Interstitial Lung Disease 18 0.2 0.2 no signal
892 Product Dose Omission Issue 105 0.2 0.2 no signal
893 Gastrointestinal Haemorrhage 31 0.2 0.2 no signal
894 Upper Respiratory Tract Infection 17 0.2 0.2 no signal
895 Lacrimation Increased 11 0.2 0.2 no signal
896 Acute Hepatic Failure 5 0.2 0.2 no signal
897 Lymphadenopathy 13 0.2 0.2 no signal
898 Akathisia 5 0.2 0.2 no signal
899 Abdominal Discomfort 61 0.2 0.2 no signal
900 Coagulopathy 6 0.2 0.2 no signal
901 Wound 10 0.2 0.2 no signal
902 Nephropathy Toxic 4 0.2 0.2 no signal
903 Aphonia 5 0.2 0.2 no signal
904 Visual Acuity Reduced 12 0.2 0.2 no signal
905 Rash 155 0.2 0.2 no signal
906 Drug-induced Liver Injury 11 0.2 0.2 no signal
907 Hepatic Enzyme Increased 24 0.2 0.2 no signal
908 Rebound Effect 4 0.2 0.2 no signal
909 Heart Rate Irregular 8 0.2 0.2 no signal
910 Cardiovascular Disorder 9 0.2 0.2 no signal
911 Incorrect Drug Administration Duration 10 0.2 0.2 no signal
912 Haematuria 12 0.2 0.2 no signal
913 Platelet Count Decreased 37 0.2 0.2 no signal
914 Product Prescribing Issue 7 0.2 0.2 no signal
915 Palmar-plantar Erythrodysaesthesia Syndrome 8 0.2 0.2 no signal
916 Treatment Failure 28 0.2 0.2 no signal
917 White Blood Cell Count Decreased 37 0.2 0.2 no signal
918 Rhabdomyolysis 14 0.2 0.2 no signal
919 Colon Cancer 5 0.2 0.2 no signal
920 Pulmonary Hypertension 7 0.2 0.2 no signal
921 Vaginal Haemorrhage 14 0.2 0.2 no signal
922 Blood Thyroid Stimulating Hormone Increased 3 0.2 0.2 no signal
923 Agranulocytosis 6 0.2 0.2 no signal
924 Blood Glucose Abnormal 6 0.2 0.2 no signal
925 Psoriatic Arthropathy 13 0.2 0.2 no signal
926 Libido Decreased 4 0.2 0.2 no signal
927 Thrombosis 26 0.2 0.2 no signal
928 Femur Fracture 10 0.2 0.2 no signal
929 Blood Cholesterol Increased 15 0.2 0.2 no signal
930 Wheezing 19 0.2 0.2 no signal
931 Eye Inflammation 3 0.2 0.2 no signal
932 Hair Colour Changes 4 0.2 0.2 no signal
933 Disease Progression 37 0.2 0.2 no signal
934 International Normalised Ratio Increased 9 0.2 0.2 no signal
935 Covid-19 55 0.2 0.2 no signal
936 Chromaturia 7 0.2 0.2 no signal
937 Choking 6 0.2 0.2 no signal
938 Laboratory Test Abnormal 9 0.2 0.2 no signal
939 Inflammatory Bowel Disease 3 0.2 0.2 no signal
940 Rash Generalised 8 0.2 0.2 no signal
941 Mania 5 0.2 0.2 no signal
942 Complication Associated With Device 4 0.2 0.2 no signal
943 Multiple Fractures 5 0.2 0.2 no signal
944 Haematocrit Decreased 6 0.2 0.2 no signal
945 Candida Infection 5 0.2 0.2 no signal
946 Malignant Melanoma 4 0.2 0.2 no signal
947 Product Dose Omission In Error 8 0.2 0.2 no signal
948 Frequent Bowel Movements 8 0.2 0.2 no signal
949 Hair Texture Abnormal 4 0.2 0.2 no signal
950 Jaundice 8 0.2 0.2 no signal
951 Uveitis 4 0.2 0.2 no signal
952 Pneumonitis 8 0.2 0.2 no signal
953 Prostate Cancer 24 0.2 0.2 no signal
954 Neutropenia 40 0.2 0.2 no signal
955 Fluid Retention 15 0.2 0.2 no signal
956 Inappropriate Schedule Of Product Administration 52 0.2 0.2 no signal
957 Prostatic Specific Antigen Increased 4 0.2 0.2 no signal
958 Tardive Dyskinesia 8 0.2 0.2 no signal
959 Hypoacusis 12 0.2 0.2 no signal
960 Pleural Effusion 17 0.2 0.2 no signal
961 Faeces Discoloured 6 0.2 0.2 no signal
962 Therapy Interrupted 19 0.2 0.2 no signal
963 Accidental Exposure To Product 27 0.2 0.2 no signal
964 Deafness 7 0.2 0.2 no signal
965 Lung Neoplasm Malignant 11 0.2 0.2 no signal
966 Device Failure 4 0.2 0.2 no signal
967 Shock 6 0.2 0.2 no signal
968 Blood Urine Present 5 0.2 0.2 no signal
969 Myocardial Infarction 46 0.2 0.2 no signal
970 Blood Count Abnormal 4 0.2 0.2 no signal
971 Renal Disorder 12 0.2 0.2 no signal
972 Madarosis 3 0.2 0.2 no signal
973 Rash Erythematous 12 0.2 0.2 no signal
974 Intentional Dose Omission 7 0.2 0.2 no signal
975 Systemic Lupus Erythematosus 9 0.2 0.2 no signal
976 Haematochezia 14 0.2 0.2 no signal
977 Eye Pain 14 0.2 0.2 no signal
978 Erythema 52 0.2 0.2 no signal
979 Sickle Cell Anaemia With Crisis 4 0.2 0.2 no signal
980 Neuroleptic Malignant Syndrome 3 0.2 0.2 no signal
981 Pancytopenia 14 0.2 0.2 no signal
982 Menorrhagia 5 0.2 0.2 no signal
983 Premature Delivery 4 0.2 0.2 no signal
984 Thyroid Cancer 3 0.2 0.2 no signal
985 Underdose 18 0.2 0.2 no signal
986 Impaired Healing 8 0.2 0.2 no signal
987 Product Substitution Issue 14 0.2 0.2 no signal
988 Product Preparation Error 5 0.2 0.2 no signal
989 Injection Site Extravasation 3 0.2 0.2 no signal
990 Epistaxis 18 0.2 0.2 no signal
991 Cataract 14 0.1 0.1 no signal
992 Drug Reaction With Eosinophilia And Systemic Symptoms 6 0.1 0.1 no signal
993 Anaphylactic Shock 6 0.1 0.1 no signal
994 Plasma Cell Myeloma 9 0.1 0.1 no signal
995 Extra Dose Administered 9 0.1 0.1 no signal
996 Incorrect Product Storage 3 0.1 0.1 no signal
997 Haemoglobin Decreased 23 0.1 0.1 no signal
998 Pain Of Skin 6 0.1 0.1 no signal
999 Haemorrhage 23 0.1 0.1 no signal
1000 Ocular Hyperaemia 10 0.1 0.1 no signal
1001 Pain In Jaw 6 0.1 0.1 no signal
1002 Osteonecrosis 7 0.1 0.1 no signal
1003 Thrombocytopenia 23 0.1 0.1 no signal
1004 Injection Site Urticaria 5 0.1 0.1 no signal
1005 Myelosuppression 7 0.1 0.1 no signal
1006 Lung Disorder 10 0.1 0.1 no signal
1007 Maternal Exposure During Pregnancy 18 0.1 0.1 no signal
1008 Lower Respiratory Tract Infection 9 0.1 0.1 no signal
1009 Incorrect Dose Administered 44 0.1 0.1 no signal
1010 Injection Site Warmth 4 0.1 0.1 no signal
1011 Blood Glucose Increased 36 0.1 0.1 no signal
1012 Renal Failure Acute 8 0.1 0.1 no signal
1013 Device Dislocation 8 0.1 0.1 no signal
1014 Eye Disorder 6 0.1 0.1 no signal
1015 Expired Product Administered 6 0.1 0.1 no signal
1016 No Adverse Event 32 0.1 0.1 no signal
1017 Circumstance Or Information Capable Of Leading To Medication Error 6 0.1 0.1 no signal
1018 Abortion Spontaneous 7 0.1 0.1 no signal
1019 Cerebral Haemorrhage 6 0.1 0.1 no signal
1020 Product Administered At Inappropriate Site 3 0.1 0.1 no signal
1021 Injection Site Rash 5 0.1 0.1 no signal
1022 Psoriasis 21 0.1 0.1 no signal
1023 Dyspnoea Exertional 6 0.1 0.1 no signal
1024 Breast Cancer 15 0.1 0.1 no signal
1025 Acne 12 0.1 0.1 no signal
1026 Skin Irritation 7 0.1 0.1 no signal
1027 Injection Site Bruising 12 0.1 0.1 no signal
1028 Skin Exfoliation 12 0.1 0.1 no signal
1029 Eczema 7 0.1 0.1 no signal
1030 Pancreatic Carcinoma 4 0.1 0.1 no signal
1031 Device Issue 12 0.1 0.1 no signal
1032 Device Malfunction 9 0.1 0.1 no signal
1033 Injection Site Pain 40 0.1 0.1 no signal
1034 Product Storage Error 11 0.1 0.1 no signal
1035 Eye Irritation 7 0.1 0.1 no signal
1036 Dermatitis Atopic 6 0.1 0.1 no signal
1037 Extrapyramidal Disorder 3 0.1 0.1 no signal
1038 Gastric Cancer 3 0.1 0.1 no signal
1039 Injection Site Reaction 8 0.1 0.1 no signal
1040 Dry Skin 15 0.1 0.1 no signal
1041 Injection Site Haemorrhage 8 0.1 0.1 no signal
1042 Oesophageal Carcinoma 3 0.1 0.1 no signal
1043 Device Leakage 4 0.1 0.1 no signal
1044 Skin Burning Sensation 6 0.1 0.1 no signal
1045 Injection Site Swelling 6 0.0 0.0 no signal
1046 Injection Site Erythema 9 0.0 0.0 no signal