Reaction

Complex Regional Pain Syndrome reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 1,468 reports · 35 co-occurring drugs

As of the last recalculation, Complex Regional Pain Syndrome appears in 1,468 FAERS reports alongside 35 co-occurring drug terms. The strongest observed disproportionality signal is RIZATRIPTAN BENZOATE (PRR 26.8).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Rizatriptan Benzoate	19	26.8	26.9
Losartan Potassium And Hydrochlorothiazide	12	14.8	14.8
Liothyronine Sodium	9	14.7	14.8
Sodium Oxybate	65	14.6	14.6
Tizanidine Hydrochloride	18	14.3	14.3
Carisoprodol	18	13.5	13.5
Bupivacaine	8	12.2	12.2
Butalbital, Acetaminophen, And Caffeine	9	12.0	12.0
Cyclobenzaprine Hydrochloride	7	11.1	11.1
Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, And Amphetamine Sulfate	27	11.0	11.0
Armodafinil	16	10.9	10.9
Thyroid, Porcine	8	10.7	10.7
Duloxetine Hydrochloride	128	10.5	10.5
Buspirone Hydrochloride	8	10.3	10.3
Modafinil	23	10.2	10.3
Dextroamphetamine Sulfate, Dextroamphetamine Saccharate, Amphetamine Sulfate And Amphetamine Aspartate	28	9.7	9.7
Topiramate	60	9.5	9.5
Trifluridine And Tipiracil	7	9.3	9.3
Lanreotide Acetate	5	9.1	9.1
Belimumab	18	8.1	8.2
Tapentadol Hydrochloride	19	8.1	8.1
Hydromorphone Hydrochloride	51	8.1	8.1
Morphine Sulfate	59	7.1	7.1
Calcium, Magnesium, Potassium, And Sodium Oxybates	4	6.6	6.6
Etonogestrel And Ethinyl Estradiol	10	6.4	6.4
Oxycodone Hydrochloride	88	6.0	6.0
Rimegepant Sulfate	5	5.6	5.6
Hydrocodone Bitartrate And Acetaminophen	22	5.6	5.6
Panitumumab	6	5.4	5.5
Eptinezumab-Jjmr	3	4.7	4.7
Medroxyprogesterone Acetate	14	4.0	4.0
Oxymorphone Hydrochloride	3	3.7	3.7
Hydrocodone Bitartrate	11	3.6	3.6
Esketamine Hydrochloride	3	2.4	2.4
Apremilast	18	1.8	1.8

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.