Reaction
Breakthrough Pain reporting signals
As of the last recalculation, Breakthrough Pain appears in 2,300 FAERS reports alongside 27 co-occurring drug terms. The strongest observed disproportionality signal is BUPRENORPHINE (PRR 32.2).
Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.
| Drug | Co-reports | PRR | ROR |
|---|---|---|---|
| Buprenorphine | 289 | 32.2 | 32.3 |
| Tapentadol Hydrochloride | 52 | 14.4 | 14.4 |
| Carisoprodol | 29 | 13.9 | 13.9 |
| Bupivacaine | 14 | 13.6 | 13.7 |
| Fentanyl | 115 | 11.1 | 11.1 |
| Pegaspargase | 13 | 9.7 | 9.7 |
| Methocarbamol | 20 | 8.0 | 8.0 |
| Fentanyl Citrate | 15 | 7.6 | 7.6 |
| Methocarbamol Tablets | 14 | 7.6 | 7.6 |
| Tizanidine Hydrochloride | 13 | 6.5 | 6.5 |
| Methadone | 30 | 6.4 | 6.4 |
| Oxycodone Hydrochloride | 138 | 6.1 | 6.1 |
| Bicalutamide | 10 | 6.0 | 6.0 |
| Hydrocodone Bitartrate | 27 | 5.7 | 5.7 |
| Hydromorphone Hydrochloride | 56 | 5.6 | 5.6 |
| Tizanidine | 14 | 5.3 | 5.3 |
| Oxycodone | 98 | 4.9 | 4.9 |
| Buprenorphine Hydrochloride, Naloxone Hydrochloride | 13 | 4.9 | 4.9 |
| Oxycodone Hydrochloride And Acetaminophen | 51 | 4.8 | 4.8 |
| Morphine Sulfate | 56 | 4.3 | 4.3 |
| Canakinumab | 5 | 4.2 | 4.2 |
| Asfotase Alfa | 4 | 3.6 | 3.6 |
| Secukinumab | 60 | 3.4 | 3.4 |
| Hydrocodone Bitartrate And Acetaminophen | 18 | 2.9 | 2.9 |
| Fremanezumab-Vfrm | 3 | 2.4 | 2.4 |
| Enzalutamide | 13 | 2.0 | 2.0 |
| Galcanezumab-Gnlm | 4 | 1.1 | 1.1 |